Quasiperiodic graphs: structural design, scaling and entropic properties

A novel class of graphs, here named quasiperiodic, are constructed via application of the Horizontal Visibility algorithm to the time series generated along the quasiperiodic route to chaos. We show how the hierarchy of mode-locked regions represented by the Farey tree is inherited by their associated graphs. We are able to establish, via Renormalization Group (RG) theory, the architecture of the quasiperiodic graphs produced by irrational winding numbers with pure periodic continued fraction. And finally, we demonstrate that the RG fixed-point degree distributions are recovered via optimization of a suitably defined graph entropy

Post-training load-related changes of auditory working memory: An EEG study

Working memory (WM) refers to the temporary retention and manipulation of information, and its capacity is highly susceptible to training. Yet, the neural mechanisms that allow for increased performance under demanding conditions are not fully understood. We expected that post-training efficiency in WM performance modulates neural processing during high load tasks. We tested this hypothesis, using electroencephalography (EEG) (N = 39), by comparing source space spectral power of healthy adults performing low and high load auditory WM tasks. Prior to the assessment, participants either underwent a modality-specific auditory WM training, or a modality-irrelevant tactile WM training, or were not trained (active control). After a modality-specific training participants showed higher behavioral performance, compared to the control. EEG data analysis revealed general effects of WM load, across all training groups, in the theta-, alpha-, and beta-frequency bands. With increased load theta-band power increased over frontal, and decreased over parietal areas. Centro-parietal alpha-band power and central beta-band power decreased with load. Interestingly, in the high load condition a tendency toward reduced beta-band power in the right medial temporal lobe was observed in the modality-specific WM training group compared to the modality-irrelevant and active control groups. Our finding that WM processing during the high load condition changed after modality-specific WM training, showing reduced beta-band activity in voice-selective regions, possibly indicates a more efficient maintenance of task-relevant stimuli. The general load effects suggest that WM performance at high load demands involves complementary mechanisms, combining a strengthening of task-relevant and a suppression of task-irrelevant processing

Density waves in the shearing sheet I. Swing amplification

The shearing sheet model of a galactic disk is studied anew. The theoretical description of its dynamics is based on three building blocks: Stellar orbits, which are described here in epicyclic approximation, the collisionless Boltzmann equation determining the distribution function of stars in phase space, and the Poisson equation in order to take account of the self-gravity of the disk. Using these tools I develop a new formalism to describe perturbations of the shearing sheet. Applying this to the unbounded shearing sheet model I demonstrate again how the disturbances of the disk evolve always into `swing amplified' density waves, i.e. spiral-arm like, shearing density enhancements, which grow and decay while the wave crests swing by from leading to trailing orientation. Several examples are given how such `swing amplification' events are incited in the shearing sheet.Comment: small corrections, uses new A&A style fil

Topological properties and fractal analysis of recurrence network constructed from fractional Brownian motions

Many studies have shown that we can gain additional information on time series by investigating their accompanying complex networks. In this work, we investigate the fundamental topological and fractal properties of recurrence networks constructed from fractional Brownian motions (FBMs). First, our results indicate that the constructed recurrence networks have exponential degree distributions; the relationship between $H$ and $$can be represented by a cubic polynomial function. We next focus on the motif rank distribution of recurrence networks, so that we can better understand networks at the local structure level. We find the interesting superfamily phenomenon, i.e. the recurrence networks with the same motif rank pattern being grouped into two superfamilies. Last, we numerically analyze the fractal and multifractal properties of recurrence networks. We find that the average fractal dimension$$ of recurrence networks decreases with the Hurst index $H$ of the associated FBMs, and their dependence approximately satisfies the linear formula $\approx 2 - H$. Moreover, our numerical results of multifractal analysis show that the multifractality exists in these recurrence networks, and the multifractality of these networks becomes stronger at first and then weaker when the Hurst index of the associated time series becomes larger from 0.4 to 0.95. In particular, the recurrence network with the Hurst index $H=0.5$ possess the strongest multifractality. In addition, the dependence relationships of the average information dimension $$and the average correlation dimension$$ on the Hurst index $H$ can also be fitted well with linear functions. Our results strongly suggest that the recurrence network inherits the basic characteristic and the fractal nature of the associated FBM series.Comment: 25 pages, 1 table, 15 figures. accepted by Phys. Rev.

Mainstream in-patient mental health care for people with learning difficulties: service user and carer experiences.

Government guidelines stress the importance of service user views when assessing and developing quality healthcare provision. This review examines what is known about the experience of being admitted and staying on a mainstream psychiatric ward from the perspective of the patient. The review firstly provides a context to the main body of literature by discussing relevant factors such as stigma and ethnicity. In depth examination of the three main areas relevant to the experience of service users is then discussed. This includes overall key research, the studies on coercion and those focussing on treatments. Both quantitative and qualitative studies are examined along with relevant methodological issues. This review highlights the diverse nature of user views as well as how important it is to listen to people on the receiving end of help

Distinct year-to-year particle flux variations off Cape Blanc during 1988-1991: Relation to δ 18O-deduced sea-surface temperatures and trade winds

Particle fluxes measured from 1988 to 1991 adjacent to a coastal upwelling site off Cape Blanc showed significant interannual variability of fluxes and sea-surface temperatures (SST) deduced from stable oxygen isotope analysis of the planktonic foraminifera Globigerinoides ruber and, partly, of the pteropod Limacina inflata. For the duration of the study period, a decrease in the seasonality of SST\u27s was observed, as well as a significant decrease in the average annual SST from 24.4° to 20.8°C. This cooling trend was mainly the effect of a drastic decrease in the summer to fall SST (from 27.2° to 21.8°C). In comparison, the winter-spring SST decreased only slightly from 20.3° in 1988 to 19.8°C in 1991. Concomitantly, we measured decreasing annual total, carbonate, biogenic opal and lithogenic fluxes and, in contrast, increasing marine organic carbon fluxes. During 1991, when cold SST\u27s prevailed and the trade winds were rather high throughout, annual biogenic and lithogenic fluxes (except organic carbon) were lower by approximately a factor of two compared to the other years. Colder SST\u27s, generally corresponding to stronger trade winds and upwelling intensity, did not result in increased biogenic opal and lithogenic matter sedimentation; but higher marine organic carbon fluxes were recorded. Decreasing summer-fall SST from 1988 to 1991 coincided with decreased carbonate sedimentation maxima which generally occurred during the warm summer season. In the summer of 1989, when SST\u27s were the highest of the four-year sampling period and upwelling was less intense due to weak spring-summer trades, a large sedimentation pulse of pteropod shells was observed. Our data set does not yet provide conclusive evidence that the observed year-to-year flux and SST variations represent larger-scale, periodically occurring climatic variations in the eastern Atlantic but it offers insight into the prevailing large variability in biochemical cycles and processes in the eastern Atlantic

High thymidylate synthase gene expression predicts poor outcome after resection of hepatocellular carcinoma.

IntroductionPrognosis after resection of hepatocellular carcinoma (HCC) is highly variable. Compared to clinicopathologic factors, the use of molecular markers to predict outcome has not been well studied. We investigated the prognostic importance of thymidylate synthase (TS) gene expression and polymorphisms in patients after resection of HCC.MethodsPatients who underwent complete resection of HCC for whom tissue was available were identified. TS gene expression level and polymorphisms were determined in HCC specimens. Prognostic factors were evaluated using Kaplan-Meier curves and Cox proportional hazard models.ResultsThe study included 67 patients. In univariate analysis, variables that negatively influenced survival included TNM stage, microvascular invasion, and high TS expression. For the high TS expression group, median survival was 54 months and 5-year actuarial survival was 47%. For the low TS expression group, median survival was not reached and the 5-year actuarial survival was 91%. In multivariate analysis, only high TS expression remained an independent predictor of poor survival (HR = 10.77, 95% CI 1.36-84.91; P = 0.02). TS gene polymorphisms were not associated with TS expression or overall survival.ConclusionsHigh TS expression predicts poor outcome after resection of HCC. Molecular markers might be robust predictors of patient outcome after resection of HCC

Environmental distribution and genetic diversity of vegetative compatibility groups determine biocontrol strategies to mitigate aflatoxin contamination of maize by Aspergillus flavus

Published online: 27 Oct 2015Maize infected by aflatoxin-producing Aspergillus flavus may become contaminated with aflatoxins, and as a result, threaten human health, food security and farmers’ income in developing countries where maize is a staple. Environmental distribution and genetic diversity of A. flavus can influence the effectiveness of atoxigenic isolates in mitigating aflatoxin contamination. However, such information has not been used to facilitate selection and deployment of atoxigenic isolates. A total of 35 isolates of A. flavus isolated from maize samples collected from three agroecological zones of Nigeria were used in this study. Ecophysiological characteristics, distribution and genetic diversity of the isolates were determined to identify vegetative compatibility groups (VCGs). The generated data were used to inform selection and deployment of native atoxigenic isolates to mitigate aflatoxin contamination in maize. In co-inoculation with toxigenic isolates, atoxigenic isolates reduced aflatoxin contamination in grain by > 96%. A total of 25 VCGs were inferred from the collected isolates based on complementation tests involving nitrate non-utilizing (nit−) mutants. To determine genetic diversity and distribution of VCGs across agroecological zones, 832 nit− mutants from 52 locations in 11 administrative districts were paired with one self-complementary nitrate auxotroph tester-pair for each VCG. Atoxigenic VCGs accounted for 81.1% of the 153 positive complementations recorded. Genetic diversity of VCGs was highest in the derived savannah agro-ecological zone (H = 2.61) compared with the southern Guinea savannah (H = 1.90) and northern Guinea savannah (H = 0.94) zones. Genetic richness (H = 2.60) and evenness (E5 = 0.96) of VCGs were high across all agro-ecological zones. Ten VCGs (40%) had members restricted to the original location of isolation, whereas 15 VCGs (60%) had members located between the original source of isolation and a distance > 400 km away. The present study identified widely distributed VCGs in Nigeria such as AV0222, AV3279, AV3304 and AV16127, whose atoxigenic members can be deployed for a region-wide biocontrol of toxigenic isolates to reduce aflatoxin contamination in maize