Dietary nitrate does not have an effect on physical activity outcomes in healthy older adults : a randomized, cross-over trial

Dietary nitrate (〖NO〗_3^-) ingestion appears to enhance exercise capacity and performance in young individuals whereas inconclusive findings have been reported in older people. We conducted a double-blind, cross-over randomized clinical trial in older normal weight and overweight healthy participants testing whether beetroot juice (a rich source of 〖NO〗_3^-) for one week may increase nitric oxide bioavailability via the non-enzymatic pathway and enhance 1) exercise capacity during an incremental exercise test, 2) physical capability and 3) free-living physical activity. Twenty non-smoking healthy participants aged 60-75y and BMI 20.0-29.9kg/m2 were included. Pre and post supplementation resting, sub-maximal, maximal and recovery gas exchanges were measured. Physical capability was measured by hand-grip strength (HGS), time-up-and-go (TUG), repeated-chair-rising-test (RCRT), and 10m walking speed (WLS). Free-living physical activity was assessed by triaxal accelerometry. Changes in urinary and plasma 〖NO〗_3^- concentrations were measured by gas chromatography mass spectrometry. Nineteen participants (M/F=9/10) completed the study. Beetroot juice increased significantly both plasma and urinary 〖NO〗_3^- concentrations (p<0.001) compared to placebo. Beetroot juice did not influence resting, sub-maximal and maximal oxygen consumption during the incremental exercise test. In addition, measures of physical capability and physical activity levels measured in free-living conditions were not modified by beetroot juice ingestion. The positive effects of beetroot juice ingestion on exercise performance seen in young individuals were not replicated in healthy, older adults. Whether aging represents a modifier of the effects of dietary 〖NO〗_3^- on muscular performance is not known and mechanistic studies and larger trials are needed to test this hypothesis. Keywords: inorganic nitrate, nitric oxide, exercise, oxygen consumption, agin

Dietary nitrate does not affect physical activity outcomes in health older adults in a randomized, crossover trial

Although dietary nitrate (NO3−) ingestion appears to enhance exercise capacity and performance in young individuals, inconclusive findings have been reported in older people. Therefore, we conducted a double-blind, crossover randomized clinical trial using beetroot juice in older healthy participants, who were classified as normal weight and overweight. We tested whether consumption of beetroot juice (a rich source of NO3−) for 1 week would increase nitric oxide bioavailability via the nonenzymatic pathway and enhance (1) exercise capacity during an incremental exercise test, (2) physical capability, and (3) free-living physical activity. Twenty nonsmoking, healthy participants between 60 and 75 years of age and with a body mass index of 20.0 to 29.9 kg/m2 were included. Presupplementation and postsupplementation resting, submaximal, maximal, and recovery gas exchanges were measured. Physical capability was measured by hand-grip strength, time-up-and-go, repeated chair rising test, and 10-m walking speed. Free-living physical activity was assessed by triaxal accelerometry. Changes in urinary and plasma NO3− concentrations were measured by gas chromatography–mass spectrometry. Nineteen participants (male-to-female ratio, 9:10) completed the study. Beetroot juice increased significantly both plasma and urinary NO3− concentrations (P < .001) when compared with placebo. Beetroot juice did not influence resting or submaximal and maximal oxygen consumption during the incremental exercise test. In addition, measures of physical capability and physical activity levels measured in free-living conditions were not modified by beetroot juice ingestion. The positive effects of beetroot juice ingestion on exercise performance seen in young individuals were not replicated in healthy, older adults. Whether aging represents a modifier of the effects of dietary NO3− on muscular performance is not known, and mechanistic studies and larger trials are needed to test this hypothesis

Ageing modifies the effects of beetroot juice supplementation on 24-hour blood pressure variability: An individual participant meta-analysis.

Abnormal circadian oscillations of blood pressure (BP) and nocturnal-diurnal BP differences (i.e., dipping) increase cardiovascular risk. Whether inorganic nitrate supplementation influences 24-hr BP variability is currently unknown. We studied the effects of high-nitrate beetroot juice supplementation on BP variability measured by 24-hr ambulatory BP monitoring (24-hr ABPM) in older subjects