Making Markets for Merit Goods: The Political Economy of Antiretrovirals

This paper examines the role of policy entrepreneurs and global activists in shaping the international market for antiretroviral drugs to combat HIV/AIDS. When ARVs first came on the market in the 1990s they were exceedingly expensive; the cost of treatment was upwards of $10,000 per year. These drugs were thus accessible only to those patients who had high incomes. But in 2006, the “international community,” meeting at a United Nations General Assembly Special Session (UNGASS), made an astonishing pledge to those who were infected with HIV. It proclaimed that there should be universal access to ARV treatment. This UNGASS, following up on an earlier historic UN special session devoted entirely to AIDS in 2001, marked the first time in history that the international community pledged itself to chronic care for the ill, which in this case includes the approximately 30 million people around the world estimated to be HIV positive. How do we explain the transformation of ARVs from private goods, which only a few could afford, into merit goods that were (at least declaratively) to be made available to everyone? In other words, how does a norm of “universal access to treatment”—that no person should be denied these life-extending drugs—become the ethical basis for global public policy with respect to pharmaceutical allocation? What are the lessons of the ARV story for other global issues? These are the primary questions we explore in this paper. Briefly, we argue that the policy entrepreneurs and activists who promoted the creation of a universal access to treatment regime—of the transformation of ARVs into global merit goods—relied on a combination of moral arguments and ideas with favorable material circumstances. From the ethical perspective, the task of these entrepreneurs was to convince the “international community” that access to ARVs was a “human right,” or conversely to convince decision-makers that it was morally wrong to allocate these life-enhancing drugs solely on the basis of ability to pay. But from a material standpoint, these arguments were greatly facilitated by the lowering prices of ARVs caused by a combination of differential pricing (that is, lower prices for drugs in the developing world than in the advanced welfare states) and competition from generics producers, coupled with increases in foreign aid spending devoted to HIV/AIDS and other diseases.HIV/AIDS; ARVs; antiretrovirals; activists; policy entrepreneurs; merit goods; international community; global public health; global public policy; foreign aid

Interrupting the social amplification of risk process: a case study in collective emissions reduction

One of the main approaches we have for studying the progressive divergence of understandings around a risk issue is that of social risk amplification. This article describes a case study of a particular environmental contaminant, a chemical flame retardant that could be interpreted as having produced a risk amplifying process. It describes in particular how a group of industrial organizations acted collectively to reduce emissions of this contaminant, in an apparent attempt to avert regulation and boycotts—that is, to intercept the social amplification process and avoid its secondary effects. The aim of the study was to investigate the constitutive qualities of this collective action: the qualities that defined it and made it effective in the eyes of those involved. These include institutionalisation and independence, the ability to confer individual as well as collective benefit, the capacity to attract (rather than avoid) criticism, and the ‘branding’ that helps communicate what otherwise appear to be a set of unconnected, local actions. Although the risk amplification framework has been criticised for implying that there is some externally given risk level that is subsequently amplified, it does appear to capture the mentality of actors involved in issues of this kind. They talk and act as though they believe they are participants in a risk amplification process

Paleogeographic and tectonic setting of axial and western metamorphic framework rocks of the southern Sierra Nevada, California

This paper represents an update of our 1978 S.E.P.M. Mesozoic Paleogeography synthesis for the southern Sierra Nevada. We originally postulated that much of the southern Sierra Nevada pre-batholithic metamorphic framework consisted of lower Mesozoic siliciclastic, carbonate and pelitic strata with variable arc volcanic admixtures (Kings sequence). Recent syntheses, however, have attempted to minimize the importance of early Mesozoic strata in the region and to extend coherent Paleozoic terranes into the framework as the predominant protoliths. Neither lithologic correlations nor structural analysis can substantiate such a view, however, and the proposed configuration of the Paleozoic terranes is in conflict with the petrochemical zonation pattern of the Cretaceous batholith. We present stratigraphic relations for the relatively well-preserved lower Mesozoic stratified rocks of the southern Sierra which in general supports our 1978 synthesis. As pointed out by more recent syntheses, however, we now recognize the likelihood of Paleozoic basement rocks occurring in some or many of the Kings sequence pendants. Such rocks are disparate fragments of a highly dismembered polygenetic basement composed of Paleozoic ophiolitic, Shoo Fly, miogeoclinal and possibly Antler belt rocks rather than coherent terranes or crustal blocks. The lower stratal levels of the lower Mesozoic Kings sequence appears to have formed part of a regional post-Sonoman (Triassic) marine overlap sequence above this basement complex. Dismemberment and accretion of the basement complex involved transform truncation of the southwest Cordillera and Foothills ophiolite belt emplacement prior to and coincident with Sonoman thrust tectonics. Following the establishment of a Carnian-Norian carbonate platform as part of the overlap sequence, the region subsided and became part of a regional Early Jurassic forearc to intra-arc extensional basin system with the deposition of Kings sequence turbidites and olistostromes. The basin system was destroyed by Middle and Late Jurassic thrusting. The assertion that much of the Kings sequence is Paleozoic in age is based on the discovery of probable Eocambrian-Cambrian miogeoclinal strata in the Snow Lake pendant of the east-central Sierra Nevada (Lahren and others, 1991). These authors offer a reconstruction of the displacement of these strata as part of a large crustal block from the western Mojave region through the axial Sierra Nevada along a now cryptic fault. The bounds of the hypothetical crustal block, however, are at odds with batholithic petrochemical patterns. We propose a more conservative offset history for the Snow Lake pendant rocks which considers a broader uncertainty in the bounds of the possible source area for the rocks, and satisfies offsets of both batholithic petrochemical patterns and igneous-metamorphic assemblages of the Sierran batholithic complex

Computation of steady and unsteady quasi-one-dimensional viscous/inviscid interacting internal flows at subsonic, transonic, and supersonic Mach numbers

Computations of viscous-inviscid interacting internal flowfields are presented for steady and unsteady quasi-one-dimensional (Q1D) test cases. The unsteady Q1D Euler equations are coupled with integral boundary-layer equations for unsteady, two-dimensional (planar or axisymmetric), turbulent flow over impermeable, adiabatic walls. The coupling methodology differs from that used in most techniques reported previously in that the above mentioned equation sets are written as a complete system and solved simultaneously; that is, the coupling is carried out directly through the equations as opposed to coupling the solutions of the different equation sets. Solutions to the coupled system of equations are obtained using both explicit and implicit numerical schemes for steady subsonic, steady transonic, and both steady and unsteady supersonic internal flowfields. Computed solutions are compared with measurements as well as Navier-Stokes and inverse boundary-layer methods. An analysis of the eigenvalues of the coefficient matrix associated with the quasi-linear form of the coupled system of equations indicates the presence of complex eigenvalues for certain flow conditions. It is concluded that although reasonable solutions can be obtained numerically, these complex eigenvalues contribute to the overall difficulty in obtaining numerical solutions to the coupled system of equations

Hemoglobin genotype has minimal influence on the physiological response of juvenile atlantic cod (Gadus morhua) to environmental challenges

Hemoglobin (Hb) polymorphism in cod is associated with temperature‐related differences in biogeographical distribution, and several authors have suggested that functional characteristics of the various hemoglobin isoforms (HbIs) directly influence phenotypic traits such as growth rate. However, no study has directly examined whether Hb genotype translates into physiological differences at the whole animal level. Thus, we generated a family of juvenile Atlantic cod consisting of all three main Hb genotypes (HbI‐1/1, HbI‐2/2, and HbI‐1/2) by crossing a single pair of heterozygous parents, and we compared their metabolic and cortisol responses to an acute thermal challenge (10&deg;C to their critical thermal maximum [CTM] or 22&deg;C, respectively) and tolerance of graded hypoxia. There were no differences in routine metabolism (at 10&deg;C), maximum metabolic rate, metabolic scope, CTM (overall mean 22.9&deg; &plusmn; 0.2&deg;C), or resting and poststress plasma cortisol levels among Hb genotypes. Further, although the HbI‐1/1 fish grew more (by 15%&ndash;30% during the first 9 mo) when reared at 10&deg; &plusmn; 1&deg;C and had a slightly enhanced hypoxia tolerance at 10&deg;C (e.g., the critical O2 levels for HbI‐1/1, HbI‐2/2, and HbI‐1/2 cod were 35.56% &plusmn; 1.24%, and 40.20% &plusmn; 1.99% air saturation, respectively), these results are contradictory to expectations based on HbI functional properties. Thus, our findings (1) do not support previous assumptions that growth rate differences among cod Hb genotypes result from a more efficient use of the oxygen supply&mdash;that is, reduced standard metabolic rates and/or increased metabolic capacity&mdash;and (2) suggest that in juvenile cod, there is no selective advantage to having a particular Hb genotype with regards to the capacity to withstand ecologically relevant environmental challenges.<br /

Systematic comparison of monoclonal versus polyclonal antibodies for mapping histone modifications by ChIP-seq.

BackgroundThe robustness of ChIP-seq datasets is highly dependent upon the antibodies used. Currently, polyclonal antibodies are the standard despite several limitations: They are non-renewable, vary in performance between lots and need to be validated with each new lot. In contrast, monoclonal antibody lots are renewable and provide consistent performance. To increase ChIP-seq standardization, we investigated whether monoclonal antibodies could replace polyclonal antibodies. We compared monoclonal antibodies that target five key histone modifications (H3K4me1, H3K4me3, H3K9me3, H3K27ac and H3K27me3) to their polyclonal counterparts in both human and mouse cells.ResultsOverall performance was highly similar for four monoclonal/polyclonal pairs, including when we used two distinct lots of the same monoclonal antibody. In contrast, the binding patterns for H3K27ac differed substantially between polyclonal and monoclonal antibodies. However, this was most likely due to the distinct immunogen used rather than the clonality of the antibody.ConclusionsAltogether, we found that monoclonal antibodies as a class perform equivalently to polyclonal antibodies for the detection of histone post-translational modifications in both human and mouse. Accordingly, we recommend the use of monoclonal antibodies in ChIP-seq experiments

Full regularity for a C*-algebra of the Canonical Commutation Relations. (Erratum added)

The Weyl algebra,- the usual C*-algebra employed to model the canonical commutation relations (CCRs), has a well-known defect in that it has a large number of representations which are not regular and these cannot model physical fields. Here, we construct explicitly a C*-algebra which can reproduce the CCRs of a countably dimensional symplectic space (S,B) and such that its representation set is exactly the full set of regular representations of the CCRs. This construction uses Blackadar's version of infinite tensor products of nonunital C*-algebras, and it produces a "host algebra" (i.e. a generalised group algebra, explained below) for the \sigma-representation theory of the abelian group S where \sigma(.,.):=e^{iB(.,.)/2}. As an easy application, it then follows that for every regular representation of the Weyl algebra of (S,B) on a separable Hilbert space, there is a direct integral decomposition of it into irreducible regular representations (a known result). An Erratum for this paper is added at the end.Comment: An erratum was added to the original pape

Altitudinal Shifts of the Native and Introduced Flora of California in the Context of 20th-Century Warming

Aim: The differential responses of plant species to climate change are of great interest and grave concern for scientists and conservationists. One underexploited resource for better understanding these changes are the records held by herbaria. Using these records to assess the responses of different groups of species across the entire flora of California, we sought to quantify the magnitude of species elevational shifts, to measure differences in shifts among functional groups and between native and introduced species, and to evaluate whether these shifts were related to the conservation of thermal niches. Location: California. Methods: To characterize these shifts in California, we used 681,609 georeferenced herbarium records to estimate mean shifts in elevational and climatic space of 4426 plant taxa.We developed and employed a statistical method to robustly analyse the data represented in these records. Results: We found that 15% of all taxa in California have ranges that have shifted upward over the past century. There are significant differences between range shifts of taxa with different naturalization statuses: 12% of endemic taxa show significant upward range shifts, while a greater proportion (27%) of introduced taxa have shifted upward.We found significant differences between the proportion of significant range shifts across taxa with different seed sizes, but did not find evidence for differences in shift based on life-form (annual versus perennial, herbaceous versus woody). Main conclusions: Our analyses suggest that introduced species have disproportionately expanded their ranges upward in elevation over the past century when compared with native species.While these shifts in introduced species may not be exclusively driven by climate, they highlight the importance of considering the interacting factors of climate-driven range shifts and invasion to understand how floras are responding in the face of anthropogenic change

Disturbance, Pollinator Predictability, and Pollination Success Among Costa Rican Cloud Forest Plants

Cloud forest at Monteverde, Costa Rica experiences frequent natural disturbance. To determine whether species interactions vary spatially due to physical heterogeneity produced by disturbance, we examined relationships between 22 plant species and 11 nectar—feeding bird species in 14 study plots distributed among three patch types: larger landslide—like gaps (hand—cleared areas along a trail), small gaps (formed by recent treefalls), and understory of closed—canopy forest. Species we describe here flowered in two or three patch types. The aspects of pollination we examined varied little with patch type. Mean frequency of pollinator visits varied with patch type in a few plant species but not in most, and there was no significant trend across species. Pollen loads carried by 314 mist—netted hummingbirds did not vary significantly with patch type, either in total number of grains or number of species represented. Cumulative pollen loads that hummingbirds deposited on stigmas of two species of Acanthaceae (Razisea spicata and Hansteinia blepharorachis) did not vary consistently with patch type, except that Hansteinia flowers in treefall gaps received fewer heterospecific pollen grains than flowers in the other two patch types. Frequency of fruit set varied significantly with patch type in three of the four species examined, but the direction of variation in one of these was opposite to the direction of the other two. The absolute frequency with which flowers were pierced by nectar—robbing hummingbirds did not vary significantly with patch type, although the frequency of piercing relative to legitimate pollinator visits did increase in the large gaps. We attribute the latter result to aggregation of the hummingbird Eupherusa eximia, a chronic nectar robber, at dense clumps of long—flowered plant species that occurred in large gaps. Only one feature we examined suggested that patch type might directly affect the nature of species interactions: in two different analyses, the level of variation in frequency of hummingbird visits to flowers declined from large gaps to small gaps to forest. Results suggest that, unless the disturbance initiating a patch is unusually severe or widespread, interactions between the plants and hummingbirds examined are insensitive to patch type. Such species, existing in naturally dynamic forests throughout their recent evolutionary histories, presumably have become accommodated to frequent small—scale disturbance. Results also suggest that those habitat—related contrasts in plant reproductive traits and plant—pollinator interactions documented in other studies, which compare habitats initiated by anthropogenic disturbances with undisturbed patches, may be artifacts to some extent. Anthropogenically generated disturbance mosaics may promote the spread of species whose reproductive traits evolved under very different circumstances from mosaics generated by natural disturbances