Hereditary Angioedema

Hereditary angioedema (HAE) is an autosomal dominantly inherited orphan disease manifested by recurrent unpredictable nonpitting and nonpruritic swelling attacks without urticarial plaques. HAE is caused by a deficiency of the C1 esterase inhibitor (C1‐inh) or decreased function of C1‐inh. Type 1 HAE, the most common form, occurs due to C1‐inh deficiency and is seen with low‐serum C1‐inh levels. In type 2 HAE, the function of C1‐inh is impaired, and in HAE with normal C1‐inh serum levels, the function of C1‐inh is normal. HAE episodes can affect various sites in the body such as the larynx, face, extremities, gastrointestinal tract, and urogenital area. Acute episodes can be treated with C1‐inh concentrates, a kallikrein inhibitor, called ecallantide and bradykinin B2 receptor antagonist, icatibant. Depending on the frequency, severity, and location of the episodes, long-term prophylaxis regimens with plasma-derived C1-inh concentrates, antifibrinolytics, or 17α-alkylated androgens can be used. C1-inh concentrates or 17α-alkylated androgens should be administered before dental procedures and minor or major surgical interventions to provide short-term prophylaxis. In conclusion, HAE is a rare life-threatening disease of which clinical presentation is highly variable and early accurate diagnosis significantly prevents mortality and morbidity

Macro Explanatory Factors of Turkish Tourism Companies' Stock Returns

This study examines whether the stock prices of Turkish tourism companies respond to growth in eight macro-economic variables namely, consumer price index, imports, exchange rate, consumer confidence index, oil price, money supply, foreign tourist arrivals, and monthly stock market return. By applying the Granger causality procedure, we find that growth in the consumer confidence index and imports could Granger cause tourism companies’ stock returns among eight macro factors in Turkey during the 2005 to 2013 period. After considering the structural break that occurred in 2007, the pre-break results indicate that the consumer confidence index, exchange rate, and foreign tourist arrivals could Granger cause tourism stock returns. However, the results in the post-structural break period reveal that only growths in oil prices and imports are significant

Obtaining the Manning roughness with terrestrialremote sensing technique and flood modeling using FLO-2D: A case study Samsun from Turkey

Određivanje Manningovih koeficijenata hrapavosti jedan je od najvažnijih koraka u modeliranju poplava. Koeficijenti hrapavosti u procesu modeliranja uzrokuju razlike u poplavnim područjima, razinama vode i brzinama. Cilj ove studije je utvrditi koeficijent hrapavosti u riječnim odsječcima te i izvan riječnih područja korištenjem Cowanove metode i tehnike daljinskog istraživanja. U modeliranju poplave korišten je program FLO-2D Pro koji može simulirati širenje poplave u dvije dimenzije. Za područje istraživanja odabrana je rijeka Mert u provinciji Samsun koja se nalazi u sjevernom dijelu Turske. Uzorci uzeti iz rijeke analizirani su pomoću sita, gdje su vrste sastavnog materijala određene prema srednjim promjerima, a koeficijenti hrapavosti dobiveni su Cowanovom metodom. Za područja izvan rijeke primijenjena je metoda najveće vjerojatnosti koja je jedna od kontroliranih metoda klasifikacije. Manningove vrijednosti hrapavosti dodijeljene su klasificiranim odsječcima slike. Tehnike daljinskih mjerenja pomno su korištene kako bi se procijenili koeficijenti hrapavosti u područjima izvan rijeke, a novi je pristup predložen u Manningovoj procjeni poplavnih područja kako bi se osigurala ujednačenost na istraživanom području. U klasifikaciji izvedenoj metodom najveće vjerojatnosti, ukupna točnost klasifikacije bila je 92,9%, a kappa omjer “κ” 90,64%. Rezultati su kalibrirani prema posljednjim slikama opasnih poplava 2012. godine i HEC-RAS 2D programom, koji je također program za modeliranje poplave.Determining the Manning roughness coefficients is one of the most important steps in flood modeling. The roughness coefficients cause differences in flood areas, water levels, and velocities in the process of modeling. This study aims to determine both the Manning roughness coefficient in the river sections and outside of the river regions by using the Cowan method and remote sensing technique in the flood modeling. In the flood modeling, FLO-2D Pro program which can simulate flood propagation in two dimensions was utilized. Mert River in Samsun province located in the northern part of Turkey was chosen as the study area. Samples taken from the river were subjected to sieve analysis, the types of constituent material were determined according to the median diameters and the roughness coefficients were obtained using the Cowan method. For regions outside of the river were applied the maximum likelihood method being one of the controlled classification methods. Manning roughness values were assigned the classified image sections. Remote sensing techniques were meticulously employed to achieve time management in areas outside the river and a new approach was proposed in the Manning assessment of flood areas to ensure uniformity in the study area. In the classification made using the maximum likelihood method, the overall classification accuracy was 92.9% and the kappa ratio “κ” was 90.64%. The results were calibrated with the last hazardous flood images in 2012 and HEC-RAS 2D program, another flood modeling program

Risk factors for systemic reactions in typical cold urticaria: Results from the COLD‐CE study

Background: Cold urticaria (ColdU), that is, the occurrence of wheals or angioedema in response to cold exposure, is classified into typical and atypical forms. The diagnosis of typical ColdU relies on whealing in response to local cold stimulation testing (CST). It can also manifest with cold-induced anaphylaxis (ColdA). We aimed to determine risk factors for ColdA in typical ColdU. Methods: An international, cross-sectional study COLD-CE was carried out at 32 urticaria centers of reference and excellence (UCAREs). Detailed history was taken and CST with an ice cube and/or TempTest® performed. ColdA was defined as an acute cold-induced involvement of the skin and/or visible mucosal tissue and at least one of: cardiovascular manifestations, difficulty breathing, or gastrointestinal symptoms. Results: Of 551 ColdU patients, 75% (n = 412) had a positive CST and ColdA occurred in 37% (n = 151) of the latter. Cold-induced generalized wheals, angioedema, acral swelling, oropharyngeal/laryngeal symptoms, and itch of earlobes were identified as signs/symptoms of severe disease. ColdA was most commonly provoked by complete cold water immersion and ColdA caused by cold air was more common in countries with a warmer climate. Ten percent (n = 40) of typical ColdU patients had a concomitant chronic spontaneous urticaria (CSU). They had a lower frequency of ColdA than those without CSU (4% vs. 39%, p = .003). We identified the following risk factors for cardiovascular manifestations: previous systemic reaction to a Hymenoptera sting, angioedema, oropharyngeal/laryngeal symptoms, and itchy earlobes. Conclusion: ColdA is common in typical ColdU. High-risk patients require education about their condition and how to use an adrenaline autoinjector

Epidemiology of surgery associated acute kidney injury (EPIS-AKI) : a prospective international observational multi-center clinical study

The incidence, patient features, risk factors and outcomes of surgery-associated postoperative acute kidney injury (PO-AKI) across different countries and health care systems is unclear. We conducted an international prospective, observational, multi-center study in 30 countries in patients undergoing major surgery (> 2-h duration and postoperative intensive care unit (ICU) or high dependency unit admission). The primary endpoint was the occurrence of PO-AKI within 72 h of surgery defined by the Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Secondary endpoints included PO-AKI severity and duration, use of renal replacement therapy (RRT), mortality, and ICU and hospital length of stay. We studied 10,568 patients and 1945 (18.4%) developed PO-AKI (1236 (63.5%) KDIGO stage 1500 (25.7%) KDIGO stage 2209 (10.7%) KDIGO stage 3). In 33.8% PO-AKI was persistent, and 170/1945 (8.7%) of patients with PO-AKI received RRT in the ICU. Patients with PO-AKI had greater ICU (6.3% vs. 0.7%) and hospital (8.6% vs. 1.4%) mortality, and longer ICU (median 2 (Q1-Q3, 1-3) days vs. 3 (Q1-Q3, 1-6) days) and hospital length of stay (median 14 (Q1-Q3, 9-24) days vs. 10 (Q1-Q3, 7-17) days). Risk factors for PO-AKI included older age, comorbidities (hypertension, diabetes, chronic kidney disease), type, duration and urgency of surgery as well as intraoperative vasopressors, and aminoglycosides administration. In a comprehensive multinational study, approximately one in five patients develop PO-AKI after major surgery. Increasing severity of PO-AKI is associated with a progressive increase in adverse outcomes. Our findings indicate that PO-AKI represents a significant burden for health care worldwide

Discutindo a educação ambiental no cotidiano escolar: desenvolvimento de projetos na escola formação inicial e continuada de professores

A presente pesquisa buscou discutir como a Educação Ambiental (EA) vem sendo trabalhada, no Ensino Fundamental e como os docentes desta escola compreendem e vem inserindo a EA no cotidiano escolar., em uma escola estadual do município de Tangará da Serra/MT, Brasil. Para tanto, realizou-se entrevistas com os professores que fazem parte de um projeto interdisciplinar de EA na escola pesquisada. Verificou-se que o projeto da escola não vem conseguindo alcançar os objetivos propostos por: desconhecimento do mesmo, pelos professores; formação deficiente dos professores, não entendimento da EA como processo de ensino-aprendizagem, falta de recursos didáticos, planejamento inadequado das atividades. A partir dessa constatação, procurou-se debater a impossibilidade de tratar do tema fora do trabalho interdisciplinar, bem como, e principalmente, a importância de um estudo mais aprofundado de EA, vinculando teoria e prática, tanto na formação docente, como em projetos escolares, a fim de fugir do tradicional vínculo “EA e ecologia, lixo e horta”.Facultad de Humanidades y Ciencias de la Educació

Atmospheric Plasma Advantages for Mohair Fibers in Textile Applications

WOS: 000280390100007In this study, mohair fibers were treated by air and argon plasma for modifying some properties of fibers. The fibers were evaluated in terms of their hydrophilicity, grease content, fiber to fiber friction, shrinkage, dyeing, and color fastness properties. The surface morphology was characterized by SEM images. The results showed that the atmospheric plasma has an etching effect and increases the functionality of a wool surface, which is evident from SEM and FTIR-ATR analysis. The hydrophilicity, dyeability, fiber friction coefficient, and shrinkage properties of mohair fibers were improved by atmospheric plasma treatment

Design of motor controller water cooling system for a Formula SAE electric racecar

Thesis: S.B., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2019Cataloged from PDF version of thesis.Includes bibliographical references (page 39).This thesis explores the design of a water cooled cold plate system for motor controller used in an FSAE Electric racecar. Models for pressure drop and rate of heat transfer along with the constuction of Computational Fluid Dynamics (CFD) simulations are presented to predict the pressure drop and heat transfer rate. The goal is to provide a framework to design cold plates for motor controllers, along with any other components that generate heat, such as the vehicle battery. A test bench is constructed to validate the results of the models used. Preliminary results show that while such models are useful in understanding the fundamental relationships between different variables and the properties of the flow, it is difficult to construct a model that predicts pressure losses reliably using introductory material on thermodynamics and heat transfer.by Asli Demir.S.B.S.B. Massachusetts Institute of Technology, Department of Mechanical Engineerin