80'Ier döneminden itibaren siyaset ile mizah dergilerinin ilişkileri sansürler, yasaklar ve davalar

Ankara : İhsan Doğramacı Bilkent Üniversitesi İktisadi, İdari ve Sosyal Bilimler Fakültesi, Tarih Bölümü, 2014.This work is a student project of the The Department of History, Faculty of Economics, Administrative and Social Sciences, İhsan Doğramacı Bilkent University.by Emiroğlu, Kudret

Development of nanobiosensor for therapeutic drug monitoring in personalized cancer treatment approach

Docetaxel is one of the most effective and safe chemotherapy drugs according to the World Health Organization, but its clinical use has been discontinued due to its various side effects. To reduce these side effects, the amount of docetaxel drug should be kept at the most effective level, it should be monitored in body fluids. Due to the limitations of traditional analytical methods used for this purpose, such as expensive and low sensitivity, labor-intensive and time-consuming complex preliminary preparation, efficient methods are required for the determination of the docetaxel level in the body. The increasing demand for the development of personalized therapy has recently spurred significant research into biosensors for the detection of drugs and other chemical compounds. In this study, an electrochemical-based portable nanobiosensor system was developed for the rapid, low-cost, and sensitive determination of docetaxel. In this context, mg-p(HEMA)-IMEO nanoparticles to be used as nanobiosensor bioactive layer was synthesized, characterized, and docetaxel determination conditions were optimized. According to the results obtained, the developed nanobiosensor system can detect docetaxel with a sensitivity of 2.22 mg/mL in a wide calibration range of 0.25-10 mg/mL, in only 15 min, in mixed media such as commercially available artificial blood serum and urine. determined. We concluded that the developed nanobiosensor system can be successfully used in routine drug monitoring as a low-cost biomedical device capable of direct, rapid, and specific drug determination within the scope of personalized treatment, providing point-of-care testing

Use of Specifically Tailored Chelating Polymers for Boron Removal from Aqueous Solutions by Polymer Enhanced Ultrafiltration

Two selective functional polychelatogens, namely hydroxyethylaminoglycerol functioned poly(glycidylmethacrylate (PNS) and Poly(4-Vinyl-1,3-dioxalan-2-one-co-vinyl acetate) (COP) were synthesized and utilized in polymer-enhanced ultrafiltration (PEUF) to remove boron from the aqueous solution. The effect of operating parameters on boron retention was investigated. PNS was synthesized in three molecular weights to observe the effect of molecular weight in borate retention. Increase in pH increased boron retention for all of the synthesized polymers. Decrease in loading resulted in an enhancement in retention values when COP, medium (PNSM) and the low molecular weight of PNS (PNSL) were used. No significant change was observed in the permeate flux with COP (41L/m2 center dot h), PNSL (48L/m2 center dot h) and PNSM (47L/m2 center dot h). However, a decrease in the loading led to a decrease in the permeate flux for high molecular weight PNS (PNSH). Conformational changes in the polymer structure were examined using dynamic and static light-scattering. Retention results for all of the polymers were found to be remarkably higher than the literature, when polyvinyl alcohol was used as the chelating agent. Satisfactory retention results were obtained using both PNSL (R: 54%) and PNSM (R: 57%), showing that PEUF can be employed effectively for borate removal using the specifically tailored polymers

A COMPARATIVE STUDY ON THE ANTIOXIDANT ACTIVITIES AND PHENOLIC CONTENTS OF DIFFERENT EXTRACTS OF A CHILLEA NOBILIS SUBSP SIPYLEA AND ALCEA APTEROCARPA (FENZL) BOISS, ENDEMIC PLANTS IN TURKEY

The present study was designed for the comparison of the antioxidant activities and total phenolic contents of different extracts obtained from Achillea nobilis subsp. sipylea and Alcea apterocarpa (FENZL) BOISS, which are two endemic species for the flora of Turkey. Plants were extracted using various solvents with different polarities by four extraction methods (Soxhlet extraction, maceration, infusion, decoction). Antioxidant activities were determined by 2,2-iphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay and Folin Ciocalteu reagent was used to estimate total phenolic compounds in plant extracts. The results indicated that, infusion and decoction of A. nobilis subsp. sipylea exhibited relatively strong antioxidant activities with IC50 values of 61.0 mu g/m1 and 83.1 mu g/ml, respectively among all plant extracts. Similarly, total phenolic contents of infusion (139 +/- 2.78 mg GAE/g) and decoction (137 +/- 6.09 mg GAE/g) extracts of A. nobilis subsp. sipylea were found to be highest among all extracts. Although all extracts of A. apterocarpa showed varying degrees of antioxidant activity, these activities were found to be rather weak compared to A. nobilis subsp. sipylea extracts. The present results have demonstrated that, the extracts of A. nobilis subsp. sipylea and A. apterocarpa can be regarded as promising candidates for natural plant sources of antioxidants