Regression of glomerulosclerosis in response to transient treatment with angiotensin II blockers is attenuated by blockade of matrix metalloproteinase-2

Understanding mechanisms that contribute to the regression of glomerulosclerosis is important for developing new strategies to treat chronic kidney disease. We reported that transient high-dose treatment with an angiotensin receptor blocker causes regression of renal arteriolar hypertrophy and hypertension in spontaneously hypertensive rats. To extend those findings to another form of kidney disease, we examined the short- and long-term effects of transient high-dose angiotensin receptor blocker treatment in a mouse model of adriamycin-induced glomerulosclerosis. A 2-week course of candesartan caused a dose-dependent regression of established glomerulosclerotic lesions sustained for over 6 months following cessation of treatment. Highly sensitive in situ zymography and activity assays showed that glomerular matrix metalloproteinase (MMP)-2 activity was increased after high-dose angiotensin blocker therapy. Treatment of cultured podocytes with candesartan resulted in an increase in MMP-2 activity. The regression of glomerulosclerosis was partially attenuated in mice pretreated with the MMP inhibitor doxycycline, as well as in MMP-2 knockout mice. Our results suggest that transient high-dose angiotensin receptor blocker treatment effectively induced sustained regression of glomerulosclerosis by a mechanism mediated, in part, by changes in MMP-2 activity

Effect of the tangential NBI current drive on the stability of pressure and energetic particle driven MHD modes in LHD plasma

The aim of the present study is to analyze the stability of the pressure gradient driven modes (PM) and Alfvén eigenmodes (AE) in the large helical device (LHD) plasma if the rotational transform profile is modified by the current drive of the tangential neutral beam injectors (NBI). This study forms a basic search for optimized operation scenarios with reduced mode activity. The analysis is performed using the code FAR3d which solves the reduced MHD equations describing the linear evolution of the poloidal flux and the toroidal component of the vorticity in a full 3D system, coupled with equations for density and parallel velocity moments of the energetic particle (EP) species, including the effect of the acoustic modes. The Landau damping and resonant destabilization effects are added via the closure relation. On-axis and off-axis NBI current drive modifies the rotational transform which becomes strongly distorted as the intensity of the neutral beam current drive (NBCD) increases, leading to wider continuum gaps and modifying the magnetic shear. The simulations with on-axis NBI injection show that a counter (ctr-) NBCD in inward shifted and default configurations leads to a lower growth rate of the PM, although strong n  =  1 and 2 AEs can be destabilized. For the outward shifted configurations, a co-NBCD improves the AEs stability but the PM are further destabilized if the co-NBCD intensity is 30 kA T−1. If the NBI injection is off-axis, the plasma stability is not significantly improved due to the further destabilization of the AE and energetic particle modes (EPM) in the middle and outer plasma region.This work is supported in part by NIFS under contract NIFS07KLPH004

2001-GT-0083 DEVELOPMENT OF DRY LOW-NOX COMBUSTOR FOR 300 KW CLASS GAS TURBINE APPLIED TO CO-GENERATION SYSTEMS

ABSTRACT A 300 kWe class gas turbine which has a two-shaft and simple-cycle has been developed to apply to co-generation systems. The gas turbine engine is operated in the range of about 30% partial load to 100% load. The gas turbine combustor requires a wide range of stable operations and low NOx characteristics. A double staged lean premixed combustor, which has a primary combustion duct made of Si 3 N 4 ceramics, was developed to meet NOx regulations of less than 80 ppm (corrected at 0% oxygen). The gas turbine with the combustor has demonstrated superior low-emission performance of around 40 ppm (corrected at 0% oxygen) of NOx, and more than 99.5% of combustion efficiency between 30% and 100% of engine load. Endurance testing has demonstrated stable high combustion performance over 3,000 hours in spite of a wide compressor inlet air temperature (CIT) range of 5 to 35 degree C.. While increasing the gas generator turbine speed, the flow rate of primary fuel was controlled to hold a constant equivalence ratio of around 0.5 in the CIT range of more than 15 C. The output power was also decreased while increasing the CIT, in order to keep a constant temperature at the turbine inlet. The NOx decreases in the CIT range of more than 15 C. On the other hand, the NOx increases in the CIT range of less than 15 C when the output power was kept a constant maximum power. As a result, NOx emission has a peak value of about 40 ppm at 15 C

Shape Optimization Approach to a Free Boundary Problem

We take a shape optimization approach to solve a free boundary problem of the Poisson equation numerically. A numerical method called traction method invented by one of the authors are applied. We begin by changing the free boundary problem to a shape optimization problem and define a least square functional as a cost function. Then shape derivative of the cost function is derived by using Lagrange multiplier method. Detail structures and profiles of exact solutions to a concrete free boundary problem due to A. Henrot are also illustrated with proofs. They are used to check the efficiency of the traction method.Selected Papers from the International Symposium on Computational Science - International Symposium on Computational Science Kanazawa University, Japa

The Molecular Outflows in the rho Ophiuchi Main Cloud: Implications For Turbulence Generation

We present the results of CO (J=3-2) and CO (J=1-0) mapping observations toward the active cluster forming clump, L1688, in the rho Ophiuchi molecular cloud. From the CO (J=3-2) and CO (J=1-0) data cubes, we identify five outflows, whose driving sources are VLA 1623, EL 32, LFAM 26, EL 29, and IRS 44. Among the identified outflows, the most luminous outflow is the one from the prototypical Class 0 source, VLA 1623. We also discover that the EL 32 outflow located in the Oph B2 region has very extended blueshifted and redshifted lobes with wide opening angles. This outflow is most massive and have the largest momentum among the identified outflows in the CO (J=1-0) map. We estimate the total energy injection rate due to the molecular outflows identified by the present and previous studies to be about 0.2 L_solar, larger than or at least comparable to the turbulence dissipation rate [~(0.03 - 0.1) L_solar]. Therefore, we conclude that the protostellar outflows are likely to play a significant role in replenishing the supersonic turbulence in this clump.Comment: 37 pages, 9 figures, accepted for publication in The Astrophysical Journa