Exile Vol. XXVII No. 1

ANDY ACKER: Four Lane Breakfast 30 MIKE AUGUSTA: The Store 25-27 J. L. FREEMAN: Bobbie 22 Poem 33 JENNIFER E. GARDNER: Photo 3 Deeds Field 9 Photo 21 Photo 23 Photo 24 LAURA GILBERT: Photo 13 Photo 28 Photo 29 Photo 31 Photo 36 KATE GLAZER: Drawing 14 MICHAEL HEINLIN: Reflections 19 DAVE HOGSHIRE: The Life And Times Of General Worm 29 CHAD HUSSEY: Waiting for Anne Sexton 13 JOHN WHITWORTH KROPF: Friends in the Park 30 DANE LAVIN: Story 4-8 LISA LAWRENCE: Poem 17 The Man With The Red Hat 15 JAMES LUNDY: Bonds 10 Photo 30 Photo 34 Twisted Ulna 11 LISA MEAD: Resistance 9 LISA MINACCI: The Drop 33 A. PENCE: The Minstrels 1 Mussels 33 PENELOPE A. RISEBOROUGH: Poem 2 Regent Street Mannequins 2 RICK RORICK: Photo 18 A. K. SESSIONS Nervious Tension 10 SUZIE SNYDER: Photo 16 L. S. VIOLA: Trash Can JOHN ZARCHEN: In Autumn 20 ANONYMOUS: Untitled Article 32 Sandymount Strand 35 Cover drawing by Kate Glaze

Exile Vol. XXVIII No. 1

Group Poems From Sake Circle / Monologue. Polylogue. Mollylogue. (or: A musing of young writer as a poor man. Hee hee hee.) by Chris Brougham Untitled Prose by Chris Paul In A Room by Robert F. Youngblood The Escape by Anne Gilson Untitled Poem by Becky Hinshaw A Cruel Hand by Chad Hussey Shaking Heads in Copley Square by Gregory MacDonald The Coming Age by Lynn Greene Seduction by Jacqueline Ondy Pointless Polarities by Ruth Wick The Ladies From The Fairmont Unitarian Church Poverty Relief Fund by Sharon S. McCartney Confessions of a Book Burner by Andy Acker The Congress of the Gods by Tage Danielsson (translated by Ari Kokko) Marble Bags by Mike Augusta Monsters by Sharon S. McCartney Unction by Bruce Leonard Dust of Allah by Andy Acker Buffalo Mountain by Sharon S. McCartney One Marriage by Becky Hinshaw Experience by Barry Pailet The Wings by Leonora Cravotta The Tale of Frankenstein\u27s Average by Tage Danielsson (translated by Ari Kokko) Want by Roger Butler / Cornpoem by Mike Augusta Cover Drawing By Peter Brook

Stem Cell Therapy for Aging Related Diseases and Joint Diseases in Companion Animals.

Stem cell therapy is an attractive treatment for diseases in companion animals that cannot be treated by conventional veterinary medicine practices. The unique properties of stem cells, particularly the ability to differentiate into specific cell types, makes them a focal point in regenerative medicine treatments. Stem cell transplantation, especially using mesenchymal stem cells, has been proposed as a means to treat a wide range of injuries and ailments, resulting in tissue regeneration or repair. This review aims to summarize the veterinary use of stem cells for treating age-related and joint diseases, which are common conditions in pets. While additional research is necessary and certain limitations exist, the potential of stem cell therapy for companion animals is immense

The influence of peripheral afferent signals on the rating of perceived exertion and time to exhaustion during exercise at different intensities

This study determined which peripheral variables would better predict the rating of perceived exertion (RPE) and time to exhaustion (TE) during exercise at different intensities. Ten men performed exercises at first lactate threshold (LT1), second lactate threshold (LT2), 50% of the distance from LT1 to LT2 (TT50%), and 25% of the distance from LT2 to maximal power output (TW25%). Lactate, catecholamines, potassium, pH, glucose, (V) over dotO(2), VE, HR, respiratory rate (RR) and RPE were measured and plotted against the exercise duration for the slope calculation. Glucose, dopamine, and noradrenaline predicted RPE in TT50% (88%), LT2 (64%), and TW25% (77%), but no variable predicted RPE in LT1. RPE (55%), RPE+HR (86%), and RPE+RR (92% and 55%) predicted TE in LT1, TT50%, LT2, and TW25%, respectively. At intensities from TT50% to TW25%, variables associated with brain activity seem to explain most of the RPE slope, and RPE (+HR and+RR) seems to predict the TE.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Discovery HealthMedical Research CouncilUniversity of Cape TownUniv São Paulo, Sch Phys Educ & Sport, BR-05508030 São Paulo, BrazilFed Univ Alagoas UFAL, Sports Sci Res Grp, Maceio, BrazilUniversidade Federal de São Paulo, Div Nephrol, Hosp Kidney & Hypertens, São Paulo, BrazilUniv Cape Town, MRC UCT Res Unit Exercise Sci & Sports Med, ZA-7725 Newlands, South AfricaUniv Cape Town, Sports Sci Inst South Africa, ZA-7725 Newlands, South AfricaUniversidade Federal de São Paulo, Div Nephrol, Hosp Kidney & Hypertens, São Paulo, BrazilCAPES: PDEE BEX 1900/08-0FAPESP: 2006/60641-6Web of Scienc

Adaptation of the Wound Healing Questionnaire universal-reporter outcome measure for use in global surgery trials (TALON-1 study): mixed-methods study and Rasch analysis

BackgroundThe Bluebelle Wound Healing Questionnaire (WHQ) is a universal-reporter outcome measure developed in the UK for remote detection of surgical-site infection after abdominal surgery. This study aimed to explore cross-cultural equivalence, acceptability, and content validity of the WHQ for use across low- and middle-income countries, and to make recommendations for its adaptation.MethodsThis was a mixed-methods study within a trial (SWAT) embedded in an international randomized trial, conducted according to best practice guidelines, and co-produced with community and patient partners (TALON-1). Structured interviews and focus groups were used to gather data regarding cross-cultural, cross-contextual equivalence of the individual items and scale, and conduct a translatability assessment. Translation was completed into five languages in accordance with Mapi recommendations. Next, data from a prospective cohort (SWAT) were interpreted using Rasch analysis to explore scaling and measurement properties of the WHQ. Finally, qualitative and quantitative data were triangulated using a modified, exploratory, instrumental design model.ResultsIn the qualitative phase, 10 structured interviews and six focus groups took place with a total of 47 investigators across six countries. Themes related to comprehension, response mapping, retrieval, and judgement were identified with rich cross-cultural insights. In the quantitative phase, an exploratory Rasch model was fitted to data from 537 patients (369 excluding extremes). Owing to the number of extreme (floor) values, the overall level of power was low. The single WHQ scale satisfied tests of unidimensionality, indicating validity of the ordinal total WHQ score. There was significant overall model misfit of five items (5, 9, 14, 15, 16) and local dependency in 11 item pairs. The person separation index was estimated as 0.48 suggesting weak discrimination between classes, whereas Cronbach's α was high at 0.86. Triangulation of qualitative data with the Rasch analysis supported recommendations for cross-cultural adaptation of the WHQ items 1 (redness), 3 (clear fluid), 7 (deep wound opening), 10 (pain), 11 (fever), 15 (antibiotics), 16 (debridement), 18 (drainage), and 19 (reoperation). Changes to three item response categories (1, not at all; 2, a little; 3, a lot) were adopted for symptom items 1 to 10, and two categories (0, no; 1, yes) for item 11 (fever).ConclusionThis study made recommendations for cross-cultural adaptation of the WHQ for use in global surgical research and practice, using co-produced mixed-methods data from three continents. Translations are now available for implementation into remote wound assessment pathways