Semantics of the Painted Image in Hugo von Hofmannsthal’s Tod des Tizian

Form theories in Hofmannstahl’s aesthetic program aim at a reciprocal empowerment of life and art. Titian’s last painting in Tod des Tizian (1892) has to express a concept of unity and totality of all living things. Most disciples are not able to understand this, as they can’t get free of the model of existence of the aesthete, who rejects life, perceiving it as abandoned to chaos and disorder, but is incapable of replacing it with any other form because he exalts art as an object of mere idolatry, as a pure and simple instrument of defence from the pitfalls of life

Transition to resonance-rich matter in heavy ion collisions at RHIC energies

The equilibration of hot and dense nuclear matter produced in the central region in central Au+Au collisions at $\sqrt{s}=200$ AGeV is studied within the microscopic transport model UrQMD. The pressure here becomes isotropic at $t \approx 5$ fm/c. Within the next 15 fm/c the expansion of the matter proceeds almost isentropically with the entropy per baryon ratio $S/A \approx 150$. During this period the equation of state in the $(P,\epsilon)$-plane has a very simple form, $P=0.15 \epsilon$. Comparison with the statistical model (SM) of an ideal hadron gas reveals that the time of $\approx 20$ fm/$c$ may be too short to attain the fully equilibrated state. Particularly, the fractions of resonances are overpopulated in contrast to the SM values. The creation of such a long-lived resonance-rich state slows down the relaxation to chemical equilibrium and can be detected experimentally.Comment: Talk at the conference Strangeness'2000, to be published in J. of Phys.

The Journal of Biological Chemistry / Structural analyses of Arabidopsis thaliana legumain reveal differential recognition and processing of proteolysis and ligation substrates

Legumain is a dual-function proteasepeptide ligase whose activities are of great interest to researchers studying plant physiology and to biotechnological applications. However, the molecular mechanisms determining the specificities for proteolysis and ligation are unclear because structural information on the substrate recognition by a fully activated plant legumain is unavailable. Here, we present the X-ray structure of Arabidopsis thaliana legumain isoform (AtLEG) in complex with the covalent peptidic Ac-YVAD chloromethyl ketone (CMK) inhibitor targeting the catalytic cysteine. Mapping of the specificity pockets preceding the substrate-cleavage site explained the known substrate preference. The comparison of inhibited and free AtLEG structures disclosed a substrate-induced disorderorder transition with synergistic rearrangements in the substrate-recognition sites. Docking and in vitro studies with an AtLEG ligase substrate, sunflower trypsin inhibitor (SFTI), revealed a canonical, protease substratelike binding to the active sitebinding pockets preceding and following the cleavage site. We found the interaction of the second residue after the scissile bond, P2′S2′, to be critical for deciding on proteolysis versus cyclization. cis-trans-Isomerization of the cyclic peptide product triggered its release from the AtLEG active site and prevented inadvertent cleavage. The presented integrative mechanisms of proteolysis and ligation (transpeptidation) explain the interdependence of legumain and its preferred substrates and provide a rational framework for engineering optimized proteases, ligases, and substrates.W_01213M1901(VLID)266778

Equation of State, Spectra and Composition of Hot and Dense Infinite Hadronic Matter in a Microscopic Transport Model

Equilibrium properties of infinite relativistic hadron matter are investigated using the Ultrarelativistic Quantum Molecular Dynamics (UrQMD) model. The simulations are performed in a box with periodic boundary conditions. Equilibration times depend critically on energy and baryon densities. Energy spectra of various hadronic species are shown to be isotropic and consistent with a single temperature in equilibrium. The variation of energy density versus temperature shows a Hagedorn-like behavior with a limiting temperature of 130$\pm$10 MeV. Comparison of abundances of different particle species to ideal hadron gas model predictions show good agreement only if detailed balance is implemented for all channels. At low energy densities, high mass resonances are not relevant; however, their importance raises with increasing energy density. The relevance of these different conceptual frameworks for any interpretation of experimental data is questioned.Comment: Latex, 20 pages including 6 eps-figure

Equation of state of resonance-rich matter in the central cell in heavy-ion collisions at s\sqrt{s}=200 AGeV

The equilibration of hot and dense nuclear matter produced in the central cell of central Au+Au collisions at RHIC ($\sqrt{s}=200$ AGeV) energies is studied within a microscopic transport model. The pressure in the cell becomes isotropic at $t\approx 5$ fm/$c$ after beginning of the collision. Within the next 15 fm/$c$ the expansion of matter in the cell proceeds almost isentropically with the entropy per baryon ratio $S/A \approx 150$, and the equation of state in the $(P,\epsilon)$ plane has a very simple form, $P=0.15\epsilon$. Comparison with the statistical model of an ideal hadron gas indicates that the time $t \approx 20$ fm/c may be too short to reach the fully equilibrated state. Particularly, the creation of long-lived resonance-rich matter in the cell decelerates the relaxation to chemical equilibrium. This resonance-abundant state can be detected experimentally after the thermal freeze-out of particles.Comment: LATEX, 21 pages incl. 7 figure