Hypo-Loop Container Freight Transport: PART II Macro-Imagineering New World Macro-Projects

The proposed Hypo-Loop megaproject, which would tunnel under the Darién Gap, could provide a safe conduit for the transport of container freight and passengers between Panama and Colombia. The advantage of a tunnel linking Central America with South America is that transport would be via an underground low-pressure steel tube that alleviates terrestrial compromises of the environmentally sensitive Darién Gap ecosystem, which is recognized as an important natural environmental linkage between Panama and Colombia. This tunnel link is technically feasible using today’s modern tunnel boring methods that are amenable to providing infrastructure for mixed modal train transport. The Darién Gap Hypo-Loop Macro-project has the potential to provide environmentally safe transport across sensitive ecosystems by tunneling beneath them and at the same time opening up expansive transfer of goods and materials in the New World. Initiation and completion of the Hypo-Loop under the Darién Gap landscape would bring this region into the 21st Century as a showcase for enhancing the quality of life and improving New World economic systems.Key-words: Panama, Columbia, Atrato River, Hypo-Loop, passenger pods, containerized freight shipment, Darién Gap, Panama Canal, tunneling technology.===================================================================== O megaprojeto Hypo-Loop proposto, com tunelamento sob o Darién Gap, poderia fornecer um canal seguro para o transporte de contêineres e passageiros entre o Panamá e a Colômbia. A vantagem de um túnel que liga a América Central à América do Sul é que o transporte seria por meio de um tubo de aço subterrâneo de baixa pressão que evitaria o comprometimento do ecossistema Darién Gap, reconhecido como um importante vínculo ambiental natural entre o Panamá e a Colômbia. Esse  túnel é tecnicamente viável pelos métodos modernos de perfuração, capazes de fornecer infraestrutura para um modal misto. O macroprojeto Darién Gap Hypo-Loop tem o potencial de fornecer transporte ambientalmente seguro através de ecossistemas sensíveis, encapsulando-o sob eles e, ao mesmo tempo, abrindo um amplo intercâmbio de bens e materiais no Novo Mundo. No cenário do Darién Gap, a realização do Hypo-Loop faria dessa região uma vitrine sobre a melhoria da qualidade de vida e dos sistemas econômicos do Novo Mundo no século XXI.Palavras-chave: Panamá, Colômbia, Rio Atrato, Hypo-Loop, cápsulas de passageiros, remessa de carga em contêiner, Darién Gap, Canal do Panamá, tecnologia de tunelamento

Control strategies for integration of electric motor assist and functional electrical stimulation in paraplegic cycling: Utility for exercise testing and mobile cycling

AIM: The aim of this study was to investigate feedback control strategies for integration of electric motor assist and functional electrical stimulation (FES) for paraplegic cycling, with particular focus on development of a testbed for exercise testing in FES cycling, in which both cycling cadence and workrate are simultaneously well controlled and contemporary physiological measures of exercise performance derived. A second aim was to investigate the possible benefits of the approach for mobile, recreational cycling. METHODS: A recumbent tricycle with an auxiliary electric motor is used, which is adapted for paraplegic users, and instrumented for stimulation control. We propose a novel integrated control strategy which simultaneously provides feedback control of leg power output (via automatic adjustment of stimulation intensity) and cycling cadence (via electric motor control). Both loops are designed using system identification and analytical (model-based) feedback design methods. Ventilatory and pulmonary gas exchange response profiles are derived using a portable system for real-time breath-by-breath acquisition. RESULTS:We provide indicative results from one paraplegic subject in which a series of feedback-control tests illustrate accurate control of cycling cadence, leg power control, and external disturbance rejection. We also provide physiological response profiles from a submaximal exercise step test and a maximal incremental exercise test, as facilitated by the control strategy. CONCLUSION: The integrated control strategy is effective in facilitating exercise testing under conditions of well-controlled cadence and power output. Our control approach significantly extends the achievable workrate range and enhances exercise-test sensitivity for FES cycling, thus allowing a more stringent characterization of physiological response profiles and estimation of key parameters of aerobic function.We further conclude that the control approach can significantly improve the overall performance of mobile recreational cycling

Exuberant “Magic Carpet” Giga-Project Macro-Imagineering: The Arabian/Persian Gulf Shallow Draft PV-Raft Giga-Project

Processos naturais e atividades antropogênicas afetam de forma variável a diversidade climática e  ecossistêmica das nações ao redor do Golfo Pérsico-Arábico. O Magic Carpet Giga-Project, proposto como uma contramedida de enfrentamento da aridez dos ambientes regionais, é concebido como uma vasta jangada flutuante com painéis fotovoltaicos, disposta sobre o Golfo. Conectada por cabos elétricos a instalações terrestres, a energia poderia ser fornecida para cidades e para aplicações industriais que incluiriam enormes usinas de dessalinização de água do mar para uso municipal em geral. A adaptação espacial e marítima na forma de caminhos de aproximação e desvios será necessária em razão das rotas marítimas existentes, bem como do acesso adequado às plataformas da indústria petrolífera offshore que pontilham o Golfo. Os macroprojetos “The Line” e “The Loop” serão áreas bem delimitadas com vegetação controlada pelo clima, enquanto o “Magic Carpet” pode se tornar um esteio de dessalinização e fornecimento de eletricidade para a futura infraestrutura básica de cada estado do Golfo.Palavras-chave: Macroengenharia, Arábia Saudita, NEOM, jangada fotovoltaica flutuante, Golfo Pérsico-Arábico, Golfo da Califórnia. =========================================================================== Abstract: Natural processes and anthropogenic activities variably affect climate variability and meteorological drought in ecosystem-nations surrounding the Arabian-Persian Gulf. The Magic Carpet Giga-project, proposed as a counter measure to aridification of the regional environments, is envisaged as a vast floating PV-panel studded raft in the Gulf. Connected by electrical cables to land-based facilities, power could be provided for cities and industrial applications that would include enormous seawater desalination plants for municipal and commercial applications. Spatial and sea lane accommodation in the form of approach ways and bypasses will be necessary for designated sea-lanes, as well as according access to in-place offshore petroleum industry platforms dotting the Gulf. “The Line” and “The Loop” macro-projects are to be climate-controlled, vegetated enclosures whilst the “Magic Carpet” may become an electricity-desalination mainstay of the future basic infrastructure of every Gulf ecosystem-state.Keywords: Giga-project, Saudi Arabia, NEOM, floating photovoltaic raft, Arabian-Persian Gulf, Gulf of California

Mir-96 and miR-183 differentially regulate neonatal and adult post-infarct neovascularisation

Following myocardial infarction (MI), the adult heart has minimal regenerative potential. Conversely, the neonatal heart can undergo extensive regeneration, and neovascularisation capacity was hypothesised to contribute to this difference. Here, we demonstrate the higher angiogenic potential of neonatal compared to adult mouse cardiac endothelial cells (MCECs) in vitro and use this difference to identify candidate microRNAs (miRs) regulating cardiac angiogenesis after MI. MiR expression profiling revealed miR-96 and miR-183 upregulation in adult compared to neonatal MCECs. Their overexpression decreased the angiogenic potential of neonatal MCECs in vitro and prevented scar resolution and neovascularisation in neonatal mice after MI. Inversely, their inhibition improved the angiogenic potential of adult MCECs, and miR-96/miR-183 knock-out mice had increased peri-infarct neovascularisation. In silico analyses identified anillin (ANLN) as a direct target of miR-96 and miR-183. In agreement, Anln expression declined following their overexpression and increased after their inhibition in vitro. Moreover, ANLN expression inversely correlated with miR-96 expression and age in cardiac ECs of cardiovascular patients. In vivo, ANLN-positive vessels were enriched in the peri-infarct area of miR-96/miR-183 knock-out mice. These findings identify miR-96 and miR-183 as regulators of neovascularisation following MI and miR-regulated genes such as anillin as potential therapeutic targets for cardiovascular disease

Role of Esrrg in the Fibrate-Mediated Regulation of Lipid Metabolism Genes in Human ApoA-I Transgenic Mice

We have used a new ApoA-I transgenic mouse model to identify by global gene expression profiling, candidate genes that affect lipid and lipoprotein metabolism in response to fenofibrate treatment. Multilevel bioinformatical analysis and stringent selection criteria (2-fold change, 0% false discovery rate) identified 267 significantly changed genes involved in several molecular pathways. The fenofibrate-treated group did not have significantly altered levels of hepatic human APOA-I mRNA and plasma ApoA-I compared with the control group. However, the treatment increased cholesterol levels to 1.95-fold mainly due to the increase in high-density lipoprotein (HDL) cholesterol. The observed changes in HDL are associated with the upregulation of genes involved in phospholipid biosynthesis and lipid hydrolysis, as well as phospholipid transfer protein. Significant upregulation was observed in genes involved in fatty acid transport and β-oxidation, but not in those of fatty acid and cholesterol biosynthesis, Krebs cycle and gluconeogenesis. Fenofibrate changed significantly the expression of seven transcription factors. The estrogen receptor-related gamma gene was upregulated 2.36-fold and had a significant positive correlation with genes of lipid and lipoprotein metabolism and mitochondrial functions, indicating an important role of this orphan receptor in mediating the fenofibrate-induced activation of a specific subset of its target genes.National Institutes of Health (HL48739 and HL68216); European Union (LSHM-CT-2006-0376331, LSHG-CT-2006-037277); the Biomedical Research Foundation of the Academy of Athens; the Hellenic Cardiological Society; the John F Kostopoulos Foundatio