Implementation of Digital Marketing & Knowledge Transfer of Holland Park Permaculture Products

Business problems are generally related to business capital and infrastructure, especially businesses that fall into the category of small and medium-sized micro enterprises (MSMEs). But the fact that the business of the era of artifiacial intelligence leads more to how our products can dominate market share, especially the Digital market. This research focuses on the implementation of digital marketing and knowledge transfer of Hollandpark permaculture products in the Gorontalo Province. Starting from the stage of diagnosis of problems, determination of the main problem, application testing, management of insights and algorithm and maintenance or transfer of knowledge. The results showed that the implementation of digital marketing using Instagram social media and google my business was able to expand the scope of Sales and Visitors Hollandpark. And the most important thing is that the Hollandpark Manager can run digital marketing independently and more appreciation to the cooperation between researchers and Hollandpark. Keywords: Digital marketing, knowledge transfer, permacultur

Western diet‐induced increase in colonic bile acids compromises epithelial barrier in nonalcoholic steatohepatitis

There is compelling evidence implicating intestinal permeability in the pathogenesis of nonalcoholic steatohepatitis (NASH), but the underlying mechanisms remain poorly understood. Here we examined the role of bile acids (BA) in western diet (WD)‐induced loss of colonic epithelial barrier (CEB) function in mice with a genetic impairment in intestinal epithelial barrier function, junctional adhesion molecule A knockout mice, F11r−/−. WD‐fed knockout mice developed severe NASH, which was associated with increased BA concentration in the cecum and loss of CEB function. Analysis of cecal BA composition revealed selective increases in primary unconjugated BAs in the WD‐fed mice, which correlated with increased abundance of microbial taxa linked to BA metabolism. In vitro permeability assays revealed that chenodeoxycholic acid (CDCA), which was elevated in the cecum of WD‐fed mice, increased paracellular permeability, while the BA‐binding resin sevelamer hydrochloride protected against CDCA‐induced loss of barrier function. Sequestration of intestinal BAs by in vivo delivery of sevelamer to WD‐fed knockout mice attenuated colonic mucosal inflammation and improved CEB. Sevelamer also reduced hepatic inflammation and fibrosis, and improved metabolic derangements associated with NASH. Collectively, these findings highlight a hitherto unappreciated role for BAs in WD‐induced impairment of the intestinal epithelial barrier in NASH.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/155502/1/fsb220488.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/155502/2/fsb220488_am.pd

Prostate cancer cell malignancy via modulation of HIF-1 alpha pathway with isoflurane and propofol alone and in combination

BACKGROUND: Surgery is considered to be the first line treatment for solid tumours. Recently, retrospective studies reported that general anaesthesia was associated with worse long-term cancer-free survival when compared with regional anaesthesia. This has important clinical implications; however, the mechanisms underlying those observations remain unclear. We aim to investigate the effect of anaesthetics isoflurane and propofol on prostate cancer malignancy. METHODS: Prostate cancer (PC3) cell line was exposed to commonly used anaesthetic isoflurane and propofol. Malignant potential was assessed through evaluation of expression level of hypoxia-inducible factor-1α (HIF-1α) and its downstream effectors, cell proliferation and migration as well as development of chemoresistance. RESULTS: We demonstrated that isoflurane, at a clinically relevant concentration induced upregulation of HIF-1α and its downstream effectors in PC3 cell line. Consequently, cancer cell characteristics associated with malignancy were enhanced, with an increase of proliferation and migration, as well as development of chemoresistance. Inhibition of HIF-1α neosynthesis through upper pathway blocking by a PI-3K-Akt inhibitor or HIF-1α siRNA abolished isoflurane-induced effects. In contrast, the intravenous anaesthetic propofol inhibited HIF-1α activation induced by hypoxia or CoCl(2). Propofol also prevented isoflurane-induced HIF-1α activation, and partially reduced cancer cell malignant activities. CONCLUSIONS: Our findings suggest that modulation of HIF-1α activity by anaesthetics may affect cancer recurrence following surgery. If our data were to be extrapolated to the clinical setting, isoflurane but not propofol should be avoided for use in cancer surgery. Further work involving in vivo models and clinical trials is urgently needed to determine the optimal anaesthetic regimen for cancer patients

KESUKSESAN IMPLEMENTASI SAP HUMAN RESOURCE INFORMATION SYSTEM (HRIS) DI INDUSTRI OTOMOTIF SUNTER JAKARTA UTARA

Penelitian ini mengukur kesuksesan dari implementasi sistem informasi Sumber Daya Manusia (HRIS) menggunakan SAP (system application product and data processing) pada industri otomotif Sunter, Jakarta Utara. Produk HRIS SAP sangat popular dikalangan industri otomotif dan tentunya aplikasi tersebut membuat kinerja perusahaan menjadi lebih baik. Survei di sebar di beberapa titik yakni di PT AH, PT M8 dan PT SAR. Selain itu penelitian ini menggunakan mix method dimana terbagi atas analisis kuantitatif (statistic dekskriptif) dan kualitatif dengan wawancara mendalam pada user, key user dan super user agar data yang dihasilkan lebih akurat. Hasil penelitian menunjukan bahwa implementasi HRIS SAP cukup berhasil dalam periode kurang lebih satu tahun implementasi. Implementasi tidak lepas dari pengaruh data yang user friendly, akurat dan terintegrasi serta pelatihan user yang selaras dengan kebutuhan perusahaan sehingga membuat project implementasi berjalan lancar. Secara keseluruhan client PT AH. PT M8 dan PT SAR merasa puas terhadap proses implementasi HRIS ini.

Pengaruh Lingkungan Kerja dan Kesehatan dan Keselamatan Kerja (K3) Terhadap Kinerja Karyawan Pada Perusahaan Daerah Air Minum (PDAM) Bone Bolango

Penelitian ini bertujuan untuk 1) mengetahui seberapa besar pengaruh lingkungan kerja terhadap kinerja karyawan, 2) mengetahui seberapa besar pengaruh kesehatan dan keselamatan kerja (K3) terhadap kinerja karyawan, 3) mengetahui seberapa besar pengaruh lingkungan kerja dan kesehatan dan keselamatan kerja (K3) terhadap kinerja karyawan. Metode yang digunakan dalam penelitian ini adalah kuantitatif dengan pendekatan asosiatif. Data yang digunakan diperoleh dari penyebaran kuesioner kepada karyawan di Perusahaan Daerah Air Minum (PDAM) Bone Bolango. Penarikan sampel dalam penelitian ini menggunakan sampling jenuh dengan jumlah 83 responden. Analisis data dalam penelitian ini menggunakan analisis regresi linear berganda. Hasil penelitian menunjukkan 1) lingkungan kerja memiliki pengaruh terhadap kinerja karyawan, 2) kesehatan dan keselamatan kerja (K3) memiliki pengaruh terhadap kinerja karyawan, dan 3) lingkungan kerja dan kesehatan dan keselamatan kerja (K3) memiliki pengaruh terhadap kinerja karyawan. Koefisien determinasi dalam penelitian ini sebesar 64,4%. Yang berarti variabilitas kinerja karyawan dapat dijelaskan oleh lingkungan kerja dan kesehatan dan keselamatan kerja (K3) sebesar 64,4% dan 35,6% dipengaruhi oleh variabel lain yang tidak termasuk dalam model penelitian ini. Kata Kunci: Lingkungan Kerja, Kesehatan dan Keselamatan Kerja (K3), Kinerja Karyawan

Pelatihan Pengembangan Komunikasi Pemasaran pada Produk Usaha Kelompok Pemberdayaan Kesejahteraan Keluarga Desa Cukangkawung, Kabupaten Tasikmalaya

MARKETING COMMUNICATION DEVELOPMENT TRAINING ON BUSINESS PRODUCTS OF FAMILY WELFARE EMPOWERMENT GROUP IN CUKANGKAWUNG VILLAGE, TASIKMALAYA REGENCY. This community service aims to assist partners in developing partner-owned businesses through marketing communications. Cukangkawung Village is rich in natural resources, one of which is processed from nature as a product that can be marketed and has the potential to compete in the market. However, this is constrained in marketing partner products. One of the problems is that marketing is still local in nature, does not have a brand and packaging is still plain. The condition of partner product packaging is still using clear plastic with staples attached and the copy product brand, of course this does not provide added value to partner products. Therefore, assistance is needed on how to market products, one of which is packaging that attracts consumers. So that the selling value of partner products increases. The results of the activity show change in increased knowledge and understanding of the potential, benefits, importance of packaging, digital marketing and promotional techniques. Through this service, products that have added value in promoting are created and supported by providing packaging and sealer for three partner groups in Cukangkawung Village, namely Molring in Cilogata village, snacks in Bangbayang and Harapan Mukti village business group

Strengthening the Tourism Sector Business in Gorontalo Province Through the Utilization of the E-Commerce Platform and the Electronic Word of Mouth

This study was conducted to analyze the role or influence between e-commerce platforms, electronic word of mouth on the business performance of the tourism sector in several tourist attractions in Gorontalo. The design of this research was a mix method, where some of the objects of this research were visitors and residents around the tourist attractions amount 30 people. The data analysis that we used were hypothesis testing, validity, reliability, normality and multiple regression as well as interviews as additional research information. The results show that E-commerce has an influence on tourism performance, and E-WOT does not have a significant relationship with tourism business performance in Gorontalo