The effect of intestinal ischemia on plasma thiol/disulphide homeostasis in an experimental study

Aim: To investigate the effects of acute intestinal ischemia on plasma thiol/disulphide homeostasis (TDSH), which has been investigated in a limited number of studies in the related literature. Methods: Twenty-four rats were randomized into control (operation without ischemia, GIS), and ischemia groups (GII-60, GIII-180). For ischemia, the superior mesenteric artery was sutured and the rats were exposed to 60 and 180 minutes of intestinal ischemia, respectively. Plasma TDSH was measured in blood samples collected at the end of the ischemia, and the pathology of ileum segments resected was evaluated. Results: The experimental ischemic conditions provided were confirmed by the total histopathological scoring system statistically. The levels of serum human albumin and ischemia modified albumin (IMA) in groups were detected in quite a close range of each other. There was no found a statistically significant difference for IMA between groups (p>0.05).  The alternations on the levels of plasma TDSH parameters were observed in the study. According to ischemic conditions, the thiol/disulfide ratio fluctuations were detected in the plasma TDSH. The native thiol and total thiol levels seem to have decreased according to ischemia; no statistical difference was detected. In addition, the disulfide levels increasing according to ischemia either was not found significant statistically (p>0.05). Conclusion: Although this study showed the oxidative balance in intestinal ischemia had affected plasma TDSH, also it revealed that intestinal ischemia didn't create a statistically significant difference between plasma TDSH components

On an elliptic system of p(x)-Kirchhoff-type under neumann boundary condition

In the present paper, by using the direct variational method and the Ekeland variational principle, we study the existence of solutions for an elliptic system of p(x)-Kirchhoff-type under Neumann boundary condition and show the existence of a weak solution

Evaluation of some systemic inflammatory biomarkers in canine malignant mammary tumors

The aim of this study is to investigate whether neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), albumin-to-globulin ratio (AGR), and prognostic nutritional index (PNI) parameters could be used as biomarkers for canine malignant mammary tumors (MMTs), and the changes in these parameters according to different tumor (T), lymph node (N), and metastasis (M) stages (TNM I-II-III, TNM IV, TNM V) and the number of affected mammary glands (single, multiple). Thirty-seven with MMT and 20 healthy dogs were used in this study. Complete blood count and biochemistry analysis were performed in all dogs. Tumor material is removed by tru-cut and sent to the pathology laboratory for diagnosis. NLR, PLR, and SII values increased, and LMR and PNI values decreased in dogs with MMT. Median NLR values increased and median LMR and PNI values decreased as the TNM stage progressed. In dogs with a single MMT, median NLR, and PLR values were found to be lower than in dogs with multiple MMTs, and median LMR, SII, AGR, and PNI values were higher. The present results indicated that NLR, LMR, PLR, SII, and PNI parameters could be used as biomarkers for canine MMT. Also, NLR, LMR, PLR, SII, PNI, and AGR parameters may be valuable biomarkers that reveal the degree of systemic immune response according to different TNM stages and the number of affected mammary glands

Intracranial Pressure Measurement of and Investigation of the Effect of Aquaporin on Hydrocephalus Induced by Experimental Kaolin and Autologous Blood Injection: An Animal Study Deneysel Kaolin ve Otolog Kan Enjeksiyonu ile İndüklenen Hidrosefali Üzerine Aquaporin Etkisinin İntrakraniyal Basınç Ölçümü ve Araştırılması: Hayvan Deneyi

Objective: Hydrocephalus is a condition in which brain tissue is damaged due to ventricular enlargement. In experimental mod-els, hydrocephalus was induced by injecting various substances into the cerebrospinal fluid pathway or creating a subarachnoid hemorrhage model. Material and Methods: Five experimental groups were formed. The stereotaxic frame was placed in accordance with the coordinates calculated for the cisterna magna. In Group 1, only a spinal puncture was performed. In Group 2, a hydrocephalus model was created by injecting kaolin (Group 2A) and autologous blood (Group 2B). A hydrocephalus model was created with kaolin in Group 3, autologous blood in Group 4, and acetazolamide treatment was applied to both groups post-injection. Autologous blood was taken from the experimental groups before de-capitation, and the levels of tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-1 were measured by the ELISA method. After histological staining, the lateral ventricle size was measured. Intracranial pressure (ICP) measurements were taken on days 0 and 7 in all groups. Results: There was a significant increase in ICP in Groups 2A and 2B. TNF-α and IL-1 values increased more significantly in the groups that did not receive acetazolamide treatment compared to the group that received treatment. Conclusion: There was an increase in ventricle dimensions and ICP as well as TNF-α and IL-1 levels in both hydrocephalus models. Ac-etazolamide treatment was seen to be significantly more effective in kaolin group. This study is important because it is the first in the literature to perform biochemical and histopathological examination and ICP measurements all in the same hydrocephalus model

Association between endometriosis, headache, and migraine

Introduction: Available data suggest that there is an association between endometriosis and a group of disorders including autonomic nervous system irregularities. A deeper understanding of relationship between endometriosis and autonomic nervous system is needed as it may lead to novel discoveries on the causes or consequences of endometriosis. In this study, we analyzed the prevalence of migraine in patients with endometriosis. Methods: In this cross-sectional study, medical records of women were reviewed through January 2013 to December 2017. Women with laparoscopically proven endometriosis (n = 185) were compared with those without endometriosis (n = 168). The 3-item screening questions (ID Migraine (TM)) test was used to screen migraine. Data were analyzed using SPSS v25 (IBM Corporation). The chi(2) test was used for analyzing the nominal parameters and group comparisons. Pearson chi(2) was used to study the association between endometriosis and migraine. Results: The mean age was 31.86 +/- 4.49 years of the endometriosis group and 28.95 +/- 5.11 years of the controls (p = 0.408). The two pre-screening questions of ID Migraine test were answered positively by 86 patients of the endometriosis group (75.4%) and by 53 patients of the control group (54.6%) (p = 0.001). Of these patients, 51 (44.7% of endometriosis group) and 26 (26.8% of control group) were diagnosed as having migraine using 3-item Migraine questionnaire (p = 0.007). Conclusion: This study showed that the prevalence of migraine was significantly higher in patients with endometriosis. Because there is a strong correlation, patients with endometriosis should be screened for headache and migraine to increase the benefits of care

KAYSERİ İLİ POPÜLASYONUNDA DİŞ ANOMALİLERİ VE KONJENİTAL DİŞ EKSİKLİKLERİ PREVALANSI

Amaç: Bu çalışmanın amacı, gelişimsel dokuz tip diş anomalisinin (hipodonti, maksiller lateral yetersizlik, mandibular ikinci premolar yetersizlik, peg şeklinde maksiller lateral kesici dişler, taurodontizm, dilaserasyon, pulpa taşı, gömülü köpek dişleri, süpernümerer dişler) Kayseri ilinde bir grup popülasyonda prevalansını saptamaktır.Gereç ve Yöntemler: Verilerimiz Erciyes Üniversitesi'nde Ağız, Diş ve Çene Radyolojisi Anabilim Dalı'nda 6 ile 14 yaş arası 2566 hastanın panoramik radyografilerinden retrospektif olarak elde edildi. Konjenital deformiteleri, sistemik hastalıkları, ortodontik tedavi görmekte olan ve çekilmiş dişi olan bireyler çalışma dışı bırakıldı. Hastalara ait panoramik radyografi görüntüleri 6 araştırmacı tarafından değerlendirildi. İstatistiksel analiz SPSS yazılımı ve ki-kare testi kullanılarak yapıldı. Çalışmamızda tüm dental anomalilerin prevalansı ve cinsiyetler arası dağılımı istatistiksel olarak analiz edilmiştir.Bulgular: Çalışmamızda 1178 erkek 1388 kadın hastadan oluşan toplam 2566 hastanın panoramik görüntüsü incelendi. Hastaların yaş ortalaması 9.94 ± 2.38`dir. 81 hastada (% 3.16) konjenital alt premolar eksikliği, 145 hastada (% 5.65) hipodonti vardı, 92 hastada (% 3.58) gömülü kanin, 93 hastada (% 3.62) dilaserasyon tespit edildi.Sonuç: Yapılan çalışma ile Kayseri ili popülasyonunda hekimlerin karşılaşabilecekleri diş anomalileri ve diş eksikliklerinin prevalansı ve cinsiyete göre dağılımları ayrıntılı olarak bildirilmiştir. Kayseri ilinde yaşayan kadın bireylerde dental anomali görülme oranı daha çoktur.ANAHTAR KELİMELER Dental Anomali, Hipodonti, Süpernümerer Diş, Taurodontiz

Why is vaccination frequency low in elderly patients? Vaccination in elderly patients

Aim: The aim of the study is to investigate the frequency of vaccination in elderly outpatients, the reasons for not vaccinating despite vaccination recommendations and the related factors. Material and Method: The prospective study was done between June 2013-March 2015 and included patients who applied to the outpatient clinic for the first time, regularly attended to the controls and had at least 1 year of follow-up. Vaccination education was given to patients. At final assessment, the patients were interviewed by telephone. Vaccinations of all patients and why non-vaccinated patients were not vaccinated were questioned. All data were analyzed using appropriate statistical methods. Results: Of 267 patients enrolled in the study, mean age was 77 +/- 7.1 and mean follow-up period was 19.7 +/- 5.5 (month) were. At the end of follow-up, vaccination rates were: pneumococcal vaccine (PV) 21%, Influenza (IV) 35%, and tetanus-diphtheria (TdV) 8%. PV was found in a statistically significant relation between, IV (r=0.63, p<0.001), TdV (r=0.28, p<0.001), the inadequacy of information given by the physician and/or physician not telling to definitely do it (r=-0.43, p<0.001) and no previous vaccination recommendation (r=0.12, p=0.05). IV was found in a statistically significant relation between, PV (r=0.63, p<0.001), TdV (r=0.21, p<0.001), the inadequacy of information given by the physician and/or physician not telling to definitely do it (r=-0.46, p<0.001) and despite vaccination education missing to be vaccinated (r=0.20, p=0.01). Discussin: Vaccination frequency in elderly patients is lower than expected, although they are recommended to be vaccinated. The most common reason is the inadequacy of information given by the physician and/or physician not telling to definitely do it