Fluctuating parts of nuclear ground state correlation energies

Background: Heavy atomic nuclei are often described using the Hartree-Fock-Bogoliubov (HFB) method. In principle, this approach takes into account Pauli effects and pairing correlations while other correlation effects are mimicked through the use of effective density-dependent interactions. Purpose: Investigate the influence of higher order correlation effects on nuclear binding energies using Skyrme's effective interaction. Methods: A cut-off in relative momenta is introduced in order to remove ultraviolet divergences caused by the zero-range character of the interaction. Corrections to binding energies are then calculated using the quasiparticle-random-phase approximation (QRPA) and second order many-body perturbation theory (MBPT2). Result: Contributions to the correlation energies are evaluated for several isotopic chains and an attempt is made to disentangle which parts give rise to fluctuations that may be difficult to incorporate on the HFB level. The dependence of the results on the cut-off is also investigated. Conclusions: The improved interaction allows explicit summations of perturbation series which is useful for the description of some nuclear observables. However, refits of the interaction parameters are needed to obtain more quantitative results

Generating Generalized Distributions from Dynamical Simulation

We present a general molecular-dynamics simulation scheme, based on the Nose' thermostat, for sampling according to arbitrary phase space distributions. We formulate numerical methods based on both Nose'-Hoover and Nose'-Poincare' thermostats for two specific classes of distributions; namely, those that are functions of the system Hamiltonian and those for which position and momentum are statistically independent. As an example, we propose a generalized variable temperature distribution that designed to accelerate sampling in molecular systems.Comment: 10 pages, 3 figure

Initiation of hepatitis C virus infection is dependent on cholesterol and cooperativity between CD81 and scavenger receptor B type I.

In the past several years, a number of cellular proteins have been identified as candidate entry receptors for hepatitis C virus (HCV) by using surrogate models of HCV infection. Among these, the tetraspanin CD81 and scavenger receptor B type I (SR-BI), both of which localize to specialized plasma membrane domains enriched in cholesterol, have been suggested to be key players in HCV entry. In the current study, we used a recently developed in vitro HCV infection system to demonstrate that both CD81 and SR-BI are required for authentic HCV infection in vitro, that they function cooperatively to initiate HCV infection, and that CD81-mediated HCV entry is, in part, dependent on membrane cholesterol

Vergleich der muttergebundenen und der künstlichen Aufzucht in Bezug auf Gesundheit, Gewichtsentwicklung und chronischen Stress bei Milchviehkälbern

In artificial rearing, calves are separated from their dam usually within 24h after birth and any further social contacts to the mother are prevented. Although this is common in practice we expect severe consequences on the health state, weight gain and stress response of the young calf. Two groups of calves suckled by their mother (unrestricted contact, n=14; contact twice daily for 15 minutes each before milking, n=15) were compared to two control groups that were both fed via automatic milk feeder (maximal six times daily, n=14; twice daily, n=14). The calves of the four treatment groups were kept in the same barn and cows were milked twice daily. All calves were weaned at 13 weeks of age. The calves were weighed weekly until 3 weeks after weaning. The health state of each animal was assessed daily and all veterinary treatments were recorded until weaning. Stress response to a long-term stressor (absence of the mother) was assessed by stimulation of the HPA axis by ACTH administration (at 11 weeks of age). For statistical analyses, linear mixed-effects models were used. The health state of both suckled groups was poorer (p=0.046, caused by diarrhoea), but the number of animals that had to be treated by a veterinarian did not differ. During the milk feeding period, weight gain was better in suckled calves (p<0.001). After weaning, the weight gain of all treatment groups was diminished, especially in suckled calves (p<0.001). Cortisol response to ACTH administration was reduced in calves fed via an automatic milk feeder (p<0.001). The higher weight gain in suckled calves before weaning can be explained by the large milk amounts the calves received. These results suggest that suckled calves show fewer signs of chronic stress. We conclude that rearing without contact with the mother causes chronic stress in young calves in terms of desensitization of the HPA axis

The String Deviation Equation

The relative motion of many particles can be described by the geodesic deviation equation. This can be derived from the second covariant variation of the point particle's action. It is shown that the second covariant variation of the string action leads to a string deviation equation.Comment: 18 pages, some small changes, no tables or diagrams, LaTex2

Analysing the Security of Google's implementation of OpenID Connect

Many millions of users routinely use their Google accounts to log in to relying party (RP) websites supporting the Google OpenID Connect service. OpenID Connect, a newly standardised single-sign-on protocol, builds an identity layer on top of the OAuth 2.0 protocol, which has itself been widely adopted to support identity management services. It adds identity management functionality to the OAuth 2.0 system and allows an RP to obtain assurances regarding the authenticity of an end user. A number of authors have analysed the security of the OAuth 2.0 protocol, but whether OpenID Connect is secure in practice remains an open question. We report on a large-scale practical study of Google's implementation of OpenID Connect, involving forensic examination of 103 RP websites which support its use for sign-in. Our study reveals serious vulnerabilities of a number of types, all of which allow an attacker to log in to an RP website as a victim user. Further examination suggests that these vulnerabilities are caused by a combination of Google's design of its OpenID Connect service and RP developers making design decisions which sacrifice security for simplicity of implementation. We also give practical recommendations for both RPs and OPs to help improve the security of real world OpenID Connect systems

Obesity Prevalence and Dietary Intake of Antioxidants in Native American Adolescents

Antioxidants are well known for possessing anti-inflammatory properties, which can reduce the risk of chronic disease and obesity. However, very little research has been done to examine antioxidant intake among adolescent minority populations such as Native American adolescents. Our study examined the significance of antioxidant intake among Native American adolescents at an urban residential high school in Southern California. Our study population consisted of 183 male and female Native American adolescents, 14-18 years of age, representing 43 tribes from across the United States. Students' primary source of meals was provided by the school food service. Based on the BMI calculations, the rate of obesity within our population was 38% for males and 40% for females, more than two-fold the national rate indicated by NHANESIII data. We used the Harvard School of Public Health Youth/Adolescent Questionnaire (HSPH YAQ), a semi-quantitative food frequency questionnaire, to examine antioxidant nutrient intake and evaluate the differences in the intake between normal and obese weight students. Statistical analysis of the results showed that intakes of vitamins C, E, and lycopene were the antioxidant nutrients found to be significantly different between normal and obese weight students and intakes of these nutrients were found to be higher among normal weight students (p-values = 0.02451, 0.00847, and 0.04928, respectively). These results suggest that dietary intake of antioxidants could be increased among Native American adolescents. Further research is needed to confirm our findings and identify effective ways for school food service to incorporate antioxidant rich foods into school menus