Ampliación y mejora del barrio de Mumemo (Marracuene, Mozambique)

En los años 2000 y 2001 unas devastadoras inundaciones arrasaron diversas zonas de Mozambique, en especial la zona Sur del país. Más de 700 personas murieron y varios miles de cientos perdieron su casa. A raíz de esto, en el año 2004, las Misioneras Franciscanas crearon el actual distrito de Mumemo, en el distrito de Marracuene, asentada a 30 Km. de Maputo. Con la cooperación de Cáritas y Manos Unidas levantaron todo un pueblo de la nada, gracias también a la colaboración de diferentes agencias y ONGD´s. En colaboración con la ONG África Directo surge la posibilidad de darle continuidad a este proyecto, siguiendo así con el trabajo realizado en la zona por la Hermanas Franciscanas. El proyecto inicial promovía la creación de un nuevo barrio para el asentamiento de 1.777 familias (10.000 personas) las cuales, tras perder todo bajo las aguas y el fango, tuvieron que dejar su antiguo barrio de Chamanculo en el centro de Maput

Biological Activity of NHC-Gold-Alkynyl Complexes Derived from 3-Hydroxyflavones

In this paper we describe the synthesis of new N-heterocyclic carbene (NHC) gold(I) derivatives with flavone-derived ligands with a propargyl ether group. The compounds were screened for their antimicrobial and anticancer activities, showing greater activity against bacteria than against colon cancer cells (Caco-2). Complexes [Au(L2b)(IMe)] (1b) and [Au(L2b)(IPr)] (2b) were found to be active against both Gram-positive and Gram-negative strains. The mechanism of action of 1b was evaluated by measurement of thioredoxin reductase (TrxR) and dihydrofolate reductase (DHFR) activity, besides scanning electron microscopy (SEM). Inhibition of the enzyme thioredoxin reductase is not observed in either Escherichia Coli or Caco-2 cells; however, DHFR activity is compromised after incubation of E. coli cells with complex 1b. Moreover, loss of structural integrity and change in bacterial shape is observed in the images obtained from scanning electron microscopy (SEM) after treatment E. coli cells with complex 1b

Escuela de artes en Almada, Lisboa [Hojas Resumen]

Escuela de artes en Almada, Lisbo

Prácticas de laboratorio en educación superior: ¿cómo transformarlas?

Este artículo revisa la literatura acerca de algunas experiencias que describen cómo son las prácticas de laboratorio en la educación superior en la actualidad, con el fin de identificar, desde la taxonomía de Bloom, las dimensiones cognitivas y de conocimiento que estas prácticas demandan. De esta manera, se determinan factores de éxito como la motivación, la autoeficacia, el trabajo en equipo, las tecnologías de la información y la comunicación (TIC), elementos que integrados con el desarrollo de competencias investigativas permiten transformar el enfoque tradicional y potencializar un enfoque alternativo. Este artículo se constituye en una base conceptual que permitirá formular un modelo en el cual se especifiquen las estrategias y las actividades para el diseño de prácticas de laboratorio

Análisis histórico hermenéutico de los temas musicales oficiales de la copa mundial de fútbol Sudáfrica 2010 y Brasil 2014 y sus intérpretes como marcas representativas del evento

Los temas musicales oficiales de la Copa Mundial de Fútbol y los artistas que se presentan, desempeñan un papel importante dentro del plan de promoción del mismo, De acuerdo a esto, se estudió e interpretó con detalle cada elemento representativo que rodea la celebración, la canción, la letra, los artistas como marcas, su conexión y cohesión con el contexto del país organizador. Todo esto se logró a partir de un análisis histórico hermenéutico, análisis de documentos, creando matrices con variables de semiótica, retórica de la imagen, criterios para la elección de una celebridad, pragmática y contexto. Con base en cada variable, se hizo un cruce para comparar la pertinencia de cada elemento tanto de “Waka waka” como de “We are one”, igualmente con las celebridades elegidas para participar, Shakira, Jennifer López, Pitbull y Claudia Leitte. Los resultados obtenidos, fueron realmente satisfactorios, ya que se encontró la congruencia entre Interprete-Contexto, Tema musical- Contexto, Video-Contexto y al enlazarlos se halló una conexión. Al realizar la comparación entre países se encontraron varias diferencias, sin embargo en general se halló el significado de las letras, su coherencia con el contexto y se determinó la pertinencia de la elección del intérprete como marca representativ

An examination of QTL architecture underlying pod shattering resistance in common bean

Póster presentado en la "8th International Conference on Legume Genetics and Genomics (ICLGG)", que tuvo lugar en Siófok, Hungría, entre el 18 y el 22 de septiembre de 2017.The domesticated common bean (Phaseolus vulgaris) originated in the Mesoamerican and Andean regions independently. Similar to other legume crops, the reduction of pod shattering represents a key domestication syndrome in the domesticated common bean. Understanding the genetic variation of common bean in relation to pod shattering is important for elucidating the underlying genetic mechanisms of parallel evolution (Don and Wang, 2015) and also because this will provide breeders with key tools to improve this trait, thus reducing yield loss (Santalla et al., 2004). Most of these studies have been conducted in cereals (Lin et al., 2012), while in legumes, the identification of pod-shattering genes lag far behind those of the cereal crops (Li and Olsen, 2016). In this study, we identified quantitative trait loci (QTLs) controlling pod fiber in the ventral suture (string) and pod shattering in a recombinant inbred line (RIL) population derived from a cross between a cultivated common bean and wild nuña bean. F2:7 flines were grown under short-day conditions and pod string and pod shattering were analysed at several developmental stages. Correlation analysis showed positive relationship among pod string and shattering. Multi-environment QTL mapping revealed that a major QTL on linkage group 2 (LG02) controlled pod string and co-localized to pod shattering. In addition, minor QTLs related to pod string and pod shattering were identified on LGs01, 03, 04 and 07. Genes underlying the pleiotropic QTL regions could be potential targets for improving shattering resistance performance through marker assisted selection. These QTLs not only provide useful information for isolating candidate genes involved in pod development but also mean potential targets for improving pod shattering resistance by marker assisted selection.This work was financially supported by the Ministerio de Economía y Competitividad (AGL2014-51809-R and AGL2015-64991-C3-1-R) and UE-FEDER Program.Peer Reviewe

Ultra-low dose whole-body CT for attenuation correction in a dual tracer PET/CT protocol for multiple myeloma

Purpose: To investigate within phantoms the minimum CT dose allowed for accurate attenuation correction of PET data and to quantify the effective dose reduction when a CT for this purpose is incorporated in the clinical setting. Methods: The NEMA image quality phantom was scanned within a large parallelepiped container. Twenty-one different CT images were acquired to correct attenuation of PET raw data. Radiation dose and image quality were evaluated. Thirty-one patients with proven multiple myeloma who underwent a dual tracer PET/CT scan were retrospec- tively reviewed. 18F-fluorodeoxyglucose PET/CT included a diagnostic whole-body low dose CT (WBLDCT: 120 kV-80mAs) and 11C-Methionine PET/CT included a whole-body ultra-low dose CT (WBULDCT) for attenuation correction (100 kV-40mAs). Effective dose and image quality were analysed. Results: Only the two lowest radiation dose conditions (80 kV-20mAs and 80 kV-10mAs) produced artifacts in CT images that degraded corrected PET images. For all the other conditions (CTDIvol ≥ 0.43 mGy), PET contrast recovery coefficients varied less than ± 1.2%. Patients received a median dose of 6.4 mSv from diagnostic CT and 2.1 mSv from the attenuation correction CT. Despite the worse image quality of this CT, 94.8% of bone lesions were identifiable. Conclusion: Phantom experiments showed that an ultra-low dose CT can be implemented in PET/CT procedures without any noticeable degradation in the attenuation corrected PET scan. The replacement of the standard CT for this ultra-low dose CT in clinical PET/CT scans involves a significant radiation dose reductio

Ultra-low dose whole-body CT for attenuation correction in a dual tracer PET/CT protocol for multiple myeloma

Purpose: To investigate within phantoms the minimum CT dose allowed for accurate attenuation correction of PET data and to quantify the effective dose reduction when a CT for this purpose is incorporated in the clinical setting. Methods: The NEMA image quality phantom was scanned within a large parallelepiped container. Twenty-one different CT images were acquired to correct attenuation of PET raw data. Radiation dose and image quality were evaluated. Thirty-one patients with proven multiple myeloma who underwent a dual tracer PET/CT scan were retrospec- tively reviewed. 18F-fluorodeoxyglucose PET/CT included a diagnostic whole-body low dose CT (WBLDCT: 120 kV-80mAs) and 11C-Methionine PET/CT included a whole-body ultra-low dose CT (WBULDCT) for attenuation correction (100 kV-40mAs). Effective dose and image quality were analysed. Results: Only the two lowest radiation dose conditions (80 kV-20mAs and 80 kV-10mAs) produced artifacts in CT images that degraded corrected PET images. For all the other conditions (CTDIvol ≥ 0.43 mGy), PET contrast recovery coefficients varied less than ± 1.2%. Patients received a median dose of 6.4 mSv from diagnostic CT and 2.1 mSv from the attenuation correction CT. Despite the worse image quality of this CT, 94.8% of bone lesions were identifiable. Conclusion: Phantom experiments showed that an ultra-low dose CT can be implemented in PET/CT procedures without any noticeable degradation in the attenuation corrected PET scan. The replacement of the standard CT for this ultra-low dose CT in clinical PET/CT scans involves a significant radiation dose reductio