88 research outputs found

    Review on various Pharmaceuticals and their Pharmacology of Anti-repellents- As a Preventive aspect of Vector (mosquito species) borne Disease

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    Mosquito is one of the most vexing bloodsucking insects. Malaria, Filariasis, Japanese Encephalitis, Dengue fever, Yellow fever, Chikungunya, and Zika are all transmitted by mosquito species belonging to the genera Anopheles, Culex, & Aedes. Mosquitoes alone infect almost 700 million people each year, resulting in one million fatalities. Malaria, which is caused by Plasmodium parasites and transmitted by female Anopheles mosquito bites, is still a substantial illness that impacts the development of infants and kids. Present review work aims to review various pharmaceutical dosage forms of anti-repellent products and their molecules, mechanism of repellent activity as a preventive of different vector bone diseases. Malaria cases were over 207 million in 2012, with 627,000 deaths reported. In addition, Yellow fever, which is spread by the Haematologus and Aedes mosquitoes, causes 200,000 instances of disease and 30,000 fatalities worldwide each year. Dengue fever is spread by Aedes aegypti and Aedes albopictus mosquitos, which are responsible for more than 100 million infections yearly. Furthermore, more than 2.5 billion individuals, or about 40% of the world's population, are now in danger of contracting Dengue fever. This review helped to understand the various kinds of vector bone disease and the surveillance of disease data. In addition, the review revealed the various pharmaceutical products would help control the Mosquitoes bits and related disease as preventive aspects and the components of pharmaceutical and their mechanism of action to inhibit the spread of various insects’ related disease

    Simultaneous direct visualisation of liquid water in the cathode and anode serpentine flow channels of proton exchange membrane (PEM) fuel cells

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    Water flooding is detrimental to the performance of the proton exchange membrane fuel cell (PEMFC) and therefore it has to be addressed. To better understand how liquid water affects the fuel cell performance, direct visualisation of liquid water in the flow channels of a transparent PEMFC is performed under different operating conditions. Two high-resolution digital cameras were simultaneously used for recording and capturing the images at the anode and cathode flow channels. A new parameter extracted from the captured images, namely the wetted bend ratio, has been introduced as an indicator of the amount of liquid water present at the flow channel. This parameter, along with another previously used parameter (wetted area ratio), has been used to explain the variation in the fuel cell performance as the operating conditions of flow rates, operating pressure and relative humidity change. The results have shown that, except for hydrogen flow rate, the wetted bend ratio strongly linked to the operating condition of the fuel cell; namely: the wetted bend ratio was found to increase with decreasing air flow rate, increasing operating pressure and increasing relative humidity. Also, the status of liquid water at the anode was found to be similar to that at the cathode for most of the cases and therefore the water dynamics at the anode side can also be used to explain the relationships between the fuel cell performance and the investigated operating conditions

    Intensification of biodiesel processing from waste cooking oil, exploiting cooperative microbubble and bifunctional metallic heterogeneous catalysis

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    Waste resources are an attractive option for economical the production of biodiesel; however, oil derived from waste resource contains free fatty acids (FFA). The concentration of FFAs must be reduced to below 1 wt.% before it can be converted to biodiesel using transesterification. FFAs are converted to fatty acid methyl esters (FAMEs) using acid catalysis, which is the rate-limiting reaction (~4000 times slower than transesterification), with a low conversion as well, in the over biodiesel production process. The study is focused on synthesizing and using a bifunctional catalyst (7% Sr/ZrO2) to carry out esterification and transesterification simultaneously to convert waste cooking oil (WCO) into biodiesel using microbubble-mediated mass transfer technology. The results reveal that a higher conversion of 85% is achieved in 20 min using 7% Sr/ZrO2 for biodiesel production. A comprehensive kinetic model is developed for the conversion of WCO in the presence of a 7% Sr/ZrO2 catalyst. The model indicates that the current reaction is pseudo-first-order, controlled by the vapor–liquid interface, which also indicates the complex role of microbubble interfaces due to the presence of the bifunctional catalyst. The catalyst could be recycled seven times, indicating its high stability during biodiesel production. The heterogeneous bifunctional catalyst is integrated with microbubble-mediated mass transfer technology for the first time. The results are unprecedented; furthermore, this study might be the first to use microbubble interfaces to “host” bifunctional metallic catalysts. The resulting one-step process of esterification and transesterification makes the process less energy-intensive and more cost-efficient, while also reducing process complexity

    Simultaneous thermal and visual imaging of liquid water of the PEM fuel cell flow channels

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    Water flooding and membrane dry-out are two major issues that could be very detrimental to the performance and/or durability of the proton exchange membrane (PEM) fuel cells. The above two phenomena are well-related to the distributions of and the interaction between the water saturation and temperature within the membrane electrode assembly (MEA). To obtain further insights into the relation between water saturation and temperature, the distributions of liquid water and temperature within a transparent PEM fuel cell have been imaged using high-resolution digital and thermal cameras. A parametric study, in which the air flow rate has been incrementally changed, has been conducted to explore the viability of the proposed experimental procedure to correlate the relation between the distribution of liquid water and temperature along the MEA of the fuel cell. The results have shown that, for the investigated fuel cell, more liquid water and more uniform temperature distribution along MEA at the cathode side are obtained as the air flow rate decreases. Further, the fuel cell performance was found to increase with decreasing air flow rate. All the above results have been discussed

    Form factors and branching ratio for the B -> l nu gamma decay

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    Form factors parameterizing radiative leptonic decays of heavy mesons (B+γl+νl)% (B^{+}\to \gamma l^{+}\nu_{l}) for photon energy are computed in the language of dispersion relation. The contributing states to the absorptive part in the dispersion relation are the multiparticle continum, estimated by quark triangle graph and resonances with quantum numbers 11^{-} and 1+1^{+} which includes BB^{*} and BAB_{A}^{*} and thier radial excitations, which model the higher state contributions. Constraints provided by the asymptotic behavior of the structure dependent amplitude, Ward Identities and gauge invariance are used to provide useful information for parameters needed. The couplings gBBγg_{BB^{*}\gamma} and % f_{BB_{A}^{*}\gamma} are predicted if we restrict to first radial excitation; otherwise using these as an input the radiative decay coupling constants for radial excitations are predicted. The value of the branching ratio for the process B+γμ+νμB^{+}\to \gamma \mu ^{+}\nu_{\mu} is found to be in the range 0.5×1060.5\times 10^{-6}. A detailed comparison is given with other approaches.Comment: 22 pages+two ps figures; Paper has been throughly revised and Sudakov resummation has been discussed; published versio

    Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970–2016: a systematic analysis for the Global Burden of Disease Study 2016

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    BACKGROUND: Detailed assessments of mortality patterns, particularly age-specific mortality, represent a crucial input that enables health systems to target interventions to specific populations. Understanding how all-cause mortality has changed with respect to development status can identify exemplars for best practice. To accomplish this, the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) estimated age-specific and sex-specific all-cause mortality between 1970 and 2016 for 195 countries and territories and at the subnational level for the five countries with a population greater than 200 million in 2016. METHODS: We have evaluated how well civil registration systems captured deaths using a set of demographic methods called death distribution methods for adults and from consideration of survey and census data for children younger than 5 years. We generated an overall assessment of completeness of registration of deaths by dividing registered deaths in each location-year by our estimate of all-age deaths generated from our overall estimation process. For 163 locations, including subnational units in countries with a population greater than 200 million with complete vital registration (VR) systems, our estimates were largely driven by the observed data, with corrections for small fluctuations in numbers and estimation for recent years where there were lags in data reporting (lags were variable by location, generally between 1 year and 6 years). For other locations, we took advantage of different data sources available to measure under-5 mortality rates (U5MR) using complete birth histories, summary birth histories, and incomplete VR with adjustments; we measured adult mortality rate (the probability of death in individuals aged 15-60 years) using adjusted incomplete VR, sibling histories, and household death recall. We used the U5MR and adult mortality rate, together with crude death rate due to HIV in the GBD model life table system, to estimate age-specific and sex-specific death rates for each location-year. Using various international databases, we identified fatal discontinuities, which we defined as increases in the death rate of more than one death per million, resulting from conflict and terrorism, natural disasters, major transport or technological accidents, and a subset of epidemic infectious diseases; these were added to estimates in the relevant years. In 47 countries with an identified peak adult prevalence for HIV/AIDS of more than 0·5% and where VR systems were less than 65% complete, we informed our estimates of age-sex-specific mortality using the Estimation and Projection Package (EPP)-Spectrum model fitted to national HIV/AIDS prevalence surveys and antenatal clinic serosurveillance systems. We estimated stillbirths, early neonatal, late neonatal, and childhood mortality using both survey and VR data in spatiotemporal Gaussian process regression models. We estimated abridged life tables for all location-years using age-specific death rates. We grouped locations into development quintiles based on the Socio-demographic Index (SDI) and analysed mortality trends by quintile. Using spline regression, we estimated the expected mortality rate for each age-sex group as a function of SDI. We identified countries with higher life expectancy than expected by comparing observed life expectancy to anticipated life expectancy on the basis of development status alone. FINDINGS: Completeness in the registration of deaths increased from 28% in 1970 to a peak of 45% in 2013; completeness was lower after 2013 because of lags in reporting. Total deaths in children younger than 5 years decreased from 1970 to 2016, and slower decreases occurred at ages 5-24 years. By contrast, numbers of adult deaths increased in each 5-year age bracket above the age of 25 years. The distribution of annualised rates of change in age-specific mortality rate differed over the period 2000 to 2016 compared with earlier decades: increasing annualised rates of change were less frequent, although rising annualised rates of change still occurred in some locations, particularly for adolescent and younger adult age groups. Rates of stillbirths and under-5 mortality both decreased globally from 1970. Evidence for global convergence of death rates was mixed; although the absolute difference between age-standardised death rates narrowed between countries at the lowest and highest levels of SDI, the ratio of these death rates-a measure of relative inequality-increased slightly. There was a strong shift between 1970 and 2016 toward higher life expectancy, most noticeably at higher levels of SDI. Among countries with populations greater than 1 million in 2016, life expectancy at birth was highest for women in Japan, at 86·9 years (95% UI 86·7-87·2), and for men in Singapore, at 81·3 years (78·8-83·7) in 2016. Male life expectancy was generally lower than female life expectancy between 1970 and 2016, an
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