Measuring cycle riding comfort in Southampton using an instrumented bicycle

The increased environmental awareness and the rising fuel costs make bicycles a more and more attractive mode of travel for short journeys. Considering the future prospect of this mode of transportation and the great advantages that it offers in terms of space consumption, health and environmental sustainability, several city authorities worldwide are presently undertaking schemes aiming at improving cycling infrastructure. The aim of the present study is to monitor the impact of such schemes on the riding comfort of cyclists, as expressed by the, usually lower, quantity and magnitude of vibrations occurring as a result of cycling over pavement defects. Millbrook Road East in the western edge of the city center of Southampton is used as a case study, where vibration measurements are taken by means of an instrumented bicycle during periods before and after a redevelopment scheme involving the resurfacing of the road pavement. The results show a clear overall improvement in cycling comfort post-redevelopment, with statistically significant reductions in both the number of high severity vibrations and of their magnitude in "typical" cycling trips taken on the road. However, instances of finishing "snags" in some parts of the surface appear to introduce new minor defects (e.g. around manholes) that are not visible to the naked eye, and these still have some negative effect on the riding experience. Moreover, the study highlights the detrimental impact that widespread pavement defects can have on riding comfort, which affect cyclists of all ages, abilities and styles

EFFECT OF INTELLECTUAL STIMULATION ON STRATEGY IMPLEMENTATION IN COUNTY GOVERNMENTS IN WESTERN REGION, KENYA

County governments in Kenya have been in operation since 2013, but the performance of most of them is still an issue for debate despite the reforms that have been put in place. Consequently, for the achievement of exceptional performance in the current dynamic and uncertain socio-economic environment, a blend of buoyant leadership capabilities and potent management styles is required. Transformational leadership has been touted as a possible remedy to such scenarios. The study sought to determine how intellectual stimulation affects strategy implementation. The study was anchored on the power and influence theory of leadership. A pilot study was conducted in Trans Nzoia County. The study was a census targeting 268 respondents and was anchored on a positivism paradigm and utilized a descriptive-correlational research design. A purposive sampling design was adopted and data was collected using questionnaires and an interview guide. Data was analyzed using descriptive and inferential statistics descriptive analysis by the aid of SPSS version 23. Results were presented in form of tables and models. The findings revealed that intellectual stimulation significantly accounts for a 30.1% variation in strategy implementation. Further, intellectual stimulation (β=0.448, P=0.000) has a significant statistical effect on strategy implementation. The study concluded that intellectual stimulation has a significant effect on strategy implementation. The study recommends that county management need to develop the competence of their staff at their place of work, appreciate each staff as an individual rather than as a group, and ensure fair workload distribution. These will encourage staff to perform their jobs effectively and put extra effort into their work hence strategy implementation.JEL: G18; H11  Article visualizations

HPV16 E1^E4 protein is phosphorylated by Cdk2/cyclin A and relocalizes this complex to the cytoplasm

AbstractThe human papillomavirus type 16 E1^E4 protein is expressed abundantly in cells supporting viral DNA amplification, but its expression is lost during malignant progression. In cell culture, 16E1^E4 causes G2 cell cycle arrest by associating with and preventing the nuclear entry of Cdk1/cyclin B1 complexes. Here, we show that 16E1^E4 is also able to associate with cyclin A and Cdk2 during the G2 phase of the cell cycle. Only a weak association was apparent during S-phase, and progression through S-phase appeared unaffected. As with cyclin B1, the interaction of 16E1^E4 with cyclin A is dependent on residues T22/T23 and results in the accumulation of cyclin A in the cytoplasm where it colocalizes with 16E1^E4. 16E1^E4 serine 32 was found to be phosphorylated by Cdk2/cyclin A. We hypothesize that the interaction of 16E1^E4 with cyclin A may serve to increase the efficiency with which 16E1^E4 is able to prevent mitotic entry

A real-world exploration into clinical outcomes of direct oral anticoagulant therapy in people with chronic kidney disease: a large hospital-based study

Background There is limited evidence to support definite clinical outcomes of direct oral anticoagulant (DOAC) therapy in chronic kidney disease (CKD). By identifying the important variables associated with clinical outcomes following DOAC administration in patients in different stages of CKD, this study aims to assess this evidence gap. Methods An anonymised dataset comprising 97,413 patients receiving DOAC therapy in a tertiary health setting was systematically extracted from the multidimensional electronic health records and prepared for analysis. Machine learning classifiers were applied to the prepared dataset to select the important features which informed covariate selection in multivariate logistic regression analysis. Results For both CKD and non-CKD DOAC users, features such as length of stay, treatment days, and age were ranked highest for relevance to adverse outcomes like death and stroke. Patients with Stage 3a CKD had significantly higher odds of ischaemic stroke (OR 2.45, 95% Cl: 2.10–2.86; p = 0.001) and lower odds of all-cause mortality (OR 0.87, 95% Cl: 0.79–0.95; p = 0.001) on apixaban therapy. In patients with CKD (Stage 5) receiving apixaban, the odds of death were significantly lowered (OR 0.28, 95% Cl: 0.14–0.58; p = 0.001), while the effect on ischaemic stroke was insignificant. Conclusions A positive effect of DOAC therapy was observed in advanced CKD. Key factors influencing clinical outcomes following DOAC administration in patients in different stages of CKD were identified. These are crucial for designing more advanced studies to explore safer and more effective DOAC therapy for the population

Performance of Floriculture Industry in East Africa: What Lessons can Tanzania Learn from Kenya?

In the recent days Sub-Saharan African counties look at floriculture as a viable alternative to boost their foreign earnings through export of cut flowers. However, while the sector is second largest contributor to foreign earnings for Kenya, Tanzania is yet to fully exploit the potential for both production and export of cut flowers. This paper was set with an aim to make comparative assessment of performance of floriculture industries in Kenya and Tanzania. The study relied mainly on secondary data obtained from International Trade Centre (ITC) database, published previous survey reports and several national policies and strategies. The findings revealed that Kenya was performing better than Tanzania in terms of quantity of cut flowers exported to different destinations in the World and in-terms of value of earnings from export of those flowers. It was observed that while the floriculture sector for both countries had been growing in the past nine years, Kenya’s performance was far beyond Tanzania’s. Among the major hurdles to the growth of Tanzania’s floriculture industry included lack of efficient air transportation, absence of a National Horticulture Policy in place, unorganized farming systems without clusters and foreigners domination of the sector. The paper recommended for a number of measures to improve performance of floriculture industry in Tanzania including need to: (a) formulate national horticulture policy to guide expansion of the sector (b)engage in strategic negotiations with big cargo Airline Companies so that they can frequently land at Kilimanjaro International Airport for easy transportation of cut flowers to the different destinations in the world and (c) launch coordinated efforts by experts from the Tanzania’s ministries of agriculture, trade, transportation and finance to draw lessons from Kenya on how to grow floriculture in the country

A survey of eMedia-delivered interventions for schizophrenia used in randomized controlled trials

Background: Randomized trials evaluating electronic Media (eMedia) delivery of interventions are increasingly frequent in mental health. Although a number of reviews have reported efficacy of these interventions, none has reviewed the type of eMedia interventions and quality of their description. We therefore decided to conduct a survey of eMedia-delivered interventions for schizophrenia. Methods: We surveyed all relevant trials reliably identified in the Cochrane Schizophrenia Group’s comprehensive register of trials by authors working independently. Data were extracted regarding the size of the trial, interventions, outcomes and how well the intervention was described. Results: eMedia delivery of interventions is increasingly frequent in trials relevant to the care of people with schizophrenia. The trials varied considerably in sample sizes (mean =123, median =87, range =20–507), and interventions were diverse, rarely evaluating the same approaches and were poorly reported. This makes replication impossible. Outcomes in these studies are limited, have not been noted to be chosen by end users and seem unlikely to be easy to apply in routine care. No study reported on potential adverse effects or cost, end users satisfaction or ease of use. None of the papers mentioned the use of CONSORT eHealth guidelines. Conclusion: There is a need to improve reporting and testing of psychosocial interventions delivered by eMedia. New trials should comply with CONSORT eHealth guidance on design, conduct and reporting, and existing CONSORT should be updated regularly, as the field is constantly evolving

Factor analysis of body measurements of local cows of Manipur, India

Eighteen different biometric traits in 250 local cows of Manipur from their breeding zone, i.e. Imphal valley of Manipur, India, were recorded and analyzed by principal component analysis to explain body conformation. The averages of height at withers (HW), body length, heart girth, paunch girth, forehead width, ear length, tail length, switch length, neck circumference, neck length, arm length,  elbow length, fore-shank length, thigh length, hind-shank length, pes length, head length and eye to eye space were 103.92±0.33, 111.34±0.92, 135.34±0.47, 140.31±0.53, 14.90±0.15, 15.24±0.13, 75.50±0.55, 31.04±0.24, 58.61±0.53, 29.95±0.21, 29.34±0.19, 29.88±0.17, 29.59±0.20, 30.32±0.20, 29.88±0.13, 31.65±0.25, 37.30±0.25 and 26.47±0.20 cm, respectively. The correlation coefficients ranged from -0.20 (hind shank length and eye to eye width) to 0.74 (heart girth and paunch girth).  Factor analysis with promax rotation revealed seven factors which explained about 64.31% of the total variation. Factor 1 described the general body conformation and explained 17.74% of total variation. It was represented by significant positive high loading of height at wither, heart girth, paunch girth and ear length. The remaining factors described 11.71%, 8.88%, 7.47%, 6.60%, 6.04% and 5.86% of total variability.  It was necessary to include some more variables for a reliable analysis of factors as there were less than three variables except the first factor in the present study. The communality ranged from 0.493 (elbow length) to 0.782 (neck circumference) and unique factors ranged from 0.507 to 0.218 for all these 18 different biometric traits. The lower communalities for some of the traits like ear length, tail length, arm length, elbow length and thigh length might indicate that these traits were less effective to account for total variation of body conformation as compared to the other traits in local cows of Manipur. The result suggests that principal component analysis (PCA) could be used in breeding programs with a drastic reduction in the number of biometric traits to be recorded to explain body conformation

Determination of Single Hybridization Temperature for Serotyping of Human Group A Rotavirus with Oligonucleotide Probes

The possibility of use of a single hybridization temperature instead of different temperature for different probes for detection of human group A rotavirus (HRV) was explored. The sensitivity and specificity of the 5 oligonucleotide probes were assessed using cell culture adapted rotavirus (RV) strains by carrying out hybridization at a fixed temperature of 50℃. The results obtained indicate that a single hybridization temperature may be used for all the probes with virtually no decrease in specificity and sensitivity

Geographic and facility variation in initial use of non-tunneled catheters for incident maintenance hemodialysis patients

Abstract Background Non-tunneled (temporary) hemodialysis catheters (NTHCs) are the least-optimal initial vascular access for incident maintenance hemodialysis patients yet little is known about factors associated with NTHC use in this context. We sought to determine factors associated with NTHC use and examine regional and facility-level variation in NTHC use for incident maintenance hemodialysis patients. Methods We analyzed registry data collected between January 2001 and December 2010 from 61 dialysis facilities within 12 geographic regions in Canada. Multi-level models and intra-class correlation coefficients were used to evaluate variation in NTHC use as initial hemodialysis access across facilities and geographic regions. Facility and patient characteristics associated with the lowest and highest quartiles of NTHC use were compared. Results During the study period, 21,052 patients initiated maintenance hemodialysis using a central venous catheter (CVC). This included 10,183 patients (48.3 %) in whom the initial CVC was a NTHC, as opposed to a tunneled CVC. Crude variation in NTHC use across facilities ranged from 3.7 to 99.4 % and across geographic regions from 32.4 to 85.1 %. In an adjusted multi-level logistic regression model, the proportion of total variation in NTHC use explained by facility-level and regional variation was 40.0 % and 34.1 %, respectively. Similar results were observed for the subgroup of patients who received greater than 12 months of pre-dialysis nephrology care. Patient-level factors associated with increased NTHC use were male gender, history of angina, pulmonary edema, COPD, hypertension, increasing distance from dialysis facility, higher serum phosphate, lower serum albumin and later calendar year. Conclusions There is wide variation in NTHC use as initial vascular access for incident maintenance hemodialysis patients across facilities and geographic regions in Canada. Identifying modifiable factors that explain this variation could facilitate a reduction of NTHC use in favor of more optimal initial vascular access