Opportunity for development or necessary nuisance? The case for viewing working with interpreters as a bonus in therapeutic work

This paper explores the central role a language interpreter can play in the process of the therapeutic relationship. Although others have described the changes to the therapeutic dyad that the presence of a third party (an interpreter) brings, little attention has been paid to the advantages and additional opportunities of this altered therapeutic situation. This paper details these gains and further argues that clinicians who are willing to gain experience of working with interpreters will find that benefits accrue at the micro and macro levels: at the micro level, through enhancement of their work with individual non English speaking clients, and at the macro level through learning about different cultural perspectives, idioms of distress and the role of language in the therapeutic endeavour. This is in addition to developing skills to fulfil legal and professional requirements relating to equity of service provision. Some ideas are offered to explain the negative slant than runs throughout the literature in this area and tends to colour the overall discussion of therapeutic work with interpreters and, before the final section, makes some specific suggestions which may help maximise the gains possible in such work while reducing difficulties

The lattice Boltzmann advection-diffusion model revisited

Advection-diffusion processes can be simulated by the Lattice Boltzmann method. Two formulations have been proposed in the literature. We show that they are not fully correct (only first order accurate). A new formulation is proposed, which is shown to produce better results, both from the point of view of the Chapman-Enskog expansion or when comparing simulations with an exact time-dependent solution of the advection-diffusion equatio

Squeezing out predictions with leptogenesis from SO(10)

We consider the see-saw mechanism within a non-supersymmetric SO(10) model. By assuming the SO(10) quark-lepton symmetry, and after imposing suitable conditions that ensure that the right-handed (RH) neutrino masses are at most mildly hierarchical (compact RH spectrum) we obtain a surprisingly predictive scenario. The absolute neutrino mass scale, the Dirac and the two Majorana phases of the neutrino mixing matrix remain determined in terms of the set of already measured low energy observables, modulo a discrete ambiguity in the signs of two neutrino mixing angles and of the Dirac phase. The RH neutrinos mass spectrum is also predicted, as well as the size and sign of the leptogenesis CP asymmetries. We compute the cosmological baryon asymmetry generated through leptogenesis and obtain the correct sign and a size compatible with observations.Comment: 18 pages, 2 figures; minor changes, version accepted for publication in PR

MicroRNA-222 regulates muscle alternative splicing through Rbm24 during differentiation of skeletal muscle cells

A number of microRNAs have been shown to regulate skeletal muscle development and differentiation. MicroRNA-222 is downregulated during myogenic differentiation and its overexpression leads to alteration of muscle differentiation process and specialized structures. By using RNA-induced silencing complex (RISC) pulldown followed by RNA sequencing, combined with in silico microRNA target prediction, we have identified two new targets of microRNA-222 involved in the regulation of myogenic differentiation, Ahnak and Rbm24. Specifically, the RNA-binding protein Rbm24 is a major regulator of muscle-specific alternative splicing and its downregulation by microRNA-222 results in defective exon inclusion impairing the production of muscle-specific isoforms of Coro6, Fxr1 and NACA transcripts. Reconstitution of normal levels of Rbm24 in cells overexpressing microRNA-222 rescues muscle-specific splicing. In conclusion, we have identified a new function of microRNA-222 leading to alteration of myogenic differentiation at the level of alternative splicing, and we provide evidence that this effect is mediated by Rbm24 protei

Fermion masses and mixings in gauge theories

The recent evidence for neutrino oscillations stimulate us to discuss again the problem of fermion masses and mixings in gauge theories. In the standard model, several forms for quark mass matrices are equivalent. They become ansatze within most extensions of the standard model, where also relations between quark and lepton sectors may hold. In a seesaw framework, these relations can constrain the scale of heavy neutrino mass, which is often related to the scale of intermediate or unification gauge symmetry. As a consequence, two main scenarios arise. Hierarchies of masses and mixings may be explained by broken horizontal symmetries.Comment: 25 pages, RevTex, no figures. Few misprints corrected and two references adde

Automating Vehicles by Deep Reinforcement Learning using Task Separation with Hill Climbing

Within the context of autonomous driving a model-based reinforcement learning algorithm is proposed for the design of neural network-parameterized controllers. Classical model-based control methods, which include sampling- and lattice-based algorithms and model predictive control, suffer from the trade-off between model complexity and computational burden required for the online solution of expensive optimization or search problems at every short sampling time. To circumvent this trade-off, a 2-step procedure is motivated: first learning of a controller during offline training based on an arbitrarily complicated mathematical system model, before online fast feedforward evaluation of the trained controller. The contribution of this paper is the proposition of a simple gradient-free and model-based algorithm for deep reinforcement learning using task separation with hill climbing (TSHC). In particular, (i) simultaneous training on separate deterministic tasks with the purpose of encoding many motion primitives in a neural network, and (ii) the employment of maximally sparse rewards in combination with virtual velocity constraints (VVCs) in setpoint proximity are advocated.Comment: 10 pages, 6 figures, 1 tabl

X-ray flares from propagation instabilities in long Gamma-Ray Burst jets

We present a numerical simulation of a gamma-ray burst jet from a long-lasting engine in the core of a 16 solar mass Wolf-Rayet star. The engine is kept active for 6000 s with a luminosity that decays in time as a power-law with index -5/3. Even though there is no short time-scale variability in the injected engine luminosity, we find that the jet's kinetic luminosity outside the progenitor star is characterized by fluctuations with relatively short time scale. We analyze the temporal characteristics of those fluctuations and we find that they are consistent with the properties of observed flares in X-ray afterglows. The peak to continuum flux ratio of the flares in the simulation is consistent with some, but not all, the observed flares. We propose that propagation instabilities, rather than variability in the engine luminosity, are responsible for the X-ray flares with moderate contrast. Strong flares such as the one detected in GRB 050502B, instead, cannot be reproduced by this model and require strong variability in the engine activity.Comment: 6 pages, MNRAS in pres

Electronic structure of warm dense copper studied by ultrafast x-ray absorption spectroscopy

We use time-resolved x-ray absorption spectroscopy to investigate the unoccupied electronic density of states of warm dense copper that is produced isochorically through the absorption of an ultrafast optical pulse. The temperature of the superheated electron-hole plasma, which ranges from 4000 to 10 000 K, was determined by comparing the measured x-ray absorption spectrum with a simulation. The electronic structure of warm dense copper is adequately described with the high temperature electronic density of state calculated by the density functional theory. The dynamics of the electron temperature is consistent with a two-temperature model, while a temperature-dependent electron-phonon coupling parameter is necessary