Increasing atmospheric CO2 concentrations outweighs effects of stand density in determining growth and water use efficiency in Pinus ponderosa of the semi-arid grasslands of Nebraska (U.S.A.)

This study investigated the impacts of environmental (e.g., climate and CO2 level) and ecological (e.g., stand density) factors on the long-term growth and physiology of ponderosa pine (Pinus ponderosa) in a semi-arid north American grassland. We hypothesized that ponderosa pine long-term growth patterns were positively influenced by an increase in atmospheric CO2 concentrations and a decrease in stand density. To test this hypothesis, comparison of long-term trends in tree-ring width and carbon and oxygen stable isotopic composition of trees growing in dense and sparse forest stands were carried out at two sites located in the Nebraska National Forest. Results indicated that tree-ring growth increased over time, more at the sparse than at the dense stands. In addition, the carbon and oxygen isotopic ratios showed long-term increases in intrinsic water use efficiency (WUEi), with little difference between dense and sparse stands. We found a clear trend over time in ponderosa pine tree growth and WUEi, mechanistically linked to long-term changes in global CO2 concentration. The study also highlighted that global factors tend to outweigh local effects of stand density in determining long-term trends in ponderosa pine growth. Finally, we discuss the implications of these results for woody encroachment into grasslands of Nebraska and we underlined how the use of long-term time series is crucial for understanding those ecosystems and to guarantee their conservation

High Spin Gauge Fields and Two-Time Physics

All possible interactions of a point particle with background electromagnetic, gravitational and higher-spin fields is considered in the two-time physics worldline formalism in (d,2) dimensions. This system has a counterpart in a recent formulation of two-time physics in non-commutative field theory with local Sp(2) symmetry. In either the worldline or field theory formulation, a general Sp(2) algebraic constraint governs the interactions, and determines equations that the background fields of any spin must obey. The constraints are solved in the classical worldline formalism (h-bar=0 limit) as well as in the field theory formalism (all powers of h-bar). The solution in both cases coincide for a certain 2T to 1T holographic image which describes a relativistic particle interacting with background fields of any spin in (d-1,1) dimensions. Two disconnected branches of solutions exist, which seem to have a correspondence as massless states in string theory, one containing low spins in the zero Regge slope limit, and the other containing high spins in the infinite Regge slope limit.Comment: LaTeX 22 pages. Typos corrected in version

Challenges and Knowledge Gaps with Immune Checkpoint Inhibitors Monotherapy in the Management of Patients with Non-Small-Cell Lung Cancer: a Survey of Oncologist Perceptions

Background: Immune checkpoint-inhibitors (ICIs) are changing outcomes in different cancer settings, notably for patients with non-small-cell lung cancer (NSCLC). There are, however, still important gaps of evidence for clinical practice when using these novel treatments. In this study, we assessed physicians' opinion and experience on challenges for clinical practice with ICIs monotherapy in NSCLC. Methods: A survey was conducted on experienced physicians treating patients with NSCLC with ICIs. Two rounds of pilot tests were carried out for validation among a group of experts. Topics under analysis were in relation to treatment of elderly populations, performance status, brain metastases, use of steroids or antibiotics, the effects of gut microbiome, autoimmune diseases, human immunodeficiency virus infection, solid organ transplants, use of anti-programmed cell death protein 1 versus anti-programmed death-ligand 1 drugs, atypical tumour responses, predictors of response, duration of treatment and a final open question on additional relevant challenges. Results: Two hundred and twenty-one answers were collected, including 106 (48%) valid answers from experts for final analysis (physicians who have treated at least 20 patients with NSCLC with ICIs). The vast majority agreed that the selected topics in this study are important challenges ahead and more evidence is needed. Moreover, predictors of response, treating brain metastasis, shorter duration of treatment, the effects of gut microbiome and concomitant use of steroids were voted the most important topics to be further addressed in prospective clinical research. Conclusions: This survey contributed to understanding which are the main challenges for clinical practice with ICIs monotherapy in NSCLC. It can also contribute to guide further clinical research, considering the opinions and experience of those who regularly treat NSCLC patients with ICIs.info:eu-repo/semantics/publishedVersio

Universality of Sypersymmetric Attractors

The macroscopic entropy-area formula for supersymmetric black holes in N=2,4,8 theories is found to be universal: in d=4 it is always given by the square of the largest of the central charges extremized in the moduli space. The proof of universality is based on the fact that the doubling of unbroken supersymmetry near the black hole horizon requires that all central charges other than Z=M vanish at the attractor point for N=4,8. The ADM mass at the extremum can be computed in terms of duality symmetric quartic invariants which are moduli independent. The extension of these results for d=5, N=1,2,4 is also reported. A duality symmetric expression for the energy of the ground state with spontaneous breaking of supersymmetry is provided by the power 1/2 (2/3) of the black hole area of the horizon in d=4 (d=5). It is suggested that the universal duality symmetric formula for the energy of the ground state in supersymmetric gravity is given by the modulus of the maximal central charge at the attractor point in any supersymmetric theory in any dimension.Comment: few misprints removed, version to appear in Phys. Rev. 20 pages, 1 figur

Unified Maxwell-Einstein and Yang-Mills-Einstein Supergravity Theories in Five Dimensions

Unified N=2 Maxwell-Einstein supergravity theories (MESGTs) are supergravity theories in which all the vector fields, including the graviphoton, transform in an irreducible representation of a simple global symmetry group of the Lagrangian. As was established long time ago, in five dimensions there exist only four unified Maxwell-Einstein supergravity theories whose target manifolds are symmetric spaces. These theories are defined by the four simple Euclidean Jordan algebras of degree three. In this paper, we show that, in addition to these four unified MESGTs with symmetric target spaces, there exist three infinite families of unified MESGTs as well as another exceptional one. These novel unified MESGTs are defined by non-compact (Minkowskian) Jordan algebras, and their target spaces are in general neither symmetric nor homogeneous. The members of one of these three infinite families can be gauged in such a way as to obtain an infinite family of unified N=2 Yang-Mills-Einstein supergravity theories, in which all vector fields transform in the adjoint representation of a simple gauge group of the type SU(N,1). The corresponding gaugings in the other two infinite families lead to Yang-Mills-Einstein supergravity theories coupled to tensor multiplets.Comment: Latex 2e, 28 pages. v2: reference added, footnote 14 enlarge

Orbifolds and Flows from Gauged Supergravity

We examine orbifolds of the IIB string via gauged supergravity. For the gravity duals of the A_{n-1} quiver gauge theories, we extract the massless degrees of freedom and assemble them into multiplets of N=4 gauged supergravity in five dimensions. We examine the embedding of the gauge group into the isometry group of the scalar manifold, as well as the symmetries of the scalar potential. From this we find that there is a large SU(1,n) symmetry group which relates different RG flows in the dual quiver gauge theory. We find that this symmetry implies an extension of the usual duality between ten-dimensional IIB solutions which involves exchanging geometric moduli with background fluxes.Comment: 37 pages, harvma

Consistent truncation of d = 11 supergravity on AdS_4 x S^7

We study the system of equations derived twenty five years ago by B. de Wit and the first author [Nucl. Phys. B281 (1987) 211] as conditions for the consistent truncation of eleven-dimensional supergravity on AdS_4 x S^7 to gauged N = 8 supergravity in four dimensions. By exploiting the E_7(7) symmetry, we determine the most general solution to this system at each point on the coset space E_7(7)/SU(8). We show that invariants of the general solution are given by the fluxes in eleven-dimensional supergravity. This allows us to both clarify the explicit non-linear ansatze for the fluxes given previously and to fill a gap in the original proof of the consistent truncation. These results are illustrated with several examples.Comment: 41 pages, typos corrected, published versio

Holography in asymptotically flat space-times and the BMS group

In a previous paper (hep-th/0306142) we have started to explore the holographic principle in the case of asymptotically flat space-times and analyzed in particular different aspects of the Bondi-Metzner-Sachs (BMS) group, namely the asymptotic symmetry group of any asymptotically flat space-time. We continue this investigation in this paper. Having in mind a S-matrix approach with future and past null infinity playing the role of holographic screens on which the BMS group acts, we connect the IR sectors of the gravitational field with the representation theory of the BMS group. We analyze the (complicated) mapping between bulk and boundary symmetries pointing out differences with respect to the AdS/CFT set up. Finally we construct a BMS phase space and a free hamiltonian for fields transforming w.r.t BMS representations. The last step is supposed to be an explorative investigation of the boundary data living on the degenerate null manifold at infinity.Comment: 31 pages, several changes in section 3 and 7 and references update