Estados alérgicos em clínica

Tópicos:- O estado alérgico- A especificidade- Do laboratório à clínica- As manifestações alérgicas- O alergizado- Os alérgenos- Outros problemas clínicos- O critério clínico- Orientação terapêutic

Preparo do solo pós-colheita do arroz irrigado.

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Avaliação econômica de sistemas de produção de arroz irrigado em regiões selecionadas do Rio Grande do Sul, safras 2007/2008 a 2009/2010.

O presente trabalho objetivou o levantamento e avaliação da viabilidade dos Sistemas de produção modais de arroz irrigado praticados na Fronteira Oeste e na região Sul do RS

Trypanosoma rangeli: a new perspective for studying the modulation of immune reactions of Rhodnius prolixus

Insects are exposed to a wide range of microorganisms (bacteria, fungi, parasites and viruses) and have interconnected powerful immune reactions. Although insects lack an acquired immune system they have well-developed innate immune defences that allow a general and rapid response to infectious agents

Projeto Marca - avaliação da implantação do projeto na ETB, safra 2004/05.

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Neoadjuvant chemotherapy and trastuzumab versus neoadjuvant chemotherapy followed by post-operative trastuzumab for patients with HER2-positive breast cancer

Neoadjuvant chemotherapy plus trastuzumab (NCT) increases the rate of pathological complete response (pCR) and event-free survival (EFS) compared to neoadjuvant chemotherapy (NC) alone in women with HER2 positive breast cancer (BC). pCR in this setting is associated with improved EFS. Whether NCT preferentially improves EFS in comparison to NC followed by adjuvant trastuzumab initiated postoperatively (NCAT) has not been addressed. Using clinical data from women with HER2 positive BC treated at 7 European institutions between 2007 and 2010 we sought to investigate the impact on breast cancer outcomes of concomitant (NCT) versus sequential (NCAT) treatment in HER2 positive early BC. The unadjusted hazard ratio (HR) for event free survival with NCT compared with NCAT was 0.63 (95% CI 0.37–1.08; p = 0.091). Multivariable analysis revealed that treatment group, tumour size and ER status were significantly associated with EFS from diagnosis. In the whole group NCT was associated with a reduced risk of an event relative to NCAT, an effect that was confined to ER negative (HR: 0.25; 95% CI, 0.10–0.62; p = 0.003) as opposed to ER positive tumours (HR: 1.07; 95% CI, 0.46–2.52; p = 0.869). HER2 positive/ER negative BC treated with NC gain greatest survival benefit when trastuzumab is administered in both the neoadjuvant and adjuvant period rather than in the adjuvant period alone. These data support the early introduction of targeted combination therapy in HER2 positive/ER negative BC

A cirurgia atual do glaucoma crônico simples

A cirurgia atual do glaucoma crônico simple