A comparison of three different target-controlled remifentanil infusion rates during target-controlled propofol infusion for oocyte retrieval

OBJECTIVE: To evaluate the effects of three different target-controlled remifentanil infusion rates during target-controlled propofol infusion on hemodynamic parameters, pain, sedation, and recovery score during oocyte retrieval. METHODS: Sixty-nine women were scheduled for oocyte retrieval. Target-controlled propofol infusion at an effectsite concentration of 1.5 μg/mL was instituted. The patients were randomly allocated to receive remifentanil at an effect-site concentration of either 1.5 (group I, n = 23), 2 (group II, n = 23) or 2.5 ng/mL (group III, n = 23). Hemodynamic variables, sedation, pain, the Aldrete recovery score, and side effects were recorded. RESULTS: Hemodynamic variables, sedation and pain scores and the number of patients with the maximum Aldrete recovery score 10 min after the procedure were comparable among the groups. The number of patients in group III with the maximum Aldrete recovery score 5 min after the procedure was significantly lower than that in groups I and II. One patient in group II and one patient in group III suffered from nausea. CONCLUSION: Similar pain-free conscious sedation conditions without significant changes in hemodynamic parameters were provided by all three protocols. However, target controlled infusion of remifentanil at 1.5 or 2 ng/mL proved superior at providing early recovery compared to 2.5 ng/mL

Laparoscopic Excision of Omental Infarction Mass: A Case Report

Omental infarction is a very rare cause of an acute abdomen in children. Symptoms, in particular, display a great similarity to those of appendicitis. A 10-year-old boy with omental infarction was successfully treated by laparoscopic excision. The authors have demonstrated that laparoscopic excision is a technically feasible and safe method associated with a shorter hospital stay, no requirement for analgesics and a good cosmetic outcome. [Arch Clin Exp Surg 2014; 3(4.000): 247-250

The relationship between ASIC3 gene polymorphism and fibromyalgia syndrome

Fibromyalgia syndrome (FMS) is a chronic pain syndrome characterized by widespread body pain over a long period, the cause of which is not yet clearly known. FMS patients usually have high pain sensitivity. We aimed to investigate whether rs4148855 and rs2288646 polymorphisms of acid-sensing ion channel 3 (ASIC3), one of the factors contributing to pain, cause a predisposition to FMS in the Turkish population

Does dietary intake of acrylamide affect hydroxyproline levels? An animal study

Acrylamide is a chemical that occurs due to high temperatures during cooking. It consists of an amino acid found in foods and sugars. Studies have shown that cancer formation occurs within the scope of oxidant reagents and DNA damage due to exposure to acrylamide. Our study aims to examine the effects of dietary acrylamide intake on plasma hydroxyproline levels in rats. In this study, 4 groups were formed with 8 rats in each group (total number=32). Blood samples were collected on days 14 and 28. Acrylamide solution was applied to each rat in the treatment group by gastric gavage process at 5 mg/kg three times a week. Hydroxyproline levels in rats' plasma samples were measured. The median (IQR) hydroxyproline levels were 7.40(2.45) µg/L in group 1 (14. days control group) and 7.98(3.34) µg/L in group 2 (14. days acrylamide applied) who received acrylamide. The mean hydroxyproline levels were 7.25(1.96) µg/L in group 3 (28. days control group) and 9.76(2.64) µg/L in group 4 (28. days acrylamide applied) who received acrylamide. No difference was observed between the groups. Dietary acrylamide intake did not have a significant effect on hydroxyproline levels at the application dose and duration in our study. [Med-Science 2022; 11(4.000): 1478-81

Spinal anaesthesia for a caesarean section in a patient with paraneoplastic cerebellar ataxia

Paraneoplastic cerebellar ataxia (PCA) is most frequently observed in gynaecological cancers, small cell lung cancer, breast cancer, Hodgkin's lymphoma, cancer testis or malignant thymoma. In the literature, there is no data related to the effects of PCA during pregnancy or reports on the effects of anaesthesia in patients with PCA. We present management of a pregnant woman with PCA who was suddenly unable to walk with PCA and for whom effective spinal anaesthesia was performed for an elective caesarean section with no complications

Anesthetic Techniques in Octogenarians and Older Undergoing Orthopedic Surgery for Hip Fracture

Objectives: Hip fracture is common orthopedic problems for patients aged 80 years and older. Because of their decreased cardiopulmonary capacity, an optimal anesthetic technique should be chosen by anesthesiologists. The purpose of the present study is to analyze anesthetic techniques and related postoperative mortality in octogenarians and older who underwent hip fractures surgery. Patients and Methods: We analyzed hip fracture surgeries and identified patients aged 80 years and older between January 2012 and December 2013. Patient age, gender, coexisting diseases, American Society of Anesthesiologists (ASA) Physical Status classification, anesthetic technique, hematocrit, hemoglobin, total lymphocyte count (TLC), the length of surgery, intraoperative blood transfusion requirements, postoperative discharge ward, the length of postoperative hospital stay, and postoperative status were recorded. Results: We retrospectively identified 106 patients aged 80 years and older underwent hip fracture surgeries. Six (5.6%), 36 (34.0%), 2 (1.9%), 53 (50.0%), and 9 (8.5%) of procedures were performed under general anesthesia (GA), spinal anesthesia (SA), epidural anesthesia, combined spinal-epidural anesthesia (CSEA), and peripheral nerve block (PNB), respectively. The postoperative 7 and 30-day mortality were 6.6% and 10.4%, respectively. Age, gender, ASA, hematocrit, hemoglobin, TLC, discharge to the ward, the length of postoperative hospital stay, and the postoperative mortality rates were similar between the GA, SA, CSEA, and PNB. There was no relationship between postoperative mortality and anesthetic technique. Conclusion: In octogenarians and older, the postoperative mortality is higher after hip fracture and is not associated with the anesthetic technique

The effects of colostrum on some biochemical parameters in the experimental intoxication of rats with paracetamol

In the current study, the possible prophylactic and therapeutic effects of colostrum (COL) on acute organ injury caused by paracetamol (PAR) in rats were evaluated. Within the scope of this study, a 2-month-old male (150-200 g) 70 Wistar Albino rat was used and a total of seven groups were designed. The first group (CNT) was maintained for control purposes. The second group (COL-1) was given COL for 1 day, at a dose of 500 mg/kg at 6-h intervals, and blood and tissue sampling was performed at 24 h. The third group (COL-7) received COL for 7 days, at a dose of 500 mg/kg at 6-h intervals on day 1 and at a daily dose of 500 mg/kg on the following days, and blood and tissue samples were taken at the end of seventh day. The fourth group (PAR-1) was administered with PAR at a dose of 1.0 g/kg bw and was blood and tissue sampled at 24 h. The fifth group (PAR-7) received PAR at a dose of 1.0 g/kg bw on day 1 and was blood and tissue was removed at the end of day 7. The sixth group (PAR+COL-1) was administered with a combination of PAR (1 g/kg bw) and COL (500 mg/kg at 6-h intervals), and blood and tissue samples were collected at 24 h. The seventh group (PAR+COL-7) received 1.0 g/kg bw of PAR on day 1 and was given COL throughout the 7-day study period (at a dose of 500 mg/kg at 6-h intervals on day 1 and at a daily dose of 500 mg/kg on the following days). In the seventh group, blood and tissue samples were taken at the end of seventh day. Alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), glucose, creatinine, triglyceride, total bilirubin, total protein and albumin levels/activities were analysed in the serum samples. The malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) levels/activities, known as oxidative stress parameters, were assayed for tissue homogenates and blood (erythrocytes/plasma); in addition, enzyme activities of GSH S-transferase (GST), cytochrome P4502E1 (CYP2E1), NADH-cytochrome b5 reductase (CYTB5), glucose-6-phosphate dehydrogenase (G6PD), NADPH-cytochrome P450 C reductase (CYTC) and glutathione (GSH) levels/activities defined as drug metabolising parameters were measured in liver homogenates. In result, it was determined that PAR caused significant alterations in some biochemical and lipid peroxidation parameters and the activities/levels of drug metabolising parameters in the liver and that COL normalised some of these parameters and reduced PAR-induced tissue damage