Investigation of environmental effects on coatings for thermal control

Accomplishments made during study of coatings are reported. Development of structure/property theory for selecting most appropriate pigments for space vehicle paints is discussed along with improvements made in zinc-oxide pigmented potassium silicate paint

The Age Evolution of the Radio Morphology of Supernova Remnants

Recent hydrodynamical models of supernova remnants (SNRs) demonstrate that their evolution depends heavily on the inhomogeneities of the surrounding medium. As SNRs expand, their morphologies are influenced by the non-uniform and turbulent structure of their environments, as reflected in their radio continuum emission. In this paper, we measure the asymmetries of 96 SNRs in radio continuum images from three surveys of the Galactic plane and compare these results to the SNRs' radii, which we use as a proxy for their age. We find that larger (older) SNRs are more elliptical/elongated and more mirror asymmetric than smaller (younger) SNRs, though the latter vary in their degrees of asymmetry. This result suggests that SNR shells become more asymmetric as they sweep up the interstellar medium (ISM), as predicted in hydrodynamical models of SNRs expanding in a multi-phase or turbulent ISM.Comment: 16 pages, 5 figures, accepted by ApJ; sample expanded from 22 to 96 source

Analysis of Inclined Shear Waves in Vertical Bluffs

The effect of inclined shear waves on the seismic response of vertical bluffs is analyzed using the generalized hyperelement. The bluffs are modeled as a stepped halfspace in the frequency domain. It is shown that the response, normalized as a function of slope height (H) divided by wavelength (λ), is amplified for waves travelling into the slope and attenuation for waves travelling away from the slope. This amplification can be as much as twice the amplification for vertically propagating waves. The results of the analysis suggest that wave orientation and inclination in relation to the slope may need to be considered in performing stability analyses

Development of a space stable thermal control coatings for use in large space vehicles

The preparation and evaluation of zinc orthotitanate and of several new pigments and the environmental testing and evaluation of these pigments and of coatings made from them constitute the bulk of the work accomplished. New pigments were prepared and EPR spectra of pigments and their precursor compounds studied. Results of extensive testing of commercially-available, strippable, protective coatings are reported; Owens-Illinois 650 glass resin has been stabilized against progressive mechanical failures; and definite improvements have been noted. A zinc oxide pigmented lithium silicate paint has demonstrated very good ultraviolet stability

Development of space stable thermal control coatings for use on large space vehicles

The evaluation and environmental testing of zinc orthotitanate pigments for use as space stable thermal control coatings on large space vehicles are discussed. Electron paramagnetic resonance spectra of the pigments and their precursor compounds are examined. A continuing study of the spectral intensity of mercury-argon and mercury-xenon sources in reported. Results of long term environmental testing of commercially available, strippable, protective coatings are discussed

Workers' Compensation

Apresentação do tema em debate sobre a "qualidade da vida"

Exploiting Opportunities for Pollution Prevention in EPA Enforcement Agreements

Two relatively new EPA policies encourage the inclusion of pollution prevention in regulatory enforcement settlements. The advantages to a firm include reduction or elimination of environmental problems at the source (thus decreasing reliance on end-of-pipe controls), enhanced prospects for future compliance, and a potential for a reduction in the assessed penalty. We discuss the factors that influence both EPA and firms to include pollution prevention in enforcement settlements, characterize the process in a few exemplary cases, and recommend ways to enhance and expand these activities. The research presented focused on case study analysis of 10 recent EPA-negotiated enforcement settlements that included chemical substitutions, process changes, or closed-loop recyclin

Empirical approaches for the investigation of toxicant-induced loss of tolerance.

It has been hypothesized that sensitivity to low-level chemical exposures develops in two steps: initiation by an acute or chronic chemical exposure, followed by triggering of symptoms by low levels of previously tolerated chemical inhalants, foods, or drugs. The Working Group on Toxicant-induced Loss of Tolerance has formulated a series of research questions to test this hypothesis: Do some individuals experience sensitivity to chemicals at levels of exposure unexplained by classical toxicological thresholds and dose-response relationships, and outside normally expected variation in the population? Do chemically sensitive subjects exhibit masking that may interfere with the reproducibility of their responses to chemical challenges? Does chemical sensitivity develop because of acute, intermittent, or continuous exposure to certain substances? If so, what substances are most likely to initiate this process? An experimental approach for testing directly the relationship between patients' reported symptoms and specific exposures was outlined in response to the first question, which was felt to be a key question. Double-blind, placebo-controlled challenges performed in an environmentally controlled hospital facility (environmental medical unit) coupled with rigorous documentation of both objective and subjective responses are necessary to answer this question and to help elucidate the nature and origins of chemical sensitivity

CD44 targeted delivery of siRNA by using HA-decorated nanotechnologies for KRAS silencing in cancer treatment

KRAS is a small GTPase that regulates cell proliferation and survival. In tumors, the KRAS gene is mutated, and leading to unregulated tumor growth. Despite the recognized importance of KRAS in cancer, attempts to develop small molecule inhibitors have proved unsuccessful. An alternative strategy is gene silencing and the use of small nucleic acid sequences (e.g. siRNA, shRNA), has been reported to successfully downregulate KRAS. In this study we developed ternary nanocomplexes to deliver an anti-KRAS siRNA to colorectal cancer cells, exploiting the interaction of hyaluronic acid (HA) with CD44 as a means to achieve selective targeting of CD44-positive cancer cells. Two different polycations, poly(hexamethylene biguanide) and chitosan, were complexed with siRNA and coated with HA. Physico-chemical properties and stability of nanoparticles were characterized, including size, surface charge, and degree of siRNA protection. We demonstrate nanoparticle internalization (flow cytometry), siRNA cytosolic release (confocal microscopy) and KRAS silencing (RT-qPCR) in CD44+/KRAS+ colorectal cancer cell line, HCT-116. Further we demonstrate that the uptake of HA-decorated nanoparticles in cancer cells is higher when co-cultured with fibroblasts