Struktur Dan Fungsi Pantun Managua Pada Upacara Pernikahan Di Koto Baru Kecamatan Rao Utara Kabupaten Pasaman

The purpose of this study was to describe the structure, function, and educational values ​​contained in the poem managua on wedding ceremony in New Koto Pasaman District of North Rao. The data of this study is the structure, functions, and values ​​education in managua rhyme. The data source of this research is the primary source of oral sources as spoken directly by the original speaker. Data collected using methods and techniques refer to record and advanced engineering techniques noted as descriptive method. The study's findings are managua rhyme structure consists of the physical structure and inner structure, function managua poem consists of eight of the ten functions rhymes Minangkabau, and educational values ​​managua poem consists of religious education and moral values​

The Impact of the Environment and People’s Attitudes on Greywater Management in Slum Coastal Settlements

The rapid population growth in many countries will ultimately impact the provision of essential services and engender many challenges, such as inadequate sanitation. Indonesia has an extensive coastline and densely populated coastal areas that have grown sporadically, creating slums. These areas have long been associated with poor greywater management. Greywater is dumped into beaches, roads, and yards without pre-treatment, thus harming the environment and society. This study aims to identify various factors influencing community actions to manage and overcome greywater-related problems in coastal slum areas. Using methods by combining qualitative and quantitative approaches. The influential factors in the physical condition of the built environment, the natural environment, community activities, and government involvement related to greywater were analyzed qualitatively, while the public understanding of greywater management was assessed quantitatively. The results showed that these four factors significantly influenced people's attitudes towards wastewater treatment. The findings show that these four factors affect people's mind-set about handling greywater, which becomes an obstacle to changing their attitudes and views on greywater. The four factors have the same level and cannot be separated in dealing with greywater. Treatment strategies are in accordance with coastal nature, settlements physical conditions and communities are then chosen Treatment Horizontal Flow. Doi: 10.28991/CEJ-2022-08-12-05 Full Text: PD

Analisis Pengendalian Persediaan Bahan Baku Butsudan menggunakan Model Dynamic Lot Sizing pada PT. XYZ

Pengendalian persediaan merupakan hal penting bagi suatuperusahaan untuk mengetahui jumlah frekuensi pemesananyang tepat untuk perusahaan tersebut  sehingga dapat meminimalisirkan biaya persediaan yang ada. PT. XYZmerupakan perusahaan yang bergerak di bidang pengerjaankayu. Produk yang dihasilkan oleh perusahaan yaituButsudan modan. Sejak 3 tahun terakhir terdapat beberapamaterial kayu nyatoh dan juga hardboard yang tersimpan di gudang yang menyebabkan tingginya cost dalam menyimpanbahan baku. Tahun 2021 tercatat total cost yang dikeluarkanperusahaan untuk persediaan bahan baku kayu nyatoh dan hardboard mencapai Rp424.762.952. Pada penelitian iniakan di terapkan model Dynamic Lot Sizing yaitumenggunakan metode Period Order Quantity, metode Least Unit Cost, metode Silver Meal Algorithm serta metode Algorithm Wagner-Within untuk mengendalikan sertamenentukan metode yang paling optimal yang dapat di terapkan oleh perusahaan. Hasil penelitian didapatkanbahwa metode Silver Meal Algorithm merupakan metodeyang optimal untuk digunakan karena mampu memiliki total cost yang rendah sehingga mampu menghemat total cost hingga Rp52.630.477. Metode Silver Meal ini dapatditerapkan oleh perusahan karena mampu meminimkan total cost yang di keluarkan serta mempertimbangkan kapasitasgudang yang ada pada perusahaan

Associations of premorbid adjustment with type and timing of childhood trauma in first-episode schizophrenia spectrum disorders

CITATION: Smit, A. M. et al. 2021. Associations of premorbid adjustment with type and timing of childhood trauma in first-episode schizophrenia spectrum disorders. South African Journal of Psychiatry, 27:a1639, doi:10.4102/sajpsychiatry.v27i0.1639.The original publication is available at https://sajp.org.zaBackground: Childhood trauma may contribute to poorer premorbid social and academic adjustment which may be a risk factor for schizophrenia. Aim: We explored the relationship between premorbid adjustment and childhood trauma, timing of childhood trauma’s moderating role as well as the association of clinical and treatment-related confounders with premorbid adjustment. Setting: We conducted a secondary analysis in 111 patients with first-episode schizophrenia (FES) disorders that formed part of two parent studies, EONKCS study (n =73) and the Shared Roots study (n =38). Methods: Type of childhood trauma was assessed with the Childhood Trauma Questionnaire, short-form and premorbid adjustment using the Premorbid Adjustment Scale. Timing of childhood trauma was assessed using the Life Events Checklist and life events timeline. Linear regression analyses were used to assess the moderating effect of timing of childhood trauma. Clinical and treatment-related confounders were entered into sequential hierarchical regression models to identify independent predictors of premorbid adjustment across key life stages. Results: Childhood physical neglect was associated with poorer premorbid academic functioning during childhood and early adolescence, and poorer premorbid social functioning during early and late adolescence. By hierarchical regression modelling (r2 = 0.13), higher physical neglect subscale scores (p = 0.011) independently predicted poorer premorbid social adjustment during early adolescence. Timing of childhood trauma did not moderate the relationship between childhood trauma and premorbid functioning. Conclusion: In patients with FES, childhood physical neglect may contribute to poorer premorbid social functioning during early adolescence. This may provide us with an opportunity to identify and treat at-risk individuals earlier.https://sajp.org.za/index.php/sajp/article/view/1639Publisher's versio

lentiglobin gene therapy for transfusion dependent β thalassemia outcomes from the phase 1 2 northstar and phase 3 northstar 2 studies

Introduction Transfusion-dependent β-thalassemia (TDT) is a severe genetic disease characterized by anemia, iron overload and serious comorbidities for which gene therapy may be an effective treatment option. LentiGlobin gene therapy contains autologous CD34+ hematopoietic stem cells (HSCs) transduced ex vivo with the BB305 lentiviral vector (LVV) encoding β-globin with a T87Q substitution. Objective Evaluate the efficacy and safety of LentiGlobin in patients with TDT in the phase 1/2 Northstar (HGB-204; NCT01745120) and phase 3 Northstar-2 (HGB-207; NCT02906202) studies. Methods Patients with TDT (≥100 mL/kg/yr of red blood cells [RBCs] or ≥8 RBC transfusions/yr) received G-CSF and plerixafor for mobilization and HSCs were transduced with the BB305 LVV. Patients underwent single agent busulfan myeloablative conditioning, were infused with transduced cells, and were followed for engraftment, safety, and efficacy. Statistics are presented as median (min – max). Results As of March 7, 2018, 18 patients (12 – 35 yrs) were treated in Northstar (follow-up 32.1 [23.1 – 41.9] months) and as of May 15, 2018, 11 patients (12 – 24 yrs) were treated in Northstar-2 (follow-up 8.5 [0.3 – 16.2] months). Patients received a median cell dose of 8.0 (5.0 – 19.4) CD34+ cells × 106/kg in both studies. The median time to neutrophil and platelet engraftment in both studies was 19 (14 – 30) days and 44 (19 – 191) days, respectively; 1 patient in Northstar-2 (0.3 months follow-up) had not engrafted at time of analysis. Of 6 patients with platelet engraftment ≥ Day 60, 4 had non-serious bleeding events prior to engraftment. All 6 had intact spleens and 3/6 received G-CSF between Days 0 – 21. Both factors appeared associated with time to platelet engraftment. In Northstar, 8/10 patients with non-β0/β0 genotypes and 2/8 patients with β0/β0 genotypes achieved transfusion independence (TI; weighted average hemoglobin [Hb] ≥ 9 g/dL without RBC transfusions for ≥ 12 months). Median Hb during TI was 10.0 (9.3 – 13.1) g/dL. In Northstar-2, 7/8 patients with non-β0/β0 genotypes and ≥ 6 months follow-up stopped RBC transfusions with Hb of 11.1 – 13.3 g/dL at last visit; the first patient treated achieved TI. Non-hematologic grade ≥ 3 adverse events post-infusion in ≥ 5/29 (15%) patients were stomatitis, febrile neutropenia, and pharyngeal inflammation. Veno-occlusive liver disease attributed to busulfan occurred in 4/29 patients (Table 1). There was no transplant-related mortality, vector-mediated replication competent lentivirus, or clonal dominance. Conclusion In Northstar, 80% of patients with non-β0/β0 genotypes achieved TI and early Northstar-2 data suggest that patients can achieve near-normal Hb without transfusions. The safety profile of LentiGlobin is consistent with myeloablative busulfan conditioning. Longer time to platelet engraftment was observed in few patients, but no graft failure or deaths were reported

Hybrid carboxymethyl kappa-carrageenan/carboxymethyl cellulose- based biopolymer electrolytes for dye-sensitized solar cell application

Natural biopolymers have recently attracted a lot of attention for the development of new polymer electrolytes due to their environmental friendliness, nontoxicity, and abundance in nature. Biopolymer electrolytes based on carboxymethyl kappa carrageenan/carboxymethyl cellulose incorporated with sodium iodide were prepared and their structural and electrochemical stability were investigated using electrochemical impedance spectroscopy, Fourier transform infrared spectroscopy, transference number measurement, and linear sweep voltammetry. The film containing 30 wt% sodium iodide had the highest ionic conductivity and the highest relative number of charge carriers at room temperature. The relative number of charge carriers for each prepared electrolyte film in this study increased with salt concentration, according to Barker's electrolyte dissociation theory. The highest conducting electrolyte and the lowest salt concentration electrolyte films were used to fabricate and characterise dye-sensitized solar cell (DSSC). These DSSCs responded well to a light intensity of 100 mW cm-2

Betibeglogene Autotemcel Gene Therapy for Non-β⁰/β⁰ Genotype β-Thalassemia

BACKGROUND: Betibeglogene autotemcel (beti-cel) gene therapy for transfusion-dependent β-thalassemia contains autologous CD34+ hematopoietic stem cells and progenitor cells transduced with the BB305 lentiviral vector encoding the β-globin (βA-T87Q) gene. METHODS: In this open-label, phase 3 study, we evaluated the efficacy and safety of beti-cel in adult and pediatric patients with transfusion-dependent β-thalassemia and a non-β0/β0 genotype. Patients underwent myeloablation with busulfan (with doses adjusted on the basis of pharmacokinetic analysis) and received beti-cel intravenously. The primary end point was transfusion independence (i.e., a weighted average hemoglobin level of ≥9 g per deciliter without red-cell transfusions for ≥12 months). RESULTS: A total of 23 patients were enrolled and received treatment, with a median follow-up of 29.5 months (range, 13.0 to 48.2). Transfusion independence occurred in 20 of 22 patients who could be evaluated (91%), including 6 of 7 patients (86%) who were younger than 12 years of age. The average hemoglobin level during transfusion independence was 11.7 g per deciliter (range, 9.5 to 12.8). Twelve months after beti-cel infusion, the median level of gene therapy-derived adult hemoglobin (HbA) with a T87Q amino acid substitution (HbAT87Q) was 8.7 g per deciliter (range, 5.2 to 10.6) in patients who had transfusion independence. The safety profile of beti-cel was consistent with that of busulfan-based myeloablation. Four patients had at least one adverse event that was considered by the investigators to be related or possibly related to beti-cel; all events were nonserious except for thrombocytopenia (in 1 patient). No cases of cancer were observed. CONCLUSIONS: Treatment with beti-cel resulted in a sustained HbAT87Q level and a total hemoglobin level that was high enough to enable transfusion independence in most patients with a non-β0/β0 genotype, including those younger than 12 years of age. (Funded by Bluebird Bio; HGB-207 ClinicalTrials.gov number, NCT02906202.)

Factors moderating the relationship between childhood trauma and premorbid adjustment in first-episode schizophrenia

CITATION: Kilian, S. et al. 2017. Factors moderating the relationship between childhood trauma and premorbid adjustment in first-episode schizophrenia. PLoS ONE, 12(1):e0170178, doi:10.1371/journal.pone.0170178.The original publication is available at http://journals.plos.org/plosoneChildhood trauma is a recognised risk factor for schizophrenia. It has been proposed that childhood trauma interferes with normal neurodevelopment, thereby establishing a biological vulnerability to schizophrenia. Poor premorbid adjustment is frequently a precursor to schizophrenia, and may be a manifestation of neurodevelopmental compromise. We investigated the relationship between childhood trauma and premorbid adjustment in 77 patients with first-episode schizophrenia spectrum disorders. We also investigated possible mediating roles for other selected risk factors in the relationship. We found several significant correlations between different trauma types and both social and academic premorbid adjustment from childhood to late adolescence. There were no significant moderating effects for family history of schizophrenia or family history of psychiatric disorder. History of obstetric complications, substance abuse and poor motor coordination weakened some of the associations between childhood trauma and premorbid adjustment, while poor sequencing of motor acts strengthened the association. Our results confirm previous studies indicating an association between childhood trauma and premorbid adjustment. Results indicate a general rather than specific association, apparent with different types of trauma, and affecting both social and academic components of premorbid adjustment across childhood, early and late adolescence. Further, our results suggest a complex interplay of various risk factors, supporting the notion of different pathways to psychosis.http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0170178Publisher's versio

Serpin Induced Antiviral Activity of Prostaglandin Synthetase-2 against HIV-1 Replication

The serine protease inhibitors (serpins) are anti-inflammatory proteins that have various functions. By screening a diverse panel of viruses, we demonstrate that the serpin antithrombin III (ATIII) has a broad-spectrum anti-viral activity for HIV-1, HCV and HSV. To investigate the mechanism of action in more detail we investigated the HIV-1 inhibition. Using gene-expression arrays we found that multiple host cell signal transduction pathways were activated by ATIII in HIV-1 infected cells but not in uninfected controls. Moreover, the signal pathways initiated by ATIII treatment, were more than 200-fold increased by the use of heparin-activated ATIII. The most up-regulated transcript in HIV-1 infected cells was prostaglandin synthetase-2 (PTGS2). Furthermore, we found that over-expression of PTGS2 reduced levels of HIV-1 replication in human PBMC. These findings suggest a central role for serpins in the host innate anti-viral response. Host factors such as PTGS2 elicited by ATIII treatment could be exploited in the development of novel anti-viral interventions