17 research outputs found
PLANEACIÓN DIDÁCTICA GENERAL DE LA ASIGNATURA INGLÉS 4
GUÍA DIDÁCTICA / PLANEACIÓN DIDÁCTICA (NMS
PLANEACIÓN DIDÁCTICA GENERAL DE LA ASIGNATURA: CULTURA AMBIENTAL Y DESARROLLO SUSTENTABLE
GUÍA DIDÁCTICA / PLANEACIÓN DIDÁCTICA (NMS
Estrogen and androgen receptor expression in surface epithelium and inclusion cyst in the ovary of premenopausal and postmenopausal women
PLANEACIÓN DIDÁCTICA GENERAL DE LA ASIGNATURA DE INGLÉS 3
GUÍA DIDÁCTICA / PLANEACIÓN DIDÁCTICA (NMS
Post-mortem neuropathologic examination of a 5-case series of CAR T-cell treated patients
Introduction: Chimeric antigen receptor (CAR) T-cell therapy is a promising immunotherapy for the treatment of refractory hematopoietic malignancies. Adverse events are common, and neurotoxicity is one of the most important. However, the physiopathology is unknown and neuropathologic information is scarce.Materials and methods: Post-mortem examination of 6 brains from patients that underwent CAR T-cell therapy from 2017 to 2022. In all cases, polymerase chain reaction (PCR) in paraffin blocks for the detection of CAR T cells was performed.Results: Two patients died of hematologic progression, while the others died of cytokine release syndrome, lung infection, encephalomyelitis, and acute liver failure. Two out of 6 presented neurological symptoms, one with extracranial malignancy progression and the other with encephalomyelitis. The neuropathology of the latter showed severe perivascular and interstitial lymphocytic infiltration, predominantly CD8+, together with a diffuse interstitial histiocytic infiltration, affecting mainly the spinal cord, midbrain, and hippocampus, and a diffuse gliosis of basal ganglia, hippocampus, and brainstem. Microbiological studies were negative for neurotropic viruses, and PCR failed to detect CAR T -cells. Another case without detectable neurological signs showed cortical and subcortical gliosis due to acute hypoxic-ischemic damage. The remaining 4 cases only showed a mild patchy gliosis and microglial activation, and CAR T cells were detected by PCR only in one of them.Conclusions: In this series of patients that died after CAR T-cell therapy, we predominantly found non-specific or minimal neuropathological changes. CAR T-cell related toxicity may not be the only cause of neurological symptoms, and the autopsy could detect additional pathological findings
PLANEACIÓN DIDÁCTICA GENERAL DE LA ASIGNATURA DE INGLÉS PARA PROPÓSITOS ACADÉMICOS
GUÍA DIDÁCTICA / PLANEACIÓN DIDÁCTICA (NMS
PLANEACION DIDACTICA DE LA ASIGNATURA DE INGLES I MODALIDAD MIXTA DE SEGUNDO SEMESTRE
GUIA DIDACTICA / PLANEACION DIDACTICA (NMS
PLANEACION DIDACTICA GENERAL DE LA ASIGNATURA DE INGLES 3
GUIA DIDACTICA / PLANEACION DIDACTICA (NMS
ACTUALIZACION DE LA PLANEACION DIDACTICA DE LA ASIGNATURA DE CULTURA AMBIENTAL Y DESARROLLO SUSTENTABLE. MODALIDAD PRESENCIAL. 2019-B
GUIA DIDACTICA / PLANEACION DIDACTICA (NMS
ACTUALIZACIÓN DE LA PLANEACIÓN DE LA ASIGNATURA: CULTURA AMBIENTAL Y DESARROLLO SUSTENTABLE
GUÍA DIDÁCTICA / PLANEACIÓN DIDÁCTICA (NMS