12 research outputs found
Pharmacists in Pharmacovigilance: Can Increased Diagnostic Opportunity in Community Settings Translate to Better Vigilance?
- Author
- AG Granas
- AI Wertheimer
- B Gray
- C Gonzalez-Gonzalez
- C Su
- Christine Randall
- Consumers’ Association
- Consumers’ Association
- Consumers’ Association
- D Brown
- D Stewart
- David Brown
- DM Ashcroft
- E Horsley
- E Kroger
- E Richardson
- G Marchildon
- GD Lansam
- JK Jesson
- Justine Howard
- K Grootheest van
- KB Blake
- L Emmerton
- L Hanna
- M Jadeja
- M Rosenthal
- M Tobaiqy
- MA Hadi
- MP Smith
- N Black
- N Iqbal
- P Chan
- P Gavaza
- P Rutter
- Paul Rutter
- S Keyhani
- SS Sardas
- T Kimura
- V Paudyal
- Z Austin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 20/06/2014
- Field of study
The pharmacy profession has undergone substantial change over the last two to three decades. Whilst medicine supply still remains a central function, pharmacist’s roles and responsibilities have become more clinic and patient focused. In the community (primary care), pharmacists have become important providers of healthcare as Western healthcare policy advocates patient self-care. This has resulted in pharmacists taking on greater responsibility in managing minor illness and the delivery of public health interventions. These roles require pharmacists to more fully use their clinical skills, and often involve diagnosis and therapeutic management. Community pharmacists are now, more than ever before, in a position to identify, record and report medication safety incidents. However, current research suggests that diagnostic ability of community pharmacists is questionable and they infrequently report to local or national schemes. The aim of this paper is to highlight current practice and suggest ways in which community pharmacy can more fully contribute to patient safety
Filing Suit, or Legal Paperwork
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
The Curious Incident of the Falling Win Rate
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
The Just-Barely-Sustainable California Prisonerss Rights Ecosystem
- Author
- Ashcroft V Iqbal
- Ashker V Brown
- Carrillo V. Zunggeemoge
- Castillo V. Alameida
- Christina L Boyd
- Clark V Wilson
- Coleman V Brown
- E Carson
- Estate Of Bock V
- Farrell V Harper
- Gates V Deukmejian
- Gray V
- Hadsell Stormer
- Hall V Mims
- Harrison N D Barnes
- Harvard Law School
- Hecker V
- Herbert Kritzer
- Hernandez V. Kalinowski
- Hudson V Dennehy
- Jack Leonard
- Johnson V
- Ketchum V Moses
- L H V Schwarzenegger
- Lancaster V. Tilton
- Lee Epstein
- Llp Rosen Bien Galvan &
- Madrid V Gomez
- Margo Schlanger
- Margo Schlanger
- Margo Schlanger
- Margo Schlanger
- Margo Schlanger
- Mayfield V Orozco
- Mclane Kaye
- Michael Simkovic
- Mitchell V Cate
- Myriam Gilles
- Perdue V Kenny
- Perez V Tilton
- Plata V Brown
- Prasad V Estate Of
- Prison Law Office
- Robert Faturechi
- Rosas V Baca
- Samuel R Bagenstos
- Scott L Cummings
- Scott L Cummings
- Shumate V Wilson
- Stephen Daniels
- Todd D Minton
- Toussaint V Mccarthy
- U
- U S C
- U S C
- U S C
- U S Census
- Valdivia V Davis
- Wal-Mart Stores
- Woodford V Ngo
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2015
- Field of study
Comprehensive Proteomic Study Identifies Serpin and Cystatin Antiproteases as Novel Correlates of HIV-1 Resistance in the Cervicovaginal Mucosa of Female Sex Workers
- Author
- A. Burgener
- Anderson B. L.
- Ashcroft G. S.
- Ashcroft G. S.
- Ashton-Rickardt P. G.
- Askew D. J.
- Ball T. B.
- Bantscheff M.
- Benarafa C.
- Bingle C. D.
- Bryan C. L.
- Burgener A.
- C. Mesa
- C. Wachihi
- Card C. M.
- Challacombe S. J.
- Chen C. H.
- Chertov O.
- Congote L. F.
- Congote L. F.
- El Messaoudi K.
- Elmaleh D. R.
- F. Plummer
- Fahey J. V.
- Fowke K. R.
- Garber D. A.
- Hasan L.
- Hashemi F. B.
- Herrick S.
- Heutinck K. M.
- Hirbod T.
- Horton R. E.
- Iqbal S. M.
- Iqbal S. M.
- J. Kimani
- J. Lajoie
- Janciauskiene S.
- Jayakumar A.
- Jensen L. E.
- K. Fowke
- Kaul R.
- Kaul R.
- Kramer H. B.
- Law R. H.
- Li Q.
- Lim J. K.
- Mangan M. S.
- McLaren P. J.
- McNeely T. B.
- Miller C. J.
- Moriuchi H.
- Munch J.
- Nita I. M.
- Oelschlager C.
- Pott G. B.
- Potthoff A. V.
- R. Ahmad
- Remold-O’Donnell E.
- Rerks-Ngarm
- S. Brunet
- S. Carr
- S. Rahman
- S. Ramdahin
- Sambrano G. R.
- Schellenberg J. J.
- Schick C.
- Shapiro L.
- Shattock R. J.
- Silverman G. A.
- Silverman G. A.
- Simonsen J. N.
- Subramaniyam D.
- T. B. Ball
- Taggart C. C.
- van Gent D.
- Venkataraman N.
- Virgin H. W.
- Whisstock J. C.
- Wilson T. J.
- Zhou X.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
Temperature Dependence of the Band-Gap Energy and Sub-Band-Gap Absorption Tails in Strongly Quantized ZnSe Nanocrystals Deposited as Thin Films
- Author
- Abay B.
- Abay B.
- Abay B.
- Abay B.
- Abay B.
- Abay B.
- Abay B.
- Adachi S.
- Adachi S.
- Artemyev M. V.
- Artemyev M. V.
- Artemyev M. V.
- Artemyev M. V.
- Ashcroft N. W.
- Ate A.
- Badr Y.
- Baldereschi A.
- Bauer S.
- Berger J. M.
- Callister W. D.
- Chestnoy N.
- Cody G. D.
- Cody G. D.
- Collier C. P.
- Coulibaly S. P.
- Cui J.
- Dalven R.
- Desnica D. I.
- Empedocles S. A.
- Fritze M.
- Gindele F.
- Gorer S.
- Grein C. H.
- Iqbal Z.
- Jarzbek B.
- Kagan C. R.
- Kagan C. R.
- Kim B. S.
- Kim B. S.
- Kim C. C.
- Kim D. E.
- Klingshirn C. F.
- Kranjcec M.
- Kranjec M.
- Kranjec M.
- Landman U.
- Lin S.
- Martienssen W.
- Medvedkin G. A.
- Meeder A.
- Melsheimer J.
- Memming R.
- Micic O. I.
- Mullins J. T.
- Nakata H.
- Nesheva D.
- Novoselova A. B.
- Ohring M.
- Ohtake Y.
- Pankove J. I.
- Pejova B.
- Pejova B.
- Pejova B.
- Pejova B.
- Pejova B.
- Pejova B.
- Pejova B.
- Pejova B.
- Pejova B.
- Pejova B.
- Pejova B.
- Pejova B.
- Pejova B.
- Pejova B.
- Pejova B.
- Pramanik P.
- Rai B. K.
- Rakhshani A. E.
- Rakhshani A. E.
- Richter H.
- Saitoh A.
- Seeger K.
- Seeger K.
- Shioda T.
- Stokes A. R.
- Studenyak I. P.
- Studenyak I. P.
- Studenyak I. P.
- Takemura Y.
- Tews R.
- Turner A. K.
- Urbach F.
- Varshni Y. P.
- Vijaya Prakash G.
- Wasim S. M.
- Wasim S. M.
- Wasim S. M.
- Weinstein I. A.
- Weller M. T.
- Yang Z.
- Yoffe A. D.
- Yoffe A. D.
- Yu P. Y.
- Zi J.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
BJS commission on surgery and perioperative care post-COVID-19
- Author
- Abahuje E.
- Abbas A.
- Abd el Aziz Abd el Maksoud M.
- Abdelhady A.
- Abdelhamid S.
- Abdelkarem Ahmed Faraj H.
- Abdelqader B.
- Abdelrahman T.
- Abdou H.
- Abdullah A.
- Abedua Harrison M.
- Abem Owusu E.
- Aboalazayem A.
- Aboulhosn R.
- Abu Oda S.
- Abubakar A.
- Abutaka A.
- Acevedo Fontalvo D.
- Acuna S.
- Adefemi A.
- Adegbola S.
- Adenuga T.
- Adeyeye A.
- Adil Hilmi A.
- Adisa A.
- Aditya K.
- Adjeso T.
- Aftab R.
- Afzal A.
- Aggarwal A.
- Aggarwal V.
- Aguilera R.
- Aguilera-Arévalo M. L.
- Aguirre Salamanca E. J.
- Aguirre-Allende I.
- Ahari D.
- Ahmad Rauf F.
- Ahmad Zartasht Khan A.
- Ahmad H.
- Ahmed Fieturi N.
- Ahmed Mohamed S.
- Ahmed S.
- Ahmed-Bakhsh Z.
- Ahsan Javed M.
- Akano L.
- Akbar A.
- Akhbari M.
- Akhmedov P.
- Aksit G.
- Akula Y.
- Al Majid S.
- Al Mukhtar O.
- Al Omran H.
- Al-Azzawi M.
- Al-Habsi R.
- Al-Hasan A. J. M. S.
- Al-Iraqi H.
- Al-Naggar H.
- Alagaratnam A. S.
- Alameer E.
- AlAsali N.
- Albirnawi H.
- Alderson D.
- Aldulaijan F.
- Alejandro Miranda Ojeda R.
- AlHasan A.
- Ali Khan M.
- Ali A.
- Ali S.
- Alimova Y.
- Aljanadi F.
- Aljubure R.
- Allopi N.
- Almedbal H.
- Almubarak M.
- Alqaidoom Z.
- Alselaim N.
- Alshaar M.
- Alshammari R.
- Altaf K.
- Altiner S.
- Altunpak B.
- Alvarez Lozada L. A.
- Amal Nahal E.
- Amer A.
- Amin K.
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- Amisi Numbi N.
- Amjad T.
- Amoah R.
- An Y.
- Anastasopoulos N. A.
- Andrés Urrutia J.
- Angarita F.
- Angarita K. L.
- Antypas A.
- Anwar H.
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- Apampa T. O.
- Apostolou K.
- Aquina C.
- Arachchige Adithi Himika Randeni R.
- Archila Godínez M. I.
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- Ángel Freiría Eiras M.
- Öhlberger L.
- Ölçüm M.
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2021
- Field of study
Background: Coronavirus disease 2019 (COVID-19) was declared a pandemic by the WHO on 11 March 2020 and global surgical practice was compromised. This Commission aimed to document and reflect on the changes seen in the surgical environment during the pandemic, by reviewing colleagues experiences and published evidence. Methods: In late 2020, BJS contacted colleagues across the global surgical community and asked them to describe how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had affected their practice. In addition to this, the Commission undertook a literature review on the impact of COVID-19 on surgery and perioperative care. A thematic analysis was performed to identify the issues most frequently encountered by the correspondents, as well as the solutions and ideas suggested to address them. Results: BJS received communications for this Commission from leading clinicians and academics across a variety of surgical specialties in every inhabited continent. The responses from all over the world provided insights into multiple facets of surgical practice from a governmental level to individual clinical practice and training. Conclusion: The COVID-19 pandemic has uncovered a variety of problems in healthcare systems, including negative impacts on surgical practice. Global surgical multidisciplinary teams are working collaboratively to address research questions about the future of surgery in the post-COVID-19 era. The COVID-19 pandemic is severely damaging surgical training. The establishment of a multidisciplinary ethics committee should be encouraged at all surgical oncology centres. Innovative leadership and collaboration is vital in the post-COVID-19 era
Evaluation of prognostic risk models for postoperative pulmonary complications in adult patients undergoing major abdominal surgery: a systematic review and international external validation cohort study
- Author
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/06/2022
- Field of study
Background Stratifying risk of postoperative pulmonary complications after major abdominal surgery allows clinicians to modify risk through targeted interventions and enhanced monitoring. In this study, we aimed to identify and validate prognostic models against a new consensus definition of postoperative pulmonary complications. Methods We did a systematic review and international external validation cohort study. The systematic review was done in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We searched MEDLINE and Embase on March 1, 2020, for articles published in English that reported on risk prediction models for postoperative pulmonary complications following abdominal surgery. External validation of existing models was done within a prospective international cohort study of adult patients (≥18 years) undergoing major abdominal surgery. Data were collected between Jan 1, 2019, and April 30, 2019, in the UK, Ireland, and Australia. Discriminative ability and prognostic accuracy summary statistics were compared between models for the 30-day postoperative pulmonary complication rate as defined by the Standardised Endpoints in Perioperative Medicine Core Outcome Measures in Perioperative and Anaesthetic Care (StEP-COMPAC). Model performance was compared using the area under the receiver operating characteristic curve (AUROCC). Findings In total, we identified 2903 records from our literature search; of which, 2514 (86·6%) unique records were screened, 121 (4·8%) of 2514 full texts were assessed for eligibility, and 29 unique prognostic models were identified. Nine (31·0%) of 29 models had score development reported only, 19 (65·5%) had undergone internal validation, and only four (13·8%) had been externally validated. Data to validate six eligible models were collected in the international external validation cohort study. Data from 11 591 patients were available, with an overall postoperative pulmonary complication rate of 7·8% (n=903). None of the six models showed good discrimination (defined as AUROCC ≥0·70) for identifying postoperative pulmonary complications, with the Assess Respiratory Risk in Surgical Patients in Catalonia score showing the best discrimination (AUROCC 0·700 [95% CI 0·683–0·717]). Interpretation In the pre-COVID-19 pandemic data, variability in the risk of pulmonary complications (StEP-COMPAC definition) following major abdominal surgery was poorly described by existing prognostication tools. To improve surgical safety during the COVID-19 pandemic recovery and beyond, novel risk stratification tools are required. Funding British Journal of Surgery Society
BJS commission on surgery and perioperative care post-COVID-19
- Author
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- M. Deniz Tepe
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- M. E. Kelly
- M. E. van Leerdam
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- N. Ahmed Fieturi
- N. AlAsali
- N. Allopi
- N. Alselaim
- N. Amisi Numbi
- N. Avellaneda
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- N. Chinai
- N. Christou
- N. Cos¸gun Acar
- N. D. A. Bankole
- N. Demartines
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- No. 10 Sá-Marta
- O. A. Castaneda Ramı´rez
- O. A. Minayeva
- O. Al Mukhtar
- O. Arez
- O. Burton
- O. Can Tatar
- O. Eldurssi
- O. Falade
- O. Jagiella-Lodise
- O. M. Pavan Kumar
- O. Medzhidov
- O. Mekinde
- O. Sandli
- O. Santes Jasso
- O. Solo´ rzano Pineda
- O. Wroe Wright
- P. -C. Yang
- P. A. Naess
- P. Akhmedov
- P. Armonis
- P. Boland
- P. Bostro¨ m
- P. Botelho de Alencar Ferreira Cruz
- P. C. Arteaga Asensio
- P. Chandrasinghe
- P. de Dieu Ngo
- P. Etienne
- P. Fruhling
- P. Giannakis
- P. Goffredo
- P. Gwodog
- P. Higgins
- P. Howard
- P. Ignatavicius
- P. Kumar Garg
- P. Lapolla
- P. Lynn
- P. Malkomes
- P. Martinez
- P. Marwaha
- P. Mhango
- P. Miller
- P. Mutambanengwe
- P. Mu¨ ller
- P. Myint
- P. Naidoo
- P. Patel
- P. Patel
- P. Petersson
- P. Plum
- P. Prasad
- P. Sucharitkul
- P. Sutton
- P. Tejedor
- P. Vadim
- P. Vieira
- R. -J. Coelen
- R. A. R. Mora´ n
- R. A. Valdez Gonzalez
- R. Aboulhosn
- R. Aftab
- R. Aguilera
- R. Al-Habsi
- R. Alejandro Miranda Ojeda
- R. Aljubure
- R. Alshammari
- R. Amoah
- R. Arachchige Adithi Himika Randeni
- R. Balachandran
- R. Barnett
- R. Blanco
- R. Boden
- R. Booth
- R. C. Grossman
- R. Clifford
- R. Das
- R. Dave
- R. de la Caridad Espinosa Luis
- R. Dudley
- R. D’alessio
- R. Faulder
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- R. Wilkin
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- S. A. Mohammad
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- V. Vizcaya Rodrı´guez
- Vol. 108
- W. Cambridge
- W. Doherty
- W. Dossou
- W. Ebrahim
- W. English
- W. Ghareeb
- W. J. Wong
- W. Mugla
- W. Nardi
- W. Raby-Smith
- W. Rea
- W. Stupalkowska
- W. Tummers
- W. Xia
- W. Xu
- W. Yang
- W. Zahra
- W. Zegers
- W. ~ Mushiwokufa
- X. Ponte de Sousa
- X. Va´ squez Ojeda
- Y. Akula
- Y. Alimova
- Y. An
- Y. Farid
- Y. Huang
- Y. Jang
- Y. Jiayan
- Y. Kanemitsu
- Y. Medkova
- Y. Singh
- Y. Takamizawa
- Y. Voronovskyi
- Y. W. Smart
- Y. Y. Wang
- Y. Yue
- Z. Ahmed-Bakhsh
- Z. Alqaidoom
- Z. Bentounsi
- Z. Bilgili
- Z. H. Sam
- Z. Jessop
- Z. Li
- Z. MinHua Zheng
- Z. Nowinka
- Z. Varga
- Z. Xu
- Z. Younis Ringshawl
- Z. Zhagniyev
- ~ M. Jose´ Pizarro
- Ł. Masior
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2021
- Field of study
Coronavirus disease 2019 (COVID-19) was declared a pandemic by the WHO on 11 March 2020 and global surgical practice was compromised. This Commission aimed to document and reflect on the changes seen in the surgical environment during the pandemic, by reviewing colleagues' experiences and published evidence
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies
- Author
- Aanensen D. M.
- Abnizova I.
- Abudahab K.
- Acheson E.
- Adams A.
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- Afifi S.
- Aggarwal D.
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
Transmission of SARS-CoV-2 is uncontrolled in many parts of the world; control is compounded in some areas by the higher transmission potential of the B.1.1.7 variant1, which has now been reported in 94 countries. It is unclear whether the response of the virus to vaccines against SARS-CoV-2 on the basis of the prototypic strain will be affected by the mutations found in B.1.1.7. Here we assess the immune responses of individuals after vaccination with the mRNA-based vaccine BNT162b22. We measured neutralizing antibody responses after the first and second immunizations using pseudoviruses that expressed the wild-type spike protein or a mutated spike protein that contained the eight amino acid changes found in the B.1.1.7 variant. The sera from individuals who received the vaccine exhibited a broad range of neutralizing titres against the wild-type pseudoviruses that were modestly reduced against the B.1.1.7 variant. This reduction was also evident in sera from some patients who had recovered from COVID-19. Decreased neutralization of the B.1.1.7 variant was also observed for monoclonal antibodies that target the N-terminal domain (9 out of 10) and the receptor-binding motif (5 out of 31), but not for monoclonal antibodies that recognize the receptor-binding domain that bind outside the receptor-binding motif. Introduction of the mutation that encodes the E484K substitution in the B.1.1.7 background to reflect a newly emerged variant of concern (VOC 202102/02) led to a more-substantial loss of neutralizing activity by vaccine-elicited antibodies and monoclonal antibodies (19 out of 31) compared with the loss of neutralizing activity conferred by the mutations in B.1.1.7 alone. The emergence of the E484K substitution in a B.1.1.7 background represents a threat to the efficacy of the BNT162b2 vaccine