888 research outputs found
The Social and Cultural Context of Coping with Sickle Cell Disease: III. Stress, Coping Tasks, Family Functioning, and Children’s Adjustment
Conceptions of individual and family coping with sickle cell disease (SCD) must incorporate several disease and sociocultural factors. This article proposes an integrative model and tests the relative contribution of model parameters to the prediction of social, academic, and psychological adjustment of children with SCD. The individual coping and family functioning variables most highly predictive of the child’s psychological outcomes (anxiety, depression, and positive mood) include parental psychological functioning, maturity demands made of the ill child, and the quality of relations with parents and siblings. Academic adjustment was significantly predicted by parental academic expectations and by the child’s rejection of a restrictive sick role. Competent social functioning also was predicted by the extent to which the ill child rejected the role of being sick.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67288/2/10.1177_0095798499025003006.pd
Eosinophils Are Important for Protection, Immunoregulation and Pathology during Infection with Nematode Microfilariae
Eosinophil responses typify both allergic and parasitic helminth disease. In helminthic disease, the role of eosinophils can be both protective in immune responses and destructive in pathological responses. To investigate whether eosinophils are involved in both protection and pathology during filarial nematode infection, we explored the role of eosinophils and their granule proteins, eosinophil peroxidase (EPO) and major basic protein-1 (MBP-1), during infection with Brugia malayi microfilariae. Using eosinophil-deficient mice (PHIL), we further clarify the role of eosinophils in clearance of microfilariae during primary, but not challenge infection in vivo. Deletion of EPO or MBP-1 alone was insufficient to abrogate parasite clearance suggesting that either these molecules are redundant or eosinophils act indirectly in parasite clearance via augmentation of other protective responses. Absence of eosinophils increased mast cell recruitment, but not other cell types, into the broncho-alveolar lavage fluid during challenge infection. In addition absence of eosinophils or EPO alone, augmented parasite-induced IgE responses, as measured by ELISA, demonstrating that eosinophils are involved in regulation of IgE. Whole body plethysmography indicated that nematode-induced changes in airway physiology were reduced in challenge infection in the absence of eosinophils and also during primary infection in the absence of EPO alone. However lack of eosinophils or MBP-1 actually increased goblet cell mucus production. We did not find any major differences in cytokine responses in the absence of eosinophils, EPO or MBP-1. These results reveal that eosinophils actively participate in regulation of IgE and goblet cell mucus production via granule secretion during nematode-induced pathology and highlight their importance both as effector cells, as damage-inducing cells and as supervisory cells that shape both innate and adaptive immunity
Multi-material additive manufacturing of low sintering temperature Bi2Mo2O9 ceramics with Ag floating electrodes by selective laser burnout
Additive manufacturing (AM) of co-fired low temperature ceramics offers a unique route for fabrication of novel 3D radio frequency (RF) and microwave communication components, embedded electronics and sensors. This paper describes the first-ever direct 3D printing of low temperature co-fired ceramics/floating electrode 3D structures. Slurry-based AM and selective laser burnout (SLB) were used to fabricate bulk dielectric, Bi2Mo2O9 (BMO, sintering temperature = 620–650°C, εr = 38) with silver (Ag) internal floating electrodes. A printable BMO slurry was developed and the SLB optimised to improve edge definition and burn out the binder without damaging the ceramic. The SLB increased the green strength needed for shape retention, produced crack-free parts and prevented Ag leaching into the ceramic during co-firing. The green parts were sintered after SLB in a conventional furnace at 645°C for 4 h and achieved 94.5% density, compressive strength of 4097 MPa, a relative permittivity (εr) of 33.8 and a loss tangent (tan δ) of 0.0004 (8 GHz) for BMO. The feasibility of using SLB followed by a post-printing sintering step to create BMO/Ag 3D structures was thus demonstrated
Measurements of Deuteron Photodisintegration up to 4.0 GeV
The first measurements of the differential cross section for the d(gamma,p)n
reaction up to 4.0 GeV were performed at Continuous Electron Beam Accelerator
Facility (CEBAF) at Jefferson Lab. We report the cross sections at the proton
center-of-mass angles of 36, 52, 69 and 89 degrees. These results are in
reasonable agreement with previous measurements at lower energy. The 89 and 69
degree data show constituent-counting-rule behavior up to 4.0 GeV photon
energy. The 36 and 52 degree data disagree with the counting rule behavior. The
quantum chromodynamics (QCD) model of nuclear reactions involving reduced
amplitudes disagrees with the present data.Comment: 5 pages (REVTeX), 1 figure (postscript
Evidence from d+Au measurements for final-state suppression of high hadrons in Au+Au collisions at RHIC
We report measurements of single-particle inclusive spectra and two-particle
azimuthal distributions of charged hadrons at high transverse momentum (high
) in minimum bias and central d+Au collisions at =200 GeV.
The inclusive yield is enhanced in d+Au collisions relative to binary-scaled
p+p collisions, while the two-particle azimuthal distributions are very similar
to those observed in p+p collisions. These results demonstrate that the strong
suppression of the inclusive yield and back-to-back correlations at high
previously observed in central Au+Au collisions are due to final-state
interactions with the dense medium generated in such collisions.Comment: Final journal version. Data tables for figures may be downloaded from
the STAR home page: http://www.star.bnl.gov --> Publications --> Access to
STAR published dat
Pion-Xi correlations in Au-Au collisions at STAR
We present pion-Xi correlation analysis in Au-Au collisions at sqrt(s_NN)=
200 GeV and sqrt(s_NN) = 62.4 GeV, performed using the STAR detector at RHIC. A
Xi*(1530) resonance signal is observed for the first time in Au-Au collisions.
Experimental data are compared with theoretical predictions. The strength of
the Xi* peak is reproduced in the correlation function assuming that pions and
Xis emerge from a system in collective expansion.Comment: To appear in the proceedings of 18th Nuclear Physics Division
Conference of the EPS (NPDC18),Prague, 23.8.-29.8. 200
Particle-type dependence of azimuthal anisotropy and nuclear modification of particle production in Au+Au collisions at s(NN)**(1/2) = 200-GeV
We present STAR measurements of the azimuthal anisotropy parameter and
the binary-collision scaled centrality ratio for kaons and lambdas
() at mid-rapidity in Au+Au collisions at
GeV. In combination, the and
particle-type dependencies contradict expectations from partonic energy loss
followed by standard fragmentation in vacuum. We establish
GeV/c as the value where the centrality dependent baryon enhancement ends. The
and values are consistent with
expectations of constituent-quark-number scaling from models of hadron
fromation by parton coalescence or recombination.Comment: 6 pages, 4 figures, 1 table. As published in PRL on Feb. 2, 2004;
Significant revisions have been made to the text and color has been added to
plot
Rapidity and centrality dependence of proton and antiproton production from 197Au + 197Au collisions at √SNN = 130 GeV
We report on the rapidity and centrality dependence of proton and antiproton transverse mass distributions from 197Au + 197Au collisions at sqrt[sNN ]=130 GeV as measured by the STAR experiment at the Relativistic Heavy Ion Collider (RHIC). Our results are from the rapidity and transverse momentum range of |y| <0.5 and 0.35< pt <1.00 GeV/c . For both protons and antiprotons, transverse mass distributions become more convex from peripheral to central collisions demonstrating characteristics of collective expansion. The measured rapidity distributions and the mean transverse momenta versus rapidity are flat within |y| <0.5 . Comparisons of our data with results from model calculations indicate that in order to obtain a consistent picture of the proton (antiproton) yields and transverse mass distributions the possibility of prehadronic collective expansion may have to be taken into account
Inclusive pi0 spectra at high transverse momentum in d-Au collisions at RHIC
Preliminary results on inclusive neutral pion production in d-Au collisions
at sqrt(s_NN) = 200 GeV in the pseudo-rapidity range 0<eta<1 are presented. The
measurement is performed using the STAR Barrel Electromagnetic calorimeter
(BEMC). In this paper, the analysis of the first BEMC hadron measurement is
described and the results are compared with earlier RHIC findings. The pi0
invariant differential cross sections show good agreement with next-to-leading
order (NLO) perturbative QCD calculations.Comment: 4 pages, 5 figures, 18th Nuclear Physics Division Conference of the
EPS, Prague, submitted to Nucl. Phys.
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