Analytical method for designing dispersion-managed fiber systems

This paper was published in Optics Letters and is made available as an electronic reprint with the permission of OSA. The paper can be found at the following URL on the OSA website: http://www.opticsinfobase.org/abstract.cfm?URI=ol-26-20-1544. Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under law.Peer reviewedPublisher PD

Pengembangan Order Management System untuk Mendukung Perbaikan Proses Bisnis Pengelolaan Pemesanan Jasa Inbound dan Outbound Gudang Disertai Audit System Development Life Cycle Guna Menanggulangi Risiko Pengembangan Sistem

PT XYZ adalah salah satu Perusahaan penyedia jasa logistic atau bisa disebut 3PL. Salah satu customer yang menggunakan jasa 3PL adalah DEF Company. DEF company adalah Perusahaan yang bergerak dalam bidang pendistribusian dan import barang. Ketika melakukan aktivitas pelaporan dokumen pada proses inbound dan outbound, XYZ company mengalami keterlambatan pada bulan April 2014 sebesar 5%. Keterlambatan dokumen ini disebabkan oleh tidak terorganisirnya order dokumen yang ada, sehingga akan berdampak pada terlambatnya waktu pengiriman barang kepada konsumen. Pemetaan kondisi aktual dilakukan untuk mengetahui keterkaitan antar aktivitas yang terdapat pada proses inbound dan outbound DEF company produk pada XYZ Company Warehouse. Perbaikan  pada  penelitian  ini menggunakan  pendekatan  metode  Business  Process  Improvement  (BPI)  dengan melakukan analisis Streamlining. Perbaikan proses bisnis yang diajukan menggunakan bantuan sistem informasi manajemen yang dapat mengelola proses pemesanan jasa inbound dan outbound gudang PT XYZ, yaitu Order Management System (OMS). OMS merupakan web application yang dibangun menggunakan bahasa pemrograman PHP dengan menggunakan framework laravel dan menggunakan iterative dan incremental sebagai metodologi pengembangannya. Selama berjalannya seluruh proses, dari mulai proses dokumentasi proses bisnis aktual sampai pengembangan OMS selesai, dilakukan pengawasan audit system development life cycle yang bertujuan untuk memeriksa, mengawasi, dan memastikan bahwa proses pengembangan berjalan dengan lancar sehingga dapat terhindar dari keterlambatan bahkan kegagalan. Dalam melakukan audit terhadap pengembangan OMS, digunakan metodologi risk based audit serta mengacu pada framework atau best practice COBIT 5

Pengaruh Frekuensi Akses Bbm, Path, Facebook Terhadap Intensitas Komunikasi Antar Pribadi

Komunikasi menjadi hal yang tidak dapat dihindari selama kita melakukan aktivitas.Semakin seringnya seseorang berkomunikasi informasi yang dipertukarkan semakin dalam dan luas.Tingginya frekuensi komunikasi melalui alat komunikasi yang disebabkan banyak faktor menjadikan orang lebih sering bertukar informasi melalui aplikasi yang tersedia, terlebih lagi kecanggihan teknologi membuat aplikasi komunikasi semakin baik hanya dengan memiliki smartphone sudah tersedia aplikasi seperti BBM, Path dan Facebook yang dijadikan sebagai media untuk bertukar cerita maupun informasi yang bersifat formal.Penelitian ini menggunakan teori CMC (Computer Mediated Communication) teori dimana program-program suatu aplikasi yang dapat menghubungkan dua orang atau lebih dengan suatu jaringan komputer atau format komputer di berbeda tempat. Sedangkan menurut Fulk dan Collins teori Computer Mediated Communication adalah teori yang dimaksudkan bukan tentang bagaimana dua atau lebih mesin saling berhubungan atau berinteraksi tetapi bagaimana dua atau lebih manusia bisa saling berubungan atau berinteraksi dengan dibantu menggunakan alat komputer pada program aplikasi tertentu yang tersedia pada komputer (Fulk dan Collins, 2001). Computer Mediated Communication juga melihat dan mempelajari cara membentuk kepribadian seseorang dengan pertukaran informasi melalui komputer khususnya pada jaringan internet pada komputer. Computer Mediated Communication memberikan dampak sosial kepada manusia. Rice dan Gattiker (2001) menyatakan bahwa Computer Mediated Communication berbeda dari komunikasi tatap muka. Computer Mediated Communication membatasi tingkat interaksi yang bisa menyebabkan penurunan aktifitas. Computer Mediated Communication dapat mengatasi masalah waktu dan keberadaan. Secara keseluruhan penggunaan Computer Mediated Communication menghasilkan beberapa perbedaan dalam komunikasi tatap muka yang dalam hal ini menjelaskan mengenai frekuensi tingginya orang menggunakan aplikasi BBM, Path, Facebook sehingga mengurangi intensitas komunikasi antar pribadi pada mahasiswa perantau yang ada di Semarang. Sampel dalam penelitian ini berjumlah 50 orang.Analisis yang digunakan adalah korelasi kendalls dengan spss. Hasil uji hipotesis pertama menunjukan bahwa variabel frekuensi akses BBM berpengaruh terhadap variabel intensitas komunikasi antar pribadi dan signifikan (sig.= 0,000) dengan koefisien korelasi -,509. Hasil uji hipotesis kedua menunjukan bahwa variabel frekuensi akses Path berpengaruh terhadap variabel intensitas komunikasi antar pribadi dan signifikan (sig.=0,000) dengan koefisien korelasi -,403. Dan hasil uji hipotesis ketiga menunjukan bahwa variabel frekuensi akses Facebook berpengaruh terhadap variabel intensitas komunikasi antar pribadi dan signifikan (sig.= 0,000) dengan koefisien korelasi -,536.Saran yang diberikan penelitian ini adalah menjadikan aplikasi media sosial seperti BBM, Path dan Facebook sebagai media komunikasi dengan menjaga intensitas komunikasi antar pribadi terutama komunikasi pribadi tatap muka agar mampu menghasilkan kualitas komunikasi yang jauh lebih baik

Analysis of Optical Pulse Propagation with ABCD Matrices

We review and extend the analogies between Gaussian pulse propagation and Gaussian beam diffraction. In addition to the well-known parallels between pulse dispersion in optical fiber and CW beam diffraction in free space, we review temporal lenses as a way to describe nonlinearities in the propagation equations, and then introduce further concepts that permit the description of pulse evolution in more complicated systems. These include the temporal equivalent of a spherical dielectric interface, which is used by way of example to derive design parameters used in a recent dispersion-mapped soliton transmission experiment. Our formalism offers a quick, concise and powerful approach to analyzing a variety of linear and nonlinear pulse propagation phenomena in optical fibers.Comment: 10 pages, 2 figures, submitted to PRE (01/01

Synthesis, structure, solution behaviour and biological evaluation of oxidovanadium(IV/V) complexes: Substrate specific DMSO assisted methylation of a thiosemicarbazone

The synthesis and characterization of an oxidovanadium(IV) [VIVO(L)(acac)] (1) and of two dioxidovanadium(V) [VVO2(L')] (2) and [VVO2(L)] (2a) complexes of the Schiff base formed from the reaction of 4-(p-fluorophenyl) thiosemicarbazone with pyridine-2-aldehyde (HL) is described.The oxidovanadium(IV) species [VIVO(L)(acac)] (1) was synthesized by the reaction of VIVO(acac)2 with the thiosemicarbazone HL in refluxing ethanol. The recrystallization of [VIVO(L)(acac)] (1) in DMF, CH3CN or EtOH gave the same product i.e. the dioxidovanadium(V) complex [VVO2(L)] (2a); however, upon recrystallization of 1 in DMSO a distinct compound [VVO2(L')] (2) was formed, wherein the original ligand L- is transformed to a rearranged one, L’-. In the presence of DMSO the ligand in complex 1 is found to undergo methylation at the carbon centre attached to imine nitrogen (aldimine) and transformed to the corresponding V VO2- species through in situ reaction. The synthesized HL and the metal 2 complexes were characterized by elemental analysis, IR, UV–Vis, NMR and EPR spectroscopy. The molecular structure of [VVO2(L')] (2) was determined by single crystal X–ray crystallography.The methylation of various other ligands and complexes prepared from different vanadium precursors under similar reaction conditions was also attempted and it was confirmed that the imine methylation observed is both ligand and metal precursor specific. Complexes 1 and 2 show in vitro insulin-like activity against insulin responsive L6 myoblast cells, with complex 1 being more potent. In addition, the in vitro cytotoxicity studies of HL, and of complexes 1 and 2 against the MCF–7 and Vero cell lines were also done. The ligand is not cytotoxic and complex 2 is significantly more cytotoxic than 1. DAPI staining experiments indicate that increase in time of incubation as well as increase of concentration of the complexes lead to increase in cell death

Preparation of anti-vicinal amino alcohols: asymmetric synthesis of D-erythro-Sphinganine, (+)-spisulosine and D-ribo-phytosphingosine

Two variations of the Overman rearrangement have been developed for the highly selective synthesis of anti-vicinal amino alcohol natural products. A MOM-ether directed palladium(II)-catalyzed rearrangement of an allylic trichloroacetimidate was used as the key step for the preparation of the protein kinase C inhibitor D-erythro-sphinganine and the antitumor agent (+)-spisulosine, while the Overman rearrangement of chiral allylic trichloroacetimidates generated by asymmetric reduction of an alpha,beta-unsaturated methyl ketone allowed rapid access to both D-ribo-phytosphingosine and L-arabino-phytosphingosine

Applying refinement to the use of mice and rats in rheumatoid arthritis research

Rheumatoid arthritis (RA) is a painful, chronic disorder and there is currently an unmet need for effective therapies that will benefit a wide range of patients. The research and development process for therapies and treatments currently involves in vivo studies, which have the potential to cause discomfort, pain or distress. This Working Group report focuses on identifying causes of suffering within commonly used mouse and rat ‘models’ of RA, describing practical refinements to help reduce suffering and improve welfare without compromising the scientific objectives. The report also discusses other, relevant topics including identifying and minimising sources of variation within in vivo RA studies, the potential to provide pain relief including analgesia, welfare assessment, humane endpoints, reporting standards and the potential to replace animals in RA research

Integrity as a Moderator of the Influence of the Internal Control System on Accounting Fraud

Organizations in the financial sector, like the Village Credit Institution (LPD) in Bali, are highly prone to accounting fraud. Despite their importance, fraudulent actions by LPD managers are still common. To reduce fraud, an effective internal control system is essential. Motivated by inconsistent results in previous studies, this research introduces individual integrity as a moderating variable. The study focuses on LPDs in Badung Regency, using purposive sampling to select participants based on specific criteria. The criteria used as the basis for selecting sample members in this study were LPDs with healthy and fairly healthy categories, totaling 71 LPDs. Meanwhile, the respondents to the study in each LPD were the Head of LPD, LPD Treasurer and Credit Division, while the number of respondents was 213 research respondents. The data analysis technique in this study uses the structural equation modeling (SEM) method based on partial least square (PLS). The statistical test results obtained the results that the internal control system variable has a significant negative effect on the tendency of accounting fraud. While the individual integrity level variable strengthens the influence of the internal control system on the tendency of accounting fraud

Oroxylum indicum (L.) Kurz extract inhibits adipogenesis and lipase activity in vitro

Background: Oroxylum indicum (L.) Kurz (O. indicum) is found in Thailand. It has been used for the treatment of obesity. This study aimed to investigate the effects of an O. indicum extract (OIE) on the adipogenic and biomolecular change in 3T3-L1 adipocytes. Methods: Initial studies examined the chemical components of OIE. The cell line 3T3-L1 was used to establish potential toxic effects of OIE during the differentiation of pre-adipocytes to adipocytes. The inhibitory effect of OIE on lipid accumulation in 3T3-L1 cells was investigated. Moreover, the impact of OIE on pancreatic lipase activity was determined. In further experiments, Fourier Transform Infrared (FTIR) was used to monitor and discriminate biomolecular changes caused by the potential anti-adipogenic effect of OIE on 3T3-L1 cells. Results: Chemical screening methods indicated that OIE was composed of flavonoids, alkaloids, steroids, glycosides, and tannins. The percentage viability of 3T3-L1 cells was not significantly decreased after exposure to either 200 or 150 μg/mL of OIE for 2 and 10 days, respectively compared to control cells. The OIE exhibited a dose-dependent reduction of lipid accumulation compared to the control (p < 0.05). The extract also demonstrated a dosedependent inhibitory effect upon lipase activity compared to the control. The inhibitory effect of the OIE on lipid accumulation in 3T3-L1 cells was also confirmed using FTIR microspectroscopy. The signal intensity and the integrated areas relating to lipids, lipid esters, nucleic acids, glycogen and carbohydrates of the OIE-treated 3T3-L1 adipocytes were significantly lower than the non-treated 3T3-L1 adipocytes (p < 0.05). Principal component analysis (PCA) indicated four distinct clusters for the FTIR spectra of 3T3-L1 adipocytes based on biomolecular changes (lipids, proteins, nucleic acids, and carbohydrates). This observation was confirmed using Unsupervised hierarchical cluster analysis (UHCA). Conclusions: These novel findings provide evidence that the OIE derived from the fruit pods of the plant is capable of inhibiting lipid and carbohydrate accumulation in adipocytes and also has the potential to inhibit an enzyme associated with fat absorption. The initial observations indicate that OIE may have important properties which in the future may be exploited for the management of the overweight or obese