Book Review:Culturally Responsive Pedagogy: Teaching Like Our Students \u27Lives Matter

The book clarifies the key concepts and issues that language teachers, language learners, administrators, and language test experts are faced with. It was written to provide a connection between the theories of culturally responsive pedagogy with practicalities of this pedagogy. It covers our language teacher-students\u27 questions about how to ‘deal with\u27 culturally responsive pedagogy. It provides not only a set of tools or methods for teaching language but also an amalgamation of theory, research, and a conceptual structure for dealing with cultural responsiveness to students

What is the right theory for Anderson localization of light?

Anderson localization of light is traditionally described in analogy to electrons in a random potential. Within this description the disorder strength -- and hence the localization characteristics -- depends strongly on the wavelength of the incident light. In an alternative description in analogy to sound waves in a material with spatially fluctuating elastic moduli this is not the case. Here, we report on an experimentum crucis in order to investigate the validity of the two conflicting theories using transverse-localized optical devices. We do not find any dependence of the observed localization radii on the light wavelength. We conclude that the modulus-type description is the correct one and not the potential-type one. We corroborate this by showing that in the derivation of the traditional, potential-type theory a term in the wave equation has been tacititly neglected. In our new modulus-type theory the wave equation is exact. We check the consistency of the new theory with our data using a field-theoretical approach (nonlinear sigma model)

Composite fermions close to the one-half filling of the lowest Landau level revisited

By strictly adhering to the microscopic theory of composite fermions for the Landau-level filling fractions nu_e = p/(2 p + 1), we reproduce, with remarkable accuracy, the surface-acoustic-wave (SAW)-based experimental results by Willett and co-workers concerning two-dimensional electron systems with nu_e close to 1/2. Our results imply that the electron band mass m_b, as distinct from the composite fermion mass m_*, must undergo a substantial increase under the conditions corresponding to nu_e approximately equal to 1/2. In view of the relatively low aerial electronic densities n_e to which the underlying SAW experiments correspond, our finding conforms with the experimental results by Shashkin et al. [Phys. Rev. B 66, 073303 (2002)], concerning two-dimensional electrons in silicon, that signal sharp increase in m_b for n_e decreasing below approximately 2 x 10^{11} cm^{-2}. We further establish that a finite mean-free path l_0 is essential for the observed linearity of the longitudinal conductivity sigma_{xx}(q) as deduced from the SAW velocity shifts.Comment: 5 pages, 2 postscript figure

Presence of lead in opium.

Opium addiction is a common form of addiction in Middle East countries such as Iran. Recently several reports suggested some kinds of pathologic findings such as abdominal pain, nephropathy, and anemia in opium addict patients. Such pathologic findings suggest lead poisoning in the patients. In this study, the concentration of lead in 10 opium samples was evaluated. The mean concentration of lead in the opium samples was 1.88 ppm. This may explain some of the pathologic findings found in addict patients. The authors would suggest further investigations to evaluate the lead concentration in opium addicts' sera and also routine screening for lead poisoning in opium addict patients

An evaluation of the TRIPS computer system

The TRIPS system employs a new instruction set architecture (ISA) called Explicit Data Graph Execution (EDGE) that renegotiates the boundary between hardware and software to expose and exploit concurrency. EDGE ISAs use a block-atomic execution model in which blocks are composed of dataflow instructions. The goal of the TRIPS design is to mine concurrency for high performance while tolerating emerging technology scaling challenges, such as increasing wire delays and power consumption. This paper evaluates how well TRIPS meets this goal through a detailed ISA and performance analysis. We compare performance, using cycles counts, to commercial processors. On SPEC CPU2000, the Intel Core 2 outperforms compiled TRIPS code in most cases, although TRIPS matches a Pentium 4. On simple benchmarks, compiled TRIPS code outperforms the Core 2 by 10% and hand-optimized TRIPS code outperforms it by factor of 3. Compared to conventional ISAs, the block-atomic model provides a larger instruction window, increases concurrency at a cost of more instructions executed, and replaces register and memory accesses with more efficient direct instruction-to-instruction communication. Our analysis suggests ISA, microarchitecture, and compiler enhancements for addressing weaknesses in TRIPS and indicates that EDGE architectures have the potential to exploit greater concurrency in future technologies

Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs

Helicobacter pylori specifically colonizes the human gastric epithelium and is the major causative agent for ulcer disease and gastric cancer development. Here, we identify members of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family as receptors of H. pylori and show that HopQ is the surface-exposed adhesin that specifically binds human CEACAM1, CEACAM3, CEACAM5 and CEACAM6. HopQ-CEACAM binding is glycan-independent and targeted to the N-domain. H. pylori binding induces CEACAM1-mediated signalling, and the HopQ-CEACAM1 interaction enables translocation of the virulence factor CagA into host cells and enhances the release of pro-inflammatory mediators such as interleukin-8. Based on the crystal structure of HopQ, we found that a beta-hairpin insertion (HopQ-ID) in HopQ's extracellular 3+4 helix bundle domain is important for CEACAM binding. A peptide derived from this domain competitively inhibits HopQ-mediated activation of the Cag virulence pathway, as genetic or antibody-mediated abrogation of the HopQ function shows. Together, our data suggest the HopQ-CEACAM1 interaction to be a potentially promising novel therapeutic target to combat H. pylori-associated diseases.</p

Investigation of TSGA10 gene expression, localization and protein interaction in human and mouse spermatogenesis.

Isolation of the testis-specific human gene TSGA10 was reported in 2001 (Modarressi et al.). In this project, I have carried on the work by further characterising the gene and its product by cloning and sequencing the mouse homologue (Tsga10) (GenBank Accession no. AF5300501). Tsga10 was localised by FISH to mouse chromosome 1 band B, and RNA in situ hybridization and RT-PCR experiments showed that Tsga10 transcripts were developmentally regulated and expressed in pachytene cells of the testis. It was also expressed in some other actively dividing cells such as foetal tissues, primary tumors and astrocytes. Interestingly, the program Pfam (which predicts protein structural motifs) suggests that the Tsga10 protein contains a 'myosin like' coiled-coil domain. A Green fluorescent protein (GFP)-Tsgal10 fusion gene was constructed and cell transfection resulted in the formation of short thick protein filaments. Antibodies raised individually against the N-terminus and C-terminus parts of the Tsga10 protein were used to localise Tsga10 protein expression by immunohistochemistry. In collaboration with Hossein Modarressi and Frans Van der Hoorn, using immuno-blotting and staining techniques, I discovered that Tsga10 encodes a 82 kD precursor protein in spermatids which is incorporated into sperm tails. Upon passage of sperm into the epididymis this is processed to a 27 kD protein which is associated with the fibrous sheath, a major tail structure. Using Tsga10 as bait in a yeast two-hybrid experiment, citestis cDNA library was screened for proteins that interacted with Tsga10. Three candidate interacting proteins were found; Odf2, a previously described protein of the fibrous sheath, the rat homologue of FU32880, (a hypothetical human protein whose gene is expressed predominantly in spermatocytes, spermatids and mature sperm cells), and the mitochondrial protein cytochrome cl. Using immunocytochemistry I then localised FLJ32880 (newly named as TSGA10 interacting protein, TSGA10IP) in the sperm tail as another fibrous sheath protein. These results support the theory that Tsga10 has a role to play in the fibrous sheath of the sperm tail, and also suggest a possible functional involvement with a mitochondrial protein. Antibody was raised against the mouse homologue of TSGA10IP for further study. I suggest that Tsga10 plays multiple roles, one in sperm tail formation and possibly a second role in cell cycle regulation