4,311 research outputs found
B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells.
Dendritic cells comprise a system of highly efficient antigen-presenting cells involved in the initiation of T cell responses. Herein, we investigated the role of the CD28 pathway during alloreactive T cell proliferation induced by dendritic-Langerhans cells (D-Lc) generated by culturing human cord blood CD34+ progenitor cells with granulocyte/macrophage colony-stimulating factor and tumor necrosis factor alpha. In addition to expressing CD80 (B7/BB1), a subset of D-Lc expressed B70/B7-2. Binding of the CTLA4-Ig fusion protein was completely inhibited by a combination of monoclonal antibodies (mAbs) against CD80 and B70/B7-2, indicating the absence of expression of a third ligand for CD28/CTLA-4. It is interesting to note that mAbs against CD86 completely prevented the binding of CTLA4-Ig in the presence of mAbs against CD80 and bound to a B70/B7-2-transfected fibroblast cell line, demonstrating that the B70/B7-2 antigen is identical to CD86. CD28 triggering was essential during D-Lc-induced alloreaction as it was inhibited by mAbs against CD28 (9 out of 11 tested). However, none of six anti-CD80 mAbs demonstrated any activity on the D-Lc-induced alloreaction, though some were previously described as inhibitory in assays using CD80-transfected cell lines. In contrast, a mAb against CD86 (IT-2) was found to suppress the D-Lc-dependent alloreaction by 70%. This inhibitory effect was enhanced to > or = 90% when a combination of anti-CD80 and anti-CD86 mAbs was used. The present results demonstrate that D-Lc express, in addition to CD80, the other ligand for CTLA-4, CD86 (B70/B7-2), which plays a primordial role during D-Lc-induced alloreaction
Mycophenolate mofetil inhibits lymphocyte binding and the upregulation of adhesion molecules in acute rejection of rat kidney allografts.
Mycophenolate mofetil (MMF) interacts with purine metabolism and possibly with the expression of adhesion molecules. In the present study, we analysed the expression of these molecules in transplanted kidney allografts treated with RS LBNF1 kidneys were orthotopically transplanted into Lewis rats and either treated with RS (20 mg/kg/day) or vehicle. Rats were harvested 3, 5 and 7 days following transplantation. For binding studies, fresh-frozen sections of transplanted kidneys were incubated with lymph node lymphocytes (LNL) derived from transplanted rats. Additionally, immunohistology was performed with various monoclonal antibodies. In general, MMF resulted in better preservation of graft structure by 7 days. Cellular infiltration and tubular atrophy were less pronounced. At day 3, macrophages were diminished in MMF-treated animals to a high extent, while the number of T cells was almost identical to that of controls. In addition, the number of cells positive for MHC class II and LFA-1 was reduced in the MMF-treated animals. These findings correlated with the binding results. Three days following engraftment, LNL bound to MMF-treated kidneys to a lesser extent compared to controls. In conclusion, MMF resulted in a markedly reduced leucocytic infiltrate, presumably based on a reduced expression of lymphocytic adhesion molecules and an interaction with macrophages
Analysis of the total 12C(α,γ)16O cross section based on available angular distributions and other primary data
Because a knowledge of the 12C/16O ratio is crucial to the understanding of the later evolution of massive stars, new R- and K-matrix fits have been completed using the available angular distribution data from radiative α capture and elastic α scattering on 12C. Estimates of the total 12C(α,γ)16O rate at stellar energies are reported. In contrast with previous work, the analyses generally involve R- and K-matrix fits directly to the primary data, i.e., the energy- and angle-dependent differential yields, with all relevant partial waves fitted simultaneously (referred to here as surface fits). It is shown that, while the E1 part of the reaction is well constrained by a recent experiment on the β-delayed α-particle decay of 16N, only upper limits can be placed on the E2 ground state cross section factor which we take conservatively as SE2(300)<140 keV b. Simulations were then carried out to explore what kind of new data could lead to better restrictions on SE2(300). We find that improved elastic scattering data may be the best short-term candidate for such restrictions while significantly improving S(300) with new radiative capture data may require a longer-term effort. Theoretical models and estimates from α-transfer reactions for the E2 part of 12C(α,γ)16O are then discussed for comparison with the R- and K-matrix fits of the present work
Notes on noncommutative supersymmetric gauge theory on the fuzzy supersphere
In these notes we review Klimcik's construction of noncommutative gauge
theory on the fuzzy supersphere. This theory has an exact SUSY gauge symmetry
with a finite number of degrees of freedom and thus in principle it is amenable
to the methods of matrix models and Monte Carlo numerical simulations. We also
write down in this article a novel fuzzy supersymmetric scalar action on the
fuzzy supersphere
Spin wave dispersion softening in the ferromagnetic Kondo lattice model for manganites
Spin dynamics is calculated in the ferromagnetic (FM) state of the
generalized Kondo lattice model taking into account strong on-site correlations
between e_g electrons and antiferromagnetic (AFM) exchange among t_{2g} spins.
Our study suggests that competing FM double-exchange and AFM super-exchange
interaction lead to a rather nontrivial spin-wave spectrum. While spin
excitations have a conventional Dq^2 spectrum in the long-wavelength limit,
there is a strong deviation from the spin-wave spectrum of the isotropic
Heisenberg model close to the zone boundary. The relevance of our results to
the experimental data are discussed.Comment: 6 RevTex pages, 3 embedded PostScript figure
Dynamical aspects of the fuzzy CP in the large reduced model with a cubic term
``Fuzzy CP^2'', which is a four-dimensional fuzzy manifold extension of the
well-known fuzzy analogous to the fuzzy 2-sphere (S^2), appears as a classical
solution in the dimensionally reduced 8d Yang-Mills model with a cubic term
involving the structure constant of the SU(3) Lie algebra. Although the fuzzy
S^2, which is also a classical solution of the same model, has actually smaller
free energy than the fuzzy CP^2, Monte Carlo simulation shows that the fuzzy
CP^2 is stable even nonperturbatively due to the suppression of tunneling
effects at large N as far as the coefficient of the cubic term () is
sufficiently large. As \alpha is decreased, both the fuzzy CP and the fuzzy
S^2 collapse to a solid ball and the system is essentially described by the
pure Yang-Mills model (\alpha = 0). The corresponding transitions are of first
order and the critical points can be understood analytically. The gauge group
generated dynamically above the critical point turns out to be of rank one for
both CP^2 and S^2 cases. Above the critical point, we also perform perturbative
calculations for various quantities to all orders, taking advantage of the
one-loop saturation of the effective action in the large-N limit. By
extrapolating our Monte Carlo results to N=\infty, we find excellent agreement
with the all order results.Comment: 27 pages, 7 figures, (v2) References added (v3) all order analyses
added, some typos correcte
Swift Highly Charged Ion Channelling
We review recent experimental and theoretical progress made in the scope of
swift highly charged ion channelling in crystals. The usefulness of such
studies is their ability to yield impact parameter information on charge
transfer processes, and also on some time related problems. We discuss the
cooling and heating phenomena at MeV/u energies, results obtained with
decelerated H-like ion beams at GSI and with ions having an excess of electrons
at GANIL, the superdensity effect along atomic strings and Resonant Coherent
Excitation.Comment: to be published in Journal of Physics
Unconditional Security of Single-Photon Differential Phase Shift Quantum Key Distribution
In this Letter, we prove the unconditional security of single-photon
differential phase shift quantum key distribution (DPS-QKD) protocol, based on
the conversion to an equivalent entanglement-based protocol. We estimate the
upper bound of the phase error rate from the bit error rate, and show that
DPS-QKD can generate unconditionally secure key when the bit error rate is not
greater than 4.12%. This proof is the first step to the unconditional security
proof of coherent state DPS-QKD.Comment: 5 pages, 2 figures; shorten the length, improve clarity, and correct
typos; accepted for publication in Physical Review Letter
63Cu NQR evidence of dimensional crossover to anisotropic 2d regime in S= 1/2 three-leg ladder Sr2Cu3O5
We probed spin-spin correlations up to 725 K with 63Cu NQR in the S= 1/2
three-leg ladder Sr2Cu3O5. We present experimental evidence that below 300 K,
weak inter-ladder coupling causes dimensional crossover of the spin-spin
correlation length \xi from quasi-1d (\xi ~ 1/T) to anisotropic 2d regime (\xi
\~ exp[2\pi\rho_{s}/T], where 2\pi\rho_{s} = 290 +/- 30 K is the effective spin
stiffness). This is the first experimental verification of the renormalized
classical behavior of the anisotropic non-linear sigma model in 2d, which has
been recently proposed for the striped phase in high T_{c} cuprates.Comment: 4 pages, 3 figure
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