Pattern-Aided Regression Modelling and Prediction Model Analysis

In this research, we develop an application for generating a pattern aided regression (PXR) model, a new type of regression model designed to represent accurate and interpretable prediction model. Our goal is to generate a PXR model using Contrast Pattern Aided Regression (CPXR) method and compare it with the multiple linear regression method. The PXR models built by CPXR are very accurate in general, often outperforming state-of-the-art regression methods by big margins. CPXR is especially effective for high-dimensional data. We use pruning to improve the classification accuracy and to remove outliers from the dataset. We provide implementation details and give experimental results. Finally, we show that the system is practical and better in comparison to other available methods

Tensile properties of textile composites

The importance of textile composite materials in aerospace structural applications has been gaining momentum in recent years. With a view to better understand the suitability of these materials in aerospace applications, an experimental program was undertaken to assess the mechanical properties of these materials. Specifically, the braided textile preforms were infiltrated with suitable polymeric matrices leading to the fabrication of composite test coupons. Evaluation of the tensile properties and the analyses of the results in the form of strength moduli, Poisson's ratio, etc., for the braided composites are presented. Based on our past experience with the textile coupons, the fabrication techniques have been modified (by incorporating glass microballoons in the matrix and/or by stabilizing the braid angle along the length of the specimen with axial fibers) to achieve enhanced mechanical properties of the textile composites. This paper outlines the preliminary experimental results obtained from testing these composites

Characterization of Boundary Element-Associated Factors BEAF-32A and BEAF-32B and Identification of Novel Interaction Partners in Drosophila Melanogaster

Regulatory elements are DNA sequences which have specialized activities that coordinate the functions of the genome. Promoters, enhancers, locus control regions, boundary elements (or insulator elements) are examples of DNA sequences that have regulatory properties. In transgenic assays insulator elements have been shown to block communication between regulatory regions, such as enhancers and promoters, when placed between these sequences and also protect genes from position effects when bracketing them, thereby affecting gene expression. Insulator sequences are bound by insulator proteins that direct the function of these sequences. One such insulator protein is the Boundary Element Associated Factor-32 (BEAF-32), a 32 kDa protein which was originally found to bind to the scs’ insulator sequence in the 87A heat shock locus of the Drosophila genome. BEAF-32 has two isoforms: 32A and 32B. BEAF was immunolocalized to numerous binding sites across the Drosophila genome. This was substantiated by various genome-wide mapping experiments, which have identified from 1800 to 6000 BEAF binding sites across the genome. Hence, BEAF-32 likely plays an important role in chromatin organization and gene regulation in combination with other proteins in the nucleus. However, it is not clear how BEAF-32 affects genome organization and gene regulation. We characterized essential domains in the BEAF-32 protein and identified protein partners, some of which include Transcription Factors (TFs). We further mapped the interaction regions inside BEAF and these TFs. We then attempted Fluorescent Recovery After Photobleaching (FRAP) to assess the dynamics of BEAF-32 on polytene chromosomes and also observed banding patterns, with the help of fluorescent protein labels, and evaluated its behavior during mitosis in early embryos. Finally, results obtained with BEAF prompted us to test for physical interactions between various insulator proteins and to check contradictory reported results from the literature to document interactions

Current Status in Cavitation Modeling

Cavitation is a common problem for many engineering devices in which the main working fluid is in liquid state. In turbomachinery applications, cavitation generally occurs on the inlet side of pumps. The deleterious effects of cavitation include: lowered performance, load asymmetry, erosion and pitting of blade surfaces, vibration and noise, and reduction of the overall machine life. Cavitation models in use today range from rather crude approximations to sophisticated bubble dynamics models. Details about bubble inception, growth and collapse are relevant to the prediction of blade erosion, but are not necessary to predict the performance of pumps. An engineering model of cavitation is proposed to predict the extent of cavitation and performance. The vapor volume fraction is used as an indicator variable to quantify cavitation. A two-phase flow approach is employed with the assumption of the thermal equilibrium between liquid and vapor. At present velocity slip between the two phases is selected. Preliminary analyses of 2D flows shows qualitatively correct results

Experiences with two-equation turbulence models

This viewgraph presentation discusses the following: introduction to CFD Research Corporation; experiences with two-equation models - models used, numerical difficulties, validation and applications, and strengths and weaknesses; and answers to three questions posed by the workshop organizing committee - what are your customers telling you, what are you doing in-house, and how can NASA-CMOTT (Center for Modeling of Turbulence and Transition) help

Fabrication and Evaluation of Graphite Fiber-Reinforced Polyimide Composite Tube Forms Using Modified Resin Transfer Molding

The techniques necessary for the fabrication of a complex three-dimensional tubular form using a PMR-type resin have been developed to allow for the construction of several tubes with good physical and mechanical properties. Employing established resin transfer molding practices, the relatively non-hazardous AMB-21 in acetone formulation was used to successfully impregnate four layers of AS4 braided graphite fiber preform previously loaded around an aluminum cylindrical core in an enclosed mold cavity. Using heat and vacuum, the solvent was evaporated to form a prepreg followed by a partial imidization and removal of condensation products. The aluminum core was replaced by a silicone rubber bladder and the cure cycle continued to the final stage of 550 F with a bladder internal pressure of 200 lbs/sq in while simultaneously applying a strong vacuum to the prepreg for removal of any additional imidization products. A combination of several modifications to the standard resin transfer molding methodology enabled the mold to 'breathe', allowing the imidization products a pathway for escape. AMB-21 resin was chosen because of the carcinogenic nature of the primary commercial polyimide PMR-15. The AMB-21 resin was formulated using commercially available monomers or monomer precursors and dissolved in a mixture of methyl alcohol and acetone. The viscosity of the resulting monomer solution was checked by use of a Brookfield rheometer and adjusted by adding acetone to an easily pumpable viscosity of about 600 cP. In addition, several types of chromatographic and thermal analyses were of the braids, and excess handling of the preforms broke some of the microscopic fibers, needlessly decreasing the strength of the finished part. In addition, three dimensional braided preforms with fibers along the length of the tube will be significantly stronger in tension than the braided preforms used in this study

Promoter-proximal chromatin domain insulator protein BeaF mediates local and long-range communication with a transcription factor and directly activates a housekeeping promoter in Drosophila

Copyright © 2020 by the Genetics Society of America BEAF (Boundary Element-Associated Factor) was originally identified as a Drosophila melanogaster chromatin domain insulator-binding protein, suggesting a role in gene regulation through chromatin organization and dynamics. Genome-wide mapping found that BEAF usually binds near transcription start sites, often of housekeeping genes, suggesting a role in promoter function. This would be a nontraditional role for an insulator-binding protein. To gain insight into molecular mechanisms of BEAF function, we identified interacting proteins using yeast two-hybrid assays. Here, we focus on the transcription factor Serendipity d (Sry-d). Interactions were confirmed in pull-down experiments using bacterially expressed proteins, by bimolecular fluorescence complementation, and in a genetic assay in transgenic flies. Sry-d interacted with promoter-proximal BEAF both when bound to DNA adjacent to BEAF or. 2-kb upstream to activate a reporter gene in transient transfection experiments. The interaction between BEAF and Sry-d was detected using both a minimal developmental promoter (y) and a housekeeping promoter (RpS12), while BEAF alone strongly activated the housekeeping promoter. These two functions for BEAF implicate it in playing a direct role in gene regulation at hundreds of BEAF-associated promoters

Crimea at the Boundary of the 19th-20th Centuries: Historiography of Creation of National-Oriented Educational Literature for Elementary School, Traditional National Clothes, Formation and Development of Higher Education

Significant changes taking place in the socio-economic and cultural life of Crimea, in connection with joining the Russian Federation, determine priorities in the field of national policy and education, the main of which are the formation of national and universal values, ensuring the educational needs of Crimeans, preserving cultural and historical traditions of education and training of the younger generation. The development of primary education in Crimea at the end of the 19th and beginning of the 20th centuries differs significantly from other regions due to the specificity of ethno-religious identities. The ethno-confessional situation in the territory of Crimea in the second half of the 19th - early 20th centuries was rather complicated. Multi-faceted study of the history of the Crimea show that Crimea remained multinational at any given period of history, such as the dominance of one of the ethnic groups of the peninsula, the various state systems

Combustion chamber analysis code

A three-dimensional, time dependent, Favre averaged, finite volume Navier-Stokes code has been developed to model compressible and incompressible flows (with and without chemical reactions) in liquid rocket engines. The code has a non-staggered formulation with generalized body-fitted-coordinates (BFC) capability. Higher order differencing methodologies such as MUSCL and Osher-Chakravarthy schemes are available. Turbulent flows can be modeled using any of the five turbulent models present in the code. A two-phase, two-liquid, Lagrangian spray model has been incorporated into the code. Chemical equilibrium and finite rate reaction models are available to model chemically reacting flows. The discrete ordinate method is used to model effects of thermal radiation. The code has been validated extensively against benchmark experimental data and has been applied to model flows in several propulsion system components of the SSME and the STME