Artificial Intelligence-Based Surface Roughness Estimation Modelling for Milling of AA6061 Alloy

This study introduces the improvement of mathematical and predictive models of surface roughness parameter (Ra) in milling AA6061 alloy using carbide cutting tools coated with CVD-TiCN in dry condition. An experimental model has been improved for estimating the surface roughness using artificial neural networks (ANN) and response surface methodology (RSM). For these models, cutting speed, depth of cut, and feed rate were evaluated as input parameters for experimental design. For the ANN modelling, the standard backpropagation algorithm was established to be the optimum selection for training the model. In the forming of the network construction, five different learning algorithms were used: the conjugate gradient backpropagation, Levenberg-Marquardt, scaled conjugate gradient, quasi-Newton backpropagation, and resilient backpropagation. The best consequent with single hidden layers for the surface roughness was obtained by 3-8-1 network structures. The statistical analysis was performed with RSM-based second-order mathematics model. The influences of the cutting parameters on surface roughness were defined by using analysis of variance (ANOVA). The ANOVA results show that the depth of cut is the most effective parameter on surface roughness. Prediction models developed using ANN and RSM were compared in terms of prediction accuracy R2, MEP, and RMSE. The data estimated from ANN and RSM were realized to be very close to the data acquired from experimental studies. The value R-2 of RSM model was higher than the values of the ANN model which demonstrated the stability and sturdiness of the RSM method.WOS:0006218375000012-s2.0-8510152661

Two New Species and a New Record of Oppioid Mites (Acari: Oribatida) from Turkey

Two new species Oppiella (Perspicuoppia) ozkani sp. n. and Epimerella ankaraensis sp. n. are recorded from Aegean region of Turkey (Izmir province) and pine forest in the province of Ankara in Turkey, respectively. The principal diagnostic features of the new species Oppiella (Perspicuoppia) ozkani sp. n. are shape of notogastral crista and humeral process and shape of costula. The new species Epimerella ankaraensis diferentiated from the other species of genus by entire rostrum. This is the first records of subgenus Subiasella (Dividoppia) of oppiid mites from Turkey. Subiasella (Dividoppia) aperta (Mahunka, 1987) recorded from Eastern Anatolian region of Turkey (Erzurum province) and redescribed

Morphometric analysis of oppiid mites (Acari, Oribatida) collected from Turkey

In order to assess the relationship between the oppiid mite species (Acari, Oribatida) collected from Turkey, traditional and geometric morphometric methods were used. We have taken photographs of 128 specimens belonging to 11 species from six subfamilies of Oppiidae. These photographs were digitized and 17 interval measurements were taken for traditional morphometric analysis, and 20 landmarks were recognized on the ventral surface of each specimen for geometric morphometric analysis. The effectiveness to separate taxa was compared between the two morphometric analyses. In both dendrograms Oppia nitens formed a single cluster, Oxyoppia ilicaensis was singled out from the remaining nine species, which were clustered together. Two species, Lauroppia fallax and Rhinoppia obsoleta, clustered together implying a very close relationshipIn order to assess the relationship between the oppiid mite species (Acari, Oribatida) collected from Turkey, traditional and geometric morphometric methods were used. We have taken photographs of 128 specimens belonging to 11 species from six subfamilies of Oppiidae. These photographs were digitized and 17 interval measurements were taken for traditional morphometric analysis, and 20 landmarks were recognized on the ventral surface of each specimen for geometric morphometric analysis. The effectiveness to separate taxa was compared between the two morphometric analyses. In both dendrograms Oppia nitens formed a single cluster, Oxyoppia ilicaensis was singled out from the remaining nine species, which were clustered together. Two species, Lauroppia fallax and Rhinoppia obsoleta, clustered together implying a very close relationshi

Late presentation of posttraumatic pulmonary arteriovenous fistulea occlusion with septal occluder device

Posttraumatic pulmonary arteriovenous fistula is a rare complication of penetrating injury. Cases may remain asymptomatic for years prior to diagnosis. We present a case of pulmonary arteriovenous fistula related to a penetrating injury of the thorax 6 years previously that was occluded with a septal occluder device. Consistent use of CT or conventional catheter pulmonary angiography following penetrating injury to the thorax is essential to the early diagnosis of pulmonary arteriovenous fistula during the asymptomatic stage. Modern occlude devices facilitate the transcatheter approach as a viable alternative to surgery for the closure large, high pressure defects

Late Presented Posttraumatic Pulmonary Arteriovenous Fistulea Occlusion With Septal Occluder Device

Posttraumatic pulmonary arteriovenous fistula is a rare complication of penetrating injury. Cases may remain asymptomatic for years prior to diagnosis. We present a case of pulmonary arteriovenous fistula related to a penetrating injury of the thorax 6 years previously that was occluded with a septal occluder device. Consistent use of CT or conventional catheter pulmonary angiography following penetrating injury to the thorax is essential to the early diagnosis of pulmonary arteriovenous fistula during the asymptomatic stage. Modern occlude devices facilitate the transcatheter approach as a viable alternative to surgery for the closure large, high pressure defects

A New Cause of Obesity Syndrome Associated with a Mutation in the Carboxypeptidase Gene Detected in Three Siblings with Obesity, Intellectual Disability and Hypogonadotropic Hypogonadism

AYKUT, Ayca/0000-0002-1460-0053; COGULU, OZGUR/0000-0002-9037-5599; Ata, Aysun/0000-0002-6987-0923; Ozen, Samim/0000-0001-7037-2713WOS:000624138000006PubMed: 32936766Objective: Carboxypeptidase E (CPE) plays a critical role in the biosynthesis of peptide hormones and neuropeptides in the endocrine system and central nervous system. CPE knockout mice models exhibit disorders such as diabetes, hyperproinsulinaemia, low bone mineral density and neurodevelopmental disorders. Only one patient is described with morbid obesity, intellectual disability, abnormal glucose homeostasis and hypogonadotropic hypogonadism, which was associated with a homozygous frameshift deletion in CPE. Methods: Herein are described three siblings with obesity, intellectual disability and hypogonadotropic hypogonadism. Whole exome sequencing (WES) was performed in the index case. Candidate variants were prioritised and segregation of the variant, consistent with the phenotype of the index case, was assessed by Sanger sequencing in affected siblings and parents. Results: WES analysis revealed a homozygous nonsense c.405C>A (p.Y135*) mutation in CPE. Validation and segregation analysis confirmed the homozygous mutation in the index case and his affected siblings. The parents were phenotypically normal heterozygous mutation carriers. Conclusion: This study provides additional evidence of the association between a homozygous nonsense mutation in CPE and a clinical phenotype consisting of obesity, intellectual disability and hypogonadotropic hypogonadism, which may be considered as a new monogenic obesity syndrome

The frequency of and factors affecting functional gastrointestinal disorders in infants that presented to tertiary care hospitals

This study aimed to determine the prevalence of infantile functional gastrointestinal disorders (FGIDs) based on Rome IV diagnostic criteria, and to determine the associated patient demographic and nutritional characteristics. A total of 2383 infants aged 1-12 months which were evaluated by 28 general pediatricians and pediatric gastroenterologists on the same day at nine tertiary care hospitals around Istanbul, Turkey, between November 2017 and March 2018, were included in the study. Patients included consulted the pediatric outpatient clinics because of any complaints, but not for vaccines and/or routine well child follow-ups as this is not part of the activities in the tertiary care hospitals. The patients were diagnosed with FGIDs based on Rome IV diagnostic criteria. The patients were divided into a FGID group and non-FGID group, and anthropometric measurements, physical examination findings, nutritional status, risk factors, and symptoms related to FGIDs were evaluated using questionnaires. Among the 2383 infants included, 837 (35.1%) had >= 1 FGIDs, of which 260 (31%) had already presented to hospital with symptoms of FGIDs and 577 (69%) presented to hospital with other symptoms, but were diagnosed with FGIDs by a pediatrician. Infant colic (19.2%), infant regurgitation (13.4%), and infant dyschezia (9.8%) were the most common FGIDs. One FGID was present in 76%, and >= 2 FGIDs were diagnosed in 24%. The frequency of early supplementary feeding was higher in the infants in the FGID group aged <= 6 months than in the non-FGID group (P = 0.039)