Fluctuations of the Casimir-Polder force between an atom and a conducting wall

We consider the quantum fluctuations of the Casimir-Polder force between a neutral atom and a perfectly conducting wall in the ground state of the system. In order to obtain the atom-wall force fluctuation we first define an operator directly associated to the force experienced by the atom considered as a polarizable body in an electromagnetic field, and we use a time-averaged force operator in order to avoid ultraviolet divergences appearing in the fluctuation of the force. This time-averaged force operator takes into account that any measurement involves a finite time. We also calculate the Casimir-Polder force fluctuation for an atom between two conducting walls. Experimental observability of these Casimir-Polder force fluctuations is also discussed, as well as the dependence of the relative force fluctuation on the duration of the measurement.Comment: 6 page

Elliptic Flow, Initial Eccentricity and Elliptic Flow fluctuations in Heavy Ion Collisions at RHIC

We present measurements of elliptic flow and event-by-event fluctuations established by the PHOBOS experiment. Elliptic flow scaled by participant eccentricity is found to be similar for both systems when collisions with the same number of participants or the same particle area density are compared. The agreement of elliptic flow between Au+Au and Cu+Cu collisions provides evidence that the matter is created in the initial stage of relativistic heavy ion collisions with transverse granularity similar to that of the participant nucleons. The event-by-event fluctuation results reveal that the initial collision geometry is translated into the final state azimuthal particle distribution, leading to an event-by-event proportionality between the observed elliptic flow and initial eccentricity.Comment: To appear in the proceedings of the Lake Louise Winter Institute 2007. The proceedings of the institute will be published by World Scientifi

Simulation tools for future interferometers

For the design and commissioning of the LIGO interferometer, simulation tools have been used explicitly and implicitly. The requirement of the advanced LIGO interferometer is much more demanding than the first generation interferometer. Development of revised simulation tools for future interferometers are underway in the LIGO Laboratory. The outline of those simulation tools and applications are discussed

GAELS Project Final Report: Information environment for engineering

The GAELS project was a collaboration commenced in 1999 between Glasgow University Library and Strathclyde University Library with two main aims:· to develop collaborative information services in support of engineering research at the Universities of Glasgow and Strathclyde· to develop a CAL (computer-aided learning package) package in advanced information skills for engineering research students and staff The project was funded by the Scottish Higher Education Funding Council (SHEFC) from their Strategic Change Initiative funding stream, and funding was awarded initially for one year, with an extension of the grant for a further year. The project ended in June 2001.The funding from SHEFC paid for two research assistants, one based at Glasgow University Library working on collaborative information services and one based at Strathclyde University Library developing courseware. Latterly, after these two research assistants left to take up other posts, there has been a single researcher based at Glasgow University Library.The project was funded to investigate the feasibility of new services to the Engineering Faculties at both Universities, with a view to making recommendations for service provision that can be developed for other subject areas

Regulated Inositol‐Requiring Protein 1‐Dependent Decay as a Mechanism of Corin RNA and Protein Deficiency in Advanced Human Systolic Heart Failure

BACKGROUND: The compensatory actions of the endogenous natriuretic peptide system require adequate processing of natriuretic peptide pro‐hormones into biologically active, carboxyl‐terminal fragments. Natriuretic peptide pro‐peptide processing is accomplished by corin, a transmembrane serine protease expressed by cardiomyocytes. Brain natriuretic peptide (BNP) processing is inadequate in advanced heart failure and is independently associated with adverse outcomes; however, the molecular mechanisms causing impaired BNP processing are not understood. We hypothesized that the development of endoplasmic reticulum stress in cardiomyocytes in advanced heart failure triggers inositol‐requiring protein 1 (IRE1)‐dependent corin mRNA decay, which would favor a molecular substrate favoring impaired natriuretic peptide pro‐peptide processing. METHODS AND RESULTS: Two independent samples of hearts obtained from patients with advanced heart failure at transplant demonstrated that corin RNA was reduced as Atrial natriuretic peptide (ANP)/BNP RNA increased. Increases in spliced X‐box protein 1, a marker for IRE1‐endoribonuclease activity, were associated with decreased corin RNA. Moreover, ≈50% of the hearts demonstrated significant reductions in corin RNA and protein as compared to the nonfailing control sample. In vitro experiments demonstrated that induction of endoplasmic reticulum stress in cultured cardiomyocytes with thapsigargin activated IRE1s endoribonuclease activity and time‐dependent reductions in corin mRNA. In HL‐1 cells, overexpression of IRE1 activated IRE1 endoribonuclease activity and caused corin mRNA decay, whereas IRE1‐RNA interference with shRNA attenuated corin mRNA decay after induction of endoplasmic reticulum stress with thapsigargin. Pre‐treatment of cells with Actinomycin D to inhibit transcription did not alter the magnitude or time course of thapsigargin‐induced corin mRNA decline, supporting the hypothesis that this was the result of IRE1‐mediated corin mRNA degradation. CONCLUSIONS: These data support the hypothesis that endoplasmic reticulum stress‐mediated, IRE1‐dependent targeted corin mRNA decay is a mechanism leading to corin mRNA resulting in corresponding corin protein deficiency may contribute to the pathophysiology of impaired natriuretic peptide pro‐hormone processing in humans processing in humans with advanced systolic heart failure

Possible Local Spiral Counterparts to Compact Blue Galaxies at Intermediate Redshift

We identify nearby disk galaxies with optical structural parameters similar to those of intermediate-redshift compact blue galaxies. By comparing HI and optical emission-line widths, we show that the optical widths substantially underestimate the true kinematic widths of the local galaxies. By analogy, optical emission-line widths may underrepresent the masses of intermediate-z compact objects. For the nearby galaxies, the compact blue morphology is the result of tidally-triggered central star formation: we argue that interactions and minor mergers may cause apparently compact morphology at higher redshift.Comment: 5 pages, uses emulateapj5 and psfig. To appear in ApJ

Multiplexed DNA-Modified Electrodes

We report the use of silicon chips with 16 DNA-modified electrodes (DME chips) utilizing DNA-mediated charge transport for multiplexed detection of DNA and DNA-binding protein targets. Four DNA sequences were simultaneously distinguished on a single DME chip with 4-fold redundancy, including one incorporating a single base mismatch. These chips also enabled investigation of the sequence-specific activity of the restriction enzyme Alu1. DME chips supported dense DNA monolayer formation with high reproducibility, as confirmed by statistical comparison to commercially available rod electrodes. The working electrode areas on the chips were reduced to 10 μm in diameter, revealing microelectrode behavior that is beneficial for high sensitivity and rapid kinetic analysis. These results illustrate how DME chips facilitate sensitive and selective detection of DNA and DNA-binding protein targets in a robust and internally standardized multiplexed format

Background Independent Algebraic Structures in Closed String Field Theory

We construct a Batalin-Vilkovisky (BV) algebra on moduli spaces of Riemann surfaces. This algebra is background independent in that it makes no reference to a state space of a conformal field theory. Conformal theories define a homomorphism of this algebra to the BV algebra of string functionals. The construction begins with a graded-commutative free associative algebra \C built from the vector space whose elements are orientable subspaces of moduli spaces of punctured Riemann surfaces. The typical element here is a surface with several connected components. The operation $\Delta$ of sewing two punctures with a full twist is shown to be an odd, second order derivation that squares to zero. It follows that (\C, \Delta) is a Batalin-Vilkovisky algebra. We introduce the odd operator $\delta = \partial + \hbar\Delta$, where $\partial$ is the boundary operator. It is seen that $\delta^2=0$, and that consistent closed string vertices define a cohomology class of $\delta$. This cohomology class is used to construct a Lie algebra on a quotient space of \C. This Lie algebra gives a manifestly background independent description of a subalgebra of the closed string gauge algebra.Comment: phyzzx.tex, MIT-CTP-234

Dynamic substructuring for shock spectrum analysis using component mode synthesis

Component mode synthesis was used to analyze different types of structures with MSC NASTRAN. The theory and technique of using Multipoint Constraint Equations (MPCs) to connect substructures to each other or to a common foundation is presented. Computation of the dynamic response of the system from shack spectrum inputs was automated using the DMAP programming language of the MSC NASTRAN finite element code