La Chambre des comptes de Bretagne au temps de la Fronde

Pendant la période de la Fronde, la Chambre des comptes de Bretagne est un exemple de fidélité au roi de France. Une étude du personnel de cette cour nous renseigne sur l’origine des officiers, leur renouvellement et la place de l’argent dans leur carrière. Ces magistrats, largement recrutés dans le monde des officiers bretons, continuent d’assurer avec régularité, pendant des années troublées, un triple rôle : ils enregistrent les décisions royales, ils rendent la justice dans tous les litiges financiers et, enfin, ils contrôlent les finances publiques.During the period of the Fronde, the Chambre des comptes of Brittany is an example of fidelity to the king of France. A study of the personnel of this court informs us about the origin of the officers, their renewal and the place of money in their career. These magistrates, largely borned of the world of the Breton officers, played with regularity, during these disturbed years, a triple role: they book the royal decisions, they do justice in all the financial litigations and, finally, they control the public finance

Monitoring of asparagine depletion and anti-L-asparaginase antibodies in adult acute lymphoblastic leukemia treated in the pediatric-inspired GRAALL-2005 trial

International audienceno abstrac

Efficacy of L-asparaginase with methotrexate and dexamethasone (AspaMetDex regimen) in patients with refractory or relapsing extranodal NK/T-cell lymphoma, a phase 2 study.

Extranodal NK/T-cell lymphoma, nasal type, is a rare and highly aggressive disease with a grim prognosis. No therapeutic strategy is currently identified in relapsing patients. We report the results of a French prospective phase II trial of an L-asparaginase-containing regimen in 19 patients with relapsed or refractory disease treated in 13 centers. Eleven patients were in relapse and 8 patients were refractory to their first line of treatment. L-Asparaginase-based treatment yielded objective responses in 14 of the 18 evaluable patients after 3 cycles. Eleven patients entered complete remission (61%), and only 4 of them relapsed. The median overall survival time was 1 year, with a median response duration of 12 months. The main adverse events were hepatitis, cytopenia, and allergy. The absence of antiasparaginase antibodies and the disappearance of Epstein-Barr virus serum DNA were significantly associated with a better outcome. These data confirm the excellent activity of L-asparaginase-containing regimens in extranodal NK/T-cell lymphoma. L-Asparaginase-based treatment should thus be considered for salvage therapy, especially in patients with disseminated disease. First-line L-asparaginase combination therapy for extranodal NK/T-cell lymphoma warrants evaluation in prospective trials. This trial is registered at www.clinicaltrials.gov as #NCT00283985