Yaws

Introduction Yaws, caused by Treponema pallidum ssp. pertenue, is endemic in parts of West Africa, Southeast Asia and the Pacific. The WHO has launched a campaign based on mass treatment with azithromycin, to eradicate yaws by 2020. Sources of data We reviewed published data, surveillance data and data presented at yaws eradication meetings. Areas of agreement Azithromycin is now the preferred agent for treating yaws. Point-of-care tests have demonstrated their value in yaws. Areas of controversy There is limited data from 76 countries, which previously reported yaws. Different doses of azithromycin are used in community mass treatment for yaws and trachoma. Growing points Yaws eradication appears an achievable goal. The programme will require considerable support from partners across health and development sectors. Areas timely for developing research Studies to complete baseline mapping, integrate diagnostic tests into surveillance and assess the impact of community mass treatment with azithromycin are ongoing

Re-Evaluation of Yam Mosaic Virus (YMV) Detection Methods

Accurate and timely detection is vital for mitigation of tuber yield losses resulting from yam mosaic virus (YMV) infection on yam, a major food security crop in West Africa. The observation, from our previous studies, that the triple antibody sandwich enzyme-linked immunosorbent assay (TAS-ELISA), the most commonly used detection method for YMV, detected the virus in significantly less leaf samples than immunocapture reverse transcription polymerase chain reaction (IC-RT-PCR) necessitated a re-evaluation of YMV detection methods. In the present study, eighteen previously tested YMV positive leaf samples from Benin and Ghana were re-tested using TAS-ELISA, Protein A-sandwich (PAS) ELISA and IC-RT-PCR. Three sap dilutions, 1/10, 1/50 and 1/100, were tested for each sample. Both at 1/10 and 1/50 dilutions, PAS-ELISA and IC-RT-PCR detected YMV in 11 (61.1%) and 12 (66.7%) of the leaves respectively. Virus detection by PAS-ELISA reduced to 50% at 1/100 sap dilution and increased to 77.8% in IC-RT-PCR. YMV detection by TAS-ELISA varied between 38.9% and 16.7% at 1/10 and 1/100 dilutions respectively. These results indicate a deficiency in the use of TAS-ELISA as a sole YMV certification method since the detecting monoclonal antibody used in this assay may be strain specific. The use of PAS-ELISA at a 1/10 sap dilution is suggested for YMV detection where the facilities for molecular detection are unavailabl

Evaluation of multi-stress tolerant maize varieties for sustainable intensification in Northern Guinea Savanna of north eastern Nigeria

Maize productivity is limited by multiple stresses in the savannas of West and Central Africa. Field trials were conducted in northern Guinea savanna of Nigeria in 2011 and 2012 to evaluate the performance of multi-stress tolerant maize varieties. Thirteen varieties including Local Check replicated three times were tested in randomized complete block design. Plant and ear heights were significantly higher for LNTP x LNP-WC3 and 2004 TZE-W DT-STRC4 than POOL 18-SR, 2009 TZE-W POP-STR, EVDT 99-W STR; and EVDT 2000-Y STRQPM, respectively. Striga count was significantly lower for EVDT 99-W STR and LNTP x LNP-WC3 than all the other entries. Days to 50% tassel and 50% silk were each significantly earlier for EVDT 99STR W-STR QPM, DT-W STR SYN, EVDT-99W STR and 2009 TZEW DT STR than the Local Check. Anthesis Silk Interval (ASI) was significantly lower for TZE COMP3 DT-WC2, 2009 TZEW DT STR, and EVDT 99-W STR than Local Check. Number of ears plant-1 was sig¬nificantly higher for 2008 DTMA-Y STR than Local Check. Grain yield ha-1 was significantly superior for DT-Y STR SYN, 2008 DTMA-Y STR, 2004 TZE-W DTSTR C4, 2009 TZEW DT STR and EVDT 99-W STRQPM, respectively. Plant height was positively correlated with ASI and ear height, while ear height was positively associated with ears plant-1, days to 50% silk and 50% tassel. Grain yield ha-1 was positively correlated with ears plant-1, days to 50 % silk, days to 50% tassel and ear height, while ears plant-1 was negatively correlated with ear weight. Farmer selec¬tion criteria for acceptance of variety were in the order: Striga tolerance > nutrient value > drought tolerance > flour value > good taste > high yield > early maturity. The five varieties: DTY STR SYN, 2008 DTMA-Y STR, 2004 TZE-W DT STRC4, 2009 TZEW DT STR and EVDT 99-W STRQPM satisfied farmers criteria and were promising and thus nominated for on-farm demonstration and subsequent adoption in the region

Reactive vaccination as a control strategy for pneumococcal meningitis outbreaks in the African meningitis belt: analysis of outbreak data from Ghana

Streptococcus pneumoniae is increasingly recognised as an important cause of bacterial meningitis in the African meningitis belt. The World Health Organization sets guidelines for response to outbreaks of meningococcal meningitis, but there are no current guidelines for outbreaks where S. pneumoniae is implicated. We aimed to evaluate the impact of using a similar response to target outbreaks of vaccine-preventable pneumococcal meningitis in the meningitis belt. Here, we adapt a previous model of reactive vaccination for meningococcal outbreaks to estimate the potential impact of reactive vaccination in a recent pneumococcal meningitis outbreak in the Brong-Ahafo region of central Ghana using weekly line list data on all suspected cases over a period of five months. We determine the sensitivity and specificity of various epidemic thresholds and model the cases and deaths averted by reactive vaccination. An epidemic threshold of 10 suspected cases per 100,000 population per week performed the best, predicting large outbreaks with 100% sensitivity and more than 85% specificity. In this outbreak, reactive vaccination would have prevented a lower number of cases per individual vaccinated (approximately 15,300 doses per case averted) than previously estimated for meningococcal outbreaks. Since the burden of death and disability from pneumococcal meningitis is higher than that from meningococcal meningitis, there may still be merit in considering reactive vaccination for outbreaks of pneumococcal meningitis. More outbreak data are needed to refine our model estimates. Whatever policy is followed, we emphasize the importance of timely laboratory confirmation of suspected cases to enable appropriate decisions about outbreak response.LVC is supported by a studentship from Trinity Hall College

The Cost of Annual versus Biannual Community-Directed Treatment of Onchocerciasis with Ivermectin: Ghana as a Case Study

BACKGROUND: It has been proposed that switching from annual to biannual (twice yearly) mass community-directed treatment with ivermectin (CDTI) might improve the chances of onchocerciasis elimination in some African foci. However, historically, relatively few communities have received biannual treatments in Africa, and there are no cost data associated with increasing ivermectin treatment frequency at a large scale. Collecting cost data is essential for conducting economic evaluations of control programmes. Some countries, such as Ghana, have adopted a biannual treatment strategy in selected districts. We undertook a study to estimate the costs associated with annual and biannual CDTI in Ghana. METHODOLOGY: The study was conducted in the Brong-Ahafo and Northern regions of Ghana. Data collection was organized at the national, regional, district, sub-district and community levels, and involved interviewing key personnel and scrutinizing national records. Data were collected in four districts; one in which treatment is delivered annually, two in which it is delivered biannually, and one where treatment takes place biannually in some communities and annually in others. Both financial and economic costs were collected from the health care provider's perspective. PRINCIPAL FINDINGS: The estimated cost of treating annually was US Dollars (USD) 0.45 per person including the value of time donated by the community drug distributors (which was estimated at USD 0.05 per person per treatment round). The cost of CDTI was approximately 50–60% higher in those districts where treatment was biannual than in those where it was annual. Large-scale mass biannual treatment was reported as being well received and considered sustainable. CONCLUSIONS/SIGNIFICANCE: This study provides rigorous evidence of the different costs associated with annual and biannual CDTI in Ghana which can be used to inform an economic evaluation of the debate on the optimal treatment frequency required to control (or eliminate) onchocerciasis in Africa

Enhancing crop productivity through community-based seed multiplication system

Improved quality seeds out-yield farmers' saved seeds significantly. However, the limited availability of such seeds through the conventional seed supply system is due to socio-economic factors and inadequacy of skilled personnel and infrastructure. A community-based seed multiplication system was, therefore, adopted and small seed stocks of soybean, cowpea and yam were distributed to farmer groups in the rural communities in northern Ghana, northern Nigeria and central Togo, respectively, between 1996 and 1999 for further multiplication. An impact assessment after 4 years showed a significant ease of farmers' access to improved seeds and development of linkages with pesticide dealers, credit sources, and extension services as a result of opting for this system. Quality of farmers' saved seeds had improved and farmers' yield had increased over 90 per cent. Extra incomes earned were used to purchase household items, and part invested in transport businesses and rearing of small ruminants as well as in human capital such as paying children's school fees and family hospital bills and meeting other social responsibilities. This system was, therefore, effective in diffusing improved seeds and associated technologies and services to many more farmers and communities within a very short time to improve their socio-economic status.Les graines de qualité améliorée dépassaient considérablement en rendement les graines gardées par les agriculteurs. Cependant, la disponibilité de telles graines par le système conventionnel de provision de graine est limitée en raison de facteurs socio-économiques, l'insuffisance de personnel qualifié et l'infrastructure. Un système de multiplication de graine basé à la communauté était donc adopté et une petite quantité de stocks de graine de soja, de dolique et d'igname étaient distribués aux groupes d'agriculteurs dans les communautés rurales dans le nord du Ghana, le nord du Nigéria et le centre du Togo respectivement entre les années 1996 et 1999 pour de multiplication davantage. L'évaluation d'impact entreprise après quatre années montrait une aisance considérable avec laquelle les agriculteurs avaient accès aux graines améliorées et aux liens de développement avec les marchands de pesticide, les lignes de crédit et les services de vulgarisation agricole à la suite d' opter pour ce système. La qualité de graines gardées par les agriculteurs avait amélioré et les rendements d'agriculteurs avaient augmenté plus de 90%. Les suppléments de revenus gagnés étaient dépensés pour les articles ménagers, et une partie du revenun était investie en entreprises de transport et en élévage de petits ruminants ainsi qu'en ressources humaines telles que le paiement de frais de scolarité de la jeunesse, les factures hospitalières et pour régler d'autres responsabilités sociales. Ce système était donc efficace pour la distribution de graines améliorées et la vulgarisation de services et de technologies liées à l'agriculture à beaucoup plus d'agriculteurs et aux communautés dans très peu de temps pour améliorer leur situation socio-économique. Ghana Journal of Agricultural Science Vol. 39 (2) 2006: pp. 181-18