Cholecystectomy, gallstones, tonsillectomy, and pancreatic cancer risk: a population-based case-control study in minnesota

Background: Associations between medical conditions and pancreatic cancer risk are controversial and are thus evaluated in a study conducted during 1994–1998 in Minnesota. Methods: Cases (n=215) were ascertained from hospitals in the metropolitan area of the Twin Cities and the Mayo Clinic. Controls (n=676) were randomly selected from the general population and frequency matched to cases by age and sex. The history of medical conditions was gathered with a questionnaire during in-person interviews. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated using unconditional logistic regression. Results: After adjustment for confounders, subjects who had cholecystectomy or gallstones experienced a significantly higher risk of pancreatic cancer than those who did not (OR (95% CI): 2.11 (1.32–3.35) for cholecystectomy and 1.97 (1.23–3.12) for gallstones), whereas opposite results were observed for tonsillectomy (0.67 (0.48–0.94)). Increased risk associated with cholecystectomy was the greatest when it occurred ⩽2 years before the cancer diagnosis (5.93 (2.36–15.7)) but remained statistically significant when that interval was ⩾20 years (2.27 (1.16–4.32)). Conclusions: Cholecystectomy, gallstones, and tonsillectomy were associated with an altered risk of pancreatic cancer. Our study suggests that cholecystectomy increased risk but reverse causality may partially account for high risk associated with recent cholecystectomy

Intensity measures for the seismic response of pile foundations

In this study the efficacy of various ground motion intensity measures for the seismic response of pile foundations embedded in liquefiable and non-liquefiable soils is investigated. A soil-pile-structure model consisting of a two-layer soil deposit with a single pile and a single degree-of-freedom superstructure is used in a parametric study to determine the salient features of the seismic response of the soil-pile-structure system. A suite of ground motion records scaled to various levels of intensity are used to investigate the full range of pile behaviour, from elastic response to failure. Various intensity measures are used to inspect their efficiency in predicting the seismic demand on the pile foundation for a given level of ground motion intensity. It is found that velocity-based intensity measures are the most efficient in predicting the pile response, which is measured in terms of maximum curvature or pile-head displacement. In particular, velocity spectrum intensity (VSI), which represents the integral of the pseudo-velocity spectrum over a wide period range, is found to be the most efficient intensity measure in predicting the seismic demands on the pile foundation. VSI is also found to be a sufficient intensity measure with respect to earthquake magnitude, sourceto- site distance, and epsilon, and has a good predictability, thus making it a prime candidate for use in seismic response analysis of pile foundations

Assessment of Yield and Yield Attributing Characters of Hybrid Maize using Nutrient Expert® Maize Model in Eastern Terai of Nepal

Indiscriminate use of fertilizer and lack of site specific nutrient management technology is the main cause of low maize productivity in Nepal. Thus, field experiments on farmer\u27s field were conducted on maize to assess the productivity at two sites of Jhapa district viz. Damak and Gauradaha using Nutrient Expert® Maize model from November 2015 to May 2016. The experiment was laid out in Randomized Completely Block Design consisting two treatments viz. NE (Nutrient Expert recommendation) and FFP (Farmer\u27s Fertilizer Practice) with twenty replications. The result revealed significant differences in terms of grain yield, stover yield, biological yield, and yield attributing characters. NE based practices produced higher grain yield (9.22 t ha-1), which was 86.6 percent higher than FFP (4.94 t ha-1). Similarly, higher average cob number m 2 (8.2), average kernel rows cob-1 (14.2), average kernels number row-1 (589.9) and test weight (361.4 g) were recorded in NE based practice. Thus, NE based practice can be adopted for obtaining higher productivity in eastern terai region of Nepal

Genetic variability in energy balance and pancreatic cancer risk in a population-based case-control study in Minnesota

OBJECTIVES: Accumulating evidence suggests that energy imbalance plays a role in pancreatic carcinogenesis. However, it remains unclear whether single-nucleotide polymorphisms (SNPs) in genes regulating energy homeostasis influence pancreatic cancer risk. We investigated this question in a case-control study conducted from 1994 to 1998. METHODS: Patients (n = 173) were ascertained from hospitals in the Twin Cities and Mayo Clinic, Minnesota. Control subjects (n = 476) were identified from the general population and frequency matched to patients by age and sex. Seven SNPs were evaluated in relation to pancreatic cancer using unconditional logistic regression. RESULTS: After adjustment for confounders, the leucine/proline or proline/proline genotype of the neuropeptide Y (NPY) gene rs16139 was associated with a lower risk than the leucine/leucine genotype (odds ratio, 0.40 [95% confidence interval, 0.15-0.91]). Conversely, an increased risk was observed for the glycine/arginine or arginine/arginine genotype of the adrenoceptor β2, surface (ADRB2) gene rs1042713 as compared with the glycine/glycine genotype (odds ratio, 1.52 [95% confidence interval, 1.01-2.31]). CONCLUSIONS: This study first reveals that SNPs in genes modulating energy intake (NPY) and energy expenditure (ADRB2) altered pancreatic cancer risk. If confirmed by other studies, our findings may shed new light on the etiology and prevention of pancreatic cancer

Productivity and Profitability Assessment of Drought Tolerant Rice Cultivars under Different Crop Management Practices in Central Terai of Nepal

Reduction in productivity has led to lower profitability of rice production in Nepal. Proper selections of resource conservation technologies and drought tolerant cultivars are being potential strategies determining productivity of rice in drought prone areas. Thus, a field experiment was accomplished in central-terai of Nepal during 2014 to assess the productivity and profitability of drought tolerant rice cultivars under different crop management practices. The experiment was carried out in strip-plot design with three replications consisting four drought tolerant rice cultivars and three crop management practices. The analyzed data revealed that SRI (System of Rice Intensification) produced significantly higher grain yield (5.28 t ha-1) than other management practices. The straw yield of SRI (5.12 t ha-1) was also significantly higher than other management practices. The cultivars had no influence on grain yield, but the straw yield was significantly influenced by cultivars, with the highest straw yield in Sukkha-3 (5.21 t ha-1). Similarly, SRI management practice also had significantly higher gross returns (NRs. 144652 ha-1), net return (NRs. 56647 ha-1) and B:C ratio (1.64:1). Thus, SRI management practice can be adopted as adaptation approach for obtaining higher productivity and profitability in central terai and similar agro-climatic regions of Nepal

Improved seismic hazard model with application to probabilistic seismic demand analysis

An improved seismic hazard model for use in performance-based earthquake engineering is presented. The model is an improved approximation from the so-called 'power law' model, which is linear in log-log space. The mathematics of the model and uncertainty incorporation is briefly discussed. Various means of fitting the approximation to hazard data derived from probabilistic seismic hazard analysis are discussed, including the limitations of the model. Based on these 'exact' hazard data for major centres in New Zealand, the parameters for the proposed model are calibrated. To illustrate the significance of the proposed model, a performance-based assessment is conducted on a typical bridge, via probabilistic seismic demand analysis. The new hazard model is compared to the current power law relationship to illustrate its effects on the risk assessment. The propagation of epistemic uncertainty in the seismic hazard is also considered. To allow further use of the model in conceptual calculations, a semi-analytical method is proposed to calculate the demand hazard in closed form. For the case study shown, the resulting semi-analytical closed form solution is shown to be significantly more accurate than the analytical closed-form solution using the power law hazard model, capturing the 'exact' numerical integration solution to within 7% accuracy over the entire range of exceedance rat

Low-loss singlemode PECVD silicon nitride photonic wire waveguides for 532-900 nm wavelength window fabricated within a CMOS pilot line

PECVD silicon nitride photonic wire waveguides have been fabricated in a CMOS pilot line. Both clad and unclad single mode wire waveguides were measured at lambda = 532, 780, and 900 nm, respectively. The dependence of loss on wire width, wavelength, and cladding is discussed in detail. Cladded multimode and singlemode waveguides show a loss well below 1 dB/cm in the 532-900 nm wavelength range. For singlemode unclad waveguides, losses < 1 dB/cm were achieved at lambda = 900 nm, whereas losses were measured in the range of 1-3 dB/cm for lambda = 780 and 532 nm, respectively

Nutritive Values of Fodders at Different Seasons and Altitudes in Gandaki River Basin of Nepal

This study aimed to assess the seasonal and ecological variation of chemical and nutritional values of locally preferred fodders in Gandaki River Basin (GRB) areas. The study was conducted in four altitudinal gradients viz. &lt;400m, 400-800m, 800-1200m and 1200–1600m altitude above sea level in different looping seasons: rainy, spring and winter seasons. The most important five species of fodder trees Artocarpus lakoocha, Ficus roxburghii, Thysanolaena maxima, Ficus semicordata and Bauhinia purpurea were selected based on farmers' preferences in nutritional values. Fodder samples comprised young leaves, old leaves and young twigs that were taken in July, September and December. It was revealed that nutritive value is not very much influenced by altitude but it is strongly influenced by lopping seasons. Among Thysanolaena maxima, Artocarpus lakoocha, Ficus roxburghii and Bauhinia purpurea the cellulose contents were significantly different (p&lt;0.001) with seasons but there was no significant variation with altitudes. Similarly, Acid Detergent Fibre (ADF) contents in Thysanolaena maxima, Ficus roxburghii and Bauhinia purpurea were found significantly different with seasons. Ficus roxburghii fodder tree was found significantly different in Neutral Detergent Fibre (NDF), ADF, Cellulose and Potassium content with seasons. Similarly, fodder tree Bauhinia purpurea was found significant on Dry matter (DM), Crude fibre (CF), NDF, ADF, cellulose, tannin and potassium with seasons. The study hinted how careful planning of species selection and prudent decision in scheduling looping and feeding fodder trees can help improve animal metabolism, health, growth and productivity

Abrasive water jet drilling of advanced sustainable bio-fibre-reinforced polymer/hybrid composites : a comprehensive analysis of machining-induced damage responses

This paper aims at investigating the effects of variable traverse speeds on machining-induced damage of fibre-reinforced composites, using the abrasive water jet (AWJ) drilling. Three different types of epoxy-based composites laminates fabricated by vacuum bagging technique containing unidirectional (UD) flax, hybrid carbon-flax and carbon fibre-reinforced composite were used. The drilling parameters used were traverse speeds of 20, 40, 60 and 80 mm/min, constant water jet pressure of 300 MPa and a hole diameter of 10 mm. The results obtained depict that the traverse speed had a significant effect with respect to both surface roughness and delamination drilling-induced damage responses. Evidently, an increase in water jet traverse speed caused an increase in both damage responses of the three samples. Significantly, the CFRP composite sample recorded the lowest surface roughness damage response, followed by C-FFRP, while FFRP exhibited the highest. However, samples of FFRP and hybrid C-FFRP recorded lowest and highest delamination damage responses, respectively. The discrepancy in both damage responses, as further validated with micrographs of colour video microscopy (CVM), scanning electron microscopy (SEM) and X-ray micro-computed tomography (X-ray μCT), is attributed to the different mechanical properties of the reinforced fibres, fibre orientation/ply stacking and hybridisation of the samples.Peer reviewe