ELABORACIÓN DE UN SISTEMA ADMINISTRATIVO PARA MEJORAR LA EFICACIA EN LA SELECCIÓN DE PERSONAL DE LA UGEL DE HUANCAYO – JUNIN EN EL AÑO 2016

El presente trabajo de investigación fue creado para ayudar a la Ugel de Huancayo a la selección de personal, para cubrir las plazas vacantes, en las diferentes áreas de la Ugel de Huancayo. El trabajo trata de la selección del personal para el desempeño laboral en la UGEL de Huancayo en el Departamento de Junín, ya que la realidad en la que vivimos vemos que existe mucha burocracia, y muchos pagos por favores Políticos, o por corrupción, muchas veces las plazas son ocupadas por personas que no están capacitadas y sus documentos pasan sin ser correctamente evaluados. Para una organización es vital la selección de personas, que a las ves incorporar un miembro nuevo a la entidad es decisivo, debido a que todo el esfuerzo de la entidad estará reflejado en el desempeño del mismo. Por tal razón es que a la hora de pensar en incorporar a alguien, se debe meditar en términos de inversión, en cómo los resultados de esta persona puede aportar valor a la entidad, que de no haber sido bien seleccionados, en vez de beneficiar podría perjudicar el cumplimiento de los objetivos de la organización en que trabaja. Para entonces es necesario iniciar un correcto proceso de reclutamiento y selección, para eso es indispensable detectar cual es el área que requiere más personal y porqué, luego evaluar de que necesidades se habla, esto permitirá definir con más precisión las características indispensables para la posición, detectar qué tipo de empleado podría cubrir la vacante y su adecuación a la organización misma. Es importante además resaltar que la búsqueda deberá dirigirse básicamente hacia personas dispuestas a obtener excelentes resultados y flexibles con capacidad de adaptarse a los cambios inesperados que se presentan día a día.Tesi

Wallenberg's Syndrome: An Unusual Case of Dysphagia

A 56-year-old man presented with sudden-onset oropharyngeal dysphagia and vomiting of central etiology. Neurological evaluation showed uvula deviation to the left, paresis of the mid-right portion of the soft palate, lateralization of gaze to the right side, and dysphonia. Magnetic resonance imaging (MRI) showed an infarction in the left lateral medullary region, therefore the diagnosis of Wallenberg's syndrome was established. The neurological issues along with the dysphagia gradually improved and the patient was discharged

Spreading versus biomass production by colonies of the fish pathogen Flavobacterium psychrophilum: role of the nutrient concentration

Colonies of the fish pathogen Flavobacterium psychrophilum have gliding motility in media with low agar concentrations. Although gliding motility, particularly in Flavobacterium johnsoniae, has been well-studied, little is known about its regulation by environmental factors. The work described here shows that the ability of F. psychrophilum to spread over surfaces depends on nutrient availability. In fact, as the nutrient contents of the medium decreased, spreading was favored and the diameter of the colonies increased. Macroscopy examination revealed modifications in colony morphology as nutrient depletion increased: from a dense and defined colony to the formation of microcolonies inside a general colony structure. Additionally, colony expansion dynamics and population density across the colony radius varied inversely with bacterial biomass production. Motility was an immediate response when bacteria were transferred from a rich to a more diluted medium. Our results suggest that, when nutrients are limiting, F. psychrophilum activates a specific growth mode that enables it to colonize surfaces by means of gliding motility. The use of diluted media allowed the differentiation, among previously isolated F. psychrophilum non-gliding mutants, of those completely unable to glide and those with only partially impaired gliding ability. [Int Microbiol 2009; 12(4):207-214

A Novel Role For Nanog As An Early Cancer Risk Marker In Patients With Laryngeal Precancerous Lesions

NANOG is a master regulator of embryonic stem cell pluripotency, found to be frequently aberrantly expressed in a variety of cancers, including laryngeal carcinomas. This study investigates for the first time the role of NANOG expression in early stages of laryngeal tumourigenesis and its potential utility as cancer risk marker. NANOG protein expression was evaluated by immunohistochemistry using two large independent cohorts of patients with laryngeal precancerous lesions, and correlated with clinicopathological parameters and laryngeal cancer risk. NANOG expression was detected by immunohistochemistry in 49 (60%) of 82 laryngeal dysplasias, whereas expression was negligible in patient-matched normal epithelia. Strong NANOG expression was found in 22 (27%) lesions and was established as cut-off point, showing the most robust association with laryngeal cancer risk (P = 0.003) superior to the histological classification (P = 0.320) the current gold standard in the clinical practice. Similar trends were obtained using a multicenter validation cohort of 86 patients with laryngeal dysplasia. Our findings uncover a novel role for NANOG expression in laryngeal tumourigenesis, and its unprecedented application as biomarker for cancer risk assessment

Common and Specific Associations of Anti-SSA/Ro60 and Anti-Ro52/TRIM21 Antibodies in Systemic Lupus Erythematosus

Little information exists about the association of anti-SSA/Ro60 and anti-Ro52/TRIM21 with systemic lupus erytematosus (SLE) features. In this work, we analysed the associations of both anti-Ro reactivities with clinical and immunological manifestations in 141 SLE patients. Photosensitivity and xerophtalmia/xerostomia were found to be positively associated with both anti-SSA/Ro60 (P=0.024 and P=0.019, resp.) and anti-Ro52/TRIM21 (P=0.026 and P=0.022, resp.). In contrast, a negative association was detected regarding anti-phospholipid antibodies, anti-SSA/Ro60 having a stronger effect (P=0.014) than anti-Ro52/TRIM21. Anti-SSA/Ro60 showed a specific positive association with hypocomplementemia (P=0.041), mainly with low C4 levels (P=0.008), whereas anti-Ro52/TRIM21 was found to be positively associated with Raynaud’s phenomenon (P=0.026) and cytopenia (P=0.048) and negatively associated with anti-dsDNA (P=0.013). Lymphocytes are involved in the relationship between anti-Ro52/TRIM21 and cytopenia since positive patients showed lower cell levels than negative patients (P=0.036). In conclusion, anti-SSA/Ro60 and anti-Ro52/TRIM21 showed both common and specific associations in SLE. These data thus increase evidence of the different associations of the two anti-Ro specificities even in a particular disease