Integrative Modeling of Electrical Properties of Pacemaker Cardiac Cells

This work represents modeling of electrical properties of pacemaker (sinus) cardiac cells. Special attention is paid to electrical potential arising from transmembrane current of Na{+}, K{+} and Ca{2+} ions. This potential is calculated using the NaCaX model. In this respect, molar concentration of ions in the intercellular space which is calculated on the basis of the GENTEX model is essential. Combined use of two different models allows referring this approach to integrative modeling

Assessment of the DNA damage level in peripheral blood leukocytes of mice treated orally with Rapitalam in acute and therapeutic doses

Centre there was performed experimental research, which carried out the identification and quantitative assessment of alkali-labile sites and DNA strand breaks in leukocytes of peripheral blood of male mice treated with Rapitalam. The method is based on the assessment of the integrity of DNA in leukocytes of the whole blood of animals. Rapitalam was administered to animals orally according to 2 schemes: a single acute dose (413 mg/kg, which corresponds to 1/5 LD50 dose) and once daily in a therapeutic dose (3 mg/kg) for 4 day

Pharmacokinetic studies of new antiparkinsonian drug Rapitalam

The aim of this study was to investigate the pharmacokinetic parameters of the mGluR4 receptor blocker Rapitalam on rabbits. There was developed the method of the quantitative determination of Rapitalam in the blood plasma of rabbits using high performance liquid chromatography with tandem mass spectrometric detection. The study was performed on 12 rabbits (males, weighing between 3,300 to 3,500 g). In intragastric dosing of the substance was administered using a gastric tube in the form of suspension in water 0.9 mg/ml, 9 mg/ml, and 90 mg/ml at a dose of 0.3 mg/kg, 3 mg/kg and 30 mg/kg. The main pharmacokinetic parameters of the substance was established on rabbits that allow you to optimize the future use of it's as a potential drug for the treatment of Parkinson's diseas

The definition of specific antiparkinsonian effects of Rapitalam

Previously, we identified a metabotropic glutamate receptor 4 (mGluR4) as a potential target for drugs and predicted that activation of mGluR4 could provide a palliative advantage in the treatment of Parkinson's disease. Determine the mechanism of action of Rapitalam in vitro on a cell culture with mGluR4 over expression. The HEK293T cell line expressing human mGluR4 was used in the wor

Determination of the critical values of power density in laser marking of textile materials

Представлено фізичну модель процесу лазерного маркування текстильних матеріалів. Визначено межі застосування лазерного маркування для бавовняних і поліефірних тканин.Представлена физическая модель процесса лазерной маркировки текстильных материалов. Определены границы применимости лазерной маркировки для хлопчатобумажных и полиэфирных тканей.A physical model of the process of laser marking of textile materials is presented. The limits of applicability of laser marking for cotton and polyester fabrics have been defined

Sobre el tema de la efectividad de la regulación legal basada en aspectos psicológicos

This article is devoted to the analysis of problems regarding the main approaches to understanding the effectiveness of legal regulation and the search for its criteria. It is known that this issue serves as the basis for ongoing social development, ensuring optimal law-making and law enforcement activities of state bodies, achieving the goals of the procedural and legal regulation, consisting in ensuring, within certain stages of the legal and reasonable consideration and resolution of legal cases, the adoption of appropriate procedural decisions in the interests of subjects of law. The effectiveness of legal regulation is determined by a kind of evaluation category, the essence of which is to determine the level of functionality and effectiveness of this process in its dynamics. As criteria for the effectiveness of procedural and legal regulation are called effectiveness, achievement of the goal, procedural savings and others.Este artículo está dedicado al análisis de problemas relacionados con los principales enfoques para comprender la efectividad de la regulación legal y la búsqueda de sus criterios. Se sabe que este tema sirve como base para el desarrollo social continuo, asegurando actividades óptimas de elaboración de la ley y de aplicación de la ley de los organismos estatales, logrando los objetivos de la regulación procesal y legal, que consiste en garantizar, dentro de ciertas etapas de lo legal y razonable consideración y resolución de casos legales, la adopción de decisiones procesales apropiadas en interés de los sujetos de derecho. La efectividad de la regulación legal está determinada por un tipo de categoría de evaluación, cuya esencia es determinar el nivel de funcionalidad y efectividad de este proceso en su dinámica. Como criterios para la efectividad de la regulación procesal y legal se llaman efectividad, logro de la meta, ahorro procesal y otros

Changes in the prevalence of atrial fibrillation in the Russian population over a 13-year follow-up

AIM: To study the prevalence of atrial fibrillation (AF) in the Russian urban population cohort aged 45-69 years and its changes over 13-year follow-up during aging. MATERIAL AND METHODS: This cross-sectional long-term prospective study included random population sample of men and women 45-69 years (n=9360, HAPIEE project, Novosibirsk), which was examined in 2003-2005 and was re-examined twice and followed up for about 13±1,00 years in men and 13,1±2,17 years in women. The incidence of AF was assessed for individuals without AF or cardiovascular disease (CVD) at the baseline examination. Statistical analysis was performed using the SPSS software package (v.13.0). RESULTS: In a population sample over a 13-year follow-up, AF prevalence increased from 1,6% (1,1% among women and 2,1% among men) at the age of 45-69 years to 4,2% (3,0% among women and 6,1% among men) aged 55-84 years according to screening rest ECG examinations. The prevalence of new AF cases over a 13-year followup in the cohort of 45-69 years old without previous CVD and AF was 5,6%, of which 40% were paroxysmal. The mean age at the time of first registered AF was 69±6,93 years, and was 2 years higher in women (70,0±6,83) than in men (68±6,93). The average period before the AF onset among people aged 45-69 years without baseline CVD and AF was 7,5±3,83 years for men and 8,1±4,02 years for women. The total prevalence of AF in the population sample was 8,3%. The highest AF prevalence was registered at the age of 65-69 years (11,4%) for men and 5 years later for women (12,0%) (p80 years decreased and amounted to 4,1% among men and 5,7% among women. CONCLUSION: In the Russian population sample (Novosibirsk) aged 45-69, the AF prevalence increased from 1,6 to 8,3% over 13 years of follow-up. In addition, 473 new AF cases were identified, ~40% of which were paroxysmal AF. The prevalence of AF in the Siberian population sample for the 45-60 years age group is comparable with the large Russian and North American studies, but higher for persons aged 60-74 years and lower for older age group, for both men and women

On the Issue of the Effectiveness of Legal Regulation Based on Psychological Aspects

This article is devoted to the analysis of problems regarding the main approaches to understanding the effectiveness of legal regulation and the search for its criteria. It is known that this issue serves as the basis for ongoing social development, ensuring optimal law-making and law enforcement activities of state bodies, achieving the goals of the procedural and legal regulation, consisting in ensuring, within certain stages of the legal and reasonable consideration and resolution of legal cases, the adoption of appropriate procedural decisions in the interests of subjects of law. The effectiveness of legal regulation is determined by a kind of evaluation category, the essence of which is to determine the level of functionality and effectiveness of this process in its dynamics. As criteria for the effectiveness of procedural and legal regulation are called effectiveness, achievement of the goal, procedural savings and others.This article is devoted to the analysis of problems regarding the main approaches to understanding the effectiveness of legal regulation and the search for its criteria. It is known that this issue serves as the basis for ongoing social development, ensuring optimal law-making and law enforcement activities of state bodies, achieving the goals of the procedural and legal regulation, consisting in ensuring, within certain stages of the legal and reasonable consideration and resolution of legal cases, the adoption of appropriate procedural decisions in the interests of subjects of law. The effectiveness of legal regulation is determined by a kind of evaluation category, the essence of which is to determine the level of functionality and effectiveness of this process in its dynamics. As criteria for the effectiveness of procedural and legal regulation are called effectiveness, achievement of the goal, procedural savings and others

Social and psychological adaptation features of newly appointed managers

In the professional environment, socio-psychological adaptation to work occurs among workers, ordinary specialists and managers. The adaptation process is the most difficult for employees appointed to a managerial position for the first time. This is because they need not only to adapt to a new job, but also to choose a suitable management strategy, as well as to meet the expectations of subordinates and match their level. They should have such managerial skills to set correctly tasks taking into account the professional level of subordinates and their socio-psychological characteristics. The authors of the article consider the main problems faced by first-time managers during the socio-psychological adaptation to professional activity. The study presents the most effective mechanisms and tools that will make the adaptation of such employees as successful as possible