Cp2ZrCl2: AN EFFICIENT CATALYST FOR MULTICOMPONENT SYNTHESIS OF CAROTENOID DEHYDROSQUALENE SYNTHASE INHIBITING PYRANO[2,3-d]PYRIMIDINEDIONES

Objectives: The present protocol deals with zirconocene dichloride (Cp2ZrCl2) catalyzed synthesis of pyrano[2,3-d]pyrimidinediones through one-pot multicomponent reactions of aromatic aldehydes with malononitrile and barbituric acid at ambient temperature. All the synthesized compounds were characterized and evaluated for antibacterial, antifungal, and antioxidant activities. Furthermore, a molecular docking was carried out to reveal the atomic insights between synthesized compounds and carotenoid dehydrosqualene synthase (PDB ID: 3ACX). Methods: All the synthesized compounds were evaluated for their in vitro antimicrobial activity by diffusion method. Antioxidant activities such as 1,1-diphenyl-2-picrylhydrazyl and radical scavenging activity. A mixture of barbituric acid 1 (1 mmol), malononitrile 2 (1 mmol), benzaldehyde 3a (1 mmol), ethanol (5 mL), and Cp2ZrCl2 (5 mol %) was stirred at ambient temperature for specified time. After completion of reaction as indicated by thin-layer chromatography, the obtained crude product was filtered and purified by column chromatography on silica gel (Merck, 60–120 mesh) using ethyl acetate:pet. ether to afford pure product which was then characterized by spectroscopic methods such by FTIR, nuclear magnetic resonance (1H NMR), 13C NMR, and mass spectroscopy. Results: All the synthesized pyrano[2,3-d]pyrimidinediones were characterized by spectroscopic analysis. The results revealed that pyrano[2,3-d] pyrimidinediones (4 a-k) displayed the zone of inhibition in the range of 3–13 mm. The most active compound 4b displayed largest zone of inhibition of 13 mm for Escherichia coli (NCIM-2832) and 9 mm for Bacillus subtilis (NCIM-2635). The antifungal and antioxidant activity of all synthesized pyrano[2,3-d]pyrimidinediones (4a-k) showed moderate to good activity. Molecular docking studies suggest that pyrano[2,3-d]pyrimidinediones might inhibit the carotenoid dehydrosqualene synthase activity. Conclusion: All the synthesized pyrano[2,3-d]pyrimidinediones display moderate to good antibacterial, antifungal, and antioxidant activity. This molecular docking studies supported that pyrano[2,3-d]pyrimidinediones might inhibit the carotenoid dehydrosqualene synthase (PDB ID: 3ACX)

An Intrusion Detection System Algorithm for Defending MANET against the DDoS Attacks.

Mobile ad hoc network (MANET) is rapidly deployable, self configuring network able to communicate with each other without the aid of any centralized system. There is no need for existing infrastructure base network. In MANET Wireless medium is radio frequencies and nodes are mobile, topology can be very dynamically. Nodes must be able to relay traffic since communicating nodes might be out of range. A MANET can be a standalone network or it can be connected to external networks like internet. Multihop operation of MANET requires a routing mechanism designed for mobile nodes are internet access mechanisms, self configuring networks requires an address allocation mechanism, mechanism to detect and act on, merging of existing networks and security mechanisms. As we know that there is no any centralized system so routing is done by node itself. Due to its mobility and self routing capability nature, there are many weaknesses in its security

Distortion Analysis of CMOS Based Analog Circuits

The amplifiers are the vital part of the analog circuit designs. The linearity of the CMOS is of most important concern in the design of many analog circuits. There are several aspects regarding nonlinear distortion analysis in analog circuits implemented in CMOS technology. Basically, the investigations visualize the nature of the total harmonic distortion (THD) dependence on the amplitude and frequency of the input signals. In this paper, the basic building blocks of analog integrated circuits such as Common source amplifier with diode connected load and Differential amplifier with current mirror load have been presented for distortion analysis. The MOSFET model used for simulation is BSIM3 SPICE model from 0.13-μm and BSIM4 SPICE model from 22-μm CMOS process technology. HSPICE circuit simulator tool is used for distortion analysis of CMOS circuits. It is evident that the above function gives remarkable insight of the nonlinear behavior of the considered circuits and it is worth considering for further investigations

User Feedback Analysis System using Natural Language Processing and Artificial Intelligence

The Web has dramatically changed the way that people express their views and opinions. Now if one wants to purchase a product, he/she is no longer limited to asking his/her friends and families because there are many product reviews on the Web which give opinions of existing users of the product. Here we present the system which provides us information about such products and services in summarization form. Finding opinion sources and monitoring them on the Web can still be a difficult task because there are a large number of diffrent sources, and each source may also have a huge volume of opinionated text (text with opinions or sentiments). In most cases, opinions are hidden in long forum posts and blogs. It is complicated for a human reader to find relable sources, extract related sentences with opinions, read them, summarize them, and manage them into usable forms. Thus, automated summarization systems are needed. Using this summarization we can recognize the importance, quality, popularity of product and services. In this system we make summarization for product. But, we can use this system anywhere, where text analysis is required. Sentiment analysis, also known as opinion mining, grows out of this need. It is a challenging natural language processing or text mining problem. Due to its tremendous value for practical applications, there has been an excessive growth of both research in academia and applications in the industry

Enhanced Distributed File Replication Protocol for Efficient File Sharing in Wireless Mobile Ad-Hoc Networks.

File sharing applications in mobile unintended networks (MANETs) have attracted additional and additional attention in recent years. The potency of file querying suffers from the distinctive properties of such networks as well as node quality and restricted communication vary and resource. associate degree intuitive methodology to alleviate this drawback is to form file replicas within the network. However, despite the efforts on file replication, no analysis has targeted on the worldwide optimum duplicate creation with minimum average querying delay. Specifically, current file replication protocols in mobile unintended networks have 2 shortcomings. First, they lack a rule to portion restricted resources to completely different files so as to reduce the typical querying delay. Second, they merely contemplate storage as offered resources for replicas, however neglect the actual fact that the file holders’ frequency of meeting different nodes additionally plays a crucial role in deciding file availableness. Actually, a node that contains a higher meeting frequency with others provides higher availableness to its files. This becomes even additional evident in sparsely distributed MANETs, during which nodes meet disruptively. during this paper, we have a tendency to introduce a replacement conception of resource for file replication, that considers each node storage and meeting frequency. we have a tendency to on paper study the influence of resource allocation on the typical querying delay and derive a resource allocation rule to reduce the typical querying delay. we have a tendency to additional propose a distributed file replication protocol to appreciate the projected rule. intensive trace-driven experiments with synthesized traces and real traces show that our protocol are able to do shorter average querying delay at a lower value than current replication protocols

Maintain the Consistency of Auditing Cloud

In day to day life cloud is most essential part. Now cloud storage are use for business purpose the cloud is popular due to their huge amount of advantages the cloud is portable we can able to access the cloud anywhere globally. A cloud service provider maintains much duplication and each piece of data are globally distributed on servers. The main problem of cloud is to handle duplication of data which is too costly to achieve powerful consistency on world wide .In this paper we present a novel consistency service model which contain a large amount of data cloud and multiple audit clouds In The Consistency Service model . a data cloud is maintain by Cloud service Provider (CSP) and the number of user constitute group and that group of user can constitute an audit cloud Which can check whether the data cloud provides the valid level of consistency or not we suggest the 2 level auditing architecture, two level auditing architecture requires a loosely synchronize clock in the audit cloud. Then, design algorithms to quantify the commonality of violations metrics, and the staleness of the value of a read metrics. Finally, a Analytical Auditing Strategy (AAS) to shows as many violations as possible. Thus system performed using a combination of simulations and real cloud deployments to validate Analytical Auditing Strategy (AAS). DOI: 10.17762/ijritcc2321-8169.15012

Photophysics of some styryl thiazolo quinoxaline dyes in organic media

The photophysics of a new class of styryl dyes, 2-styryl thiazolo quinoxaline (STQ) based structures was investigated in organic solvents and organized molecular assemblies. The absorption, steady state and time-resolved fluorescence characteristics of the STQ dyes in low-viscosity organic solvents are consistent with a single species in the ground and excited state. The one electron electrochemical oxidation and reduction potentials of the dyes are within ±1V vs. NHE. The spectral shifts of the dyes in organic solvents are linearly correlated with the variation of solvent polarity parameters. The dipole moments in the ground and excited state of the dyes were calculated without assuming a value for the cavity radius. The temperature dependence of the nonradiative rate of STQ dye in DMSO indicated an activation barrier (ΔE=10.7 kJ/mol) which is comparable to the activation energy (Ea=13.7 kJ/mol) of viscous friction in DMSO. In dichloromethane, the activation barrier is 34.0 kJ/mol which is very high compared to Ea=6.64 kJ/mol. Formation of a dye–solvent complex is suggested in dichloromethane. The fluorescence decay of STQ dye is multiexponential in a viscous solvent (2-octanol) or when bound to a protein (Lysozyme), micelle or lipid membrane. In 2-octanol, the decay parameters are wavelength dependent and the results are consistent with the mechanism of excited state kinetics of solvent relaxation. In other systems, the multiexponential decay is due to multiple sites of solubilization of the dye in the organized molecular assembly

Effect of different shading intensities on growth and yield of cherry tomato

Cherry tomato (Solanum lycopersicon var cerasiforme) is small size fruits, with a bright red colour resembling to cherry and becoming popular in the retail chains which are marketed at a premium price. The field experiment was conducted to study the effect of different (35, 50 and 75 per cent) shading intensities on growth and yield (qha-1 ) of cherry tomato. Significantly maximum yield was recorded in 35 per cent shading intensity and genotype Kalash Seeds Product (KSP)-113 (579.44 and 503.88 q ha-1 , respectively). Among the different shading intensities and genotypes, maximum plant height was observed in 75 per cent shading intensity and genotype KSP -113 at 30 days interval (74.70 and 60.95 cm, respectively). The minimum days to 50% flowering of cherry tomato were observed in cherry tomatoes grown under 35 per cent shading intensity (45.00 days) as compared to other shading intensities while minimum days to 50% flowering were observed in genotype KSP-113 (44.00 days). The maximum length of the cluster (9.58 cm), the weight of cluster (27.67 g), number of fruits per cluster (9.42) and number of pickings (11.67) were observed in 35 per cent shading intensities and in genotype KSP-113. The cultivation of KSP-113 genotype under 35 per cent shading intensity was found to be most sustainable for improving growth and yield of cherry tomato during the summer season