The sensitivity to antibiotics of nosocomial strains of acinetobacter baumanii isolated in the tertiary hospitals in the Central Kazakhstan

Del 1972, en l'actual emplaçament des de 1976. D'acer pintat, mesura 5 x 3,54 x 3,20 metres.Calder, Alexander (escultor)Pla general de l'obra. La galeria Maeght va decidir instal·lar una sucursal a Barcelona i va triar fer-ho al carrer de Montcada. Va obrir amb una exposició que incloïa una peça de Calder, Quatre ales. Després fou oferida a l'Ajuntament

Space of State Vectors in PT Symmetrical Quantum Mechanics

Space of states of PT symmetrical quantum mechanics is examined. Requirement that eigenstates with different eigenvalues must be orthogonal leads to the conclusion that eigenfunctions belong to the space with an indefinite metric. The self consistent expressions for the probability amplitude and average value of operator are suggested. Further specification of space of state vectors yield the superselection rule, redefining notion of the superposition principle. The expression for the probability current density, satisfying equation of continuity and vanishing for the bound state, is proposed.Comment: Revised version, explicit expressions for average values and probability amplitude adde

Hilbert Space Structures on the Solution Space of Klein-Gordon Type Evolution Equations

We use the theory of pseudo-Hermitian operators to address the problem of the construction and classification of positive-definite invariant inner-products on the space of solutions of a Klein-Gordon type evolution equation. This involves dealing with the peculiarities of formulating a unitary quantum dynamics in a Hilbert space with a time-dependent inner product. We apply our general results to obtain possible Hilbert space structures on the solution space of the equation of motion for a classical simple harmonic oscillator, a free Klein-Gordon equation, and the Wheeler-DeWitt equation for the FRW-massive-real-scalar-field models.Comment: 29 pages, slightly revised version, accepted for publication in Class. Quantum Gra

Effects of Methoxyisoflavone, Ecdysterone, and Sulfo-Polysaccharide Supplementation on Training Adaptations in Resistance-Trained Males

PURPOSE: Methoxyisoflavone (M), 20-hydroxyecdysone (E), and sulfo-polysaccharide (CSP3) have been marketed to athletes as dietary supplements that can increase strength and muscle mass during resistancetraining. However, little is known about their potential ergogenic value. The purpose of this study was to determine whether these supplements affect training adaptations and/or markers of muscle anabolism/catabolism in resistance-trained athletes. METHODS: Forty-five resistance-trained males (20.5±3 yrs; 179±7 cm, 84±16 kg, 17.3±9 % body fat) were matched according to FFM and randomly assigned to ingest in a double blind manner supplements containing either a placebo (P); 800 mg/day of M; 200 mg of E; or, 1,000 mg/day of CSP3 for 8-weeks during training. At 0, 4, and 8-weeks, subjects donated fasting blood samples and completed comprehensive muscular strength, muscular endurance, anaerobic capacity, and body composition analysis. Data were analyzed by repeated measures ANOVA. RESULTS: No significant differences (p>0.05) were observed in training adaptations among groups in the variables FFM, percent body fat, bench press 1RM, leg press 1RM or sprint peak power. Anabolic/catabolic analysis revealed no significant differences among groups in active testosterone (AT), free testosterone (FT), cortisol, the AT to cortisol ratio, urea nitrogen, creatinine, the blood urea nitrogen to creatinine ratio. In addition, no significant differences were seen from pr

Generalized boundary triples, I. Some classes of isometric and unitary boundary pairs and realization problems for subclasses of Nevanlinna functions

© 2020 The Authors. Mathematische Nachrichten published by Wiley‐VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.fi=vertaisarvioitu|en=peerReviewed

Venographic and dopplerographic pattern of left renal vein during varicocele and choice of treatment method of varicose veins of the spermatic cord

On the basis of flebographic, dopplerographic researches the authors consider that during varicocele the compression ot the left renal vein in aorto-mesenteric space occurs and ,as a result, the retrograde blood flow, directed into the left spermatic vein and then directed through the dilated external spermatic vein into the inferior vena cava, occurs. The surgical intervention should be directed at resection of the dilated internal and external spermatic veins near the deep inguinal ring to reverse blood flow not only by V.Testiculareslnterna, but by Testiculares externa.На основании флебографических, допплерографических исследований авторы считают, что при варикоцеле происходит сдавление левой почечной вены в аорто-мезентеральном пространстве в результате чего возникает ретроградный ток крови, направленный в левую семенную вену и далее через расширенную наружную семенную вену в нижнюю полую вену. Оперативное вмешательство должно быть направлено на резекцию расширенных вен внутренней и наружной семенной у внутреннего пахового кольца для прерывания обратного тока крови не только по V.Testiculareslnterna, но и по Testiculares externa

Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration

Background Parkinson's disease (PD) is an adult-onset movement disorder of largely unknown etiology. We have previously shown that loss-of-function mutations of the mitochondrial protein kinase PINK1 (PTEN induced putative kinase 1) cause the recessive PARK6 variant of PD. Methodology/Principal Findings Now we generated a PINK1 deficient mouse and observed several novel phenotypes: A progressive reduction of weight and of locomotor activity selectively for spontaneous movements occurred at old age. As in PD, abnormal dopamine levels in the aged nigrostriatal projection accompanied the reduced movements. Possibly in line with the PARK6 syndrome but in contrast to sporadic PD, a reduced lifespan, dysfunction of brainstem and sympathetic nerves, visible aggregates of alpha-synuclein within Lewy bodies or nigrostriatal neurodegeneration were not present in aged PINK1-deficient mice. However, we demonstrate PINK1 mutant mice to exhibit a progressive reduction in mitochondrial preprotein import correlating with defects of core mitochondrial functions like ATP-generation and respiration. In contrast to the strong effect of PINK1 on mitochondrial dynamics in Drosophila melanogaster and in spite of reduced expression of fission factor Mtp18, we show reduced fission and increased aggregation of mitochondria only under stress in PINK1-deficient mouse neurons. Conclusion Thus, aging Pink1 -/- mice show increasing mitochondrial dysfunction resulting in impaired neural activity similar to PD, in absence of overt neuronal death

ANTIARRHYTHMIC EFFICACY OF PROPAFENONE IN PATIENTS WITH PERSISTENT ATRIAL FIBRILLATION

Aim. To assess propafenone antiarrhythmic efficacy and optimal timing of the drug administration for relief of persistent atrial fibrillation (PAF). Material and methods. 24 patients (19 men, 5 women, aged 53,8±13,3) with PAF (duration is more than 7 days) were included in the study. PAF was confirmed clinically as well as by ECG and daily ECG monitoring. Indications for sinus rhythm recovery by propafenone were defined in according to the ACC/AHA/ESC recommendations (2006). 12-lead ECG was performed before the fist administration and 2, 4, 8, 12, 24 hours and some next days after propafenone therapy start. Echocardiography and thyroid hormone tests were also performed. Propafenone was administered additionally to standard treatment of the underlying disease and oral anticoagulants. The first dose of propafenone was 300 mg, after 4 hours patients received next dose of 300 mg if atrial fibrillation persisted and no side effects were observed, then doses of 300 mg were administered every 6-8 hours (but not more than 900-1200 mg per day) during 5 days. Maintenance propafenone dose of 450-600 mg daily was used in case of sinus rhythm recovery. Results. Sinus rhythm was restored in 41,6% of patients taking propafenone, and time of sinus rhythm recovery was 53,1±28,9 hours after therapy start. Propafenone antiarrhythmic efficacy in the loading dose (300 mg) was 4,2%. Propafenone efficacy during the first 24 hours (dose of 700±282,8 mg) was 12,5%. The maximum rate of sinus rhythm recovery was observed during the first 2-3 days of propafenone receiving (60% of all patients with rhythm recovery). Patients with unrecovered sinus rhythm had longer duration of PAF in comparison with this in effectively treated patients, 105,8±89,0 vs 39,7±38,9 days (p&lt;0,05), respectively, as well as the more prominent basal pulse deficit, 24,6±15,0 vs 13,56±5,7 beats per minute (p&lt;0,05), respectively. Cardiac and transient noncardiac side effects were registered in 8,6 and 4,3% of patients taking propafenone in dose of 900-1200 mg/day, respectively. Side effects did not require propafenone therapy cessation. Conclusion. Propafenone (900-1200 mg/day) antiarrhythmic efficacy in PAF was 41,6%. The probability of sinus rhythm recovery was maximal during the first 2-3 days. Ineffectively treated patients had longer duration of PAF last episode and more prominent basal pulse deficit in comparison with these in effectively treated patients. Transient side effects not requiring propafenone (900-1200 mg/day) withdrawal were observed in 12,6% of patients.</p