1,187 research outputs found
Laboratory-based and office-based Globorisk scores to predict 10-year risk of cardiovascular diseases among Iranians: results from the Fasa PERSIAN cohort.
BACKGROUND: Globorisk is a novel risk prediction model for predicting cardiovascular disease (CVD). Globorisk is a country-specific risk prediction model that determines CVD risk for all countries. This model has two versions; laboratory-based and office-based. This study aimed to determine the agreement between laboratory-based and office-based models in a large sample of the general population. METHODS: Baseline data from the Fasa cohort study was used for the current study. In total, 6810 participants ≥ 40 years without any history of cardiovascular disease or stroke were included in the study. To determine the laboratory-based risk model, factors include age, sex, current smoking status, history of diabetes, systolic blood pressure (SBP), and total cholesterol. To estimate the office-based risk model, factors were age, sex, current smoking status, SBP, and body mass index (BMI). Kappa statistics was used to distinguish the agreement between grouped scores in these two models. Additionally, correlation coefficients and scatter plots were used to determine the linear correlation between the two models. RESULTS: In this study 46.53% of the participants were men. The mean age (SD) of participants was 51.08 (7.88) years. Agreements between the two models were moderate and substantial in all women and all men, respectively. The agreement between the two CVD risk groups was 90.15% (kappa = 0.717) in all men, 92.94% (kappa = 0.571) among men aged 60 years (r = 0.94). Among all women, there was a very strong positive correlation (r = 0.87), and the strong positive correlation remained among 60 years old (r = 0.76). CONCLUSION: The Globorisk office-based model which is easier to use as it does not require blood testing can determine the risk groups in this population. The Globorisk office-based model may be used for CVD risk screening in low-middle income countries where resources are limited
Life Skills at a Tribal College: A Culturally Relevant Educational Intervention
American Indians, Alaska Natives, and Native Hawaiians (AI/AN/NH) experience the lowest rates of college retention and significant barriers to graduation. In addition, AI/AN/NH individuals face health challenges that include higher rates of obesity, overweight, and type 2 diabetes. We designed a culturally relevant life skills curriculum based on family and consumer science standards to promote educational achievement, self-efficacy, and healthful food choices among tribal college students. The Life Skills at a Tribal College course was delivered by tribal college Extension professionals in a family meal–style environment and involved culturally appropriate, traditional ways of learning to promote positive educational and health outcomes
Characterization of microbulk detectors in argon- and neon-based mixtures
A recent Micromegas manufacturing technique, so called Microbulk, has been
developed, improving the uniformity and stability of this kind of detectors.
Excellent energy resolutions have been obtained, reaching values as low as 11%
FWHM at 5.9 keV in Ar+5%iC4H10. This detector has other advantages like its
flexible structure, low material budget and high radio-purity. Two microbulk
detectors with gaps of 50 and 25 um have been characterized in argon- and
neon-based mixtures with ethane, isobutane and cyclohexane. The results will be
presented and discussed. The gain curves have been fitted to the Rose-Korff
gain model and dependences of the electron mean free path and the threshold
energy for ionization have been obtained. The possible relation between these
two parameters and the energy resolution will be also discussed.Comment: Submitted to the Journal of Instrumentatio
Lowering the background level and the energy threshold of Micromegas x-ray detectors for axion searches
Axion helioscopes search for solar axions by their conversion in x-rays in
the presence of high magnetic fields. The use of low background x-ray detectors
is an essential component contributing to the sensitivity of these searches. In
this work, we review the recent advances on Micromegas detectors used in the
CERN Axion Solar Telescope (CAST) and proposed for the future International
Axion Observatory (IAXO). The actual setup in CAST has achieved background
levels below 10 keV cm s, a factor 100 lower than
the first generation of Micromegas detectors. This reduction is based on active
and passive shielding techniques, the selection of radiopure materials, offline
discrimination techniques and the high granularity of the readout. We describe
in detail the background model of the detector, based on its operation at CAST
site and at the Canfranc Underground Laboratory (LSC), as well as on Geant4
simulations. The best levels currently achieved at LSC are low than 10
keV cm s and show good prospects for the application of
this technology in IAXO. Finally, we present some ideas and results for
reducing the energy threshold of these detectors below 1 keV, using
high-transparent windows, autotrigger electronics and studying the cluster
shape at different energies. As a high flux of axion-like-particles is expected
in this energy range, a sub-keV threshold detector could enlarge the physics
case of axion helioscopes.Comment: Proceedings of 3rd International Conference on Technology and
Instrumentation in Particle Physics (TIPP 2014
X-ray detection with Micromegas with background levels below 10 keVcms
Micromegas detectors are an optimum technological choice for the detection of
low energy x-rays. The low background techniques applied to these detectors
yielded remarkable background reductions over the years, being the CAST
experiment beneficiary of these developments. In this document we report on the
latest upgrades towards further background reductions and better understanding
of the detectors' response. The upgrades encompass the readout electronics, a
new detector design and the implementation of a more efficient cosmic muon veto
system. Background levels below 10keVcms have been
obtained at sea level for the first time, demonstrating the feasibility of the
expectations posed by IAXO, the next generation axion helioscope. Some results
obtained with a set of measurements conducted in the x-ray beam of the CAST
Detector Laboratory will be also presented and discussed
CAST microbulk micromegas in the Canfranc Underground Laboratory
During the last taking data campaigns of the CAST experiment, the micromegas
detectors have achieved background levels of keVcms between 2 and 9 keV. This performance has
been possible thanks to the introduction of the microbulk technology, the
implementation of a shielding and the development of discrimination algorithms.
It has motivated new studies towards a deeper understanding of CAST detectors
background. One of the working lines includes the construction of a replica of
the set-up used in CAST by micromegas detectors and its installation in the
Canfranc Underground Laboratory. Thanks to the comparison between the
performance of the detectors underground and at surface, shielding upgrades,
etc, different contributions to the detectors background have been evaluated.
In particular, an upper limit keVcms
for the intrinsic background of the detector has been obtained. This work means
a first evaluation of the potential of the newest micromegas technology in an
underground laboratory, the most suitable environment for Rare Event Searches.Comment: 6 pages, 8 figures. To appear in the proceedings of the 2nd
International Conference on Technology and Instrumentation for Particle
Physics (TIPP 2011
Micromegas detector developments for MIMAC
The aim of the MIMAC project is to detect non-baryonic Dark Matter with a
directional TPC. The recent Micromegas efforts towards building a large size
detector will be described, in particular the characterization measurements of
a prototype detector of 10 10 cm with a 2 dimensional readout
plane. Track reconstruction with alpha particles will be shown.Comment: 8 pages, 7 figures Proceedings of the 3rd International conference on
Directional Detection of Dark Matter (CYGNUS 2011), Aussois, France, 8-10
June 2011; corrections on author affiliation
Low Background Micromegas in CAST
Solar axions could be converted into x-rays inside the strong magnetic field
of an axion helioscope, triggering the detection of this elusive particle. Low
background x-ray detectors are an essential component for the sensitivity of
these searches. We report on the latest developments of the Micromegas
detectors for the CERN Axion Solar Telescope (CAST), including technological
pathfinder activities for the future International Axion Observatory (IAXO).
The use of low background techniques and the application of discrimination
algorithms based on the high granularity of the readout have led to background
levels below 10 counts/keV/cm/s, more than a factor 100 lower than
the first generation of Micromegas detectors. The best levels achieved at the
Canfranc Underground Laboratory (LSC) are as low as 10
counts/keV/cm/s, showing good prospects for the application of this
technology in IAXO. The current background model, based on underground and
surface measurements, is presented, as well as the strategies to further reduce
the background level. Finally, we will describe the R&D paths to achieve
sub-keV energy thresholds, which could broaden the physics case of axion
helioscopes.Comment: 6 pages, 3 figures, Large TPC Conference 2014, Pari
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