Effect of pressure on density, porosity and flexural strength during cold isostatic press of alumina-ysz chromia cutting too

This study presented the effect of pressure on the density, porosity and flexural strength when cold isostatic press (CIP) was applied to compact the ceramic powders in the form of insert cutting tools. Specific composition of alumina (Al2O3) wt.90%,yittria stabilized zirconia (YSZ) wt.10%, chromium oxide(Cr2O3) wt.0.6% and polyethylene glycol (PEG) wt.0.6% were ball milled and hand pressed to form green body of ceramic inserts. These green body were undergone further compaction inside CIP with pressures variation of 200 MPa, 300 MPa, 400 MPa with 30 seconds and 60 seconds pressuring time. The ceramic composts were then sintered at 1440°C for 9 hours before being assessed with density, porosity, Rockwell hardness (HRC) and bending test. The results show that CIP use with 300 MPa parameters with 60 seconds shows the best mechanical properties with relative density 95.5%, porosity 4.5% and HRC 65.5 hardness. Further assessment of microstructure revealed that the particles size distributed evenly along fracture surface with coarse grain and porosity dominant in the certain area

Fabrication and machining performance of ceramic cutting tool based on the Al2O3-ZrO2-Cr2O3 compositions

This study presents the cutting tool development of zirconia toughened alumina (ZTA) with chromia addition. The process used for its development is solid-state, in which the powders of Alumina (Al2O3), Zirconia (ZrO2) and Chromia (Cr2O3) were processed by a ball mill, com�pacted under a Cold Isostatic Press (CIP) and sintered at a constant temperature of 1400 ◦C with 9h soaking time. The initial study investigated the effect of Polyethylene glycol (PEG) as a binder, CIP and hardness of Al2O3-ZrO2 mixtures. The percentage composition between Al2O3 and ZrO2 was varied to choose the best for the highest mechanical performances determined by the density, porosity and properties analysis. The cutting tool that possessed the highest hardness and bending strength was selected the Al2O3-ZrO2 mixture was mixed 0.6 wt% Cr2O3 for machining trials within the cutting speed of 200–350m/min and constant feed rate and depth of cut of 0.150mm/rev and 0.5mm, respectively. The results of the ZTA mixed with Cr2O3 and combined with the ratio 80-20-0.6 wt% showed that the addition of 0.6 wt% PEG and a CIP pressure at 300 MPa and 60 s dwell time resulted maximum hardness and bending strength of 71.03 HRc and 856.02 MPa, respectively. The fabricated cutting tool was capable to reach 225 s tool life when machining AISI 1045 at a lower cutting speed of 200 m/min and higher feed rate of 0.150mm/rev

Comparison machining performance of Al2 O3 , ZTA and ZTA doped Cr2 O3 cutting tools on AISI 1045

This paper presents the comparison of machining performance for cutting tools that fabricated by pure alumina (Al2O3), Zirconia Toughened Alumina (ZTA) and Zirconia Toughened Alumina doped with Cr2O3 (ZTA Doped Cr2O3). Solid-state method was employed to prepare ceramic mixtures starting from 12 h ball milling with 40 rpm rotational speed. The green bodies were formed by 5 ton manual hydraulic press and 300 MPa Cold Isostatic Press (CIP) compaction pressure. The compacted powders then were sintered at 1400 °C and 9 h soaking time in the form of RNGN 120600 designated cutting tools. Properties assessment of the fabricated cutting tools were analysed based on hardness and density. The machining evaluation was performed by turning AISI 1045 with cutting speeds of 150–350 m min−1, feed rate of 0.125 mm/rev and depth of cut of 0.5 mm. The results show that maximum hardness recorded for ZTA Doped Cr2O3 with 13.73 GPa Vickers hardness and 3.82 g cm−3 density, followed by ZTA (12.75 GPa, 3.85 g cm−3) and pure Al2O3 (4.9 GPa, 3.76 g cm−3)In terms of machining performance, ZTA Doped Cr2O3 recorded highest tool life of 330-s with 57% improvement of tool life as compared to ZTA (210-s) and 200% improvement of pure Al2O3 (110-s). Dominant wear mechanisms for the fabricated cutting tool appeared to be notch wear, abrasive wear and chipping at the flank wear area

Observation of built-up edge formation on a carbide cutting tool with machining aluminium alloy under dry and wet conditions

This paper presents the morphology of built-up edge (BUE) formation under wet and dry conditions with low and high cutting speeds. The workpiece materials and cutting tools selected for this work were aluminium alloy and canela carbide inserts graded PM25. The cutting tools underwent turning operation machining tests and their performance was evaluated by the flank wear and observation of the tool wear area. The machining tests were conducted at different spindle speeds and feed rates while the cut depth was kept constant. The analysis showed that formation of the BUE was dominant at low cutting speeds in dry conditions, but in wet conditions at high cutting speeds, a better performance was exhibited in terms of wear analysis

Total phenolic content, antioxidative and antidiabetic properties of coconut (Cocos Nucifera L.) testa and selected bean seed coats

Natural alternatives tor the treatment of diabetes mellitus have been the interest of many researchers. In this study, the brown testas of mature coconuts were compared to beans seed coats of four varieties in terms of antioxidative and anti-hyperglycaemic properties. The total phenolic and flavonoid contents, the antioxidant potentials and the a-amvlase and a-glucosidase inhibitorv activities of the crude extracts were studied in vitro. The results showed that extracts of coconut testa and red kidney bean seed coat displayed higher a-glucosidase inhibition (IC50=19.90±5.67 and 4.84±1.43 μg/mL) and α-amylase inhibition (IC50=120.5±15.4 and 532.8±68.0 μg/mL) than the other extracts. These two extracts showed higher antioxidant capacities owing to their high phenolic and flavonoid contents. These results suggest that red kidney bean seed coat and tender coconut testa would have higher potential as nutraceuticals and could serve as natural alternative sources of anti-diabetic remedy

Observation of Built-up Edge Formation on a Carbide Cutting Tool with Machining Aluminium Alloy under Dry and Wet Conditions

This paper presents the morphology of built-up edge (BUE) formation under wet and dry conditions with low and high cutting speeds. The workpiece materials and cutting tools selected for this work were aluminium alloy and canela carbide inserts graded PM25. The cutting tools underwent turning operation machining tests and their performance was evaluated by the flank wear and observation of the tool wear area. The machining tests were conducted at different spindle speeds and feed rates while the cut depth was kept constant. The analysis showed that formation of the BUE was dominant at low cutting speeds in dry conditions, but in wet conditions at high cutting speeds, a better performance was exhibited in terms of wear analysis

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly

Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits

Anthocyanins are colored water-soluble pigments belonging to the phenolic group. The pigments are in glycosylated forms. Anthocyanins responsible for the colors, red, purple, and blue, are in fruits and vegetables. Berries, currants, grapes, and some tropical fruits have high anthocyanins content. Red to purplish blue-colored leafy vegetables, grains, roots, and tubers are the edible vegetables that contain a high level of anthocyanins. Among the anthocyanin pigments, cyanidin-3-glucoside is the major anthocyanin found in most of the plants. The colored anthocyanin pigments have been traditionally used as a natural food colorant. The color and stability of these pigments are influenced by pH, light, temperature, and structure. In acidic condition, anthocyanins appear as red but turn blue when the pH increases. Chromatography has been largely applied in extraction, separation, and quantification of anthocyanins. Besides the use of anthocyanidins and anthocyanins as natural dyes, these colored pigments are potential pharmaceutical ingredients that give various beneficial health effects. Scientific studies, such as cell culture studies, animal models, and human clinical trials, show that anthocyanidins and anthocyanins possess antioxidative and antimicrobial activities, improve visual and neurological health, and protect against various non-communicable diseases. These studies confer the health effects of anthocyanidins and anthocyanins, which are due to their potent antioxidant properties. Different mechanisms and pathways are involved in the protective effects, including free-radical scavenging pathway, cyclooxygenase pathway, mitogen-activated protein kinase pathway, and inflammatory cytokines signaling. Therefore, this review focuses on the role of anthocyanidins and anthocyanins as natural food colorants and their nutraceutical properties for health. Abbreviations: CVD: Cardiovascular disease VEGF: Vascular endothelial growth factor

Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study

Introduction: The multiorgan impact of moderate to severe coronavirus infections in the post-acute phase is still poorly understood. We aimed to evaluate the excess burden of multiorgan abnormalities after hospitalisation with COVID-19, evaluate their determinants, and explore associations with patient-related outcome measures. Methods: In a prospective, UK-wide, multicentre MRI follow-up study (C-MORE), adults (aged ≥18 years) discharged from hospital following COVID-19 who were included in Tier 2 of the Post-hospitalisation COVID-19 study (PHOSP-COVID) and contemporary controls with no evidence of previous COVID-19 (SARS-CoV-2 nucleocapsid antibody negative) underwent multiorgan MRI (lungs, heart, brain, liver, and kidneys) with quantitative and qualitative assessment of images and clinical adjudication when relevant. Individuals with end-stage renal failure or contraindications to MRI were excluded. Participants also underwent detailed recording of symptoms, and physiological and biochemical tests. The primary outcome was the excess burden of multiorgan abnormalities (two or more organs) relative to controls, with further adjustments for potential confounders. The C-MORE study is ongoing and is registered with ClinicalTrials.gov, NCT04510025. Findings: Of 2710 participants in Tier 2 of PHOSP-COVID, 531 were recruited across 13 UK-wide C-MORE sites. After exclusions, 259 C-MORE patients (mean age 57 years [SD 12]; 158 [61%] male and 101 [39%] female) who were discharged from hospital with PCR-confirmed or clinically diagnosed COVID-19 between March 1, 2020, and Nov 1, 2021, and 52 non-COVID-19 controls from the community (mean age 49 years [SD 14]; 30 [58%] male and 22 [42%] female) were included in the analysis. Patients were assessed at a median of 5·0 months (IQR 4·2–6·3) after hospital discharge. Compared with non-COVID-19 controls, patients were older, living with more obesity, and had more comorbidities. Multiorgan abnormalities on MRI were more frequent in patients than in controls (157 [61%] of 259 vs 14 [27%] of 52; p<0·0001) and independently associated with COVID-19 status (odds ratio [OR] 2·9 [95% CI 1·5–5·8]; padjusted=0·0023) after adjusting for relevant confounders. Compared with controls, patients were more likely to have MRI evidence of lung abnormalities (p=0·0001; parenchymal abnormalities), brain abnormalities (p<0·0001; more white matter hyperintensities and regional brain volume reduction), and kidney abnormalities (p=0·014; lower medullary T1 and loss of corticomedullary differentiation), whereas cardiac and liver MRI abnormalities were similar between patients and controls. Patients with multiorgan abnormalities were older (difference in mean age 7 years [95% CI 4–10]; mean age of 59·8 years [SD 11·7] with multiorgan abnormalities vs mean age of 52·8 years [11·9] without multiorgan abnormalities; p<0·0001), more likely to have three or more comorbidities (OR 2·47 [1·32–4·82]; padjusted=0·0059), and more likely to have a more severe acute infection (acute CRP >5mg/L, OR 3·55 [1·23–11·88]; padjusted=0·025) than those without multiorgan abnormalities. Presence of lung MRI abnormalities was associated with a two-fold higher risk of chest tightness, and multiorgan MRI abnormalities were associated with severe and very severe persistent physical and mental health impairment (PHOSP-COVID symptom clusters) after hospitalisation. Interpretation: After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeutic stratification