Evolutionary NAS with Gene Expression Programming of Cellular Encoding

The renaissance of neural architecture search (NAS) has seen classical methods such as genetic algorithms (GA) and genetic programming (GP) being exploited for convolutional neural network (CNN) architectures. While recent work have achieved promising performance on visual perception tasks, the direct encoding scheme of both GA and GP has functional complexity deficiency and does not scale well on large architectures like CNN. To address this, we present a new generative encoding scheme -- $symbolic\ linear\ generative\ encoding$ (SLGE) -- simple, yet powerful scheme which embeds local graph transformations in chromosomes of linear fixed-length string to develop CNN architectures of variant shapes and sizes via evolutionary process of gene expression programming. In experiments, the effectiveness of SLGE is shown in discovering architectures that improve the performance of the state-of-the-art handcrafted CNN architectures on CIFAR-10 and CIFAR-100 image classification tasks; and achieves a competitive classification error rate with the existing NAS methods using less GPU resources.Comment: Accepted at IEEE SSCI 2020 (7 pages, 3 figures

Best Thermoelectric Efficiency of Ever-Explored Materials

A thermoelectric device is a heat engine that directly converts heat into electricity. Many materials with a high figure of merit ZT have been discovered in anticipation of a high thermoelectric efficiency. However, there has been a lack of investigations on efficiency-based material evaluation, and little is known about the achievable limit of thermoelectric efficiency. Here, we report the highest thermoelectric efficiency using 13,353 published materials. The thermoelectric device efficiencies of 808,610 configurations are calculated under various heat-source temperatures (T_h) when the cold-side temperature is 300 K, solving one-dimensional thermoelectric integral equations with temperature-dependent thermoelectric properties. For infinite-cascade devices, a thermoelectric efficiency larger than 33% (~1/3) is achievable when T_h exceeds 1400 K. For single-stage devices, the best efficiency of 17.1% (~1/6) is possible when T_h is 860 K. Leg segmentation can overcome this limit, delivering a very high efficiency of 24% (~1/4) when T_h is 1100 K.Comment: 32 pages (main+table+figure captions+figures), 7 additional pages for 6 high resolution figures, Supporting Data file is not public ye

Structural and functional analyses of calcium ion response factors in the mantle of Pinctada fucata

The pearl oyster, Pinctada fucata, is cultured for pearl production in Japan. The shell of the pearl oyster consists of calcium carbonate and a small amount of organic matrix. Despite many studies of the shell matrix proteins, the mechanism by which calcium elements are transported from the mantle to the shell remains unclear. Investigating the molecular mechanism of calcium transportation, we prepared artificial seawater with a high concentration of calcium ions (10ASW) to induce calcification in the pearl oyster. When pearl oysters were cultured in 10ASW, unusual nanoparticles were precipitated on the surface of the nacreous layer. SDS-PAGE and 2D-PAGE analyses revealed that some calcium-sensing proteins (Sarcoplasmic Ca-binding Protein (Pf-SCP) and Pf-filamin A) might be related to the synthesis of these nanoparticles. The recombinant proteins of Pf-SCP can bind to calcium ions and accumulate nanoparticles of calcium carbonate crystals. However, transcriptomic analysis of the pearl oysters grown in 10ASW showed that the matrix protein genes in the shell did not differ before and after treatment with 10ASW. These results suggest that, despite increasing calcium transportation to the shell, treatment with a high concentration of calcium ions does not induce formation of the organic framework in the shell microstructure. These findings offer meaningful insights into the transportation of calcium elements from the mantle to the shell

和洋女子大学における小学生対象の科学実験プログラムの実践報告－新型コロナウイルス感染症の感染拡大下でのオンラインによる取り組み－

　日本において、子どもたちの理科離れが進んでいる中、著者らは生活科学の視点から、子どもたちの科学への関心を深め、夏休みの自由研究のヒントになればと、平成17（2005）年から毎年継続して、夏休み期間を活用した小学生対象の科学実験プログラムを実施している。理科に関連したこれまでの教育活動の取り組みとして実践してきた科学実験プログラムのなかで、新型コロナウイルス感染症により教育活動にも甚大な影響があった令和2（2020）年の取り組みについて報告する。本報告は、著者らの研究成果をベースにして構成された科学実験プログラムの取り組みのうち、令和2（2020）年に取り組んだ新型コロナウイルス感染症の感染防止対策としてのオンラインによる実施内容や安全への配慮について述べる。また、広報活動および学内の協力体制についてまとめる。今回取り組んだオンラインでの科学実験プログラムの実施方法や手順等を、今後の科学実験プログラムに活かしたい。※和歴と西暦については、関連する書類の都合上併記とする

Neuropsychological assessment of visuo-perceptual processing in children with neurodevelopmental disorders

Rey 複雑図形検査（Rey-Osterrieth Complex Figure test）は視空間構成能力や視覚性記憶，実行機能などを評価する神経心理学的検査である。本研究では板書のノートテイクや漢字の書字などの学習場面でのつまずきがみられる３名の神経発達障害をともなう子どもを対象に Rey 複雑図形検査を実施し，視覚認知処理過程に関する検討をおこなった。３名はいずれもまとまりのある要素を細分化させた方略を用いて図形を描画しており，視覚構成能力に関する指標において著しい低値を認め，視知覚能力の発達の未成熟さが推測された。本検査は子どもの抱える学習上の問題の把握に有用であり，神経発達障害における視覚認知能力の発達的経過に関するさらなる検討が必要と考えられた。独立行政法人日本学術振興会　科研費（25870931

Overexpression of TNF-α converting enzyme promotes adipose tissue inflammation and fibrosis induced by high fat diet

Obesity is a state in which chronic low-grade inflammation persists in adipose tissues. Pro-inflammatory cytokines, including TNF-α, produced by adipose tissues have been implicated as active participants in the development of obesity-related diseases. Since TNF-α converting enzyme (TACE) is the major factor that induces soluble TNF-α, TACE has been noted as a pivotal regulator in this field. To reveal the role of TACE in adipose tissue inflammation, TACE-transgenic (TACE-Tg) and wild type (WT) mice were fed with high fat diet (HFD) or control diet for 16 weeks. At 13 weeks after the beginning of the diet, serum TNF-α and macrophage-related cytokine/chemokine levels were elevated in TACE-Tg mice fed with HFD (Tg-HFD mice), and the number of the so-called crown-like adipocyte was significantly increased in adipose tissues of Tg-HFD mice at the end of the experiment. Although macrophage infiltration was not detected in the adipose tissues at this time, fibrosis was observed around the crown-like adipocytes. These findings suggested that TACE overexpression induced macrophage infiltration and subsequent fibrosis in adipose tissues under HFD regimen. The collective evidence suggested that TACE could be a therapeutic target of HFD-induced obesity-related adipose tissue inflammation