Impact of Proactive Personality on Career Adaptability and Their Intentions for Expatriate

Career decision-making is the biggest priority in an individual’s life and needs to be adapted more rigorously than anything else. Therefore, it is imperative to look for those factors that can have an influence on career adaptability. Guided by career construction theory, this research study explores the impact of proactive personality on career adaptability. This study examines the mediating effect of resilience between proactive personality and career adaptability, and the mediating effect of cultural intelligence between intentions on expatriate career and career adaptability, and the moderating role of gender between intentions for an expatriate career and career adaptability. The study revealed interesting insights in relation to career adaptability and intention for an expatriate career

Antimicrobial activity of Parrotiopsis jacquemontiana and Caesalpinia decapetala plant extracts against selected pathogens

Antimicrobial-resistant bacteria are a global health concern. Some gram-negative bacteria have acquired resistance to many notorious diseases induced by various pathogens. Therefore, new antibacterial agents are needed to combat these infections. We utilised the agar well diffusion method to find the antibacterial capabilities of Caesalpinia decapetala and Parrotiopsis jacquemontiana aqueous and methanolic extracts. We aimed to find the efficacy of these extracts and their various components against selected pathogens. Methanolic extract showed significantly higher antimicrobial activity against all tested pathogens compared to aqueous extracts, such as 20 mg/mL of MRE-CD, which showed 12.16 ± 1.04 mm inhibitions against P. aeruginosa. In contrast, 10.5± 0.5 mm against S. dysenteriae inhibition compared to 20 mg/mL of MRE-PJ showed 10.16±0.76 mm inhibition against E. coli. Meanwhile, only aqueous root extracts of P. jacquemontiana at 10 mg/mL showed the least 1.5 ± 1.32 against S. dysenteriae mm inhibitions, while E. coli appears to be the less sensitive strain at 10 mg/mL of methanolic stem extract of P. jacquemontiana compared to the aqueous extract of C. decapetala stems, significantly affecting the growth of gram-negative bacterial strains. Therefore, these plant extracts have great natural antimicrobials, and further evaluation would be necessary to use them

Science, Technology and Innovation through Entrepreneurship Education in the United Arab Emirates (UAE)

The purpose of this study is to investigate the ways of achieving Science, Technology and Innovation (STI) in UAE. Previously, sustainability within an entrepreneurship context has been related to economic viability as opposed to sustainability in its broadest sense. Through a survey research method, we have highlighted the effects of three independent variables and two intervening variables on three important outcomes, innovation, need for achievement and motivation, which ultimately contributes towards STI. These data have been collected from the students of a well-known university in Al-Ain, UAE. The responses of 251 students have been utilized for analysis. For hypotheses testing, we used AMOS 18 (Structural Equation Modeling) and SPSS 20. The study revealed that all of the predictors have a strong effect on the outcome variables, which leads to STI in UAE. There is a strong need to revise the curriculum of higher education institutions of UAE to develop self-confidence, locus of control and risk taking propensity among students. The study provides novel insight into entrepreneurship education and serves as an initial benchmark in the field

Science, Technology and Innovation through Entrepreneurship Education in the United Arab Emirates (UAE)

The purpose of this study is to investigate the ways of achieving Science, Technology and Innovation (STI) in UAE. Previously, sustainability within an entrepreneurship context has been related to economic viability as opposed to sustainability in its broadest sense. Through a survey research method, we have highlighted the effects of three independent variables and two intervening variables on three important outcomes, innovation, need for achievement and motivation, which ultimately contributes towards STI. These data have been collected from the students of a well-known university in Al-Ain, UAE. The responses of 251 students have been utilized for analysis. For hypotheses testing, we used AMOS 18 (Structural Equation Modeling) and SPSS 20. The study revealed that all of the predictors have a strong effect on the outcome variables, which leads to STI in UAE. There is a strong need to revise the curriculum of higher education institutions of UAE to develop self-confidence, locus of control and risk taking propensity among students. The study provides novel insight into entrepreneurship education and serves as an initial benchmark in the field

Long Span DNA Paired-End-Tag (DNA-PET) Sequencing Strategy for the Interrogation of Genomic Structural Mutations and Fusion-Point-Guided Reconstruction of Amplicons

10.1371/journal.pone.0046152PLoS ONE79

Landscape of transcription in human cells

Eukaryotic cells make many types of primary and processed RNAs that are found either in specific subcellular compartments or throughout the cells. A complete catalogue of these RNAs is not yet available and their characteristic subcellular localizations are also poorly understood. Because RNA represents the direct output of the genetic information encoded by genomes and a significant proportion of a cell's regulatory capabilities are focused on its synthesis, processing, transport, modification and translation, the generation of such a catalogue is crucial for understanding genome function. Here we report evidence that three-quarters of the human genome is capable of being transcribed, as well as observations about the range and levels of expression, localization, processing fates, regulatory regions and modifications of almost all currently annotated and thousands of previously unannotated RNAs. These observations, taken together, prompt a redefinition of the concept of a gene

Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021

This online publication has been corrected. The corrected version first appeared at thelancet.com on September 28, 2023BACKGROUND : Diabetes is one of the leading causes of death and disability worldwide, and affects people regardless of country, age group, or sex. Using the most recent evidentiary and analytical framework from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD), we produced location-specific, age-specific, and sex-specific estimates of diabetes prevalence and burden from 1990 to 2021, the proportion of type 1 and type 2 diabetes in 2021, the proportion of the type 2 diabetes burden attributable to selected risk factors, and projections of diabetes prevalence through 2050. METHODS : Estimates of diabetes prevalence and burden were computed in 204 countries and territories, across 25 age groups, for males and females separately and combined; these estimates comprised lost years of healthy life, measured in disability-adjusted life-years (DALYs; defined as the sum of years of life lost [YLLs] and years lived with disability [YLDs]). We used the Cause of Death Ensemble model (CODEm) approach to estimate deaths due to diabetes, incorporating 25 666 location-years of data from vital registration and verbal autopsy reports in separate total (including both type 1 and type 2 diabetes) and type-specific models. Other forms of diabetes, including gestational and monogenic diabetes, were not explicitly modelled. Total and type 1 diabetes prevalence was estimated by use of a Bayesian meta-regression modelling tool, DisMod-MR 2.1, to analyse 1527 location-years of data from the scientific literature, survey microdata, and insurance claims; type 2 diabetes estimates were computed by subtracting type 1 diabetes from total estimates. Mortality and prevalence estimates, along with standard life expectancy and disability weights, were used to calculate YLLs, YLDs, and DALYs. When appropriate, we extrapolated estimates to a hypothetical population with a standardised age structure to allow comparison in populations with different age structures. We used the comparative risk assessment framework to estimate the risk-attributable type 2 diabetes burden for 16 risk factors falling under risk categories including environmental and occupational factors, tobacco use, high alcohol use, high body-mass index (BMI), dietary factors, and low physical activity. Using a regression framework, we forecast type 1 and type 2 diabetes prevalence through 2050 with Socio-demographic Index (SDI) and high BMI as predictors, respectively. FINDINGS : In 2021, there were 529 million (95% uncertainty interval [UI] 500–564) people living with diabetes worldwide, and the global age-standardised total diabetes prevalence was 6·1% (5·8–6·5). At the super-region level, the highest age-standardised rates were observed in north Africa and the Middle East (9·3% [8·7–9·9]) and, at the regional level, in Oceania (12·3% [11·5–13·0]). Nationally, Qatar had the world’s highest age-specific prevalence of diabetes, at 76·1% (73·1–79·5) in individuals aged 75–79 years. Total diabetes prevalence—especially among older adults—primarily reflects type 2 diabetes, which in 2021 accounted for 96·0% (95·1–96·8) of diabetes cases and 95·4% (94·9–95·9) of diabetes DALYs worldwide. In 2021, 52·2% (25·5–71·8) of global type 2 diabetes DALYs were attributable to high BMI. The contribution of high BMI to type 2 diabetes DALYs rose by 24·3% (18·5–30·4) worldwide between 1990 and 2021. By 2050, more than 1·31 billion (1·22–1·39) people are projected to have diabetes, with expected age-standardised total diabetes prevalence rates greater than 10% in two super-regions: 16·8% (16·1–17·6) in north Africa and the Middle East and 11·3% (10·8–11·9) in Latin America and Caribbean. By 2050, 89 (43·6%) of 204 countries and territories will have an age-standardised rate greater than 10%. INTERPRETATION : Diabetes remains a substantial public health issue. Type 2 diabetes, which makes up the bulk of diabetes cases, is largely preventable and, in some cases, potentially reversible if identified and managed early in the disease course. However, all evidence indicates that diabetes prevalence is increasing worldwide, primarily due to a rise in obesity caused by multiple factors. Preventing and controlling type 2 diabetes remains an ongoing challenge. It is essential to better understand disparities in risk factor profiles and diabetes burden across populations, to inform strategies to successfully control diabetes risk factors within the context of multiple and complex drivers.Bill & Melinda Gates Foundation.http://www.thelancet.comam2024School of Health Systems and Public Health (SHSPH)SDG-03:Good heatlh and well-bein

THE MODERATING ROLE OF SOCIAL CLASS: EFFECT OF BRAND SERVICE SCAPES ON LOYALTY

Purpose: In this study, the impact of Services cape on Loyalty has been studied in the presence of Social Class as a moderating variable. Methodology: The probability based systematic random sampling technique is used to collect the data through a self-administered survey to test the gained hypothesis from 308 respondents living in upper, middle and lower classes. A structured questionnaire was approved of actual information from the respondents to support the collection gained. The conceptual development of costumer’s loyalty measurement scale proposed by McMullan (2005) was adopted for analyzing the loyalty and for computing the services cape of the restaurant the instrument proposed by Hightower (2010) was acquired. SPSS and AMOS were being used to check the questionnaire. The instruments' reliability was checked by using confirmatory factor analysis (CFA) and composite reliability test. SEM (structural equation modelling) through AMOS was used to examine the data. Moderation and moderation steps were analyzed by using orthogonalization and 5000 bootstrapping samples, SPSS MACRO developed by preacher &amp; Hays to check the moderation. Findings: Ambient = 0.71, social = 0.75, design = 0.72 and customer loyalty 0.70 is the outcome of CFA. The positive relation of the loyalty of restaurant with ambiance, social dimension and design dimension of services cape was tested as the first three hypotheses using linear regression. Moreover, the analyzed result of hypothesis 4, 5 and 6 indicated the outcome that social class effects while picking the restaurant. Originality/ Value: By this research, the buying and spending pattern of consumers in Pakistan and the factors that influence the repeat selection of the restaurant in the presence of their social class of the target market has been brought into attention.</jats:p

Perceived Humorand Purchase Intention:Mediating Role of Attitude towards the Advertisement and Brand

In order to investigate the purchase intention of the customers, and its relationship with perceived humor, this research analysesdifferent types of humor that havebeen used in advertising campaigns. In this regard, multi-mediation analysis has been applied keeping in mind the perspective of humor in advertising; moreover, attitudes towards the advertisement, and attitudes towards the brand are used as sequential mediators. In addition, self-monitoring and message arguments have also been included as moderators in order to estimate the interaction effect in theproposedmodel. The data has been gathered from 617 respondentsafter showing them relevant advertisements. After checking the normality of the data, the Confirmatory Factor Analysis was applied using AMOS. Also, Simple Linear Regression was used to test simple relationships; however, complex models have also been tested by usingthe hierarchal regression (to test moderation), and the bootstrapping (to test mediation) methods. A good fitbetween the data and the tested model was observed. As predicted, the purchase intentions were positively related to perceived humor, and evidence of full mediation effect was found. However, for the moderation of self-monitoring and message arguments, the findings were distinctive. In reality, this research can be used by mature brands which mostly require the use of persuasive advertising. As the results of different types of humor, collectively, are significant, it can be inferred that companies must use a mix method approach in terms of types of humor they might resort to in their advertisementcampaigns. Findings are particularly noteworthy for national and multinational media agencies in Pakistan, as well in the other parts of the world.</jats:p