A Chemocentric Approach to the Identification of Cancer Targets

A novel chemocentric approach to identifying cancer-relevant targets is introduced. Starting with a large chemical collection, the strategy uses the list of small molecule hits arising from a differential cytotoxicity screening on tumor HCT116 and normal MRC-5 cell lines to identify proteins associated with cancer emerging from a differential virtual target profiling of the most selective compounds detected in both cell lines. It is shown that this smart combination of differential in vitro and in silico screenings (DIVISS) is capable of detecting a list of proteins that are already well accepted cancer drug targets, while complementing it with additional proteins that, targeted selectively or in combination with others, could lead to synergistic benefits for cancer therapeutics. The complete list of 115 proteins identified as being hit uniquely by compounds showing selective antiproliferative effects for tumor cell lines is provided

New research of mass grave No. III at Mohács

In 2009, the Janus Pannonius Museum in Pécs renewed the archaeological research of the Battle of Mohács (1526) with outside partners (Bertók et al. 2020, 107–118). The goals of the initiative have been to identify the exact location of the historic clashes, reconstruct the chain of the related events, and conduct a scientific analysis of the final resting place of the soldiers who fell on the battlefield. We planned to complete the project by the upcoming 500th anniversary of the battle. In our hopes, this research has enabled an expansion of the current national memorial site where the remains of the heroes who sacrified their lives to protect their Hungarian homeland could finally be laid to rest. The project has provided us with a fitting opportunity to summarize previous work and present the findings of the archaeological excavations conducted in 2020–2021

A mohácsi III. számú tömegsír új kutatása

A pécsi Janus Pannonius Múzeum külső partnerek bevonásával 2009-től felújította az 1526-os mohácsi csata régészeti kutatását (ld. Bertók et al. 2020, 107–118) azzal a céllal, hogy az ütközet 500. évfordulójára megvalósulhasson a sorsdöntő eseménysor helyszínének pontos azonosítása, eseménysorának rekonstrukciója, és a csatában elhunyt katonák végső nyughelyének tudományos vizsgálata. E kutatás reményeink szerint lehetővé teszi azt is, hogy a nemzeti emlékhely kibővítése után a magyar hazáért végső áldozatot hozó hősöket végső nyughelyükre helyezzék. Mindez jó alkalmat jelent arra, hogy összefoglaljuk a legfontosabb korábbi kutatásokat és a 2020–21-ben végzett régészeti feltárás eredményeit

A chemocentric approach to the identification of cancer targets

A novel chemocentric approach to identifying cancer-relevant targets is introduced. Starting with a large chemical collection, the strategy uses the list of small molecule hits arising from a differential cytotoxicity screening on tumor HCT116 and normal MRC-5 cell lines to identify proteins associated with cancer emerging from a differential virtual target profiling of the most selective compounds detected in both cell lines. It is shown that this smart combination of differential in vitro and in silico screenings (DIVISS) is capable of detecting a list of proteins that are already well accepted cancer drug targets, while complementing it with additional proteins that, targeted selectively or in combination with others, could lead to synergistic benefits for cancer therapeutics. The complete list of 115 proteins identified as being hit uniquely by compounds showing selective antiproliferative effects for tumor cell lines is providedThis work was supported by a grant from the European Comission (CancerGrid, FP-6 LCHC-CT-2006-037559), http://ec.europa.eu/research/fp6/index_en.cf