A CLINICAL TRIAL ON THE EFFICACY OF BHALLATAKADI LEPA IN CHARMAKEELA W.S.R. CUTANEOUS WARTS

Ayurveda described few diseases under the heading of Kshudra roga. Charmakeela is one of them and it is simple and does not cause threat to life but it has a cosmetic problem, which results in considerable distress to the patients when they are seen on face and exposed part of the skin. Bhallatakadi lepa has prepared for this study. Total 15 patients suffering from Charmakeela (Warts)were selected for study, 5 patients dropped out due to various regions and remaining 10 patients treated with Bhallatakadilepa. The duration of the trial was one month with a further follow up of two months. The data collected was statistically analyzed for the interpretation of results. Bhallatakadilepa was found not effective in reducing number of warts or size of warts. Though mild ASRs (Application site reactions), including pruritus, irritation or burning sensation, erythema, hyper and hypopigmentation and LSRs (Local skin reactions) including dryness or scaling, hyperpigmentation, hypopigmentation, irritation or burning sensation and erythema were seen in some of the patients. So the conclusion of the study is that the lack of efficacy of the trial drug may be attributed mainly to the seasonal variations in the drug collection, drug potency and drug adulteration from market places, which were practically inevitable during this research work. The research may also consider a longitudinal / prospective study in order to obtain complete analysis of the drug

SYNTHESIS OF SOME NOVEL PYRAZOLE DERIVATIVES AND EVALUATION OF THEIR PURIFICATION OF CHROMATOGRAPHY IN THIN-LAYER CHROMATOGRAPHY

Objective: The main objective of the study is to synthesis some novel pyrimidine scaffold which has wide range of properties of biological activities.Methods: Synthesis of different pyrazole derivatives compounds identification and characterization (M.P, solubility, Rf values, and spectral studies). The present work was characterized by infrared, nuclear magnetic resonance, and mass spectral analysis pharmacological evaluation.Results: Identification and characterization (M.P, solubility, Rf values and spectral studies) are carried out

A STUDY OF ARTHAVAVAHA SROTAS WITH SPECIAL REFERENCE TO MAITHUNA ASAHISHNUTHA (DYSPAREUNIA)

Understanding the science of Ayurveda is based on proper concept of Tridosha – the Vata, Pitta and Kapha, as these form the physiological control factors. Prakruti, the biological or genetic constitution to a great extent influences each individual, in the way he is, the way he behaves, the way he reacts to certain things there by making a person unique and distinct from one-another. Acharya Sushruta the pioneer in the field of Shareera has gone through evaluating the anatomical structures under the name of Sroto-Shareera, which includes Srotas of Ahara, Dhatu, Mala and Upadhatu like Arthavavaha Srotas. Arthavavahasrotas gets originated from Garbashaya and Arthavavaha Dhamani injury to Arthavavahasrotas results in Vandhyathva, Nastarthava and Maitunaasahisnutha. In his purview it is the local injury to organs of reproductive system which may be due to excessive coitus, repeated curettage, LSCS and thereby, which may result in pelvic adhesions, local infections, tubal block, etc. ultimately leading to Maithunaasahishnutha (dyspareunia). In this study 20 women who were diagnosed as Maitunaasahisnutha selected for assessment of predominant Prakruti based on physiological and anatomical triats. From the statistical analysis it is evident that Kaphaprakruti were more prone for Maithunaashasinutha

Telugu Text Categorization using Language Models

Document categorization has become an emerging technique in the field of research due to the abundance of documents available in digital form. In this paper we propose language dependent and independent models applicable to categorization of Telugu documents. India is a multilingual country; a provision is made for each of the Indian states to choose their own authorized language for communicating at the state level for legitimate purpose. The availability of constantly increasing amount of textual data of various Indian regional languages in electronic form has accelerated. Hence, the Classification of text documents based on languages is crucial. Telugu is the third most spoken language in India and one of the fifteen most spoken language n the world. It is the official language of the states of Telangana and Andhra Pradesh. A variant of k-nearest neighbors algorithm used for categorization process. The results obtained by the Comparisons of language dependent and independent models

THE ACCELERATED STABILITY STUDY OF CONSTALAX CHURNA- AN AYURVEDIC FORMULATION

Constalax churna, greenish brown powder with characteristic odor and bitter salty taste was evaluated for its stability, as per ICH guidelines Q1A (R2) at accelerated conditions (Temperature: 40 °C ± 2, Relative Humidity : 75% ± 5). The real time stability is estimated at temperature: 25 °C ± 2 &relative humidity 60% ± 5.The study sample was observed for changes in different parameters like physico-chemical, organoleptic and microbial load for 6 month under accelerated conditions and for real time stability study observed for one year. Real time stability was comparatively estimated to evaluate actual degradation rate of Constalax Churna with respect to accelerated conditions. Up to six months of storage at accelerated condition, no change was observed in organoleptic parameters like colour, odour and taste of Constalax Churna. Changes in of different physico-chemical parameters were taken into account to evaluate intercept and slope. Extrapolated shelf life of Constalax Churna was calculated with 10% degradation rate from physico-chemical parameters at accelerated condition 40 °C ± 2 and 75% ± 5 RH. The present evaluation supports that the Constalax Churna was appropriate at accelerated condition up to 6 month storage. From this accelerated stability study it could be extrapolated that shelf life of Constalax Churna is 25.42 months (2.11years) for climatic zone I & II countries. Real time stability data of Constalax Churna showed very good stability up to 2 years

Drug utilization pattern in geriatric inpatients of medicine department in a Tertiary Care Teaching Hospital

Background: The objective of present study was to assess the drug utilization pattern among the geriatric patients.Methods: Totally, 150 prescriptions of patients’ ≥65 years admitted in the medicine inpatient department of MVJ Medical College and Research Hospital, Hoskote were noted from September 2013 to March 2014 and demographic profile, drug utilization pattern, commonly used drugs as per anatomical therapeutic chemical classification (ATC) and WHO core indicators were assessed after taking informed consent from the patients.Results: Out of 150 patients, average age of geriatric patients was 66.83 years with female preponderance (59%). Maximum number of patients were having respiratory disorders (66.67%) followed by diabetes mellitus (35.3%), and cardiovascular diseases (32.67%). 76% patients had co-morbid diseases like diabetes mellitus (n=53), hypertension (n=49), and chronic obstructive pulmonary disease (n=41). A total of 849 drug formulations, containing 1050 active ingredients, were prescribed with average number of 7 (1050/150) drugs per prescription. Only 70 formulations were prescribed by their generic names, which is less than that prescribed by their brand names 779 and total of 146 (17.19%) drugs were prescribed as fixed dose combinations. Only 45.47% drugs were according to WHO Essential Medicines List. Drugs acting on respiratory system (n=189) were the most commonly used drugs in our study followed by drugs acting on the gastrointestinal system (n=130), antimicrobials (n=113), cardiovascular system (n=112), endocrine (n=83), and nutritional supplements (n=72). Polypharmacy was prevalent in 62% and about 22.67% of patients received <5 drugs. Pantoprazole was most frequently prescribed drug followed by aspirin 75 mg, adrenergic, and anticholinergic bronchodilators.Conclusion: Thus, irrational prescribing and polypharmacy were prevalent among elderly. Drug utilization data can help in assessing the quality of care given to the geriatric patients and promote rational use of medicines

Secure and Reliable Data Transfer across Multiple Entities by Using LIME

A data distributor has given precise data to a set of evidently trusted agents. Some of the data are leaked and found in an unjustified place. The distributor must assess the probability that the splitted data came from one or more agents, as opposed to having been individually collected by others. We suggest data allocation techniques which can enhance the chance of identifying split. These strategies do not build on changes of the outsourced data. While sending data through the network there is a lot of dishonest user looking to hack useful data. A proper security should be provided to data which is send to network. To avoid this data leakage, we used the data lineage mechanism. We develop and analyze novel accountable data transfer protocol between two entities within a malicious environment by building upon oblivious transfer and robust Watermarking

FORMULATION AND IN VITRO EVALUATION OF RITONAVIR FLOATING TABLETS BY MELT GRANULATION TECHNIQUE

Objective: The purpose of this study was to formulate Ritonavir floating matrix tablets by melt granulation technique in order to prolong its gastric residence time thereby increasing its bioavailability. Methods: The Ritonavir tablets were prepared by melt granulation technique, using carriers such as Gelucire 43/01, Gelucire 50/02 and Geleol pellets alone or in combinations. Ethyl cellulose was used as drug release rate retarding agent and sodium bicarbonate was used as gas generating agent. The prepared granules were subjected to pre and post compressional parameters. The formulations were optimized on the basis of matrix integrity, duration of floating, swelling behavior and In vitro drug release. Results: The drug-excipients compatibility studies were performed by FT-IR and the study revealed that there is no drug excipients interaction. A combined matrix system containing Gelucire 43/01: Gelucire 50/02 with 1:1 concentration along with HPMC K 15 M shows good drug release pattern with less floating lag time and increased floating duration. Conclusion: The in vitro drug release pattern of Ritonavir floating tablets was fitted to different kinetic models which showed the highest regression for Zero order kinetics with Higuchi mechanism. Keywords: Gelucire 43/01, Gelucire 50/02, Geleol pellets, Swelling behavio