Penerapan Cooperative Learning Type Make a Match Untuk Meningkatkan Aktivitas Belajar IPA

; The title of this research is the application of Cooperative Learning Model Type Make a Match for Enhanced Learning Activities IPA MI. This study aimed to describe the increase in students\u27 learning activities using cooperative learning models make a match type in the fourth grade science learning Kuala Ambawang MIN. The research method used is descriptive method to shape classroom action research. Subjects were fourth grade students MIN Kuala Ambawang totaling 26 people. The results of data analysis showed that using cooperative learning models make a match type can enhance student learning activities both physical activity, mental or emotional. Physical activity increased by 25.97% from 70.18 to 96.15 in Cycle 1 to cycle 2. Mental activity also increased 28.85% from 61.53% in Cycle 1 to 90.38% in cycle 2. While the emotional activity also increased from 53.84% in cycle 1 to 89.74 in second cycle resulting in an increase of 35.90%. Thus, the overall average increase student learning activities for 30.24% of the 61.85% average disiklus 1 to an average of 92.09 in cycle 2 Keywords; activity,learning,models of cooperative learning types make a match

Multilocational Evaluation of Pigeonpea for Broad-Based Resistance to Fusarium Wilt in India

Nine-hundred and fifty-nine plgeonpea germplasm and breeding lines were evaluated for resistance to wilt caused by Fusarium udum Butler at 12 locations in India over a period of 7 years between 1984 and 1990. ICP 8863,9174,12745, ICPL333,8363,88047, BWR 370, DPPA 85-2,85-3,85-8,85–13,85–14 and Bandapalera were resistant or moderately resistant at 7 to 10 out of 12 locations for 3 to 5 years with an average wilt incidence of less than 15%

Maternal Practices towards Dental Treatment of Primary School Children after the Emergence of Covid 19

<p>Context COVID 19 is a highly contagious viral disease. Dental office has garnered a lot of attention as one of the potential sources of SARS-CoV-2 transmission and dissemination. Due to this, the frequency of dental visits among children and their parents have reduced substantially.Aims To assess maternal practices towards dental treatment of primary school children after the emergence of COVID 19.Settings and Design A school based cross sectional electronic survey, conducted in various schools in Chalakudy town in Kerala.Methods and Material The study was conducted among mothers of primary school children, with a sample size of 709. The data were collected using a validated questionnaire comprised of four parts, part A recorded basic demography, part B mothers' knowledge, part C attitude and part D recorded practices towards dental care and impact covid 19 on dental care.Statistical Analysis Data were analysed using the SPSS version 21. Descriptive measures and chi-square test was conducted separately for each variable. P value was set at < 0.05 level of significance.Results The findings showed that overall knowledge, attitude and practice (KAP) scores of the mothers revealed 81.3% had good KAP score. Among them 95.5% had adequate knowledge while 93.1% had positive attitude whereas a mere 40.7% was translated into practice.Conclusions Knowledge of mothers towards dental treatment of primary school children after the emergence of COVID 19 was adequate but the attitude and the practices were not and this probably due to the fear. Expecting similar pandemics in future, standard operating procedure (SOP) which would ensure absolute infection control in a dental clinic and spreading awareness of such SOP'samong parents can reduce their apprehensions to get dental treatments for their kids.</p><p>Keywords:- COVID 19, Primary School Children, Dental Treatment.</p&gt

Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers.

Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a tumor suppressor and bi-functional lipid and protein phosphatase. We report that the metabolic regulator pyruvate dehydrogenase kinase1 (PDHK1) is a synthetic-essential gene in PTEN-deficient cancer and normal cells. The PTEN protein phosphatase dephosphorylates nuclear factor κB (NF-κB)-activating protein (NKAP) and limits NFκB activation to suppress expression of PDHK1, a NF-κB target gene. Loss of the PTEN protein phosphatase upregulates PDHK1 to induce aerobic glycolysis and PDHK1 cellular dependence. PTEN-deficient human tumors harbor increased PDHK1, a biomarker of decreased patient survival. This study uncovers a PTEN-regulated signaling pathway and reveals PDHK1 as a potential target in PTEN-deficient cancers

RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK–positive lung cancer

One strategy for combating cancer-drug resistance is to deploy rational polytherapy up front that suppresses the survival and emergence of resistant tumor cells. Here we demonstrate in models of lung adenocarcinoma harboring the oncogenic fusion of ALK and EML4 that the GTPase RAS–mitogen-activated protein kinase (MAPK) pathway, but not other known ALK effectors, is required for tumor-cell survival. EML4-ALK activated RAS-MAPK signaling by engaging all three major RAS isoforms through the HELP domain of EML4. Reactivation of the MAPK pathway via either a gain in the number of copies of the gene encoding wild-type K-RAS (KRAS(WT)) or decreased expression of the MAPK phosphatase DUSP6 promoted resistance to ALK inhibitors in vitro, and each was associated with resistance to ALK inhibitors in individuals with EML4-ALK–positive lung adenocarcinoma. Upfront inhibition of both ALK and the kinase MEK enhanced both the magnitude and duration of the initial response in preclinical models of EML4-ALK lung adenocarcinoma. Our findings identify RAS-MAPK dependence as a hallmark of EML4-ALK lung adenocarcinoma and provide a rationale for the upfront inhibition of both ALK and MEK to forestall resistance and improve patient outcomes