Оценка эффективности комплекса методов медицинской реабилитации пациентов с двигательной дисфункцией кисти вследствие острых нарушений мозгового кровообращения

МЕДИЦИНСКАЯ РЕАБИЛИТАЦИЯКИСТЬ РУКИКИСТЬПСИХОМОТОРНАЯ АКТИВНОСТЬДВИГАТЕЛЬНЫХ НАВЫКОВ РАССТРОЙСТВА /РЕАБИЛРЕАБИЛИТАЦИЯ /МЕТОДЫМОЗГОВОГО КРОВООБРАЩЕНИЯ РАССТРОЙСТВА /ОСЛ /РЕАБИЛЛЕЧЕБНАЯ ГИМНАСТИКАМЕЛКАЯ МОТОРИКАЦелью исследования являлось изучение эффективности комплекса медицинской реабилитации, разработанного на основе зеркальной визуальной обратной связи, элементов двигательной терапии индуцированным ограничением, метода тренировки двигательных навыков кисти с использованием латексных резинок и авторского метода тренировки мелких моторных навыков у пациентов с двигательной дисфункцией кисти вследствие острого нарушения мозгового кровообращения различной степени выраженности. В исследовании приняли участие 62 пациента, разделенные на 2 группы сравнения, сопоставимые по полу, возрасту, реабилитационному периоду и потенциалу. Для анализа результатов использовались методы оценки эффективности медицинской реабилитации пациентов с двигательной дисфункцией кисти, утвержденные министерством здравоохранения Республики Беларусь. По результатам исследования было выявлено межгрупповое различие в восстановлении мелкой моторики, показателей кистевой динамометрии, уровне самооценки пациентом утраты функции верхней конечности, степени выраженности тревожной и депрессивной симптоматики, проявляющееся в более качественном результате у пациентов клинической группы. Также выявлено преобладание увеличений показателей и при оценке качества жизни у респондентов, проходящих предложенный комплекс методов медицинской реабилитации над пациентами контрольной группы. Разработанный комплекс, в условиях применения в соответствии с алгоритмом, позволяет более качественно по сравнению с пациентами, проходящими стандартный курс медицинской реабилитации, восстановить двигательный навык, утраченный вследствие острого нарушения мозгового кровообращения, улучшить степень самообслуживания, качества жизни и приводит к снижению выраженности тревожно-депрессивной симптоматики.Objectives. To study the efficacy of the medical rehabilitation complex developed on the basis of mirror visual feedback, elements of constraint induced movement therapy, the method of hand motor skills’ training with the use of latex rubber bands and the author’s own method of fine motor skills training in patients with motor dysfunction of the hand caused by acute cerebral circulation of different severity degree. Material and methods. The study involved 62 patients, divided into 2 comparison groups, matched by sex, age, rehabilitation period, and potential. To analyze the results we used methods for assessing the effectiveness of medical rehabilitation of patients with motor dysfunction of the hand, which were approved by the Ministry of Health of the Republic of Belarus. Results. The study revealed an intergroup difference in restoring fine motor skills, hand dynamometry indices, the patient’s self-assessment of the upper limb function loss, the severity of anxiety and depression symptoms, which manifests itself in a better result in patients of the clinical group. The prevalence of the increased indicators was also revealed when assessing the life quality of respondents undergoing the proposed complex of medical rehabilitation methods over patients of the control group. Conclusions. The developed complex, in terms of application in accordance with the algorithm, allows more qualitatively compared with patients undergoing a standard course of medical rehabilitation, to restore the motor skill lost because of acute cerebral circulation disturbance, to improve the degree of self-care, quality of life and leads to a decrease in anxiety-depression symptoms

Strategic global marketing of Nordic cleantech clusters and competencies

The purpose of the report is to map how cleantech sectors and clusters in the Nordic countries are being marketed, and to develop and suggest methods for and approaches to joint marketing of Nordic cleantech globally, paving the way for the long-term goal of developing a joint Nordic marketing model. The study was carried out by Tendensor on behalf of Nordic Innovation in the period December 2011 – March 2012

AUTOMAIN : D4.1 Improvement analysis for high performance maintenance and modular infrastructure

Godkänd; 2013; 20150627 (chrste)Augmented Usage of Track by Optimisation of Maintenance, Allocation and Inspection of railway Network

Tissue samples included for RNA expression profiling.

<p>The estimated percentages of cells are given for each tissue type. In bone marrow, cells of erythropoietic origin are mostly immature and nucleated precursors. * In secondary lymphoid organs, fully maturated erythrocytes are not included, since they are unlikely to contribute to the transcriptomic profile. ** Other cell types refer to adipocytes, fibroblasts, smooth muscle cells and glandular cells.</p><p>Tissue samples included for RNA expression profiling.</p

Summary of transcriptomic profiling of lymphohematopoietic tissues.

<p>Summary of transcriptomic profiling of lymphohematopoietic tissues.</p

Immunohistochemical staining of protein expression.

<p>The staining patterns of 19 proteins transcribed from genes in the enriched or enhanced categories are exemplified here in one to three tissue types. The gene name, tissue type and FPKM-value in brackets are shown for each image. BM: bone marrow; LN: lymph node; Appx: appendix.</p

Classification of gene expression patterns as determined over 27 tissues.

<p>Classification of gene expression patterns as determined over 27 tissues.</p

Network plot visualizing the relationship of enriched genes in the lymphohematopoietic tissues.

<p>a) Dark blue nodes represent genes that are group enriched in up to five different tissue types including at least one of the lymphohematopoietic tissues. The light blue nodes represent the total number of highly and moderately tissue enriched genes in each lymphohematopoietic tissue. The size of each blue (dark and light) node is related to the square root of the number of genes within. Black circles represent the four lymphohematopoietic tissues, and grey circles denote other tissue types. b) Names of enriched genes (and enhanced genes in brackets) that are exemplified in the text and shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0115911#pone-0115911-g004" target="_blank">Fig. 4</a>. The color codes are equal to the nodes in a). The network plot is limited to include nodes with a minimum of two genes.</p

Pie charts displaying the expression profiles for the lymphohematopoietic tissues.

<p>The upper panel shows the percentage of genes expressed within the different categories of expression, for bone marrow and for the secondary lymphoid organs respectively. The lower panel pie charts show the percentage of transcripts (FPKM) for each category.</p

Dendrogram and correlation plots for the lymphohematopoietic tissues.

<p>a) Dendrogram covering all samples of the four lymphohematopoietic tissue types visualizing clustering according to gene expression profiles. Correlation plots are shown for b) spleen and bone marrow displaying the lowest correlation between the four lymphohematopoietic tissues, and for c) lymph node and appendix displaying the highest correlation, based on the average FPKM-value of all samples within the same tissue type (n = 3–5).</p