Malignant mandibular tumors: two case reports of rare mandibular tumors in a single institution

Mandibular lesions can be benign or malignant, malignant being less common. The most common malignant tumor of mandible is squamous cell carcinoma. Others are ameloblastic carcinoma,  osteosarcoma, chondrosarcoma, fibrosarcoma, malignant fibrous histiocytoma and metastasis. Osteosarcoma is a bone tumor. It can occur in any bone, usually in the long bones of the extremities, but osteosarcoma of mandible is rare. In the initial phase, they may present as nondescript bony swellings with an indolent growth, only to become malignant towards the later stages. Osteosarcomas of the jaw are rare and they differ from osteosarcomas of the long bones in their biological behavior, even though they have the same histological appearance. Malignant fibrous histiocytoma (MFH) is the most common soft-­‐tissue sarcoma, but  relatively uncommon in head and neck region with only 30 reported cases till date. The purpose of this report is to present two cases of rare malignant mandibular tumors in a single institution.KEY WORDS: Osteosarcoma; Malignant fibrous histiocytoma; Mandibl

Synthesis and high resolution proton NMR studies on isomeric N-1-IN-2-,5,7-trisubstituted-4,6-dioxo-4,5,6,7-tetrahydropyrazolo[3,4-d]pyrimidinest

1228-123

Synthesis of stacked compounds based on pyrazolo[3,4-d]pyrimidines as new flexible models for studying intramolecular aromatic π-π interactions (APPI)

754-75

Coupled channel description of 16O+142,144,146Nd scattering around the Coulomb barrier using a complex microscopic potential

Angular distributions of elastic scattering and inelastic scattering from 2+ 1 state are measured for 16O+142,144,146Nd systems at several energies in the vicinity of the Coulomb barrier. The angular distributions are systematically analyzed in coupled channel framework. Renormalized double folded real optical and coupling potentials with DDM3Y interaction have been used in the calculation. Relevant nuclear densities needed to generate the potentials are derived from shell model wavefunctions. A truncated shell model calculation has been performed and the calculated energy levels are compared with the experimental ones. To simulate the absorption, a 'hybrid' approach is adopted. The contribution to the imaginary potential of couplings to the inelastic channels, other than the 2+ 1 target excitation channel, is calculated in the Feshbach formalism. This calculated imaginary potential along with a short ranged volume Woods-Saxon potential to simulate the absorption in fusion channel reproduces the angular distributions for 16O+146Nd quite well. But for 16O+142,144Nd systems additional surface absorption is found to be necessary to fit the angular distribution data. The variations of this additional absorption term with incident energy and the mass of the target are explored. © 2003 Elsevier Science B.V. All rights reserved

Wide-angle α-t coincidence measurement in the breakup of 7Li on 27Al

We have performed wide-angle in-plane coincidence measurements of the alpha particles and tritons emitted in the 48-MeV 7Li projectile breakup reaction on 27Al. The data have been analyzed using the post-form distorted-wave Born-approximation (DWBA) theory of breakup reactions where Coulomb and nuclear breakup as well as their interference terms are included. The theory is able to provide a good description of the experimental data particularly at large relative angles between the fragments. The interference between the Coulomb and nuclear breakup modes is found to be significant

Study of α-transfer reaction 28Si( 7Li, t) 32S

The 28Si( 7Li, t) 32S reaction has been studied at 48 MeV. Using a αt potential overlap based on a microscopic cluster model, the full finite-range distorted wave Born approximation analysis was carried out for nine low-lying states; 0.0 MeV (0+), 2.23 MeV (2+), 3.78 MeV (0+), 4.46 MeV (4+), 5.01 MeV (3-), 5.80 MeV (1-), 6.76 MeV (3-), 7.43 MeV (1-) and 8.49 MeV (1-) of the residual nucleus. A re-analysis was also done for the same states of 32S having an αd overlap for the reaction 28Si (6Li, d) 32S at 75.6 MeV. Theoretical spectroscopic factors have been calculated for the measured even-parity states of 32S using the shell model code OXBASH. The spectroscopic factors were compared for both the reactions

Inclusive and exclusive measurements in the projectile breakup of 7Li

The inclusive and exclusive measurements were carried out for 7Li projectile breakup on 27Al target at 48 MeV. In the inclusive data we have observed a broad peak around the beam velocity for alphas and tritons. The exclusive data for alpha-triton coincidences show good agreement with the post-form DWBA theory of breakup reactions

A microscopic complex potential description of elastic, inelastic cross section in the Coulomb nuclear interference region in the 28Si on 28Si system

Elastic and inelastic angular distribution and excitation functions were measured for the 28Si + 28Si system in the vicinity of the Coulomb barrier. While the elastic data could be described very well by using fully microscopic complex potential, the inelastic cross sections were found to be more sensitive to small variations in the potential. In particular the Coulomb nuclear interference dip observed in the inelastic excitation functions could not be fitted satisfactorily with calculation. Inclusion of an energy dependent term of Gaussian shape to the associated matrix element with the reorientation coupling in the phenomenological calculations leads to a better fit the inelastic excitation functions. © 1998 Elsevier Science B.V

Comparative Genomics of Helicobacter pylori Strains of China Associated with Different Clinical Outcome

In this study, a whole-genome CombiMatrix Custom oligonucleotide tiling microarray with 90000 probes covering six sequenced Helicobacter pylori (H. pylori) genomes was designed. This microarray was used to compare the genomic profiles of eight unsequenced strains isolated from patients with different gastroduodenal diseases in Heilongjiang province of China. Since significant genomic variation was found among these strains, an additional 76 H. pylori strains associated with different clinical outcomes were isolated from various provinces of China. These strains were tested by polymerase chain reaction to demonstrate this distinction. We identified several highly variable regions in strains associated with gastritis, gastric ulceration, and gastric cancer. These regions are associated with genes involved in the bacterial type I, type II, and type III R-M systems. They were also associated with the virB gene, which lies on the well-studied cag pathogenic island. While previous studies have reported on the diverse genetic characterization of this pathogenic island, in this study, we find that it is conserved in all strains tested by microarray. Moreover, a number of genes involved in the type IV secretion system, which is related to horizontal DNA transfer between H. pylori strains, were identified in the comparative analysis of the strain-specific genes. These findings may provide insight into new biomarkers for the prediction of gastric diseases

The Complete Genome Sequence of Escherichia coli EC958: A High Quality Reference Sequence for the Globally Disseminated Multidrug Resistant E. coli O25b:H4-ST131 Clone

Escherichia coli ST131 is now recognised as a leading contributor to urinary tract and bloodstream infections in both community and clinical settings. Here we present the complete, annotated genome of E. coli EC958, which was isolated from the urine of a patient presenting with a urinary tract infection in the Northwest region of England and represents the most well characterised ST131 strain. Sequencing was carried out using the Pacific Biosciences platform, which provided sufficient depth and read-length to produce a complete genome without the need for other technologies. The discovery of spurious contigs within the assembly that correspond to site-specific inversions in the tail fibre regions of prophages demonstrates the potential for this technology to reveal dynamic evolutionary mechanisms. E. coli EC958 belongs to the major subgroup of ST131 strains that produce the CTX-M-15 extended spectrum β-lactamase, are fluoroquinolone resistant and encode the fimH30 type 1 fimbrial adhesin. This subgroup includes the Indian strain NA114 and the North American strain JJ1886. A comparison of the genomes of EC958, JJ1886 and NA114 revealed that differences in the arrangement of genomic islands, prophages and other repetitive elements in the NA114 genome are not biologically relevant and are due to misassembly. The availability of a high quality uropathogenic E. coli ST131 genome provides a reference for understanding this multidrug resistant pathogen and will facilitate novel functional, comparative and clinical studies of the E. coli ST131 clonal lineage