Calcium supplementation to prevent pre-eclampsia - a systematic review

Background. Calcium supplementation during pregnancy may prevent high blood pressure and preterm labour. Objective. To assess the effects of calcium supplementation during pregnancy on hypertensive disorders of pregnancy and related maternal and child adverse outcomes. Design. A systematic review of randomised trials that compared supplementation with at least 1 g calcium daily during pregnancy with placebo. Search strategy. The Cochrane Pregnancy and Childbirth Group trials register (October 2001) and the Cochrane Controlled Trials Register (Issue 3, 2001) were searched and study s were contacted. Data collection and analysis. Eligibility and trial quality were assessed. Data were extracted and analysed. Main results. There was a modest reduction in the risk of pre-eclampsia with calcium supplementation (relative risk (RR) 0.68, 95% confidence interval (CI): 0.57- 0.81). The effect was greatest for women at high risk of hypertension (RR 0.21, 95% CI: 0.11 - 0.39) and those with low baseline calcium intake (RR 0.32, 95% CI: 0.21 - 0.49). There was no overall effect on the risk of preterm delivery, although there was a reduction in risk among women at high risk of hypertension (RR 0.42, 95% CI: 0.23 - 0.78). There was no evidence of any effect of calcium supplementation on stillbirth or death before discharge from hospital. There were fewer babies with birthweight 95th percentile was reduced (RR 0.59, 95% CI: 0.39 - 0.91). Conclusions. Calcium supplementation appears to be beneficial for women at high risk of gestational hypertension and in communities with low dietary calcium intake. These benefits were confined to several rather small trials, and were not found in the largest trial to date, conducted in a low-risk population. Further research is required. (South African Medical Journal: 2003 93(3): 224-228

Effect Times Number of Spray and Concentration of Foliar Fertilizer (PIO20) in Growth and Yield of Cucumber Variety Jamila Planted in Plastic Houses Conditions

نفذت التجربة خلال الموسم الزراعي 2016 في البيوت البلاستيكية في منطقة العزاوية بمحافظة بابل لدراسة تأثير عدد مرات الرش (رشتان، ثلاث رشات) مع اربعة مستويات للرش بالسماد الورقي PIO20 وهي 0 ،1.5 ،2 ،2.5   مل. لتر1- في نبات الخيار صنف جميلة، طّبقت تجربة عاملية وﻓﻘﴼ لتصميم (C.R.D) بثلاثة مكررات. أوضحت النتائج التفوق المعنوي لمعاملة الرش لثلاث مرات بالسماد الورقيPIO20  على معاملة الرش لمرتين في معدل طول النبات (291.4) سم وعدد الاوراق (36.63) ورقة والوزن الجاف للمجموع الخضري(25.76) غم وطول الثمرة (17.98) سم ووزن الثمرة ((109.27غم وعدد الثمار((11.80 ثمرة. نبات1- وحاصل النبات الواحد ((1.294 كغم . كما أظهرت معاملات الرش الورقي جميعها تفوﻗﴼ معنوﻴﴼ في معدل صفات النمو الخضري والثمري قياﺴﴼ لمعاملة المقارنة.  وبيّنت نتائج التداخل التفوق المعنوي لمعاملة الرش لثلاث مرات عند المستوى 2مل. لتر1- في معدل طول النبات (311.3) سم وعدد الاوراق (40.71) ورقة والوزن الجاف للمجموع الخضري(32.09) غم وطول الثمرة (19.34) سم ووزن الثمرة ((116.06 غم وعدد الثمار((12.97 ثمرة. نبات1- وحاصل النبات الواحد ((1.506 كغم.The experiment was conducted during a season of 2016 in plastic houses at Azawia- Babylon to study effect times number of spray (two times،  three times ) with four levels of spray by foliar nutrition  PIO20 (0 ،1.5 ، 2 ،2.5 ml. liter-1) in cucumber plant c.v. jamila. The experiment was conducted of factorial in design using (C.R.D) with three replicates. Results showed the treatment spray of three times significantly on the treatment spray two times when imported  plant length rate (291.4) cm ,the number of leaves (36.63) leaf and dry weight of the shoot (25.76) gm , fruit long (17.98) cm , fruit weight (109.27) gm and the number of fruits (11.80) fruit.plant-1 and the one plant yield (1.294)kg. the results also showed all the treatment of spray significantly in vegetative growth and fruiting characteristics as compared with control treatment. the results of the interaction the significant superiority of the treatment spray of three times on the level 2 ml. liter-1 plant length rate (311.3) cm ,the number of leaves (40.71) leaf and dry weight of the shoot (32.09) gm , fruit long (19.34) cm , fruit weight (116.06) gm and the number of fruits (12.97) fruit.plant-1 and the one plant yield (1.506)kg

Interventions for improving recovery from work

ObjectivesThis is a protocol for a Cochrane Review (intervention). The objectives are as follows:To compare the effectiveness of different individual interventions in recovery from work.info:eu-repo/semantics/publishedVersio

A Formal Study of the Privacy Concerns in Biometric-Based Remote Authentication Schemes

With their increasing popularity in cryptosystems, biometrics have attracted more and more attention from the information security community. However, how to handle the relevant privacy concerns remains to be troublesome. In this paper, we propose a novel security model to formalize the privacy concerns in biometric-based remote authentication schemes. Our security model covers a number of practical privacy concerns such as identity privacy and transaction anonymity, which have not been formally considered in the literature. In addition, we propose a general biometric-based remote authentication scheme and prove its security in our security model

Les Tumeurs Malignes De La Parotide

Buts : Analyser les divers aspects cliniques, histologiques et thérapeutiques des tumeurs malignes de la parotide. Méthode : Étude rétrospective portant sur 17 cancers parotidiens opérés dans le service d\'ORL de la Rabta entre 1994 et 2006. Résultats : Sur une période de13 ans, suite à 77 parotidectomies pour tumeur parotidienne, nous avons diagnostiqué 17 cas de cancers parotidiens soit un pourcentage de 22% de l\'ensemble des tumeurs parotidiennes, réparties en 6 types histologiques. L\'âge moyen des patients est de 49 ans avec des extrêmes allant de 16 à 86 ans et un pic à la 7ème décade de vie. Le sex-ratio est égal à 1,8. Quatre cas de Paralysies faciales (PF) transitoires et un cas de PF définitive ont été déplorés. Deux cas de récidive ont été notés et repris chirurgicalement. Conclusion : Les cancers de la parotide se caractérisent par une grande diversité histologique. Le pronostic dépend du type histologique, du stade évolutif et du traitement.Aim : to analyse clinical, histopathologic and therapeutic aspects of parotid cancers. Method : data from a retrospective study of 17 cases treated in the ENT department of Rabta hospital between 1994 and 2006. Result : in this period 77 patients were operated of parotid tumors, 17 of them were malignants (22%) divided on 6 different histological types. Mean age was 49 years and sex ratio was 1.8. Transitory facial pulsy was observed in 4 patients. Only one definitive facial palsy was observed. Recurrence was observed in 2 patients.They were operated and received a complement of radiptherapy. Conclusion : Parotid cancers are caracterised by great histopathological variety. Their prognosis depends on histological type, tumor stage and treatment Keywords: Parotid gland, cancer, parotid tumor. Journal Tunisien d\'ORL et de chirurgie cervico-faciale Vol. 18 2007: pp. 25-2

Plasmocytome Ganglionnaire A Propos D\'un Cas

Les plasmocytomes ganglionnaires sont très rares. Ils peuvent être en rapport avec des métastases à partir d\'un myélome multiple ou d\'un plasmocytome extramédullaire. Les localisations primaires ganglionnaires restent exceptionnelles. Nous rapportons un cas colligé et opéré au service d\'ORL et CMF de l\'hôpital la Rabta. Il s\'agit d\'une femme de 74 ans opérée d\'une tuméfaction submandibulaire gauche. Le diagnostic est fait à l\'examen histologique qui a révélé un plasmocytome ganglionnaire primaire. Le traitement est radiochirurgical. Nous présentons les aspects histopatologiques, cliniques, biologiques et thérapeuthiques de cette affection rare. Keywords: plasmocytomes ganglionnaires, adénopathie cervicale. Journal Tunisien d\'ORL et de chirurgie cervico-faciale Vol. 18 2007: pp. 53-5

Aspirin plus calcium supplementation to prevent superimposed preeclampsia: a randomized trial

Abstract Preeclampsia is an important cause of maternal and perinatal morbidity and mortality. Previous studies have tested calcium supplementation and aspirin separately to reduce the incidence of preeclampsia but not the effects of combined supplementation. The objective of this study was to investigate the effectiveness of aspirin combined with calcium supplementation to prevent preeclampsia in women with chronic hypertension. A double-blind, placebo-controlled randomized clinical trial was carried out at the antenatal clinic of a large university hospital in Sa˜o Paulo, SP, Brazil. A total of 49 women with chronic hypertension and abnormal uterine artery Doppler at 20-27 weeks gestation were randomly assigned to receive placebo (N = 26) or 100 mg aspirin plus 2 g calcium (N = 23) daily until delivery. The main outcome of this pilot study was development of superimposed preeclampsia. Secondary outcomes were fetal growth restriction and preterm birth. The rate of superimposed preeclampsia was 28.6% lower among women receiving aspirin plus calcium than in the placebo group (52.2 vs 73.1%, respectively, P=0.112). The rate of fetal growth restriction was reduced by 80.8% in the supplemented group (25 vs 4.8% in the placebo vs supplemented groups, respectively; P=0.073). The rate of preterm birth was 33.3% in both groups. The combined supplementation of aspirin and calcium starting at 20-27 weeks of gestation produced a nonsignificant decrease in the incidence of superimposed preeclampsia and fetal growth restriction in hypertensive women with abnormal uterine artery Doppler

Paclitaxel and Sorafenib: The Effective Combination of Suppressing the Self-Renewal of Cancer Stem Cells

Combination therapy, which is a treatment modality combining two or more therapeutic agents, is considered a cornerstone of cancer therapy. The combination of anticancer drugs, of which functions are different from the other, enhances the efficiency compared to the monotherapy because it targets cancer cells in a synergistic or an additive manner. In this study, the combination of paclitaxel and sorafenib in low concentration was evaluated to target cancer stem cells, miPS-BT549cmP and miPS-Huh7cmP cells, developed from mouse induced pluripotent stem cells. The synergistic effect of paclitaxel and sorafenib on cancer stem cells was assessed by the inhibition of proliferation, self-renewal, colony formation, and differentiation. While the IC(50)values of paclitaxel and sorafenib were approximately ranging between 250 and 300 nM and between 6.5 and 8 mu M, respectively, IC(50)of paclitaxel reduced to 20 and 25 nM, which was not toxic in a single dose, in the presence of 1 mu M sorafenib, which was not toxic to the cells. Then, the synergistic effect was further assessed for the potential of self-renewal of cancer stem cells by sphere formation ability. As a result, 1 mu M of sorafenib significantly enhanced the effect of paclitaxel to suppress the number of spheres. Simultaneously, paclitaxel ranging in 1 to 4 nM significantly suppressed not only the colony formation but also the tube formation of the cancer stem cells in the presence of 1 mu M sorafenib. These results suggest the combination therapy of paclitaxel and sorafenib in low doses should be an attractive approach to target cancer stem cells with fewer side effects

First narrow-band search for continuous gravitational waves from known pulsars in advanced detector data

Spinning neutron stars asymmetric with respect to their rotation axis are potential sources of continuous gravitational waves for ground-based interferometric detectors. In the case of known pulsars a fully coherent search, based on matched filtering, which uses the position and rotational parameters obtained from electromagnetic observations, can be carried out. Matched filtering maximizes the signalto- noise (SNR) ratio, but a large sensitivity loss is expected in case of even a very small mismatch between the assumed and the true signal parameters. For this reason, narrow-band analysis methods have been developed, allowing a fully coherent search for gravitational waves from known pulsars over a fraction of a hertz and several spin-down values. In this paper we describe a narrow-band search of 11 pulsars using data from Advanced LIGO’s first observing run. Although we have found several initial outliers, further studies show no significant evidence for the presence of a gravitational wave signal. Finally, we have placed upper limits on the signal strain amplitude lower than the spin-down limit for 5 of the 11 targets over the bands searched; in the case of J1813-1749 the spin-down limit has been beaten for the first time. For an additional 3 targets, the median upper limit across the search bands is below the spin-down limit. This is the most sensitive narrow-band search for continuous gravitational waves carried out so far