Origen y costumbres de los antiguos Huaruchiri

Fil: De Avila, Francisco

Zipper plot : visualizing transcriptional activity of genomic regions

Background: Reconstructing transcript models from RNA-sequencing (RNA-seq) data and establishing these as independent transcriptional units can be a challenging task. Current state-of-the-art tools for long non-coding RNA (lncRNA) annotation are mainly based on evolutionary constraints, which may result in false negatives due to the overall limited conservation of lncRNAs. Results: To tackle this problem we have developed the Zipper plot, a novel visualization and analysis method that enables users to simultaneously interrogate thousands of human putative transcription start sites (TSSs) in relation to various features that are indicative for transcriptional activity. These include publicly available CAGE-sequencing, ChIP-sequencing and DNase-sequencing datasets. Our method only requires three tab-separated fields (chromosome, genomic coordinate of the TSS and strand) as input and generates a report that includes a detailed summary table, a Zipper plot and several statistics derived from this plot. Conclusion: Using the Zipper plot, we found evidence of transcription for a set of well-characterized lncRNAs and observed that fewer mono-exonic lncRNAs have CAGE peaks overlapping with their TSSs compared to multi-exonic lncRNAs. Using publicly available RNA-seq data, we found more than one hundred cases where junction reads connected protein-coding gene exons with a downstream mono-exonic lncRNA, revealing the need for a careful evaluation of lncRNA 5′-boundaries. Our method is implemented using the statistical programming language R and is freely available as a webtool

Discurso leido el dia 21 de Octubre de 1882 en el Instituto Provincial de Avila : con motivo de la velada literaria dedicada por el mismo á Santa Teresa de Jesús en el tercer centenario de su muerte

Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2009-201

Conductive and convective heat transfer in fluid flows between differentially heated and rotating cylinders

The flow of fluid confined between a heated rotating cylinder and a cooled stationary cylinder is a canonical experiment for the study of heat transfer in engineering. The theoretical treatment of this system is greatly simplified if the cylinders are assumed to be of infinite length or periodic in the axial direction, in which cases heat transfer occurs only through conduction as in a solid. We here investigate numerically heat transfer and the onset of turbulence in such flows by using both periodic and no-slip boundary conditions in the axial direction. We obtain a simple linear criterion that determines whether the infinite-cylinder assumption can be employed. The curvature of the cylinders enters this linear relationship through the slope and additive constant. For a given length-to-gap aspect ratio there is a critical Rayleigh number beyond which the laminar flow in the finite system is convective and so the behaviour is entirely different from the periodic case. The criterion does not depend on the Prandtl number and appears quite robust with respect to the Reynolds number. In particular, it continues to work reasonably in the turbulent regime.Comment: 25 pages, 9 figure

The protoMIRAX Hard X-ray Imaging Balloon Experiment

The protoMIRAX hard X-ray imaging telescope is a balloon-borne experiment developed as a pathfinder for the MIRAX satellite mission. The experiment consists essentially in a coded-aperture hard X-ray (30-200 keV) imager with a square array (13$\times$13) of 2mm-thick planar CZT detectors with a total area of 169 cm$^2$. The total, fully-coded field-of-view is $21^{\circ}\times 21^{\circ}$ and the angular resolution is 1$^{\circ}$43'. In this paper we describe the protoMIRAX instrument and all the subsystems of its balloon gondola, and we show simulated results of the instrument performance. The main objective of protoMIRAX is to carry out imaging spectroscopy of selected bright sources to demonstrate the performance of a prototype of the MIRAX hard X-ray imager. Detailed background and imaging simulations have been performed for protoMIRAX balloon flights. The 3$\sigma$ sensitivity for the 30-200 keV range is ~1.9 $\times$ 10$^{-5}$ photons cm$^{-2}$ s$^{-1}$ for an integration time of 8 hs at an atmospheric depth of 2.7 g cm$^{-2}$ and an average zenith angle of 30$^{\circ}$. We have developed an attitude control system for the balloon gondola and new data handling and ground systems that also include prototypes for the MIRAX satellite. We present the results of Monte Carlo simulations of the camera response at balloon altitudes, showing the expected background level and the detailed sensitivity of protoMIRAX. We also present the results of imaging simulations of the Crab region. The results show that protoMIRAX is capable of making spectral and imaging observations of bright hard X-ray source fields. Furthermore, the balloon observations will carry out very important tests and demonstrations of MIRAX hardware and software in a near space environment.Comment: 9 pages, 13 figures, accepted for publication in Astronomy & Astrophysic

Diffusion of single dye molecules in hydrated TiO 2 mesoporous films

Mesoporous oxide films are attractive frameworks in technological areas such as catalysis, sensing, environmental protection, and photovoltaics. Herein, we used fluorescence correlation spectroscopy to explore how the pore dimensions of hydrated TiO2 mesoporous calcined films modulate the molecular diffusion. Rhodamine B molecules in mesoporous films follow a Fickian process 2–3 orders slower compared to the probe in water. The mobility increases with the pore and neck radii reaching an approximately constant value for a neck radius >2.8 nm. However, the pore size does not control the dye diffusion at low ionic strength emphasizing the relevance of the probe interactions with the pore walls on dye mobility. In conclusion, our results show that the thermal conditioning of TiO2 mesoporous films provides an exceptional tool for controlling the pore and neck radii on the nanometer scale and has a major impact on molecular diffusion within the mesoporous network.Fil: Angiolini, Juan Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Stortz, Martin Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Steinberg, Paula Yael. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Mocskos, Esteban Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Simulación Computacional para Aplicaciones Tecnológicas; ArgentinaFil: Bruno, Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaFil: Soler Illia, Galo Juan de Avila Arturo. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Angelome, Paula Cecilia. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Wolosiuk, Alejandro. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Inorgánica, Analítica y Química Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Levi, Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentin

Selectivity of 130 mm Mesh Size in Deep Sea Bottom Trawl Fishery in NAFO Regulatory Area

In February 1995 the European Union carried out a selectivity survey on board a Spanish commercial trawler, using the codend-cover method. The objective was to study the selectivity of 130 mm mesh size for the deep sea trawl fisheries in the NAFO Regulatory Area. One hour and four hour hauls were carried out and results obtained for Greenland halibut (Reinhardtius hippoglossoides), American plaice (Hippoglossoides platessoides), roughhead grenadier (Macrourus berglax) and threebeard rockling (Gaidropsarus ensis). For the two flatfish species, the proportion of retention increased with the duration of the haul. This increase reflected in a decrease of the corresponding selection factor. It also varied with the size of fish. The selection factor was greater in smaller individuals, and this induced an asymmetry in the selectivity curve. For the groundfish species, data were enough only to fit the four hour selectivity curves, which appeared more symmetrical than the flatfish ones

Selectivity of 130 mm Mesh Size in Deep Sea Bottom Trawl Fishery in NAFO Regulatory Area

In February 1995 the European Community carried out .a selectivity campaign on board of a Spanish commercial trawler, using the codend cover method. The objective was to study the selectivity of 130 mm mesh size for the deep sea trawl fisheries in the NAFO Regulatory Area. One hour and four hour hauls were used and results obtained for Greenland halibut, American plaice, roughhead grenadier and theebeard rockling. For the two flatfish species the proportion of retention increase with the duration of the haul. This increase, reflected in a decrease of the corresponding selection factor, also varies with the size of fish, being greater in smaller individuals, and induces an asymmetry in the selectivity curve. For the roundfish species data were enough only to fit the four hour selectivity curves, both appearing more symmetrical than the flatfishes ones