752 research outputs found
Performance Characterization of Image Feature Detectors in Relation to the Scene Content Utilizing a Large Image Database
Selecting the most suitable local invariant feature detector for a particular application has rendered the task of evaluating feature detectors a critical issue in vision research. Although the literature offers a variety of comparison works focusing on performance evaluation of image feature detectors under several types of image transformations, the influence of the scene content on the performance of local feature detectors has received little attention so far. This paper aims to bridge this gap with a new framework for determining the type of scenes which maximize and minimize the performance of detectors in terms of repeatability rate. The results are presented for several state-of-the-art feature detectors that have been obtained using a large image database of 20482 images under JPEG compression, uniform light and blur changes with 539 different scenes captured from real-world scenarios. These results provide new insights into the behavior of feature detectors
On the Microscopic Origin of Cholesteric Pitch
We present a microscopic analysis of the instability of the nematic phase to
chirality when molecular chirality is introduced perturbatively. We show that
previously neglected short-range biaxial correlations play a crucial role in
determining the cholesteric pitch. We propose an order parameter which
quantifies the chirality of a molecule.Comment: RevTeX 3.0, 4 pages, one included eps figure. Published versio
A new mechanism shapes the naïve CD8+ T cell repertoire: the selection for full diversity
During thymic T cell differentiation, TCR repertoires are shaped by negative, positive and agonist selection. In the thymus and in the periphery, repertoires are also shaped by strong inter-clonal and intra-clonal competition to survive death by neglect. Understanding the impact of these events on the T cell repertoire requires direct evaluation of TCR expression in peripheral naïve T cells. Several studies have evaluated TCR diversity, with contradictory results. Some of these studies had intrinsic technical limitations since they used material obtained from T cell pools, preventing the direct evaluation of clone sizes. Indeed with these approaches, identical TCRs may correspond to different cells expressing the same receptor, or to several amplicons from the same T cell. We here overcame this limitation by evaluating TCRB expression in individual naïve CD8+ T cells. Of the 2269 Tcrb sequences we obtained from 13 mice, 99% were unique. Mathematical analysis of this data showed that the average number of naïve peripheral CD8+ T cells expressing the same TCRB is 1.1 cell. Since TCRA co-expression studies could only increase repertoire diversity, these results reveal that the number of naïve T cells with unique TCRs approaches the number of naïve cells. Since thymocytes undergo multiple rounds of divisions after TCRB rearrangement; and 3–5% of thymocytes survive thymic selection events; the number of cells expressing the same TCRB was expected to be much higher. Thus, these results suggest a new repertoire selection mechanism, which strongly selects for full TCRB diversity
Kinetics of photoinduced ordering in azo-dye films: two-state and diffusion models
We study the kinetics of photoinduced ordering in the azo-dye SD1
photoaligning layers and present the results of modeling performed using two
different phenomenological approaches. A phenomenological two state model is
deduced from the master equation for an ensemble of two-level molecular
systems. Using an alternative approach, we formulate the two-dimensional (2D)
diffusion model as the free energy Fokker-Planck equation simplified for the
limiting regime of purely in-plane reorientation. The models are employed to
interpret the irradiation time dependence of the absorption order parameters
extracted from the available experimental data by using the exact solution to
the light transmission problem for a biaxially anisotropic absorbing layer. The
transient photoinduced structures are found to be biaxially anisotropic whereas
the photosteady and the initial states are uniaxial.Comment: revtex4, 34 pages, 9 figure
Mesoscopic organization reveals the constraints governing C. elegans nervous system
One of the biggest challenges in biology is to understand how activity at the
cellular level of neurons, as a result of their mutual interactions, leads to
the observed behavior of an organism responding to a variety of environmental
stimuli. Investigating the intermediate or mesoscopic level of organization in
the nervous system is a vital step towards understanding how the integration of
micro-level dynamics results in macro-level functioning. In this paper, we have
considered the somatic nervous system of the nematode Caenorhabditis elegans,
for which the entire neuronal connectivity diagram is known. We focus on the
organization of the system into modules, i.e., neuronal groups having
relatively higher connection density compared to that of the overall network.
We show that this mesoscopic feature cannot be explained exclusively in terms
of considerations, such as optimizing for resource constraints (viz., total
wiring cost) and communication efficiency (i.e., network path length).
Comparison with other complex networks designed for efficient transport (of
signals or resources) implies that neuronal networks form a distinct class.
This suggests that the principal function of the network, viz., processing of
sensory information resulting in appropriate motor response, may be playing a
vital role in determining the connection topology. Using modular spectral
analysis, we make explicit the intimate relation between function and structure
in the nervous system. This is further brought out by identifying functionally
critical neurons purely on the basis of patterns of intra- and inter-modular
connections. Our study reveals how the design of the nervous system reflects
several constraints, including its key functional role as a processor of
information.Comment: Published version, Minor modifications, 16 pages, 9 figure
Design and optimization of index-guiding photonic crystal fiber gas sensor
Globalization is becoming an important issue for most businesses in the world. Since globalization changes business trends and shortens product life cycles, it requires companies to be more innovative in developing new ideas, products and processes. Clustering is one of ways to promote innovation by facilitating sharing information and ideas between firms, attracting buyers and suppliers, and providing opportunities for joint training. Many researches in developed countries found that the proximity between companies facilitated collaboration and provided a more conducive environment for R&D and knowledge sharing which can develop culture of entrepreneurship and innovation. Then, the success of clusters in developed countries has led many government and companies to establish new clusters.Since products from China have been dominated Indonesia's market share with lower price, it is very difficult for Indonesian Small and Medium Enterprises to compete with lower price also. Therefore, to face the competition, innovation is perhaps as an alternative strategy for Indonesian SMEs. In facts, more than 50% of small and medium enterprises in Indonesia are located in clusters and most of them are located in Java, Bali and Nusa Tenggara. Even though they located in cluster but their innovations still very low and judging from technology perspective, most of them have low level of technologies and still remain in the underdeveloped stage. Therefore, in this research, the author tries to find (1). To what extend do cluster Indonesia promote innovation, (2). To find the reasons why clusters in Indonesia has not been working well in promoting innovation and (3). To investigate what aspects can be improved by Indonesian SMEs to boost their innovation
CSF and Brain Structural Imaging Markers of the Alzheimer's Pathological Cascade
10.1371/journal.pone.0047406PLoS ONE712
Water demand prospects for the irrigation in São Francisco River.
Abstract: This study analyzed how the irrigation expansion in São Francisco Hydrographic Region (SFRH) would affect the water availability in four specifics physiographic regions into SFRH (Upper, Middle, sub-Middle, and Lower). The TERM-BR model was used to simulate expansion scenarios in irrigated areas aiming to verify the impact in the water use for 2025 and 2035 according to with National Water Resources Plan (PNRH), and Water Resources Plan for the São Francisco River (SFP). The simulations were carried out for areas deemed potentially suitable for irrigation based on the Ministry of National Integration report (MI). The Climatic Water Balance (CWB) was estimated for São Francisco hydrographic region (SFRH) in order to compare regional water supply and demand. Results suggest that cities located in Upper and Middle São Francisco region would present greater irrigation potential due to the water availability and the proximity to neighborhoods that also irrigate. The comparative result of the CWB and the TERM-BR model shown water availability problems in the states of Alagoas and Pernambuco in particular and cities located in São Francisco Lower.GTAP Resource #5725
T-DM1 for HER2 positive advanced breast cancer:a single institution, "real-life" experience.
No abstract availabl
Evaluation of safety and activity of everolimus plus exemestane in metastatic breast cancer: a single institution experience.
Abstract not availabl
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