13 research outputs found
A Duna-Tisza köze és a Tiszántúl természetközeli növényzetének változása az elmúlt 230 évben : összegzés tájökológiai modellezések alapozásához
A néhány száz évre visszatekintő, botanikai célú történeti tájökológiai kutatások módszertana
Circulating ACE2 activity predicts mortality and disease severity in hospitalized COVID-19 patients
Objectives
Angiotensin-converting enzyme 2 (ACE2) represents the primary receptor for SARS-CoV-2 to enter endothelial cells. Here we investigated circulating ACE2 activity to predict the severity and mortality of COVID-19.
Methods
Serum ACE2 activity was measured in COVID-19 (110 critically ill and 66 severely ill subjects at hospital admission and 106 follow-up samples) and in 32 non-COVID-19 severe sepsis patients. Associations between ACE2, inflammation-dependent biomarkers, pre-existing comorbidities, and clinical outcomes were studied.
Results
Initial ACE2 activity was significantly higher in critically ill COVID-19 patients (54.4 [36.7-90.8] mU/L) than in severe COVID-19 (34.5 [25.2-48.7] mU/L; P<0.0001) and non-COVID-19 sepsis patients (40.9 [21.4-65.7] mU/L; P=0.0260) regardless of comorbidities. Circulating ACE2 activity correlated with inflammatory biomarkers and was further elevated during the hospital stay in critically ill patients. Based on ROC-curve analysis and logistic regression test, baseline ACE2 independently indicated the severity of COVID-19 with an AUC value of 0.701 (95% CI [0.621-0.781], P<0.0001). Furthermore, non-survivors showed higher serum ACE2 activity vs. survivors at hospital admission (P<0.0001). Finally, high ACE2 activity (≥45.4 mU/L) predicted a higher risk (65 vs. 37%) for 30-day mortality (Log-Rank P<0.0001).
Conclusions
Serum ACE2 activity correlates with COVID-19 severity and predicts mortality
Milyen legyen a nĂ©pegĂ©szsĂ©gĂĽgy legĂşjabb iránya? VitaindĂtĂł az Ăşj nĂ©pegĂ©szsĂ©gĂĽgyi szemlĂ©let sajátosságairĂłl
Carbon uptake changed but vegetation composition remained stable during transition from grazing to mowing grassland management
• Vegetation composition and diversity did not change for six years after the conversion from grazing to mowing.
• Even the detailed fine-scale analyses could not reveal differences.
• Carbon uptake differed between grazed vs. mowed sites due to biomass removal intensity.
• Returning from mowing to grazing would probably restore C uptake capacity at the mowed site because the vegetation composition remained stable